Effect of resveratrol and pterostilbene on aging and longevity

The Hallmarks of Aging

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Resveratrol improves health and survival of mice on a high-calorie diet

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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

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Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

Park, S.-J., Ahmad, F., Philp, A., Baar, K., Williams, T., Luo, H., Ke, H., Rehmann, H., Taussig, R., Brown, A. L., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.017 · Cited by 1,349

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

Timmers, S., Konings, E., Bilet, L., Houtkooper, R. H., van de Weijer, T., Goossens, G. H., Hoeks, J., van der Krieken, S., Ryu, D., Kersten, S., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.10.002 · Cited by 1,320

Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

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Calorie restriction, SIRT1 and metabolism: understanding longevity

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Inhibition of Amyloid Fibril Formation by Polyphenols: Structural Similarity and Aromatic Interactions as a Common Inhibition Mechanism

Porat, Y., Abramowitz, A., & Gazit, E. (2006) · Chemical Biology & Drug Design · doi:10.1111/j.1747-0285.2005.00318.x · Cited by 989

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

Miller, R. A., Harrison, D. E., Astle, C. M., Baur, J. A., Boyd, A. R., de Cabo, R., Fernandez, E., Flurkey, K., Javors, M. A., Nelson, J. F., et al. (2011) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glq178 · Cited by 896

Resveratrol Prolongs Lifespan and Retards the Onset of Age-Related Markers in a Short-Lived Vertebrate

Valenzano, D. R., Terzibasi, E., Genade, T., Cattaneo, A., Domenici, L., & Cellerino, A. (2006) · Current Biology · doi:10.1016/j.cub.2005.12.038 · Cited by 784

Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer

Speakman, J. R., Talbot, D. A., Selman, C., Snart, S., McLaren, J. S., Redman, P., Krol, E., Jackson, D. M., Johnson, M. S., & Brand, M. D. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00097.x · Cited by 761

Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications

de la Lastra, C. A., & Villegas, I. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351156 · Cited by 740

Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients

Brasnyó, P., Molnár, G. A., Mohás, M., Markó, L., Laczy, B., Cseh, J., Mikolás, E., Szijártó, I. A., Mérei, Á., Halmai, R., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511000316 · Cited by 678

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

Vingtdeux, V., Giliberto, L., Zhao, H., Chandakkar, P., Wu, Q., Simon, J. E., Janle, E. M., Lobo, J., Ferruzzi, M. G., Davies, P., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.060061 · Cited by 645

High-Dose Resveratrol Supplementation in Obese Men

Poulsen, M. M., Vestergaard, P. F., Clasen, B. F., Radko, Y., Christensen, L. P., Stødkilde-Jørgensen, H., Møller, N., Jessen, N., Pedersen, S. B., & Jørgensen, J. O. L. (2013) · Diabetes · doi:10.2337/db12-0975 · Cited by 455

Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults

Witte, A. V., Kerti, L., Margulies, D. S., & Floel, A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0385-14.2014 · Cited by 455

Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans

Bass, T. M., Weinkove, D., Houthoofd, K., Gems, D., & Partridge, L. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.07.007 · Cited by 435

Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation

Kennedy, D. O., Wightman, E. L., Reay, J. L., Lietz, G., Okello, E. J., Wilde, A., & Haskell, C. F. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28641 · Cited by 415

Sirtuins: The ‘ magnificent seven ’, function, metabolism and longevity

Dali‐Youcef, N., Lagouge, M., Froelich, S., Koehl, C., Schoonjans, K., & Auwerx, J. (2007) · Annals of Medicine · doi:10.1080/07853890701408194 · Cited by 402

Resveratrol Supplementation Does Not Improve Metabolic Function in Nonobese Women with Normal Glucose Tolerance

Yoshino, J., Conte, C., Fontana, L., Mittendorfer, B., Imai, S.-I., Schechtman, K. B., Gu, C., Kunz, I., Fanelli, F. R., Patterson, B. W., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.09.015 · Cited by 380

One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease

Tomé-Carneiro, J., Larrosa, M., Yáñez-Gascón, M. J., Dávalos, A., Gil-Zamorano, J., Gonzálvez, M., García-Almagro, F. J., Ruiz Ros, J. A., Tomás-Barberán, F. A., Espín, J. C., et al. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2013.03.011 · Cited by 378

Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans

Wilson, M. A., Shukitt‐Hale, B., Kalt, W., Ingram, D. K., Joseph, J. A., & Wolkow, C. A. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00192.x · Cited by 374

Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery disease

Magyar, K., Halmosi, R., Palfi, A., Feher, G., Czopf, L., Fulop, A., Battyany, I., Sumegi, B., Toth, K., & Szabados, E. (2012) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-2011-1424 · Cited by 364

Resveratrol and diabetes: from animal to human studies

Szkudelski, T., & Szkudelska, K. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.10.013 · Cited by 354

Resveratrol, obesity and diabetes

Szkudelska, K., & Szkudelski, T. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.02.054 · Cited by 341

