Desire and dread from the nucleus accumbens: cortical glutamate and subcortical GABA differentially generate motivation and hedonic impact in the rat.

Faure, Alexis; Richard, Jocelyn M.; Berridge, Kent C.

doi:10.1371/journal.pone.0011223

Cited by 114Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Desire and dread from the nucleus accumbens: cortical glutamate and subcortical GABA differentially generate motivation and hedonic impact in the rat.

Open access

Faure, Alexis, Richard, Jocelyn M., Berridge, Kent C.·2010·PLoS ONE

DOI 10.1371/journal.pone.0011223PMC PMC2887893

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: GABAergic signals to the nucleus accumbens (NAc) shell arise from predominantly subcortical sources whereas glutamatergic signals arise mainly from cortical-related sources. Here we contrasted GABAergic and glutamatergic generation of hedonics versus motivation processes, as a proxy for comparing subcortical and cortical controls of emotion. Local disruptions of either signals in medial shell of NAc generate intense motivated behaviors corresponding to desire and/or dread, along a rostrocaudal gradient. GABA or glutamate disruptions in rostral shell generate appetitive motivation whereas disruptions in caudal shell elicit fearful motivation. However, GABA and glutamate signals in NAc differ in important ways, despite the similarity of their rostrocaudal motivation gradients. METHODOLOGY/PRINCIPAL FINDINGS: Microinjections of a GABA(A) agonist (muscimol), or of a glutamate AMPA antagonist (DNQX) in medial shell of rats were assessed for generation of hedonic "liking" or "disliking" by measuring orofacial affective reactions to sucrose-quinine taste. Motivation generation was independently assessed measuring effects on eating versus natural defensive behaviors. For GABAergic microinjections, we found that the desire-dread motivation gradient was mirrored by an equivalent hedonic gradient that amplified affective taste "liking" (at rostral sites) versus "disliking" (at caudal sites). However, manipulation of glutamatergic signals completely failed to alter pleasure-displeasure reactions to sensory hedonic impact, despite producing a strong rostrocaudal gradient of motivation. CONCLUSIONS/SIGNIFICANCE: We conclude that the nucleus accumbens contains two functional affective keyboards for amino-acid signals: a motivation-generating keyboard and a hedonic-generating keyboard. Corticolimbic glutamate signals and subcortical GABA signals equivalently engage the motivation keyboard to generate desire and-or dread. Only subcortical GABA signals additionally engage the hedonic keyboard to amplify affective "liking" and "disliking" reactions. We thus suggest that top-down cortical glutamate signals powerfully regulate motivation components, but are relatively unable to penetrate core hedonic components of emotion. That may carry implications of limits to therapeutic regulation of pathological emotions.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1371/journal.pone.0011223

Cites

81 of 81 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Neural mechanisms that generate 'disgust' and 'fear' reactions are mostly distinct, though they do partly overlap in the posterior shell of nucleus accumbens.
“However, neural mechanisms that generate ‘disgust’ and ‘fear’ reactions are mostly distinct, though they do partly overlap in the posterior shell of nucleus accumbens (Faure et al., 2010; Maren et al., 2013; Ho and Berridge, 2014; Perusini and Fanselow, 2015; Paré and Quirk, 2017).”
From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Faure et al., 2010
In this GABA-related mode, the normally 'liked' taste of sucrose instead elicits 'disgust' gapes and headshakes from rats, as though the taste were bitter quinine.
“In this GABA-related mode, the normally ‘liked’ taste of sucrose instead elicits ‘disgust’ gapes and headshakes from rats, as though the taste were bitter quinine.”
From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Faure et al., 2010
Animal brain-manipulation studies show one interesting overlap in neural generators for intense 'disgust' and 'fear' reactions in nucleus accumbens, involving a shift in neural mode of function at the same brain location.
“Yet our animal brain-manipulation studies show one interesting overlap in neural generators for intense ‘disgust’ and ‘fear’ reactions in nucleus accumbens, involving a shift in neural mode of function at the same brain location.”
From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Faure et al., 2010
This 'disgust-plus-fear' mode is produced when the posterior shell zone receives microinjections of a drug that activates GABA receptors, such as muscimol.
“This ‘disgust-plus-fear’ mode is produced when the posterior shell zone receives microinjections of a drug that activates GABA receptors, such as muscimol (Faure et al., 2010; Ho and Berridge, 2014).”
From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Faure et al., 2010
The posterior portion of the medial shell has two 'fear' generating neurochemical modes (glutamate AMPA receptor blockade versus GABA receptor activation), and only the GABA mode also generates excessive 'disgust'.
“The posterior portion of its medial shell has two ‘fear’ generating neurochemical modes (glutamate AMPA receptor blockade versus GABA receptor activation), and only the GABA mode also generates excessive ‘disgust’.”
From Evolving Concepts of Emotion and Motivation (2018) · cites this paper as Faure et al., 2010

