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Perineuronal nets provide a polyanionic, glia‐associated form of microenvironment around certain neurons in many parts of the rat brain
Abstract
The nature and function of previously described perineuronal nets are still obscure. In the present study their polyanionic components were demonstrated in the rat brain using colloidal iron hydroxide (CIH) staining. In subcortical regions, such as the red nucleus, cerebellar, and vestibular nuclei, most neurons were ensheathed by CIH‐binding material. In the cerebral cortex perineuronal nets were seen around numerous nonpyramidal neurons. Biotinylated hyaluronectin revealed that hyaluronan occurs in perineuronal nets. Two plant lectins [ Wisteria floribunda agglutinin (WFA) and Vicia villosa agglutinin (VVA)] with affinity for N‐acetylgalactosamine visualized perineuronal nets similar to those rich in anionic components. Glutamic acid decarboxylase (GAD)‐immunoreactive synaptic boutons were shown to occupy numerous meshes of perineuronal VVA‐positive nets. Electron microscopically, VVA binding sites were scattered throughout perisynaptic profiles, but accumulated at membranes and in the extra‐cellular space except not in synaptic clefts. To investigate the spatial relationship between glial cell processes and perineuronal nets, two astrocytic markers (S100‐protein and glutamine synthetase) were visualized at the light and electron microscopic level. Two methods to detect microglia by the use of Griffonia simplicifolia agglutinin (GSA I‐B 4 ) and the monoclonal antibody, OX‐42, were also applied. Labelled structures forming perineuronal nets were observed with both astrocytic, but not with microglial, markers. It is concluded that perineuronal nets are composed of a specialized type of glia‐associated extracellular matrix rich in polyanionic groups and N‐acetylgalactosamine. The net‐like appearance is due to perisynaptic arrangement of the astrocytic processes and these extracellular components. Similar to the ensheathment of nodes of Ranvier, perineuronal nets may provide a special ion buffering capacity required around various, perhaps highly active, types of neurons. © 1993 Wiley‐Liss, Inc.
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In the citing paper
“Sulphate groups attached to these GAGs in concert with the negatively charged hyaluronic acid generate a highly polyanionic microenvironment around PN-ensheathed neurons.20, 21”
From Aggrecan, link protein and tenascin-R are essential components of the perineuronal net to protect neurons against iron-induced oxidative stress (2014) · cites this paper as [20]
In the citing paper
“the polyanionic components might also interact with ions of potential pathophysiological relevance such as iron ions involved in generating oxidative stress.20, 22, 26, 27”
From Aggrecan, link protein and tenascin-R are essential components of the perineuronal net to protect neurons against iron-induced oxidative stress (2014) · cites this paper as [20]
In the citing paper
“Astrocytes extend their processes into PNNs localized near the synapse (Brückner et al., 1993; Blümcke et al., 1995), suggesting a tetrapartite synaptic organization involving ECM, pre/post synaptic sites and astrocytes (Dityatev and Rusakov, 2011; Smith et al., 2015) whose synergistic functions remain unexplored.”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Brückner et al., 1993
In the citing paper
“First, PNNs carry a high degree of negative charge and may function as cation sinks (Bruckner et al, 1993).”
From Reduced Labeling of Parvalbumin Neurons and Perineuronal Nets in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia (2016) · cites this paper as Bruckner et al, 1993
In the citing paper
“As part of the extracellular matrix (ECM), perineuronal nets (PNs) are polyanionic, chondroitin sulfate proteoglycan (CSPG)-rich coatings of certain neurons, known to be affected in various neural diseases.”
From Damaged Neocortical Perineuronal Nets Due to Experimental Focal Cerebral Ischemia in Mice, Rats and Sheep (2017) · cites this paper as Brückner et al., 1993
In the citing paper
“They are composed of chondroitin sulfate proteoglycans (CSPGs) and their glycosaminoglycans, hyaluronic acid and tenascins, produced by various neural cell types (Brückner et al., 1993).”