A Review of Pterostilbene Antioxidant Activity and Disease Modification

McCormack, D., & McFadden, D. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/575482 · Cited by 337

Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases

Zordoky, B. N. M., Robertson, I. M., & Dyck, J. R. B. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.10.016 · Cited by 335

Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation

Feng, Y., Wang, X.-P., Yang, S.-G., Wang, Y.-J., Zhang, X., Du, X.-T., Sun, X.-X., Zhao, M., Huang, L., & Liu, R.-T. (2009) · NeuroToxicology · doi:10.1016/j.neuro.2009.08.013 · Cited by 295

Calorie restriction and prevention of age‐associated chronic disease

Omodei, D., & Fontana, L. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.015 · Cited by 293

Effect of Antioxidants Supplementation on Aging and Longevity

Sadowska-Bartosz, I., & Bartosz, G. (2014) · BioMed Research International · doi:10.1155/2014/404680 · Cited by 292

Resveratrol Does Not Benefit Patients With Nonalcoholic Fatty Liver Disease

Chachay, V. S., Macdonald, G. A., Martin, J. H., Whitehead, J. P., O'Moore–Sullivan, T. M., Lee, P., Franklin, M., Klein, K., Taylor, P. J., Ferguson, M., et al. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.02.024 · Cited by 289

Polyphenol Stilbenes: Molecular Mechanisms of Defence against Oxidative Stress and Aging-Related Diseases

Reinisalo, M., Kårlund, A., Koskela, A., Kaarniranta, K., & Karjalainen, R. O. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/340520 · Cited by 284

Pilot study of resveratrol in older adults with impaired glucose tolerance

Crandall, J. P., Oram, V., Trandafirescu, G., Reid, M., Kishore, P., Hawkins, M., Cohen, H. W., & Barzilai, N. (2012) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glr235 · Cited by 281

Resveratrol for Alzheimer's disease

Sawda, C., Moussa, C., & Turner, R. S. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13431 · Cited by 276

Dose-Dependency of Resveratrol in Providing Health Benefits

Mukherjee, S., Dudley, J. I., & Das, D. K. (2010) · Dose-Response · doi:10.2203/dose-response.09-015.mukherjee · Cited by 263

Resveratrol in Cardioprotection: A Therapeutic Promise of Alternative Medicine

Das, D. K. (2006) · Molecular Interventions · doi:10.1124/mi.6.1.7 · Cited by 258

Antihyperglycemic Effects of Short Term Resveratrol Supplementation in Type 2 Diabetic Patients

Movahed, A., Nabipour, I., Lieben Louis, X., Thandapilly, S. J., Yu, L., Kalantarhormozi, M., Rekabpour, S. J., & Netticadan, T. (2013) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2013/851267 · Cited by 257

Resveratrol supplementation: Where are we now and where should we go?

Novelle, M. G., Wahl, D., Diéguez, C., Bernier, M., & de Cabo, R. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.01.002 · Cited by 244

ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease

Maher, P., Dargusch, R., Bodai, L., Gerard, P. E., Purcell, J. M., & Marsh, J. L. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddq460 · Cited by 237

Resveratrol alleviates cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasome activation through Sirt1-dependent autophagy induction

He, Q., Li, Z., Wang, Y., Hou, Y., Li, L., & Zhao, J. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.06.029 · Cited by 233

Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease

Chang, J., Rimando, A., Pallas, M., Camins, A., Porquet, D., Reeves, J., Shukitt-Hale, B., Smith, M. A., Joseph, J. A., & Casadesus, G. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.08.015 · Cited by 217

Evaluation of Resveratrol, Green Tea Extract, Curcumin, Oxaloacetic Acid, and Medium-Chain Triglyceride Oil on Life Span of Genetically Heterogeneous Mice

Strong, R., Miller, R. A., Astle, C. M., Baur, J. A., de Cabo, R., Fernandez, E., Guo, W., Javors, M., Kirkland, J. L., Nelson, J. F., et al. (2013) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/gls070 · Cited by 212

Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.04.003 · Cited by 209

Telomere Length Variations in Aging and Age-Related Diseases

Rizvi, S., Raza, S. T., & Mahdi, F. (2015) · Current Aging Science · doi:10.2174/1874609808666150122153151 · Cited by 207

Resveratrol prevents hypertension and cardiac hypertrophy in hypertensive rats and mice

Dolinsky, V. W., Chakrabarti, S., Pereira, T. J., Oka, T., Levasseur, J., Beker, D., Zordoky, B. N., Morton, J. S., Nagendran, J., Lopaschuk, G. D., et al. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.018 · Cited by 206

Resveratrol Improves Motoneuron Function and Extends Survival in SOD1G93A ALS Mice

Mancuso, R., del Valle, J., Modol, L., Martinez, A., Granado-Serrano, A. B., Ramirez-Núñez, O., Pallás, M., Portero-Otin, M., Osta, R., & Navarro, X. (2014) · Neurotherapeutics · doi:10.1007/s13311-013-0253-y · Cited by 206