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Core affect and the psychological construction of emotion.
Russell, J. A. (2003) · Psychological Review · doi:10.1037/0033-295x.110.1.145 · Cited by 6,113 · see citing works
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,497 · see citing works
Psychosis as a state of aberrant salience: a framework linking biology, phenomenology and pharmacology in schizophrenia
Kapur, S. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.1.13 · Cited by 2,813 · see citing works
The Neural Basis of Addiction: A Pathology of Motivation and Choice
Kalivas, P. W., & Volkow, N. D. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.8.1403 · Cited by 2,757 · see citing works
The Dopamine Hypothesis of Schizophrenia: Version III--The Final Common Pathway
Howes, O. D., & Kapur, S. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp006 · Cited by 2,693 · see citing works
The human orbitofrontal cortex: linking reward to hedonic experience
Kringelbach, M. L. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1747 · Cited by 2,180 · see citing works
Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex
Cardinal, R. N., Parkinson, J. A., Hall, J., & Everitt, B. J. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00007-6 · Cited by 2,129 · see citing works
Schizophrenia
van Os, J., & Kapur, S. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60995-8 · Cited by 1,971 · see citing works
The experience of emotion
Barrett, L. F., Mesquita, B., Ochsner, K. N., & Gross, J. J. (2007) · Annual Review of Psychology · doi:10.1146/annurev.psych.58.110405.085709 · Cited by 1,425 · see citing works
The glutamate homeostasis hypothesis of addiction
Kalivas, P. W. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2515 · Cited by 1,350 · see citing works
Affective neuroscience of pleasure: reward in humans and animals
Berridge, K. C., & Kringelbach, M. L. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1099-6 · Cited by 1,254 · see citing works
Self-citation
Neural correlates of conscious self-regulation of emotion
Beauregard, M., Lévesque, J., & Bourgouin, P. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-j0001.2001 · Cited by 1,033 · see citing works
Cortico-Basal Ganglia Reward Network: Microcircuitry
Sesack, S. R., & Grace, A. A. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.93 · Cited by 985 · see citing works
Glutamate and Schizophrenia: Beyond the Dopamine Hypothesis
Coyle, J. T. (2006) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-006-9062-8 · Cited by 917 · see citing works
Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental area
Sesack, S. R., & Pickel, V. M. (1992) · Journal of Comparative Neurology · doi:10.1002/cne.903200202 · Cited by 820 · see citing works
The nucleus accumbens as a complex of functionally distinct neuronal ensembles: An integration of behavioural, electrophysiological and anatomical data
Pennartz, C. M. A., Groenewegen, H. J., & LOPESDASILVA, F. (1994) · Progress in Neurobiology · doi:10.1016/0301-0082(94)90025-6 · Cited by 802 · see citing works
Intra-Accumbens Amphetamine Increases the Conditioned Incentive Salience of Sucrose Reward: Enhancement of Reward “Wanting” without Enhanced “Liking” or Response Reinforcement
Wyvell, C. L., & Berridge, K. C. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-21-08122.2000 · Cited by 764 · cited 1× · see citing works
“It may be noteworthy that dopamine in NAc, like glutamate AMPA disruption, fails to enhance ‘liking’ reactions to sensory pleasure even when it elevates ‘wanting’, suggesting a functional similarity between ionotropic glutamate and dopamine actions in NAc [54,55].”
BackgroundSelf-citation
Measuring hedonic impact in animals and infants: microstructure of affective taste reactivity patterns
Berridge, K. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00072-x · Cited by 721 · see citing works
Self-citation
Pleasures of the brain
Berridge, K. C. (2003) · Brain and Cognition · doi:10.1016/s0278-2626(03)00014-9 · Cited by 694 · see citing works
Self-citation
Unveiling the Functions of Presynaptic Metabotropic Glutamate Receptors in the Central Nervous System
Schoepp, D. D. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29296-x · Cited by 693 · see citing works
Hedonic Hot Spot in Nucleus Accumbens Shell: Where Do μ-Opioids Cause Increased Hedonic Impact of Sweetness?
Peciña, S., & Berridge, K. C. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2329-05.2005 · Cited by 671 · see citing works
Self-citation
The Brain, Appetite, and Obesity
Berthoud, H., & Morrison, C. D. (2007) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.103006.093551 · Cited by 661 · see citing works
Ventral pallidum roles in reward and motivation
Smith, K. S., Tindell, A. J., Aldridge, J. W., & Berridge, K. C. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.038 · Cited by 548 · see citing works
Self-citation
Opioid limbic circuit for reward: interaction between hedonic hotspots of nucleus accumbens and ventral pallidum
Smith, K. S., & Berridge, K. C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4205-06.2007 · Cited by 450 · see citing works
Self-citation
Well–being and affective style: neural substrates and biobehavioural correlates
Davidson, R. J. (2004) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2004.1510 · Cited by 446 · cited 1× · see citing works
“This feature might also conceivably set limits on the range of emotional processes that can be effectively adjusted by cognitive therapies that recruit top-down circuits [45,46,47,48,49,50,51,52].”
Background
Positive and negative motivation in nucleus accumbens shell: bivalent rostrocaudal gradients for GABA-elicited eating, taste “liking”/“disliking” reactions, place preference/avoidance, and fear
Reynolds, S. M., & Berridge, K. C. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07308.2002 · Cited by 403 · see citing works
Self-citation
The Ventral Pallidum and Hedonic Reward: Neurochemical Maps of Sucrose “Liking” and Food Intake
Smith, K. S., & Berridge, K. C. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1902-05.2005 · Cited by 391 · see citing works
Self-citation
The anterior cingulate gyrus and the mechanism of self-regulation
POSNER, M. I., ROTHBART, M. K., SHEESE, B. E., & TANG, Y. (2007) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.7.4.391 · Cited by 385 · see citing works
Endocannabinoid Hedonic Hotspot for Sensory Pleasure: Anandamide in Nucleus Accumbens Shell Enhances ‘Liking’ of a Sweet Reward
Mahler, S. V., Smith, K. S., & Berridge, K. C. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301376 · Cited by 377 · see citing works
Self-citation
The Structure of Emotion: Evidence From Neuroimaging Studies
Barrett, L. F., & Wager, T. D. (2006) · Current Directions in Psychological Science · doi:10.1111/j.0963-7214.2006.00411.x · Cited by 366 · see citing works
Intrinsic GABAergic neurons in the rat central extended amygdala
Sun, N., & Cassell, M. D. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903300308 · Cited by 351 · see citing works
Glutamate systems in cocaine addiction
Kalivas, P. W. (2003) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2003.11.002 · Cited by 349 · see citing works
Evidence of a Functional Relationship between the Nucleus Accumbens Shell and Lateral Hypothalamus Subserving the Control of Feeding Behavior
Stratford, T. R., & Kelley, A. E. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-24-11040.1999 · Cited by 316 · see citing works
Glutamatergic signaling by mesolimbic dopamine neurons in the nucleus accumbens
Tecuapetla, F., Patel, J. C., Xenias, H., English, D., Tadros, I., Shah, F., Berlin, J., Deisseroth, K., Rice, M. E., Tepper, J. M., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0265-10.2010 · Cited by 310 · see citing works
Comparison of IPSCs Evoked by Spiny and Fast-Spiking Neurons in the Neostriatum
Koós, T. Z., Tepper, J. M., & Wilson, C. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2163-04.2004 · Cited by 309 · see citing works
Animal vocal communication a new approach
Owings, D. H., & Morton, E. S. (1998) · Cited by 301 · see citing works
Fear and Feeding in the Nucleus Accumbens Shell: Rostrocaudal Segregation of GABA-Elicited Defensive Behavior Versus Eating Behavior
Reynolds, S. M., & Berridge, K. C. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03261.2001 · Cited by 281 · see citing works
Self-citation
Nucleus accumbens opioid, GABAergic, and dopaminergic modulation of palatable food motivation: Contrasting effects revealed by a progressive ratio study in the rat.
Zhang, M., Balmadrid, C., & Kelley, A. E. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.2.202 · Cited by 268 · see citing works
Emotional environments retune the valence of appetitive versus fearful functions in nucleus accumbens.
Reynolds, S. M., & Berridge, K. C. (2008) · Nature Neuroscience · doi:10.1038/nn2061 · Cited by 244 · see citing works
Self-citation
Animal Vocal Communication
Owings, D. H., & Morton, E. S. (1998) · Cambridge University Press eBooks · doi:10.1017/cbo9781139167901 · Cited by 229 · see citing works
Which cue to "want?" Central amygdala opioid activation enhances and focuses incentive salience on a prepotent reward cue