From Damaged Neocortical Perineuronal Nets Due to Experimental Focal Cerebral Ischemia in Mice, Rats and Sheep (2017) · cites this paper as Brückner et al., 1993
In the citing paper
“More recent evidence indicates that WFA-labeled PNNs are associated with more heterogeneous neuronal phenotypes than previously thought, including several subgroups of interneurons, a small subset of cortico-cortical pyramidal cells, spinal cord motor neurons and cerebellum Purkinje cells (Ajmo et al., 2008; Brauer et al., 1995; Bruckner et al., 1993; Gati and Lendvai, 2013; Hartig et al., 1995;”
From Losing the sugar coating: Potential impact of perineuronal net abnormalities on interneurons in schizophrenia (2015) · cites this paper as Bruckner et al., 1993
In the citing paper
“PNNs have been implicated in ion homeostasis around highly active neurons”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Bruckner et al., 1993
In the citing paper
“They can thus potentially act as a buffering system for physiologically relevant ions such as calcium, potassium, and sodium around highly active types of neurons”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Bruckner et al., 1993
In the citing paper
“The PNN is a unique ECM structure that is most prominently displayed around GABAergic interneurons, with parvalbumin expressing cells having the highest level of colocalization (Brückner et al., 1993;Celio and Chiquet-Ehrismann, 1993;Morris and Henderson, 2000).”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Brückner et al., 1993
In the citing paper
“Perineuronal nets are extracellular matrix structures which surround synapses of highly active neuronal subtypes and are associated with microglia [156].”
From Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease (2019) · cites this paper as [156]
Citations
Cites
Handbook of Chemical Neuroanatomy
Stern, C. D. (1986) · Neurochemistry International · doi:10.1016/0197-0186(86)90021-5 · Cited by 4,160
Fine structural localization of glutamine synthetase in astrocytes of rat brain
Norenberg, M. D., & Martinez-Hernandez, A. (1979) · Brain Research · doi:10.1016/0006-8993(79)90071-4 · Cited by 1,349
Parvalbumin in Most γ-Aminobutyric Acid-Containing Neurons of the Rat Cerebral Cortex
Celio, M. R. (1986) · Science · doi:10.1126/science.3945815 · Cited by 740
A simple, non-chromatographic procedure to purify immunoglobulins from serum and ascites fluid
McKinney, M. M., & Parkinson, A. (1987) · Journal of Immunological Methods · doi:10.1016/0022-1759(87)90324-3 · Cited by 618
Wisteria floribunda agglutinin-labelled nets surround parvalbumin-containing neurons
Härtig, W., Brauer, K., & Brückner, G. (1992) · NeuroReport · doi:10.1097/00001756-199210000-00012 · Cited by 440
Self-citationOertel, W., Schmechel, D. E., Tappaz, M., & Kopin, I. J. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90113-5 · Cited by 419
Self-citationStreit, W. J. (1990) · Journal of Histochemistry & Cytochemistry · doi:10.1177/38.11.2212623 · Cited by 372
Expression of tenascin in the developing and adult cerebellar cortex
Bartsch, S., Bartsch, U., Dörries, U., Faissner, A., Weller, A., Ekblom, P., & Schachner, M. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-03-00736.1992 · Cited by 271
GABA Neurons in the Cerebral Cortex
Houser, C. R., Vaughn, J. E., Hendry, S. H. C., Jones, E. G., & Peters, A. (1984) · Cerebral cortex · doi:10.1007/978-1-4615-6610-6_3 · Cited by 261
Organization of radial glial cells during the development of the rat dentate gyrus
Rickmann, M., Amaral, D. G., & Cowan, W. M. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902640403 · Cited by 243
Self-citation
Flagged first, then by citations
Research works printed but not linked: 13
- Delpech B., 1989, The Biology of Hyaluronan. CIBA Foundation Symposion, 143
- Faissner A., 1989, Dynamics and Plasticity in Neuronal Systems. Proc. 17th Göttingen Neurobiology Conference, 1
- Golgi C., 1891, La réseau diffus des centres du système nerveux, Arch. Ital. Biol., 15, 314
- Graumann W., 1958, Weitere Untersuchungen zur Spezifität der histochemischen Polysaccharid‐Eisenreaktion, Acta Histochem., 6, 1
- Hockfield S., 1989, Neuroimmune Networks, 57
- Kettenmann H., 1988, In: Glial Cell Receptors, 95
- Kimelberg H. K., 1988, Glial Cell Receptors
- McGeer P. L., 1986, In: Neurohistochemistry: Modern Methods and Applications P. Panula, 355
- Raff M. C., 1990, In: Differentiation and Functions of Glial Cells, 17
- Ramon y Cajal S., 1906, Studien über die Hirnrinde des Menschen
- Schweizer M. Müller C. M. andStreit J. W.(1991)Perisynaptic lectin‐binding sites in cat visual cortex: an electron microscopical investigation. In: Synapse‐Transmission‐Moduluation. Proc. 19th Göttingen Neurobiology Conference. Elsner N. and eds. Thieme Stuttgart p.226.