Resveratrol regulates mitochondrial reactive oxygen species homeostasis through Sirt3 signaling pathway in human vascular endothelial cells

Zhou, X., Chen, M., Zeng, X., Yang, J., Deng, H., Yi, L., & Mi, M.-T. (2014) · Cell Death & Disease · doi:10.1038/cddis.2014.530 · Cited by 206

Resveratrol and related stilbenes: Their anti-aging and anti-angiogenic properties

Kasiotis, K. M., Pratsinis, H., Kletsas, D., & Haroutounian, S. A. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.03.038 · Cited by 205

Anti-Inflammatory and Antioxidant Effects of Resveratrol in Healthy Smokers A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial

Bo, S., Ciccone, G., Castiglione, A., Gambino, R., De Michieli, F., Villois, P., Durazzo, M., Cavallo-Perin, P., & Cassader, M. (2013) · Current Medicinal Chemistry · doi:10.2174/0929867311320100009 · Cited by 202

Epigenetics and Oxidative Stress in Aging

Guillaumet-Adkins, A., Yañez, Y., Peris-Diaz, M. D., Calabria, I., Palanca-Ballester, C., & Sandoval, J. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/9175806 · Cited by 193

Pterostilbene, a New Agonist for the Peroxisome Proliferator-Activated Receptor α-Isoform, Lowers Plasma Lipoproteins and Cholesterol in Hypercholesterolemic Hamsters

Rimando, A. M., Nagmani, R., Feller, D. R., & Yokoyama, W. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0580364 · Cited by 184

Neuroprotective Properties and Mechanisms of Resveratrol in in Vitro and in Vivo Experimental Cerebral Stroke Models

Singh, N., Agrawal, M., & Doré, S. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn400094w · Cited by 183

Pterostilbene: Biomedical applications

Estrela, J. M., Ortega, A., Mena, S., Rodriguez, M. L., & Asensi, M. (2013) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2013.805182 · Cited by 176

Resveratrol-enriched rice attenuates UVB-ROS-induced skin aging via downregulation of inflammatory cascades

Subedi, L., Lee, T. H., Wahedi, H. M., Baek, S.-H., & Kim, S. Y. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8379539 · Cited by 174

Resveratrol: From Basic Science to the Clinic

Cucciolla, V., Borriello, A., Oliva, A., Galletti, P., Zappia, V., & Ragione, F. D. (2007) · Cell Cycle · doi:10.4161/cc.6.20.4815 · Cited by 174

Resveratrol attenuates inflammation and oxidative stress induced by myocardial ischemia-reperfusion injury: role of Nrf2/ARE pathway.

Cheng, L., Jin, Z., Zhao, R., Ren, K., Deng, C., & Yu, S. (2015) · PubMed · Cited by 174

Redox theory of aging: implications for health and disease

Go, Y.-M., & Jones, D. P. (2017) · Clinical Science · doi:10.1042/cs20160897 · Cited by 173

Resveratrol prevents endothelial nitric oxide synthase uncoupling and attenuates development of hypertension in spontaneously hypertensive rats

Bhatt, S. R., Lokhandwala, M. F., & Banday, A. A. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.05.026 · Cited by 169

Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation

Wightman, E. L., Reay, J. L., Haskell, C. F., Williamson, G., Dew, T. P., & Kennedy, D. O. (2014) · British Journal of Nutrition · doi:10.1017/s0007114514000737 · Cited by 168

Calorie restriction and resveratrol in cardiovascular health and disease

Dolinsky, V. W., & Dyck, J. R. B. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.06.010 · Cited by 168

Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection

Toth, P., Tarantini, S., Springo, Z., Tucsek, Z., Gautam, T., Giles, C. B., Wren, J. D., Koller, A., Sonntag, W. E., Csiszar, A., et al. (2015) · Aging Cell · doi:10.1111/acel.12315 · Cited by 163

Oral resveratrol and calcium fructoborate supplementation in subjects with stable angina pectoris: Effects on lipid profiles, inflammation markers, and quality of life

Militaru, C., Donoiu, I., Craciun, A., Scorei, I. D., Bulearca, A. M., & Scorei, R. I. (2013) · Nutrition · doi:10.1016/j.nut.2012.07.006 · Cited by 161

Resveratrol Reverses Remodeling in Hearts with Large, Old Myocardial Infarctions through Enhanced Autophagy-Activating AMP Kinase Pathway

Kanamori, H., Takemura, G., Goto, K., Tsujimoto, A., Ogino, A., Takeyama, T., Kawaguchi, T., Watanabe, T., Morishita, K., Kawasaki, M., et al. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.11.009 · Cited by 157

Resveratrol Prevents Oxidative Stress-Induced Senescence and Proliferative Dysfunction by Activating the AMPK-FOXO3 Cascade in Cultured Primary Human Keratinocytes

Ido, Y., Duranton, A., Lan, F., Weikel, K., Breton, L., & Ruderman, N. B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0115341 · Cited by 148

Effect of pterostilbene on hepatic key enzymes of glucose metabolism in streptozotocin- and nicotinamide-induced diabetic rats