Mahler, S. V., & Berridge, K. C. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3875-08.2009 · Cited by 223 · see citing works
Self-citation
Emotions and Feelings
Damásio, A. R. (2004) · Cambridge University Press eBooks · doi:10.1017/cbo9780511806582.004 · Cited by 223 · see citing works
Where does damage lead to enhanced food aversion: the ventral pallidum/substantia innominata or lateral hypothalamus?
Cromwell, H. C., & Berridge, K. C. (1993) · Brain Research · doi:10.1016/0006-8993(93)90053-p · Cited by 220 · see citing works
Self-citation
The Synaptic Framework for Chemical Signaling in Nucleus Accumbens
Meredith, G. E. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09266.x · Cited by 215 · see citing works
The structural basis for mapping behavior onto the ventral striatum and its subdivisions
Meredith, G. E., Baldo, B. A., Andrezjewski, M. E., & Kelley, A. E. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0175-3 · Cited by 202 · see citing works
Individual Differences in the Effects of Perceived Controllability on Pain Perception: Critical Role of the Prefrontal Cortex
Salomons, T. V., Johnstone, T., Backonja, M.-M., Shackman, A. J., & Davidson, R. J. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2007.19.6.993 · Cited by 195 · see citing works
Mesolimbic dopamine in desire and dread: enabling motivation to be generated by localized glutamate disruptions in nucleus accumbens
Faure, A., Reynolds, S. M., Richard, J. M., & Berridge, K. C. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4961-07.2008 · Cited by 193 · see citing works
Self-citation
NMDA/AMPA Ratio Impacts State Transitions and Entrainment to Oscillations in a Computational Model of the Nucleus Accumbens Medium Spiny Projection Neuron
Wolf, J. A., Moyer, J. T., Lazarewicz, M. T., Contreras, D., Benoit‐Marand, M., O’Donnell, P., & Finkel, L. H. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2220-05.2005 · Cited by 192 · see citing works
Chapter 1 The cellular framework for chemical signalling in the nucleus accumbens
Meredith, G. E., Pennartz, C. M. A., & Groenewegen, H. J. (1993) · Progress in brain research · doi:10.1016/s0079-6123(08)61335-7 · Cited by 189 · see citing works
Insight into the function of Group I and Group II metabotropic glutamate (mGlu) receptors: behavioural characterization and implications for the treatment of CNS disorders
Spooren, W. P. J. M., Ballard, T. M., Gasparini, F., Amalric, M., Mutel, V., & Schreiber, R. (2003) · Behavioural Pharmacology · doi:10.1097/01.fbp.0000081783.35927.8f · Cited by 177 · see citing works
Glutamate motivational ensembles in nucleus accumbens: rostrocaudal shell gradients of fear and feeding
Reynolds, S. M., & Berridge, K. C. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02642.x · Cited by 163 · see citing works
Self-citation
GABAA receptors: structure and function in the basal ganglia
Goetz, T., Arslan, A., Wisden, W., & Wulff, P. (2007) · Progress in brain research · doi:10.1016/s0079-6123(06)60003-4 · Cited by 149 · see citing works
Pimozide Does Not Shift Palatability: Separation of Anhedonia from Sensorimotor Suppression by Taste Reactivity
Peciña, S. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00044-0 · Cited by 148 · see citing works
The Relationships Among Cognition, Motivation, and Emotion in Schizophrenia: How Much and How Little We Know
Barch, D. M. (2005) · Schizophrenia Bulletin · doi:10.1093/schbul/sbi040 · Cited by 144 · see citing works
Specific changes in food intake elicited by blockade or activation of glutamate receptors in the nucleus accumbens shell
Stratford, T. R., Swanson, C. J., & Kelley, A. E. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00140-x · Cited by 137 · see citing works
Neural Response to Emotional Salience in Schizophrenia
Taylor, S. F., Phan, K. L., Britton, J. C., & Liberzon, I. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300679 · Cited by 136 · see citing works
The evolving theory of basal forebrain functional—anatomical ‘macrosystems’
Zahm, D. S. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.06.003 · Cited by 128 · see citing works
Relative left frontal activation to appetitive stimuli: Considering the role of individual differences
Gable, P. A., & Harmon‐Jones, E. (2007) · Psychophysiology · doi:10.1111/j.1469-8986.2007.00627.x · Cited by 126 · see citing works
Hedonic Hotspots: Generating Sensory Pleasure in the Brain
Smith, K. S., Mahler, S. V., Peciña, S., & Berridge, K. C. (2009) · Oxford University Press eBooks · doi:10.1093/oso/9780195331028.003.0003 · Cited by 117 · see citing works
Self-citation
A topographically organized gamma‐aminobutyric acid projection from the ventral pallidum to the nucleus accumbens in the rat
Churchill, L., & Kalivas, P. W. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903450408 · Cited by 110 · see citing works
Functional Repression of cAMP Response Element in 6-Hydroxydopamine-treated Neuronal Cells*
Chalovich, E. M., Zhu, J.-H., Caltagarone, J., Bowser, R., & Chu, C. T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602632200 · Cited by 108 · see citing works
Neurochemical modulation of ingestive behavior in the ventral pallidum
Shimura, T., Imaoka, H., & Yamamoto, T. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04689.x · Cited by 102 · see citing works
Anatomy of the soul as reflected in the cerebral hemispheres: Neural circuits underlying voluntary control of basic motivated behaviors
Swanson, L. W. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20733 · Cited by 98 · see citing works
Evidence for the preferential localization of Glutamate Receptor-1 subunits of AMPA receptors to the dendritic spines of medium spiny neurons in rat striatum
Chen, Q., Veenman, L. S., Knopp, K. L., Yan, Z., Medina, L. M., Song, W., Surmeier, D. J., & Reiner, A. J. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00452-1 · Cited by 86 · see citing works
RAT DEFENSIVE BEHAVIOR: BURYING NOXIOUS FOOD1
Wilkie, D. M., MacLennan, A. J., & Pinel, J. P. J. (1979) · Journal of the Experimental Analysis of Behavior · doi:10.1901/jeab.1979.31-299 · Cited by 82 · see citing works
Feelings and Emotions: The Amsterdam Symposium
(2004) · doi:10.1017/cbo9780511806582 · Cited by 79 · see citing works
The Hedonic Brain: A Functional Neuroanatomy of Human Pleasure
Kringelbach, M. L. (2009) · Oxford University Press eBooks · doi:10.1093/oso/9780195331028.003.0014 · Cited by 79 · see citing works
Critical Role of the Prefrontal Cortex in the Regulation of Hippocampus–Accumbens Information Flow
Belujon, P., & Grace, A. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2200-08.2008 · Cited by 78 · see citing works
Hippocampal and amygdaloid interactions in the nucleus accumbens
Groenewegen, H. J., Mulder, A. B., Beijer, A. V. J., Wright, C. I., Lopes, F. H. D. S., & Pennartz, C. M. A. (1999) · Psychobiology · doi:10.3758/bf03332111 · Cited by 69 · see citing works
Modulation of striatal neuronal activity by glutamate and GABA: iontophoresis in awake, unrestrained rats
Kiyatkin, E. A., & Rebec, G. V. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01093-8 · Cited by 67 · see citing works
Hippocampal fibers make synaptic contacts with glutamate decar☐ylase-immunoreactive neurons in the rat nucleus accumbens
Meredith, G. E., Wouterlood, F. G., & Pattiselanno, A. (1990) · Brain Research · doi:10.1016/0006-8993(90)90476-r · Cited by 66 · see citing works
Ensemble coding in the nucleus accumbens
O’Donnell, P. (1999) · Psychobiology · doi:10.3758/bf03332113 · Cited by 58 · see citing works
Hyperphagia induced by GABAA receptor-mediated inhibition of the nucleus accumbens shell: Dependence on intact neural output from the central amygdaloid region.
Baldo, B. A., Alsene, K. M., Negrón, A., & Kelley, A. E. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.5.1195 · Cited by 41 · see citing works
Gaba and the Basal Ganglia - From Molecules to Systems
(2007) · Progress in brain research · doi:10.1016/s0079-6123(06)x6000-4 · Cited by 25 · see citing works
Advancing from the ventral striatum to the extended amygdala : implications for neuropsychiatry and drug abuse : in honor of Lennart Heimer
McGinty, J. F. (1999) · Cited by 24 · see citing works
The Pleasure Center
Kringelbach, M. L. (2008) · doi:10.1093/oso/9780195322859.001.0001 · Cited by 20 · see citing works
Electrophysiological Characterization of AMPA and NMDA Receptors in Rat Dorsal Striatum
Jeun, S. H., Cho, H. S., Kim, K., Li, Q. Z., & Sung, K.-W. (2009) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2009.13.3.209 · Cited by 17 · see citing works
Synaptic Responses of Neurons Controlling the Parotid and von Ebner Salivary Glands in Rats to Stimulation of the Solitary Nucleus and Tract
Suwabe, T., Fukami, H., & Bradley, R. M. (2008) · Journal of Neurophysiology · doi:10.1152/jn.01115.2007 · Cited by 13 · see citing works
Repetitive activation of postsynaptic GABAA receptors by rapid, focal agonist application onto intact rat striatal neurones in vitro
Behrends, J. C., Lambert, J. D. C., & Jensen, K. (2002) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-001-0740-6 · Cited by 10 · see citing works
Synaptic Organization of the Amygdalar Input to the Nucleus Accumbens in the Rat
Johnson, L. R., Aylward, R. L. M., & Totterdell, S. (1994) · Advances in behavioral biology · doi:10.1007/978-1-4613-0485-2_10 · Cited by 8 · see citing works