- Szentagothai J., 1975, In: Golgi Centennial Symposium, 1
- Wolff J. R., 1970, Proc. 6th Intern. Congr. Neuropathology, 327
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Frischknecht, R., Heine, M., Perrais, D., Seidenbecher, C. I., Choquet, D., & Gundelfinger, E. D. (2009) · Nature Neuroscience · doi:10.1038/nn.2338 · Cited by 554
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Celio, M. R., Spreafico, R., De Biasi, S., & Vitellaro-Zuccarello, L. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01298-3 · Cited by 497
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Extracellular matrix of the central nervous system: from neglect to challenge
Zimmermann, D. R., & Dours-Zimmermann, M. T. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0485-9 · Cited by 465
Favuzzi, E., Marques-Smith, A., Deogracias, R., Winterflood, C. M., Sánchez-Aguilera, A., Mantoan, L., Maeso, P., Fernandes, C., Ewers, H., & Rico, B. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.028 · Cited by 397
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Wang, D., & Fawcett, J. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1375-y · Cited by 373
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Lee, H., McKeon, R. J., & Bellamkonda, R. V. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905437106 · Cited by 323
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Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease
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Brückner, G., Hausen, D., Härtig, W., Drlicek, M., Arendt, T., & Brauer, K. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00071-8 · Cited by 196
Self-citationArendt, T. (2003) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2003.09.007 · Cited by 189
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Suttkus, A., Rohn, S., Weigel, S., Glöckner, P., Arendt, T., & Morawski, M. (2014) · Cell Death & Disease · doi:10.1038/cddis.2014.25 · Cited by 168
Brückner, G., Bringmann, A., Härtig, W., Köppe, G., Delpech, B., & Brauer, K. (1998) · Experimental Brain Research · doi:10.1007/s002210050463 · Cited by 162
Self-citationMorawski, M., Brückner, G., Jäger, C., Seeger, G., Matthews, R. T., & Arendt, T. (2012) · Brain Pathology · doi:10.1111/j.1750-3639.2011.00557.x · Cited by 157
Self-citationBurnside, E. R., & Bradbury, E. J. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12114 · Cited by 160
Ye, Q., & Miao, Q.-L. (2013) · Matrix Biology · doi:10.1016/j.matbio.2013.04.001 · Cited by 146
Berretta, S., Pantazopoulos, H., Markota, M., Brown, C., & Batzianouli, E. T. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2014.12.040 · Cited by 152
Wright, J. W., & Harding, J. W. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.03.003 · Cited by 158
Seeger, G., Brauer, K., Ha¨rtig, W., & Bru¨ckner, G. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90044-2 · Cited by 156
Self-citationPerineuronal nets in brain physiology and disease
Testa, D., Prochiantz, A., & Nardo, A. A. D. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.09.011 · Cited by 153
Ha¨rtig, W., Brauer, K., Bigl, V., & Bru¨ckner, G. (1994) · Brain Research · doi:10.1016/0006-8993(94)91452-4 · Cited by 147
Self-citationThe perineuronal net component of the extracellular matrix in plasticity and epilepsy
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Aggrecan: Beyond cartilage and into the brain
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Self-citationKim, S. Y., Senatorov, V. V., Morrissey, C. S., Lippmann, K., Vazquez, O. N., Milikovsky, D. Z., Gu, F., Parada, I., Prince, D. A., Becker, A. J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-07394-3 · Cited by 139
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Extracellular matrix protein expression is brain region dependent
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Maeda, N., Hamanaka, H., Oohira, A., & Noda, M. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00069-h · Cited by 134
Oohashi, T., Edamatsu, M., Bekku, Y., & Carulli, D. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.09.010 · Cited by 131
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Köppe, G., Brückner, G., Brauer, K., Härtig, W., & Bigl, V. (1997) · Cell and Tissue Research · doi:10.1007/s004410050790 · Cited by 129
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Axon initial segment ensheathed by extracellular matrix in perineuronal nets
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Self-citationHrabětová, S., Masri, D., Tao, L., Xiao, F., & Nicholson, C. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.170092 · Cited by 113
Ariza, J., Rogers, H., Hashemi, E., Noctor, S. C., & Martínez-Cerdeño, V. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhw349 · Cited by 101