Pari, L., & Satheesh, M. A. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.02.036 · Cited by 142

Nrf2 as a target for prevention of age‐related and diabetic cataracts by against oxidative stress

Liu, X., Hao, J., Xie, T., Malik, T. H., Lu, C., Liu, C., Shu, C., Lu, C., & Zhou, D.-D. (2017) · Aging Cell · doi:10.1111/acel.12645 · Cited by 140

Blueberry extract prolongs lifespan of Drosophila melanogaster

Peng, C., Zuo, Y., Kwan, K. M., Liang, Y., Ma, K. Y., Chan, H. Y. E., Huang, Y., Yu, H., & Chen, Z. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.12.001 · Cited by 131

Resveratrol provides late-phase cardioprotection by means of a nitric oxide- and adenosine-mediated mechanism

Bradamante, S., Barenghi, L., Piccinini, F., Bertelli, A. A. E., de Jonge, R., Beemster, P. W. T., & de Jong, J. W. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01441-9 · Cited by 129

Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans

Collins, J. J., Evason, K. J., & Kornfeld, K. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.06.038 · Cited by 127

Suppression of Oxidative Stress by Resveratrol After Isometric Contractions in Gastrocnemius Muscles of Aged Mice

Ryan, M. J., Jackson, J. R., Hao, Y., Williamson, C. L., Dabkowski, E. R., Hollander, J. M., & Alway, S. E. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq080 · Cited by 127

Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure

Gu, X. S., Wang, Z., Ye, Z., Lei, J., Li, L., Su, D., & Zheng, X. (2014) · Genetics and Molecular Research · doi:10.4238/2014.january.17.17 · Cited by 125

Topical treatment with pterostilbene, a natural phytoalexin, effectively protects hairless mice against UVB radiation-induced skin damage and carcinogenesis

Sirerol, J. A., Feddi, F., Mena, S., Rodríguez, M. L., Sirera, P. S., Aupí, M., Pérez, S., Asensi, M. A., Ortega, Á., & Estrela, J. M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.03.027 · Cited by 124

Blueberry Component Pterostilbene Protects Corneal Epithelial Cells from Inflammation via Anti-oxidative Pathway

Li, J., Deng, R., Hua, X., Zhang, L., Lü, F., Coursey, T. G., Pflugfelder, S. C., & Li, D. (2016) · Scientific Reports · doi:10.1038/srep19408 · Cited by 121

The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction

Rascón, B., Hubbard, B. P., Sinclair, D. A., & Amdam, G. V. (2012) · Aging · doi:10.18632/aging.100474 · Cited by 119

The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster

Wang, C., Wheeler, C. T., Alberico, T., Sun, X., Seeberger, J., Laslo, M., Spangler, E. L., Kern, B., de Cabo, R., & Zou, S. (2011) · AGE · doi:10.1007/s11357-011-9332-3 · Cited by 118

Significance of Resveratrol in Clinical Management of Chronic Diseases

Wahab, A., Gao, K., Jia, C., Zhang, F., Tian, G., Murtaza, G., & Chen, J. (2017) · Molecules · doi:10.3390/molecules22081329 · Cited by 114

The Proteasome and Oxidative Stress in Alzheimer's Disease

Bonet-Costa, V., Pomatto, L. C.-D., & Davies, K. J. A. (2016) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6802 · Cited by 99

Local intra-articular injection of resveratrol delays cartilage degeneration in C57BL/6 mice by inducing autophagy via AMPK/mTOR pathway

Qin, N., Wei, L., Li, W., Yang, W., Cai, L., Qian, Z., & Wu, S. (2017) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2017.06.002 · Cited by 96

SIRT1 activation by pterostilbene attenuates the skeletal muscle oxidative stress injury and mitochondrial dysfunction induced by ischemia reperfusion injury

Cheng, Y., Di, S., Fan, C., Cai, L., Gao, C., Jiang, P., Hu, W., Ma, Z., Jiang, S., Dong, Y., et al. (2016) · APOPTOSIS · doi:10.1007/s10495-016-1258-x · Cited by 95

Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms

Tang, Y., Xu, J., Qu, W., Peng, X., Peng, X., Yang, X., Ying, C., Sun, X., & Hao, L. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.08.008 · Cited by 93

Resveratrol Induces Vascular Smooth Muscle Cell Differentiation through Stimulation of SirT1 and AMPK

Thompson, A. M., Martin, K. A., & Rzucidlo, E. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085495 · Cited by 91

Influence of resveratrol on oxidative stress resistance and life span in Caenorhabditis elegans

Chen, W., Rezaizadehnajafi, L., & Wink, M. (2013) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12023 · Cited by 91

Pterostilbene attenuates lipopolysaccharide-induced learning and memory impairment possibly via inhibiting microglia activation and protecting neuronal injury in mice

Hou, Y., Xie, G., Miao, F.-R., Ding, L., Mou, Y., Wang, L., Su, G., Chen, G., Yang, J., & Wu, C. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.03.015 · Cited by 90

