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The biology , function , and biomedical applications of exosomes

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Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

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Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

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Reassessment of exosome composition

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Routes and mechanisms of extracellular vesicle uptake

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Identification and proteomic profiling of exosomes in human urine

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A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

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Biogenesis and secretion of exosomes

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Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

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Tetraspanins in Extracellular Vesicle Formation and Function

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Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

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Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

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Exosomal-like vesicles are present in human blood plasma

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Exosome Theranostics: Biology and Translational Medicine

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Exosomes with Immune Modulatory Features Are Present in Human Breast Milk

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Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

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ExoCarta 2012: database of exosomal proteins, RNA and lipids

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Exfoliation of membrane ecto-enzymes in the form of micro-vesicles

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Exosomes: Therapy delivery tools and biomarkers of diseases

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Using exosomes, naturally-equipped nanocarriers, for drug delivery

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The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis

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Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

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Molecular lipidomics of exosomes released by PC-3 prostate cancer cells

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Body fluid derived exosomes as a novel template for clinical diagnostics

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NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo

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Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection

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CD68/macrosialin: not just a histochemical marker

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Exosome uptake through clathrin-mediated endocytosis and macropinocytosis and mediating miR-21 delivery

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Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: In vitro and in vivo evaluations

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Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins

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Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery

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Exosome–Liposome Hybrid Nanoparticles Deliver CRISPR/Cas9 System in MSCs

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Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer

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Exosome-mediated delivery of siRNA in vitro and in vivo

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Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters

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Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia

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Extracellular vesicles or exosomes? On primacy, precision, and popularity influencing a choice of nomenclature

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Surface Functionalization of Exosomes Using Click Chemistry

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Surface functionalization of exosomes for target-specific delivery and in vivo imaging & tracking: Strategies and significance

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Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression

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Modification of Extracellular Vesicles by Fusion with Liposomes for the Design of Personalized Biogenic Drug Delivery Systems

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Display of GPI‐anchored anti‐EGFR nanobodies on extracellular vesicles promotes tumour cell targeting

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Macrophage-derived exosome-mimetic hybrid vesicles for tumor targeted drug delivery

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Engineered Exosomes With Ischemic Myocardium‐Targeting Peptide for Targeted Therapy in Myocardial Infarction

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Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy

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Exosome-mediated delivery of kartogenin for chondrogenesis of synovial fluid-derived mesenchymal stem cells and cartilage regeneration

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Responsive Exosome Nano-bioconjugates for Synergistic Cancer Therapy

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Exosome-SIRPα, a CD47 blockade increases cancer cell phagocytosis

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Self-assembly of extracellular vesicle-like metal–organic framework nanoparticles for protection and intracellular delivery of biofunctional proteins

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Stabilization of Exosome-targeting Peptides via Engineered Glycosylation

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Interleukin 3- receptor targeted exosomes inhibit in vitro and in vivo Chronic Myelogenous Leukemia cell growth

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RVG-modified exosomes derived from mesenchymal stem cells rescue memory deficits by regulating inflammatory responses in a mouse model of Alzheimer’s disease

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A live cell reporter of exosome secretion and uptake reveals pathfinding behavior of migrating cells

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Reprogramming Exosomes as Nanoscale Controllers of Cellular Immunity

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Quantitative Analysis of Tissue Distribution of the B16BL6-Derived Exosomes Using a Streptavidin-Lactadherin Fusion Protein and Iodine-125-Labeled Biotin Derivative After Intravenous Injection in Mice

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Bioinspired exosome-like therapeutics and delivery nanoplatforms

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Engineered Exosome-Mediated Near-Infrared-II Region V2C Quantum Dot Delivery for Nucleus-Target Low-Temperature Photothermal Therapy

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Engineered exosome-mediated delivery of functionally active miR-26a and its enhanced suppression effect in HepG2 cells

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Proteomic Analysis of Two Types of Exosomes in Human Whole Saliva

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Extracellular vesicles as a platform for membrane‐associated therapeutic protein delivery

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Dendritic Cells Release HLA-B-Associated Transcript-3 Positive Exosomes to Regulate Natural Killer Function

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Aptamer-Conjugated Extracellular Nanovesicles for Targeted Drug Delivery

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Exosomes Engineered to Express a Cardiomyocyte Binding Peptide Demonstrate Improved Cardiac Retention in Vivo

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Engineered Exosomes for Targeted Transfer of siRNA to HER2 Positive Breast Cancer Cells

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Exosome target cell selection and the importance of exosomal tetraspanins: a hypothesis

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Aptamer-Functionalized Exosomes: Elucidating the Cellular Uptake Mechanism and the Potential for Cancer-Targeted Chemotherapy

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Exosomes as Reconfigurable Therapeutic Systems

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Cell‐surface engineering with GPI‐anchored proteins

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Molecular Recognition-Based DNA Nanoassemblies on the Surfaces of Nanosized Exosomes

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Methotrexate-Loaded Extracellular Vesicles Functionalized with Therapeutic and Targeted Peptides for the Treatment of Glioblastoma Multiforme

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Nucleolin-targeted Extracellular Vesicles as a Versatile Platform for Biologics Delivery to Breast Cancer

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Exosome Display technology: Applications to the development of new diagnostics and therapeutics

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Revisiting the road to the discovery of exosomes

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Chimeric peptide engineered exosomes for dual-stage light guided plasma membrane and nucleus targeted photodynamic therapy

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Rapid Detection of Exosomal MicroRNAs Using Virus‐Mimicking Fusogenic Vesicles

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The use of RGD-engineered exosomes for enhanced targeting ability and synergistic therapy toward angiogenesis

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Exosome Targeting of Tumor Antigens Expressed by Cancer Vaccines Can Improve Antigen Immunogenicity and Therapeutic Efficacy