Flagged first, then by citations

Sorted by citations

Pleasure Systems in the Brain
Berridge, K. C., & Kringelbach, M. L. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.018 · Cited by 1,730 · see citing works
Self-citation
The neurobiology of anhedonia and other reward-related deficits
Der-Avakian, A., & Markou, A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.005 · Cited by 1,130 · see citing works
The Nucleus Accumbens: An Interface Between Cognition, Emotion, and Action
Floresco, S. B. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010213-115159 · Cited by 938 · see citing works
Disentangling the Roles of Approach, Activation and Valence in Instrumental and Pavlovian Responding
Huys, Q. J. M., Cools, R., Gölzer, M., Friedel, E., Heinz, A., Dolan, R. J., & Dayan, P. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002028 · Cited by 415 · see citing works
“Liking” and “wanting” in eating and food reward: Brain mechanisms and clinical implications
Morales, I., & Berridge, K. C. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113152 · Cited by 346 · see citing works
Self-citation
Lateral hypothalamus, nucleus accumbens, and ventral pallidum roles in eating and hunger: interactions between homeostatic and reward circuitry
Castro, D. C., Cole, S. L., & Berridge, K. C. (2015) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00090 · Cited by 333 · see citing works
Self-citation
Facial expressions of emotion states and their neuronal correlates in mice
Dolensek, N., Gehrlach, D. A., Klein, A. S., & Gogolla, N. (2020) · Science · doi:10.1126/science.aaz9468 · Cited by 327 · see citing works
Accumbal D1R Neurons Projecting to Lateral Hypothalamus Authorize Feeding
O’Connor, E. C., Kremer, Y., Lefort, S., Harada, M., Pascoli, V., Rohner, C., & Lüscher, C. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.038 · Cited by 308 · see citing works
Evolving Concepts of Emotion and Motivation
Berridge, K. C. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.01647 · Cited by 273 · see citing works
Self-citation
Dopamine or opioid stimulation of nucleus accumbens similarly amplify cue‐triggered ‘wanting’ for reward: entire core and medial shell mapped as substrates for <scp>PIT</scp> enhancement
Peciña, S., & Berridge, K. C. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12174 · Cited by 216 · see citing works
Self-citation
Affective valence in the brain: modules or modes?
Berridge, K. C. (2019) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0122-8 · Cited by 183 · see citing works
Self-citation
Mapping brain circuits of reward and motivation: In the footsteps of Ann Kelley
Richard, J. M., Castro, D. C., DiFeliceantonio, A. G., Robinson, M. J. F., & Berridge, K. C. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.008 · Cited by 175 · see citing works
Self-citation
Serotonin and decision making processes
Homberg, J. R. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.06.001 · Cited by 167 · see citing works
Anhedonia as a central factor in depression: Neural mechanisms revealed from preclinical to clinical evidence
Wang, S., Leri, F., & Rizvi, S. J. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110289 · Cited by 164 · see citing works
Battery-free, lightweight, injectable microsystem for in vivo wireless pharmacology and optogenetics
Zhang, Y., Castro, D. C., Han, Y., Wu, Y., Guo, H., Weng, Z., Xue, Y., Ausra, J., Wang, X. S., Li, R., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1909850116 · Cited by 158 · see citing works
Advances in the neurobiological bases for food ‘liking’ versus ‘wanting’
Castro, D. C., & Berridge, K. C. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.05.022 · Cited by 160 · see citing works
Self-citation
Current perspectives on incentive salience and applications to clinical disorders
Olney, J. J., Warlow, S. M., Naffziger, E. E., & Berridge, K. C. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2018.01.007 · Cited by 157 · see citing works
Self-citation
A food predictive cue must be attributed with incentive salience for it to induce c-fos mRNA expression in cortico-striatal-thalamic brain regions
Flagel, S. B., Cameron, C., Pickup, K. N., Watson, S. J., Akil, H., & Robinson, T. E. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.09.004 · Cited by 153 · see citing works
Mapping anhedonia-specific dysfunction in a transdiagnostic approach: an ALE meta-analysis
Zhang, B., Lin, P., Shi, H., Öngür, D., Auerbach, R. P., Wang, X., Yao, S., & Wang, X. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9457-6 · Cited by 152 · see citing works
Nucleus Accumbens Dopamine/Glutamate Interaction Switches Modes to Generate Desire versus Dread: D1Alone for Appetitive Eating But D1and D2Together for Fear
Richard, J. M., & Berridge, K. C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1339-11.2011 · Cited by 152 · see citing works
Self-citation
Enhanced Control of Attention by Stimulating Mesolimbic-Corticopetal Cholinergic Circuitry
Peters, M. M. M. S., Demeter, E., Lustig, C., Bruno, J., & Sarter, M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1902-11.2011 · Cited by 147 · see citing works
Architectural Representation of Valence in the Limbic System
Namburi, P., Al‐Hasani, R., Calhoon, G. G., Bruchas, M. R., & Tye, K. M. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.358 · Cited by 133 · see citing works
Orexin in Rostral Hotspot of Nucleus Accumbens Enhances Sucrose ‘Liking’ and Intake but Scopolamine in Caudal Shell Shifts ‘Liking’ Toward ‘Disgust’ and ‘Fear’
Castro, D. C., Terry, R. A., & Berridge, K. C. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.10 · Cited by 130 · see citing works
Self-citation
Optogenetic self-stimulation in the nucleus accumbens: D1 reward versus D2 ambivalence
Cole, S. L., Robinson, M. J. F., & Berridge, K. C. (2018) · PLoS ONE · doi:10.1371/journal.pone.0207694 · Cited by 108 · see citing works
Self-citation
Excessive disgust caused by brain lesions or temporary inactivations: mapping hotspots of the nucleus accumbens and ventral pallidum
Ho, C., & Berridge, K. C. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12720 · Cited by 115 · see citing works
Self-citation
Regulation of neural responses to emotion perception by ketamine in individuals with treatment-resistant major depressive disorder
Murrough, J. W., Collins, K. A., Fields, J., DeWilde, K. E., Phillips, M. L., Mathew, S. J., Wong, E., Tang, C. Y., Charney, D. S., & Iosifescu, D. V. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.10 · Cited by 109 · see citing works
μ-Opioid receptors within subregions of the striatum mediate pair bond formation through parallel yet distinct reward mechanisms
Resendez, S. L., Dome, M., Gormley, G., Franco, D., Nevárez, N., Hamid, A. A., & Aragona, B. J. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4123-12.2013 · Cited by 93 · see citing works
Coordinated Reductions in Excitatory Input to the Nucleus Accumbens Underlie Food Consumption
Reed, S. J., Lafferty, C. K., Mendoza, J. A., Yang, A. K., Davidson, T. J., Grosenick, L., Deisseroth, K. A., & Britt, J. P. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.051 · Cited by 85 · see citing works
Ventral arkypallidal neurons inhibit accumbal firing to promote reward consumption
Vachez, Y. M., Tooley, J. R., Abiraman, K., Matikainen‐Ankney, B. A., Casey, E., Earnest, T., Ramos, L. M., Silberberg, H., Godynyuk, E. A., Uddin, O., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00772-7 · Cited by 77 · see citing works
Decision-Theoretic Psychiatry
Huys, Q. J. M., Guitart‐Masip, M., Dolan, R. J., & Dayan, P. (2015) · Clinical Psychological Science · doi:10.1177/2167702614562040 · Cited by 81 · see citing works
Nucleus Accumbens AMPA Receptors Are Necessary for Morphine-Withdrawal-Induced Negative-Affective States in Rats
Russell, S. E., Puttick, D. J., Sawyer, A. M., Potter, D. N., Mague, S. D., Carlezon, W. A., & Chartoff, E. H. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2875-12.2016 · Cited by 73 · see citing works
Deep Brain Stimulation Reveals a Dissociation of Consummatory and Motivated Behaviour in the Medial and Lateral Nucleus Accumbens Shell of the Rat
Plasse, G., Schrama, R., van Seters, S., Vanderschuren, L. J. M. J., & Westenberg, H. G. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033455 · Cited by 78 · see citing works
Anhedonia correlates with functional connectivity of the nucleus accumbens subregions in patients with major depressive disorder