Resveratrol protects adult cardiomyocytes against oxidative stress mediated cell injury

Movahed, A., Yu, L., Thandapilly, S. J., Louis, X. L., & Netticadan, T. (2012) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2012.05.002 · Cited by 85

Pterostilbene protects vascular endothelial cells against oxidized low-density lipoprotein-induced apoptosis in vitro and in vivo

Zhang, L., Zhou, G., Song, W., Tan, X., Guo, Y., Zhou, B., Jing, H., Zhao, S., & Chen, L. (2011) · APOPTOSIS · doi:10.1007/s10495-011-0653-6 · Cited by 84

Pterostilbene inhibits inflammation and ROS production in chondrocytes by activating Nrf2 pathway

Xue, E., Lin, J., Zhang, Y., Sheng, S., Liu, H., Zhou, Y., & Xu, H. (2017) · Oncotarget · doi:10.18632/oncotarget.16716 · Cited by 84

Neuroprotective effect of resveratrol against brain ischemia reperfusion injury in rats entails reduction of DJ-1 protein expression and activation of PI3K/Akt/GSK3b survival pathway

Abdel‐Aleem, G. A., Khaleel, E. F., Mostafa, D. G., & Elberier, L. K. (2016) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2016.1182190 · Cited by 82

Protective effect of Pterostilbene against free radical mediated oxidative damage

Acharya, J. D., & Ghaskadbi, S. (2013) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-13-238 · Cited by 80

Exercise, Nrf2 and Antioxidant Signaling in Cardiac Aging

Narasimhan, M., & Rajasekaran, N. S. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00241 · Cited by 77

Resveratrol Attenuates the Blood-Brain Barrier Dysfunction by Regulation of the MMP-9/TIMP-1 Balance after Cerebral Ischemia Reperfusion in Rats

Wei, H., Wang, S., Zhen, L., Yang, Q., Wu, Z., Lei, X., Lv, J., Xiong, L., & Xue, R. (2014) · Journal of Molecular Neuroscience · doi:10.1007/s12031-014-0441-1 · Cited by 75

Inflammation, genetic background and longevity

Candore, G., Caruso, C., & Colonna‐Romano, G. (2010) · Biogerontology · doi:10.1007/s10522-010-9286-3 · Cited by 73

Pterostilbene Ameliorates Streptozotocin-Induced Diabetes through Enhancing Antioxidant Signaling Pathways Mediated by Nrf2

Bhakkiyalakshmi, E., Dornadula, S., Paulmurugan, R., & Ramkumar, K. M. (2015) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.5b00378 · Cited by 73

Anti-hyperlipidemic and anti-peroxidative role of pterostilbene via Nrf2 signaling in experimental diabetes

Bhakkiyalakshmi, E., Sireesh, D., Sakthivadivel, M., Sivasubramanian, S., Gunasekaran, P., & Ramkumar, K. M. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.02.054 · Cited by 73

Resveratrol attenuates myocardial ischemia/reperfusion injury through up-regulation of vascular endothelial growth factor B

Yang, L., Zhang, Y., Zhu, M., Zhang, Q., Wang, X., Wang, Y., Zhang, J., Li, J., Yang, L., Liu, J., et al. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.09.016 · Cited by 72

Anti-Inflammatory Effect of Resveratrol in Old Mice Liver

Tung, B. T., Rodríguez-Bies, E., Talero, E., Gamero-Estévez, E., Motilva, V., Navas, P., & López-Lluch, G. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.02.004 · Cited by 71 · cited 1×

Role of pterostilbene in attenuating immune mediated devastation of pancreatic beta cells via Nrf2 signaling cascade

Sireesh, D., Munuswamy‐Ramanujam, G., Umapathy, D., Sakthivadivel, M., Sivasubramanian, S., Gunasekaran, P., & Ramkumar, K. M. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.02.015 · Cited by 71

The Inhibitory Effect of Pterostilbene on Inflammatory Responses during the Interaction of 3T3-L1 Adipocytes and RAW 264.7 Macrophages

Hsu, C., Lin, Y.-J., Ho, C., & Yen, G. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf304487v · Cited by 69

Effects of Chronic Calorie Restriction or Dietary Resveratrol Supplementation on Insulin Sensitivity Markers in a Primate, Microcebus murinus

Marchal, J., Blanc, S., Epelbaum, J., Aujard, F., & Pifferi, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034289 · Cited by 69

Resveratrol protects rabbit articular chondrocyte against sodium nitroprusside-induced apoptosis via scavenging ROS

Liang, Q., Wang, X., & Chen, T. (2014) · APOPTOSIS · doi:10.1007/s10495-014-1012-1 · Cited by 69

Pterostilbene alleviates polymicrobial sepsis-induced liver injury: Possible role of SIRT1 signaling

Liu, X., Yang, X., Han, L., Ye, F., Liu, M., Fan, W., Zhang, K., Kong, Y., Zhang, J., Shi, L., et al. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.05.022 · Cited by 69