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Cellular Engineering with Membrane Fusogenic Liposomes to Produce Functionalized Extracellular Vesicles

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Virus‐Mimetic Fusogenic Exosomes for Direct Delivery of Integral Membrane Proteins to Target Cell Membranes

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The immunogenicity of dendritic cell-derived exosomes

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Engineered targeting tLyp-1 exosomes as gene therapy vectors for efficient delivery of siRNA into lung cancer cells

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Harnessing Exosomes for the Development of Brain Drug Delivery Systems

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Physiological and pathological impact of exosomes of adipose tissue

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Crystal structure of the conserved domain of the DC lysosomal associated membrane protein: implications for the lysosomal glycocalyx

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Receptor-Ligand Interaction Mediates Targeting of Endothelial Colony Forming Cell-derived Exosomes to the Kidney after Ischemic Injury

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Metabolome of Exosomes: Focus on Vesicles Released by Cancer Cells and Present in Human Body Fluids

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Effects of exosome-mediated delivery of myostatin propeptide on functional recovery of mdx mice

Ran, N., Gao, X., Dong, X., Li, J., Lin, C., Geng, M., & Yin, H. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.119826 · Cited by 100

Lysosome-associated membrane proteins-1 and -2 (LAMP-1 and LAMP-2) assemble via distinct modes

Terasawa, K., Tomabechi, Y., Ikeda, M., Ehara, H., Kukimoto‐Niino, M., Wakiyama, M., Podyma‐Inoue, K. A., Rajapakshe, A. R., Watabe, T., Shirouzu, M., et al. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.09.093 · Cited by 80

CD63-Mediated Antigen Delivery into Extracellular Vesicles via DNA Vaccination Results in Robust CD8+ T Cell Responses

Kanuma, T., Yamamoto, T., Kobiyama, K., Moriishi, E., Masuta, Y., Kusakabe, T., Ozasa, K., Kuroda, E., Jounai, N., & Ishii, K. J. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1600731 · Cited by 72

Rapid Detection of Exosomal MicroRNAs Using Virus‐Mimicking Fusogenic Vesicles

Gao, X., Li, S., Ding, F., Fan, H.-J., Shi, L., Zhu, L., Li, J., Feng, J. C., Zhu, X., & Zhang, C. (2019) · Angewandte Chemie · doi:10.1002/ange.201901997 · Cited by 65

Tumor-specific delivery of KRAS siRNA with iRGD-exosomes efficiently inhibits tumor growth

Zhou, Y., Yuan, Y., Liu, M., Hu, X., Quan, Y., & Chen, X. (2019) · ExRNA · doi:10.1186/s41544-019-0034-9 · Cited by 63

Asymmetric RNA Distribution among Cells and Their Secreted Exosomes: Biomedical Meaning and Considerations on Diagnostic Applications

Ragusa, M., Barbagallo, C., Cirnigliaro, M., Battaglia, R., Brex, D., Caponnetto, A., Barbagallo, D., Pietro, C. D., & Purrello, M. (2017) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2017.00066 · Cited by 56

Big pharma buys into exosomes for drug delivery

Zipkin, M. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0725-7 · Cited by 56

Effects of ATP9A on Extracellular Vesicle Release and Exosomal Lipid Composition

Xu, X. G., Xu, L., Zhang, P., Ouyang, K., Xiao, Y., Xiong, J., Wang, D., Liang, Y., & Duan, L. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8865499 · Cited by 17

The blood–brain barrier: Structure, regulation and drug delivery

Wu, D., Chen, Q., Chen, X., Han, F., Chen, Z., & Wang, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01481-w · Cited by 1,906

Controlled Drug Delivery Systems: Current Status and Future Directions

Adepu, S., & Ramakrishna, S. (2021) · Molecules · doi:10.3390/molecules26195905 · Cited by 1,691

Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment

Huang, Y., Guo, X., Wu, Y., Chen, X., Feng, L., Xie, N., & Shen, G. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01745-z · Cited by 537

Role of tumor microenvironment in cancer progression and therapeutic strategy

Wang, Q., Shao, X., Zhang, Y., Zhu, M., Wang, F. X. C., Mu, J., Li, J., Yao, H., & Chen, K. (2023) · Cancer Medicine · doi:10.1002/cam4.5698 · Cited by 499

Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic applications

Mondal, J., Pillarisetti, S., Junnuthula, V., Saha, M., Hwang, S. R., Park, I.-K., & Lee, Y.-K. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.12.027 · Cited by 416

Engineering Approaches for Exosome Cargo Loading and Targeted Delivery: Biological versus Chemical Perspectives

Ahmed, W., Mushtaq, A., Ali, S., Khan, N., Liang, Y., & Duan, L. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c00856 · Cited by 56

Bioengineering and modification of exosome nanovesicles for targeted drug delivery

Desai, N., Salave, S., & Vora, L. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-29052-7.00008-8 · Cited by 1

Exosomes: Cell-Derived Nanoplatforms for the Delivery of Cancer Therapeutics

Kim, H., Kim, E. H., Kwak, G., Chi, S.-G., Kim, S. H., & Yang, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010014 · Cited by 149

Encapsulation and assessment of therapeutic cargo in engineered exosomes: a systematic review

Chen, Z., Xiong, M., Tian, J., Song, D., Duan, S., & Zhang, L. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02259-6 · Cited by 163

Biology and Therapeutic Potential of Exosomes, Targeted Drug Delivery

Mateos-Ramírez, F. A. G., Hernández‐Ortega, L. D., Gurrola‐Díaz, C. M., Gasca-Lozano, L. E., Sánchez-Orozco, L. V., & Salazar-Montes, A. M. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27188145