Liu, R., Wang, Y., Chen, X., Zhang, Z., Xiao, L., & Zhou, Y. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102599 · Cited by 79 · see citing works
Expressions of emotions across species
Zych, A. D., & Gogolla, N. (2021) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2021.01.003 · Cited by 77 · see citing works
Injections of muscimol into the paraventricular thalamic nucleus, but not mediodorsal thalamic nuclei, induce feeding in rats
Stratford, T. R., & Wirtshafter, D. (2012) · Brain Research · doi:10.1016/j.brainres.2012.10.043 · Cited by 77 · see citing works
On lateral septum‐like characteristics of outputs from the accumbal hedonic “hotspot” of Peciña and Berridge with commentary on the transitional nature of basal forebrain “boundaries”
Zahm, D. S., Parsley, K. P., Schwartz, Z. M., & Cheng, A. Y. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23157 · Cited by 76 · see citing works
Reward systems and cognitions in Major Depressive Disorder
Cléry-Melin, M.-L., Jollant, F., & Gorwood, P. A. P. M. (2018) · CNS Spectrums · doi:10.1017/s1092852918001335 · Cited by 68 · see citing works
Prefrontal cortex to accumbens projections in sleep regulation of reward
Liu, Z., Wang, Y., Cai, L., Li, Y., Chen, B., Dong, Y., & Huang, Y. H. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.0347-16.2016 · Cited by 66 · see citing works
Orexins in the midline thalamus are involved in the expression of conditioned place aversion to morphine withdrawal
Li, Y., Wang, H., Qi, K., Chen, X., Li, S., Sui, N., & Kirouac, G. J. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.10.006 · Cited by 65 · see citing works
Cannabis and cocaine decrease cognitive impulse control and functional corticostriatal connectivity in drug users with low activity DBH genotypes
Ramaekers, J. G., van Wel, J. H. P., Spronk, D. B., Franke, B., Kenis, G., Toennes, S. W., Kuypers, K. P. C., Theunissen, E. L., Stiers, P. L. J., & Verkes, R. (2015) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9488-z · Cited by 60 · see citing works
Unpleasantness, Motivational Oomph, and Painfulness
Corns, J. (2014) · Mind & Language · doi:10.1111/mila.12048 · Cited by 60 · see citing works
Mapping the interconnected neural systems underlying motivation and emotion: A key step toward understanding the human affectome
Cromwell, H. C., Abe, N., Barrett, K. C., Caldwell‐Harris, C. L., Gendolla, G. H. E., Koncz, R., & Sachdev, P. S. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.032 · Cited by 54 · see citing works
Methylphenidate reduces functional connectivity of nucleus accumbens in brain reward circuit
Ramaekers, J. G., Evers, E. A. T., Theunissen, E. L., Kuypers, K. P. C., Goulas, A., & Stiers, P. L. J. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3105-x · Cited by 52 · see citing works
Altered GluA1 (Gria1) Function and Accumbal Synaptic Plasticity in the ClockΔ19 Model of Bipolar Mania
Parekh, P. K., Becker-Krail, D., Sundaravelu, P., Ishigaki, S., Okado, H., Sobue, G., Huang, Y., & McClung, C. A. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.06.022 · Cited by 48 · see citing works
Metabotropic glutamate receptor blockade in nucleus accumbens shell shifts affective valence towards fear and disgust
Richard, J. M., & Berridge, K. C. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07553.x · Cited by 45 · see citing works
Self-citation
Hippocampal Input to the Nucleus Accumbens Shell Enhances Food Palatability
Yang, A. K., Mendoza, J. A., Lafferty, C. K., Lacroix, F., & Britt, J. P. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.09.007 · Cited by 45 · see citing works
Caudal Nucleus Accumbens Core Is Critical in the Regulation of Cue-Elicited Approach-Avoidance Decisions
Hamel, L., Thangarasa, T., Samadi, O., & Ito, R. (2017) · eNeuro · doi:10.1523/eneuro.0330-16.2017 · Cited by 41 · see citing works
Long‐lasting deficits in hedonic and nucleus accumbens reactivity to sweet rewards by sugar overconsumption during adolescence
Naneix, F., Darlot, F., Coutureau, É., & Cador, M. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13149 · Cited by 40 · see citing works
Brain regulation of hunger and motivation: The case for integrating homeostatic and hedonic concepts and its implications for obesity and addiction
Morales, I. (2022) · Appetite · doi:10.1016/j.appet.2022.106146 · Cited by 39 · see citing works
Single doses of THC and cocaine decrease proficiency of impulse control in heavy cannabis users
van Wel, J. H. P., Kuypers, K. P. C., Theunissen, E. L., Toennes, S. W., Spronk, D. B., Verkes, R. J., & Ramaekers, J. G. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12425 · Cited by 38 · see citing works
Nucleus accumbens GABA ergic inhibition generates intense eating and fear that resists environmental retuning and needs no local dopamine
Richard, J. M., Plawecki, A. M., & Berridge, K. C. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12194 · Cited by 37 · see citing works
Self-citation
Resistance to antidepressant drugs
Willner, P., Scheel‐Krüger, J., & Belzung, C. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000066 · Cited by 36 · see citing works
Dopamine receptor D2 deficiency reduces mouse pup ultrasonic vocalizations and maternal responsiveness
Curry, T., Egeto, P., Wang, H., Podnos, A., Wasserman, D., & Yeomans, J. S. (2013) · Genes Brain & Behavior · doi:10.1111/gbb.12037 · Cited by 34 · see citing works
Direct hypothalamic and indirect trans-pallidal, trans-thalamic, or trans-septal control of accumbens signaling and their roles in food intake
Urstadt, K. R., & Stanley, B. G. (2015) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00008 · Cited by 32 · see citing works
Sweetened-Fat Intake Sensitizes Gamma-Aminobutyric Acid—Mediated Feeding Responses Elicited from the Nucleus Accumbens Shell
Newman, S. M., Pascal, L., Sadeghian, K., & Baldo, B. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.11.027 · Cited by 33 · see citing works
Altered emotional and motivational processing in the transgenic rat model for Huntington’s disease
Faure, A., Höhn, S., von Hörsten, S., Delatour, B., Raber, K. A., Leblanc-Veyrac, P., Samson-Desvignes, N., Doyère, V., & Massioui, N. E. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.11.010 · Cited by 30 · see citing works
Self-citation
Activation of Infralimbic to Nucleus Accumbens Shell Pathway Suppresses Conditioned Aversion in Male But Not Female Rats
Hurley, S. W., & Carelli, R. M. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0137-20.2020 · Cited by 29 · see citing works
Altered reward expectancy in individuals with recent methamphetamine dependence
Bischoff‐Grethe, A., Connolly, C. G., Jordan, S. J., Brown, G. G., Paulus, M. P., Tapert, S. F., Heaton, R. K., Woods, S. P., Grant, I., & the TMARC Group (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116668590 · Cited by 28 · see citing works
Desire or Dread from Nucleus Accumbens Inhibitions: Reversed by Same-Site Optogenetic Excitations
Baumgartner, H. M., Cole, S. L., Olney, J. J., & Berridge, K. C. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2902-19.2020 · Cited by 28 · see citing works
Self-citation
A subset of dopamine receptor-expressing neurons in the nucleus accumbens controls feeding and energy homeostasis
Liu, Y., Wang, Y., Zhao, Z., Xie, G., Zhang, C., Chen, R., & Zhang, Y. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01100-0 · Cited by 28 · see citing works
From Desire to Dread—A Neurocircuitry Based Model for Food Avoidance in Anorexia Nervosa
Frank, G. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10112228 · Cited by 24 · see citing works
Acute Food Deprivation Rapidly Modifies Valence-Coding Microcircuits in the AmygdalaPreprint
Calhoon, G. G., Sutton, A. K., Chang, C.-J., Libster, A. M., Glober, G. F., Lévêque, C. L., Murphy, G., Namburi, P., Leppla, C. A., Siciliano, C. A., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/285189 · Cited by 23 · see citing works
Homeostatic regulation of reward via synaptic insertion of calcium-permeable AMPA receptors in nucleus accumbens
Carr, K. D. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.112850 · Cited by 22 · see citing works
Effects of muscimol, amphetamine, and DAMGO injected into the nucleus accumbens shell on food-reinforced lever pressing by undeprived rats
Stratford, T. R., & Wirtshafter, D. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.02.010 · Cited by 23 · see citing works
Anxiety during abstinence from alcohol: A systematic review of rodent and human evidence for the anterior insula's role in the abstinence network