Nuclear Factor–Erythroid-2–Related Factor 2 in Aging and Lung Fibrosis

Swamy, S., Rajasekaran, N. S., & Thannickal, V. J. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2016.02.022 · Cited by 67

Resveratrol protects CA1 neurons against focal cerebral ischemic reperfusion-induced damage via the ERK-CREB signaling pathway in rats

Li, Z., Fang, F., Wang, Y., & Wang, L. (2016) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2016.04.007 · Cited by 65

Resveratrol ameliorates diet-induced dysregulation of lipid metabolism in zebrafish (Danio rerio)

Ran, G., Li, Y., Lin, L., Yan, Q., Yi, W., Ying, C., Wu, H., & Ye, X. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180865 · Cited by 65

Beyond Diabetes: Does Obesity-Induced Oxidative Stress Drive the Aging Process?

Salmon, A. B. (2016) · Antioxidants · doi:10.3390/antiox5030024 · Cited by 64

Restoration of sirt1 function by pterostilbene attenuates hypoxia-reoxygenation injury in cardiomyocytes

Guo, Y., Zhang, L., Li, F., Hu, C., & Zhang, Z. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.02.052 · Cited by 62

Effects of daily blueberry consumption on circulating biomarkers of oxidative stress, inflammation, and antioxidant defense in postmenopausal women with pre- and stage 1-hypertension: a randomized controlled trial

Johnson, S. A., Feresin, R. G., Navaei, N., Figueroa, A., Elam, M. L., Akhavan, N. S., Hooshmand, S., Pourafshar, S., Payton, M. E., & Arjmandi, B. H. (2016) · Food & Function · doi:10.1039/c6fo01216g · Cited by 61

Modulation of endogenous antioxidant activity by resveratrol and exercise in mouse liver is age dependent

Tung, B. T., Rodríguez-Bies, E., Ballesteros-Simarro, M., Motilva, V., Navas, P., & López-Lluch, G. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt102 · Cited by 60

Neuroprotective effects of pterostilbene against oxidative stress injury: Involvement of nuclear factor erythroid 2-related factor 2 pathway

Wang, B., Liu, H., Yue, L., Li, X., Zhao, L., Yang, X., Wang, X., Yang, Y., & Qu, Y. (2016) · Brain Research · doi:10.1016/j.brainres.2016.04.048 · Cited by 59

Resveratrol attenuates peripheral and brain inflammation and reduces ischemic brain injury in aged female mice

Jeong, S. I., Shin, J. A., Cho, S., Kim, H. W., Lee, J. Y., Kang, J. L., & Park, E. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.04.007 · Cited by 59

Pterostilbene attenuates high glucose-induced oxidative injury in hippocampal neuronal cells by activating nuclear factor erythroid 2-related factor 2

Yang, Y., Fan, C., Wang, B., Ma, Z., Wang, D., Gong, B., Di, S., Jiang, S., Li, Y., Li, T. X., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.01.005 · Cited by 59

The effects of the dietary polyphenol resveratrol on human healthy aging and lifespan

Fernández, A., & Fraga, M. (2011) · Epigenetics · doi:10.4161/epi.6.7.16499 · Cited by 53

Pterostilbene, a natural small-molecular compound, promotes cytoprotective macroautophagy in vascular endothelial cells

Zhang, L., Cui, L., Zhou, G., Jing, H., Guo, Y., & Sun, W. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.06.008 · Cited by 53

Resveratrol Protects Against Pulmonary Arterial Hypertension in Rats via Activation of Silent Information Regulator 1

Yu, L., Tu, Y., Jia, X., Fang, K., Liu, L., Wan, L., Xiang, C., Wang, Y., Sun, X., Liu, T., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000477115 · Cited by 53

Idebenone and Resveratrol Extend Lifespan and Improve Motor Function of HtrA2 Knockout Mice

Gerhardt, E., Gräber, S., Szegő, É. M., Moisoi, N., Martins, L. M., Outeiro, T. F., & Kermer, P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028855 · Cited by 52

Postprandial Inflammatory Responses and Free Fatty Acids in Plasma of Adults Who Consumed a Moderately High-Fat Breakfast with and without Blueberry Powder in a Randomized Placebo-Controlled Trial

Ono‐Moore, K. D., Snodgrass, R. G., Huang, S., Singh, S., Freytag, T. L., Burnett, D. J., Bonnel, E. L., Woodhouse, L. R., Zunino, S. J., Peerson, J. M., et al. (2016) · Journal of Nutrition · doi:10.3945/jn.115.223909 · Cited by 51

Pterostilbene reduces oxidative stress, prevents hypertrophy and preserves systolic function of right ventricle in cor pulmonale model

Lacerda, D. D. S., Türck, P., Seolin, B. G. D. L., Colombo, R., Ortiz, V. D., Bonetto, J. H. P., Carraro, C. C., Bianchi, S. E., Belló‐Klein, A., Bassani, V. L., et al. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13948 · Cited by 51

Resveratrol Attenuates Radiation Damage in Caenorhabditis elegans by Preventing Oxidative Stress

Ye, K., Ji, C., Lu, X., Ni, Y., Gao, C., Xiao-Hui, C. H. E. N., Zhao, Y., Gu, G., & Guo, X. (2010) · Journal of Radiation Research · doi:10.1269/jrr.10009 · Cited by 50

Resveratrol-induced augmentation of telomerase activity delays senescence of endothelial progenitor cells.

