Cited by 2,878Gut microbiota and healthMicrobial Metabolites in Food BiotechnologyProbiotics and Fermented Foods

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Gut microbiota functions: metabolism of nutrients and other food components

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Rowland, Ian, Gibson, Glenn, Heinken, Almut, Scott, Karen, Swann, Jonathan, Thiele, Ines, Tuohy, Kieran·2018·European Journal of Nutrition

DOI 10.1007/s00394-017-1445-8PMC PMC5847071

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Abstract

The diverse microbial community that inhabits the human gut has an extensive metabolic repertoire that is distinct from, but complements the activity of mammalian enzymes in the liver and gut mucosa and includes functions essential for host digestion. As such, the gut microbiota is a key factor in shaping the biochemical profile of the diet and, therefore, its impact on host health and disease. The important role that the gut microbiota appears to play in human metabolism and health has stimulated research into the identification of specific microorganisms involved in different processes, and the elucidation of metabolic pathways, particularly those associated with metabolism of dietary components and some host-generated substances. In the first part of the review, we discuss the main gut microorganisms, particularly bacteria, and microbial pathways associated with the metabolism of dietary carbohydrates (to short chain fatty acids and gases), proteins, plant polyphenols, bile acids, and vitamins. The second part of the review focuses on the methodologies, existing and novel, that can be employed to explore gut microbial pathways of metabolism. These include mathematical models, omics techniques, isolated microbes, and enzyme assays.

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Probiotics and prebiotics in intestinal health and disease: from biology to the clinic
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Authors: Rowland, I., Gibson, G., Heinken, A., Scott, K., Swann, J., Thiele, I., & Tuohy, K.
Affiliations: University of Reading (GB)
University of Luxembourg (LU)
University of Aberdeen (GB)
Imperial College London (GB)
Fondazione Edmund Mach (IT)
Corresponding author: Rowland, Ian
ORCID: Rowland, Ian
Gibson, Glenn
Heinken, Almut
Scott, Karen
Swann, Jonathan
Thiele, Ines
Tuohy, Kieran
Venue: European Journal of Nutrition
Publisher: Springer Science and Business Media LLC
Published: 2017-04-09
Volume: 57
Issue: 1
Pages: 1-24
ISSN: 1436-6207 (ISSN-L)
1436-6215
DOI: 10.1007/s00394-017-1445-8
PMC: PMC5847071
OpenAlex: W2604323123
Cited by: 2,878
References: 166
Citations by year: 2026: 317 · 2025: 393 · 2024: 431 · 2023: 382 · 2022: 424 · 2021: 365 · 2020: 305 · 2019: 173 · 2018: 65 · 2017: 17
FWCI: 14.34
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (unspecified)
Locations: European Journal of Nutrition (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
CentAUR (University of Reading) (acceptedVersion, other-oa)
ePrints Soton (University of Southampton) (acceptedVersion)
Aberdeen University Research Archive (Aberdeen University) (submittedVersion, other-oa)
CINECA IRIS Institutional Research Information System (Fondazione Edmund Mach) (submittedVersion, cc-by)
Open Repository and Bibliography (University of Luxembourg) (submittedVersion, cc-by-nc-sa)
Spiral (Imperial College London) (submittedVersion, cc-by)
Funders: International Life Sciences Institute Europe
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: gut microbiota, host-microbe interactions, nutrient metabolism, dietary carbohydrates, short-chain fatty acids, protein metabolism, plant polyphenols, bile acids, vitamin metabolism, microbial metabolic pathways, enzyme activity assay
MeSH terms: Gastrointestinal Microbiome, Bacteria, Bile Acids and Salts, Diet, Dietary Carbohydrates, Dietary Proteins, Fatty Acids, Food, Health Promotion, Humans, Models, Theoretical, Plants, Edible, Vitamins, Proteomics, Metagenomics, Polyphenols, Phytochemicals

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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Gut microbiota functions: metabolism of nutrients and other food components

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

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Cited by

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