Flook, E. A., Luchsinger, J. R., Silveri, M. M., Winder, D. G., Benningfield, M. M., & Blackford, J. U. (2020) · Addiction Biology · doi:10.1111/adb.12861 · Cited by 22 · see citing works
Mapping excessive “disgust” in the brain: Ventral pallidum inactivation recruits distributed circuitry to make sweetness “disgusting”
Khan, H. A., Urstadt, K. R., Mostovoi, N. A., & Berridge, K. C. (2019) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-019-00758-4 · Cited by 21 · see citing works
Self-citation
Opposing Roles of Rapid Dopamine Signaling Across the Rostral–Caudal Axis of the Nucleus Accumbens Shell in Drug-Induced Negative Affect
Hurley, S. W., West, E. A., & Carelli, R. M. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.05.009 · Cited by 20 · see citing works
From valence encoding to motivated behavior: A focus on the nucleus accumbens circuitry
Vieitas‐Gaspar, N., Soares‐Cunha, C., & Rodrigues, A. J. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106125 · Cited by 18 · see citing works
Reduced Expression of Nogo-A Leads to Motivational Deficits in Rats
Enkel, T., Berger, S. M., Schönig, K., Tews, B., & Bartsch, D. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00010 · Cited by 17 · see citing works
A behavioral and micro positron emission tomography imaging study in a rat model of hypothyroidism
Yu, J., Tang, Y.-Y., Feng, H., & Cheng, X. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.06.019 · Cited by 15 · see citing works
μ-Opioid and dopamine-D2 receptor expression in the nucleus accumbens of male Sprague-Dawley rats whose sucrose consumption, but not preference, decreases after nerve injury
Hakim, J. D., Chami, J., & Keay, K. A. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112416 · Cited by 13 · see citing works
Striatopallidal adenosine A2A receptors in the nucleus accumbens confer motivational control of goal-directed behavior
Li, Y., Ruan, Y., He, Y., Cai, Q., Pan, X., Zhang, Y. L., Liu, C., Pu, Z., Yang, J., Chen, M., et al. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108010 · Cited by 11 · see citing works
Brain reward response in adolescents and young adults with anorexia nervosa is moderated by changes in body weight and sweetness perception
Frank, G., Shott, M. E., Pryor, T. L., Swindle, S., & Stoddard, J. (2022) · International Journal of Eating Disorders · doi:10.1002/eat.23814 · Cited by 10 · see citing works
Roles of nucleus accumbens shell small-conductance calcium-activated potassium channels in the conditioned fear freezing
Zhang, M., Luo, Y., Wang, J., Sun, Y., Xie, B., Zhang, L., Cong, B., Ma, C., & Wen, D. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.05.057 · Cited by 8 · see citing works
Compulsion and choice in addiction
Holton, R., & Berridge, K. C. (2016) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198727224.003.0009 · Cited by 8 · see citing works
Self-citation
The galanin receptor-3 antagonist, SNAP 37889, inhibits cue-induced reinstatement of alcohol-seeking and increases c-Fos expression in the nucleus accumbens shell of alcohol-preferring rats
Wilson, K.-E., Limburg, S., Duggan, M. K., Lawther, A. J., Williams, S. J., Lawrence, A. J., Hale, M. W., & Djouma, E. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881118780015 · Cited by 8 · see citing works
Inactivation of the Lateral Hypothalamus Attenuates Methamphetamine-Induced Conditioned Place Preference through Regulation of Kcnq3 Expression
Liu, M., Tan, X., Liu, E., Hang, Z., Song, R., Mu, S., Han, W., Yue, Q., & Sun, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137305 · Cited by 7 · see citing works
Serotonin and Emotional Decision-Making
Puig‐Pérez, S. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.81506 · Cited by 6 · see citing works
Value-based cognition and drug dependency
Loganathan, K. (2021) · Addictive Behaviors · doi:10.1016/j.addbeh.2021.107070 · Cited by 5 · see citing works
Intra-Accumbens Baclofen, But Not Muscimol, Increases Second Order Instrumental Responding for Food Reward in Rats
Pulman, K. G. T., Somerville, E. M., & Clifton, P. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040057 · Cited by 5 · see citing works
Attentional Modulation of Brain Responses to Primary Appetitive and Aversive Stimuli
Field, B. A., Buck, C., McClure, S. M., Nystrom, L., Kahneman, D., & Cohen, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130880 · Cited by 4 · see citing works
Valence and salience encoding by parallel circuits from the paraventricular thalamus to the nucleus accumbensPreprint
Rivera-Irizarry, J. K., Hámor, P. U., Rowson, S. A., Asfouri, J. J., Liu, D., Zallar, L. J., Garcia, A. F., Skelly, M. J., & Pleil, K. E. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.03.547570 · Cited by 6 · see citing works
Why Don’t You Just Eat? Neuroscience and the Enigma of Eating Disorders
Pinson, C. K., & Frank, G. (2024) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20240006 · Cited by 16 · see citing works
Co-expression of glutamatergic and autism-related genes in the hippocampus of male mice with disturbances of social behavior
Kovalenko, I. L., Galyamina, A. G., Смагин, Д. А., & Kudryavtseva, N. N. (2020) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vj20.42-o · Cited by 4 · see citing works
The Ventral Pallidum as a Limbic Pleasure Generator.
Ho, C. (2010) · Deep Blue (University of Michigan) · Cited by 4 · see citing works
Wanting what hurts: D1 dopamine neuronal stimulation in CeA is sufficient to induce maladaptive attraction
Nguyen, D. T., & Berridge, K. C. (2025) · Communications Biology · doi:10.1038/s42003-025-08944-6 · Cited by 3 · see citing works
Self-citation
GABAergic and glutamatergic transmission reveals novel cardiovascular and urinary bladder control features in the shell nucleus accumbens
de Carvalho, R. P., Vale, B. D. M., Dsouki, N. A., Cafarchio, E. M., Junior, L. A. D. L., Aronsson, P., & Sato, M. A. (2023) · Brain Research · doi:10.1016/j.brainres.2023.148520 · Cited by 4 · see citing works
Delayed but not immediate effects of estrogen curtail gamma-aminobutyric acid-mediated feeding responses elicited from the nucleus accumbens shell.
Diaz, J. C., Dunaway, K., Sheil, E., Sadeghian, K., Auger, A. P., & Baldo, B. A. (2022) · Behavioral Neuroscience · doi:10.1037/bne0000511 · Cited by 2 · see citing works
Contributions of Philip Teitelbaum to affective neuroscience
Berridge, K. C. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.10.030 · Cited by 2 · see citing works
Self-citation
Anhedonia in Parkinson’s Disease and Other Movement Disorders
Spalletta, G., Assogna, F., Caltagirone, C., & Leentjens, A. F. G. (2014) · Springer eBooks · doi:10.1007/978-94-017-8610-2_13 · Cited by 1 · see citing works
A molecularly defined NAcSh D1 subtype controls feeding and energy homeostasisPreprint
Liu, Y., Wang, Y., Zhao, Z., Xie, G., Zhang, C., Chen, R., & Zhang, Y. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.27.530275 · Cited by 1 · see citing works
The nucleus accumbens shell regulates hedonic feeding via a rostral hotspotPreprint
Marinescu, A., Kamal, E., Leary, P., Batista, K. N. I., Klug, M., Savić, N., Foll, C. L., & Labouesse, M. A. (2025) · eLife · doi:10.7554/elife.108639 · Cited by 1 · see citing works
Characterization of GABAergic projection from the ventral tegmental area to the nucleus accumbens: Effects of dopamine and cocaine
Otaka, M. (2015) · D-Scholarship@Pitt (University of Pittsburgh)
Place Preference Can Be Conditioned by Corticolimbic Glutamate Blockade of Accumbens Shell in a Familiar Environment
Wilensky, A. (2012) · Deep Blue (University of Michigan)
Modulación del sistema nitrérgico por nicotina: estudio con ratones mutantes
Murias, A. R. (2011) · doi:10.14201/gredos.110565
Motivational Systems: Rewards and Incentive Value
LaLumiere, R. T., & Kalivas, P. W. (2012) · Wiley eBooks · doi:10.1002/9781118133880.hop203014
Applications of Sensory Perceptual Metrics to Screen, to Track Changes in, and to Differentiate Clinical Populations
Nguyen, R. H. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/4fvb-6v35
Approach and Avoidance Processing: Investigating a Rostrocaudal Gradient in the Nucleus Accumbens Core
Hamel, L. (2014) · TSpace (University of Toronto)
The Neural Encoding of Reward in the Striatal-Pallidal Circuitry
Chan, C. L. (2017) · e-Publications@Marquette (Marquette University)
Mechanisms of Motivation in the Nucleus Accumbens
Cole, S. L. (2017) · Deep Blue (University of Michigan)