Wang, X., Zhu, L., HUANG, J. C., Yin, Y., Kong, X., Rong, Q.-F., Shi, A., & Cao, K. (2011) · PubMed · Cited by 50

Resveratrol relieves ischemia‑induced oxidative stress in the hippocampus by activating SIRT1

Meng, Z., Li, J., Zhao, H., Liu, H., Zhang, G., Wang, L., Hu, H., Li, D., Liu, M., Bi, F.-L., et al. (2015) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2015.2555 · Cited by 49

The effects of calorie restriction on aging: a brief review.

Al-Regaiey, K. (2016) · PubMed · Cited by 49

Neuroprotective actions of pterostilbene on hypoxic‐ischemic brain damage in neonatal rats through upregulation of heme oxygenase‐1

Li, D., Song, T., Yang, L., Wang, X., Yang, C., & Jiang, Y. (2016) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2016.08.005 · Cited by 47

The effect of antioxidant supplementation on bacterial translocation after intestinal ischemia and reperfusion

Tassopoulos, A., Chalkias, A. F., Papalois, A. E., Iacovidou, N. M., & Xanthos, T. T. (2016) · Redox Report · doi:10.1080/13510002.2016.1229893 · Cited by 47

Pterostilbene protects against UVB-induced photo-damage through a phosphatidylinositol-3-kinase-dependent Nrf2/ARE pathway in human keratinocytes

Li, H., Jiang, N., Liang, B., Liu, Q., Zhang, E., Peng, L., Deng, H., Li, R., Li, Z., & Zhu, H. (2017) · Redox Report · doi:10.1080/13510002.2017.1329917 · Cited by 45

Pterostilbene ameliorates insulin sensitivity, glycemic control and oxidative stress in fructose-fed diabetic rats

Kosuru, R., & Singh, S. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.06.015 · Cited by 45

A critical role of nicotinamide phosphoribosyltransferase in human telomerase reverse transcriptase induction by resveratrol in aortic smooth muscle cells

Huang, P., Riordan, S. M., Heruth, D. P., Grigoryev, D. N., Zhang, L. Q., & Ye, S. Q. (2015) · Oncotarget · doi:10.18632/oncotarget.3580 · Cited by 44

Resveratrol prevents pathological but not physiological cardiac hypertrophy

Dolinsky, V. W., Soltys, C.-L. M., Rogan, K. J., Chan, A. Y. M., Nagendran, J., Wang, S., & Dyck, J. R. B. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1220-8 · Cited by 44

Resveratrol protects against peroxynitrite-induced thiol oxidation in blood platelets.

Olas, B., Nowak, P., & Wachowicz, B. (2004) · PubMed · Cited by 44

AMPK as a Pro-longevity Target

Burkewitz, K., Weir, H. J. M., & Mair, W. B. (2016) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-319-43589-3_10 · Cited by 43

Molecular targets of the natural antioxidant pterostilbene: effect on protein kinase C, caspase-3 and apoptosis in human neutrophils in vitro.

Perečko, T., Drábiková, K., Račková, L., Čı́ž, M., Podborská, M., Lojek, A., Harmatha, J., Šmidrkal, J., Nosáľ, R., & Jančinová, V. (2010) · PubMed · Cited by 41

Pterostilbene exerts anti-neuroinflammatory effect on lipopolysaccharide-activated microglia via inhibition of MAPK signalling pathways

Hou, Y., Li, N., Xie, G., Wang, J., Yuan, Q., Jia, C., Liu, X., Li, G., Tang, Y., & Wang, B. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.10.002 · Cited by 41

Resveratrol more effectively than quercetin reduces endothelium degeneration and level of necrosis factor α in patients with coronary artery disease.

Чекаліна, Н. І., Kazakov, Y. M., Tv, M., Vesnina, L. E., & Кайдашев, І. П. (2016) · PubMed · Cited by 39

Caloric Restriction Mimetics Slow Aging of Neuromuscular Synapses and Muscle Fibers

Stockinger, J., Maxwell, N. D., Shapiro, D., de Cabo, R., & Valdez, G. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx023 · Cited by 38

Effects of resveratrol supplementation on risk factors of non-communicable diseases: A meta-analysis of randomized controlled trials

Guo, X., Li, J., Tang, J., & Li, D. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1349076 · Cited by 36

Resveratrol worsens survival in SCID mice with prostate cancer xenografts in a cell‐line specific manner, through paradoxical effects on oncogenic pathways

Klink, J. C., Tewari, A. K., Masko, E. M., Antonelli, J. A., Febbo, P. G., Cohen, P., Dewhirst, M. W., Pizzo, S. V., & Freedland, S. J. (2012) · The Prostate · doi:10.1002/pros.22619 · Cited by 35

