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Advanced methods in meta‐analysis: multivariate approach and meta‐regression
Abstract
This tutorial on advanced statistical methods for meta‐analysis can be seen as a sequel to the recent Tutorial in Biostatistics on meta‐analysis by Normand, which focused on elementary methods. Within the framework of the general linear mixed model using approximate likelihood, we discuss methods to analyse univariate as well as bivariate treatment effects in meta‐analyses as well as meta‐regression methods. Several extensions of the models are discussed, like exact likelihood, non‐normal mixtures and multiple endpoints. We end with a discussion about the use of Bayesian methods in meta‐analysis. All methods are illustrated by a meta‐analysis concerning the efficacy of BCG vaccine against tuberculosis. All analyses that use approximate likelihood can be carried out by standard software. We demonstrate how the models can be fitted using SAS Proc Mixed. Copyright © 2002 John Wiley & Sons, Ltd.
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Metadata
- Authors
- van Houwelingen, H. C., Arends, L. R., & Stijnen, T.
- Venue
- Statistics in Medicine
- Publisher
- Wiley
- Published
- 2002-01-25
- Volume
- 21
- Issue
- 4
- Pages
- 589-624
- ISSN
- 0277-6715 (ISSN-L)
- 1097-0258
- OpenAlex
- W2126602143
- Cited by
- 1,580
- References
- 12
- FWCI
- 35.86
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.