Mesocorticolimbic Generation of Desire and Dread along a Rostrocaudal Gradient in Medial Shell of Nucleus Accumbens.
Richard, J. M. (2012) · Deep Blue (University of Michigan)
Self-citation
Nucleus Accumbens Dopamine/Glutamate Interaction Switches Modes to Generate Desire versus Dread: D1Alone for Appetitive Eating But D1and D2Together for Fear
Richard, J. M., & Berridge, K. C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1339-11.2011 · Cited by 152 · see citing works
Self-citation
Positive and negative motivation in nucleus accumbens shell: bivalent rostrocaudal gradients for GABA-elicited eating, taste “liking”/“disliking” reactions, place preference/avoidance, and fear
Reynolds, S. M., & Berridge, K. C. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07308.2002 · Cited by 403 · see citing works
Self-citation
Glutamate motivational ensembles in nucleus accumbens: rostrocaudal shell gradients of fear and feeding
Reynolds, S. M., & Berridge, K. C. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02642.x · Cited by 163 · see citing works
Self-citation
Mesolimbic dopamine in desire and dread: enabling motivation to be generated by localized glutamate disruptions in nucleus accumbens
Faure, A., Reynolds, S. M., Richard, J. M., & Berridge, K. C. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4961-07.2008 · Cited by 193 · see citing works
Self-citation