The Effect of Resveratrol on the Werner Syndrome RecQ Helicase Gene and Telomerase Activity

Uchiumi, F., Watanabe, T., Hasegawa, S., Hoshi, T., Higami, Y., & Tanuma, S.-I. (2011) · Current Aging Science · doi:10.2174/1874609811104010001 · Cited by 33

Resveratrol-Loaded Nanoparticles Reduce Oxidative Stress Induced by Radiation or Amyloid- in Transgenic Caenorhabditis elegans

Yin, H., Jin, S., Xu, H., et al. (2014) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2014.1897 · Cited by 32

Resveratrol Cardioprotection Against Myocardial Ischemia/Reperfusion Injury Involves Upregulation of Adiponectin Levels and Multimerization in Type 2 Diabetic Mice

Yang, Q., Wang, H., Liu, Y., Gao, C., Sun, L., & Tao, L. (2016) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000417 · Cited by 31

Protective Effects of Pterostilbene Against Myocardial Ischemia/Reperfusion Injury in Rats

Wu, M., Lu, S., Zhong, J., Huang, K., & Zhang, S. (2017) · Inflammation · doi:10.1007/s10753-016-0504-2 · Cited by 31

AMPK Function in Aging Process

Ruiz, R., Pérez-Villegas, E. M., & Carrión, Á. M. (2016) · Current Drug Targets · doi:10.2174/1389450116666151102095825 · Cited by 27

Pterostilbene mediates neuroprotection against oxidative toxicity via oestrogen receptor α signalling pathways

Song, Z., Han, S., Pan, X., Gong, Y., & Wang, Μ. (2015) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12360 · Cited by 26

Calorie restriction-induced changes in the secretome of human adipocytes, comparison with resveratrol-induced secretome effects

Renes, J., Rosenow, A., Roumans, N. J. T., Noben, J., & Mariman, E. C. M. (2014) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2014.04.023 · Cited by 26

Suppression of Nitric Oxide Production and Cardiovascular Risk Factors in Healthy Seniors and Hypercholesterolemic Subjects by a Combination of Polyphenols and Vitamins

Qureshi, A. A., Khan, D. A., & Mahjabeen, W. (2012) · Journal of Clinical & Experimental Cardiology · doi:10.4172/2155-9880.s5-008 · Cited by 26

Natural polyphenols based new therapeutic avenues for advanced biomedical applications

Agrawal, M. (2015) · Drug Metabolism Reviews · doi:10.3109/03602532.2015.1102933 · Cited by 25

Resveratrol via activation of AMPK lowers blood pressure in DOCA-salt hypertensive mice

Sun, G., Li, Y., Du, B., & Meng, Y. (2015) · Clinical and Experimental Hypertension · doi:10.3109/10641963.2015.1036060 · Cited by 23

Resveratrol and food effects on lifespan and reproduction in the model crustacean Daphnia

Kim, E., Ansell, C. M., & Dudycha, J. L. (2013) · Journal of Experimental Zoology Part A Ecological Genetics and Physiology · doi:10.1002/jez.1836 · Cited by 23

Stress in biology and medicine, role in aging

Robert, L., & Labat‐Robert, J. (2015) · Pathologie Biologie · doi:10.1016/j.patbio.2015.07.008 · Cited by 18

Deciphering hallmark processes of aging from interaction networks

Smita, S., Lange, F., Wolkenhauer, O., & Köhling, R. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.07.017 · Cited by 15

Aging and age‐related diseases: from mechanisms to therapeutic strategies

Li, Z., Zhang, Z., Ren, Y., Wang, Y., Fang, J., Yue, H., Ma, S., & Guan, F. (2021) · Biogerontology · doi:10.1007/s10522-021-09910-5 · Cited by 640

Beneficial Role of Phytochemicals on Oxidative Stress and Age-Related Diseases

Forni, C., Facchiano, F., Bartoli, M., Pieretti, S., Facchiano, A., D’Arcangelo, D., Norelli, S., Valle, G., Nisini, R., Beninati, S., et al. (2019) · BioMed Research International · doi:10.1155/2019/8748253 · Cited by 513

Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases

(2018) · International Review of Cell and Molecular Biology · doi:10.1016/bs.ircmb.2018.05.006 · Cited by 455

Neuroprotective Mechanisms of Resveratrol in Alzheimer’s Disease: Role of SIRT1

Gomes, B. A. Q., Silva, J. P. B., Romeiro, C. F. R., dos Santos, S. M., Rodrigues, C. A., Gonçalves, P. R., Sakai, J. T., Mendes, P. F. S., Varela, E. L. P., & Monteiro, M. C. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8152373 · Cited by 403

Effects and Mechanisms of Resveratrol on Aging and Age‐Related Diseases

Zhou, D.-D., Luo, M., Huang, S.-Y., Saimaiti, A., Shang, A., Gan, R.-Y., & Li, H.-B. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9932218 · Cited by 363