Loss of perineuronal net N-acetylgalactosamine in Alzheimer’s disease
Baig, S., Wilcock, G. K., & Love, S. (2005) · Acta Neuropathologica · doi:10.1007/s00401-005-1060-2 · Cited by 112
Protective Properties of Neural Extracellular Matrix
Suttkus, A., Morawski, M., & Arendt, T. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8990-4 · Cited by 110
Extracellular matrix organization in various regions of rat brain grey matter
Brückner, G., Härtig, W., Kacza, J., Seeger, J., Welt, K., & Brauer, K. (1996) · Journal of Neurocytology · doi:10.1007/bf02284806 · Cited by 109
Self-citationNeurons Produce a Neuronal Cell Surface-Associated Chondroitin Sulfate Proteoglycan
Lander, C., Zhang, H., & Hockfield, S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00174.1998 · Cited by 107
Wegner, F., Härtig, W., Bringmann, A., Grosche, J., Wohlfarth, K., Zuschratter, W., & Brückner, G. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00313-3 · Cited by 107
Self-citationInatani, M., & Tanihara, H. (2002) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(02)00009-5 · Cited by 105
Hobohm, C., Günther, A., Grosche, J., Roßner, S., Schneider, D., & Brückner, G. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20459 · Cited by 103
Self-citationPerineuronal net degradation in epilepsy
Rankin‐Gee, E. K., McRae, P. A., Baranov, E., Rogers, S., Wandrey, L., & Porter, B. E. (2015) · Epilepsia · doi:10.1111/epi.13026 · Cited by 100
Perineuronal nets protect against amyloid β-protein neurotoxicity in cultured cortical neurons
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Morris, N. P., & Henderson, Z. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00970.x · Cited by 98
Perineuronal nets and schizophrenia: The importance of neuronal coatings
Bitanihirwe, B. K. Y., & Woo, T.-U. W. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.018 · Cited by 95
Krishnaswamy, V. R., Benbenishty, A., Blinder, P., & Sagi, I. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03182-6 · Cited by 96
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Self-citationLendvai, D., Morawski, M., Négyessy, L., Gáti, G., Jäger, C., Baksa, G., Glasz, T., Attems, J., Tanila, H., Arendt, T., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-012-1042-0 · Cited by 93
Distribution of pyramidal cells associated with perineuronal nets in the neocortex of rat
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Self-citationHayani, H., Song, I., & Dityatev, A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00149 · Cited by 84
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Aggrecan-based extracellular matrix is an integral part of the human basal ganglia circuit
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Self-citation(2012) · Europe PMC (PubMed Central) · Cited by 88
Persistent decrease in multiple components of the perineuronal net following status epilepticus
McRae, P. A., Baranov, E., Rogers, S. L., & Porter, B. E. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08268.x · Cited by 85
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The crosstalk of hyaluronan-based extracellular matrix and synapses
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Metadata
- Authors
- Brückner, G., Brauer, K., Härtig, W., Wolff, J. R., Rickmann, M. J., Derouiche, A., Delpech, B., Girard, N., Oertel, W. H., & Reichenbach, A.
- Affiliations
- Leipzig University (DE)
- University of Göttingen (DE)
- Goethe University Frankfurt (DE)
- Centre Henri Becquerel (FR)
- Ludwig-Maximilians-Universität München (DE)
- Corresponding author
- Brückner, Gert
- Venue
- Glia
- Publisher
- Wiley
- Published
- 1993-07
- Volume
- 8
- Issue
- 3
- Pages
- 183-200
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- OpenAlex
- W2099040370
- Cited by
- 358
- References
- 74
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 7 · 2023: 9 · 2022: 17 · 2021: 13 · 2020: 16 · 2019: 13 · 2018: 25 · 2017: 19 · 2016: 17 · 2015: 10 · 2014: 10 · 2013: 13 · 2012: 14
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Glia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- perineuronal nets, N-acetylgalactosamine, hyaluronic acid, astrocytes, microglia, glutamine synthetase, S-100 protein, glutamic acid decarboxylase, synaptic boutons, red nucleus, cerebellar nuclei, vestibular nuclei, cerebral cortex, lectin binding
- MeSH terms
- Acetylgalactosamine, Animals, Anions, Brain, Brain Chemistry, Colloids, Cytoplasm, Extracellular Matrix, gamma-Aminobutyric Acid, Glutamate Decarboxylase, Glutamate-Ammonia Ligase, Hyaluronic Acid, Hydroxides, S100 Proteins, Neuroglia, Neurons, Organic Chemicals, Staining and Labeling, Synapses, Biomarkers, Rats, Sprague-Dawley, Rats, Wistar, Microglia, Lectins, Rats, Iron Compounds
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