Authors: Faure, A., Richard, J. M., & Berridge, K. C.
Affiliations: University of Michigan (US)
Corresponding author: Faure, Alexis
ORCID: Faure, Alexis
Richard, Jocelyn M.
Berridge, Kent C.
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2010-06-18
Volume: 5
Issue: 6
Pages: e11223
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0011223
PMC: PMC2887893
OpenAlex: W2084903850
Cited by: 114
References: 81
Citations by year: 2026: 1 · 2025: 6 · 2024: 3 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 10 · 2019: 10 · 2018: 8 · 2017: 5 · 2016: 6 · 2015: 11 · 2014: 11 · 2013: 7 · 2012: 9
FWCI: 3.75
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS ONE (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Institutes of Health
National Institute of Mental Health (MH-63649, R01MH063649)
National Institute on Drug Abuse (DA015188, R01DA015188)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: nucleus accumbens shell, GABAergic neurotransmission, glutamatergic signaling, motivation, desire, dread, appetitive motivation, muscimol, DNQX, rostrocaudal gradient, emotion regulation
MeSH terms: Animals, Fear, Feeding Behavior, gamma-Aminobutyric Acid, Motivation, Muscimol, Nucleus Accumbens, Quinoxalines, Glutamic Acid, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Desire and dread from the nucleus accumbens: cortical glutamate and subcortical GABA differentially generate motivation and hedonic impact in the rat.

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks