The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Intercellular Coupling Confers Robustness against Mutations in the SCN Circadian Clock Network
Open accessAbstract
Molecular mechanisms of the mammalian circadian clock have been studied primarily by genetic perturbation and behavioral analysis. Here, we used bioluminescence imaging to monitor Per2 gene expression in tissues and cells from clock mutant mice. We discovered that Per1 and Cry1 are required for sustained rhythms in peripheral tissues and cells, and in neurons dissociated from the suprachiasmatic nuclei (SCN). Per2 is also required for sustained rhythms, whereas Cry2 and Per3 deficiencies cause only period length defects. However, oscillator network interactions in the SCN can compensate for Per1 or Cry1 deficiency, preserving sustained rhythmicity in mutant SCN slices and behavior. Thus, behavior does not necessarily reflect cell-autonomous clock phenotypes. Our studies reveal previously unappreciated requirements for Per1, Per2, and Cry1 in sustaining cellular circadian rhythmicity and demonstrate that SCN intercellular coupling is essential not only to synchronize component cellular oscillators but also for robustness against genetic perturbations.
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Citations
Cites
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379
Mammalian circadian biology: elucidating genome-wide levels of temporal organization
Lowrey, P. L., & Takahashi, J. S. (2004) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.5.061903.175925 · Cited by 976
Self-citationNonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock.
Zheng, B., Albrecht, U., Kaasik, K., Sage, M., Lu, W., Vaishnav, S., Li, Q., Sun, Z. S., Eichele, G., Bradley, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00380-4 · Cited by 900
Kornmann, B., Schaad, O., Bujard, H., Takahashi, J. S., & Schibler, U. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050034 · Cited by 658
Self-citationZheng (1999) · doi:10.1038/22659 · Cited by 293
Clock genes, oscillators, and cellular networks in the suprachiasmatic nuclei
Hastings, M. H., & Herzog, E. D. (2004) · Journal of Biological Rhythms · doi:10.1177/0748730404268786 · Cited by 246
Why pancreatic islets burst but single beta cells do not. The heterogeneity hypothesis
Smolen, P., Rinzel, J., & Sherman, A. (1993) · Biophysical Journal · doi:10.1016/s0006-3495(93)81539-x · Cited by 158
Cited by
Dibner, C., Schibler, U., & Albrecht, U. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135821 · Cited by 2,421
Central and Peripheral Circadian Clocks in Mammals
Mohawk, J. A., Green, C. B., & Takahashi, J. S. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153128 · Cited by 2,265
Self-citationThe genetics of mammalian circadian order and disorder: implications for physiology and disease
Takahashi, J. S., Hong, H.-K., Ko, C. H., & McDearmon, E. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2430 · Cited by 1,611
Self-citationMolecular architecture of the mammalian circadian clock
Partch, C. L., Green, C. B., & Takahashi, J. S. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.07.002 · Cited by 1,449
Self-citationSuprachiasmatic Nucleus: Cell Autonomy and Network Properties
Welsh, D. K., Takahashi, J. S., & Kay, S. A. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135919 · Cited by 1,216
Self-citationGeneration of circadian rhythms in the suprachiasmatic nucleus
Hastings, M. H., Maywood, E. S., & Brancaccio, M. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0026-z · Cited by 1,065
Molecular components of the mammalian circadian clock
Buhr, E. D., & Takahashi, J. S. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25950-0_1 · Cited by 738
Self-citationCrosstalk between components of circadian and metabolic cycles in mammals
Asher, G., & Schibler, U. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.006 · Cited by 601
Clocks not winding down: unravelling circadian networks
Zhang, E. E., & Kay, S. A. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2995 · Cited by 446
Self-citationCircadian clocks: regulators of endocrine and metabolic rhythms
Hastings, M., O’Neill, J. S., & Maywood, E. S. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0378 · Cited by 426
Molecular insights into human daily behavior
Brown, S. A., Kunz, D., Dumas, A., Westermark, P. O., Vanselow, K., Tilmann-Wahnschaffe, A., Herzel, H., & Kramer, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707772105 · Cited by 270
New Insights Into the Circadian Rhythm and Its Related Diseases
Xie, Y., Tang, Q., Chen, G., Xie, M., Yu, S., Zhao, J., & Chen, L. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00682 · Cited by 250
Yagita, K., Horie, K., Koinuma, S., Nakamura, W., Yamanaka, I., Urasaki, A., Shigeyoshi, Y., Kawakami, K., Shimada, S., Takeda, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913256107 · Cited by 241
Molecular components of the circadian clock in mammals
Takahashi, J. S. (2015) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12514 · Cited by 230
Self-citationLandgraf, D., Long, J. E., Proulx, C. D., Barandas, R., Malinow, R., & Welsh, D. K. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.03.1050 · Cited by 212
Self-citationCircadian Rhythms, the Molecular Clock, and Skeletal Muscle
Harfmann, B. D., Schroder, E. A., & Esser, K. A. (2015) · Journal of Biological Rhythms · doi:10.1177/0748730414561638 · Cited by 211
Cellular Circadian Clocks in Mood Disorders
McCarthy, M. J., & Welsh, D. K. (2012) · Journal of Biological Rhythms · doi:10.1177/0748730412456367 · Cited by 203
Self-citationLee, I. T., Chang, A. S., Manandhar, M., Shan, Y., Fan, J., Izumo, M., Ikeda, Y., Motoike, T., Dixon, S., Seinfeld, J. E., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.006 · Cited by 180
Self-citationDoi, M., Ishida, A., Miyake, A., Sato, M., Komatsu, R., Yamazaki, F., Kimura, I., Tsuchiya, S., Kori, H., Seo, K., et al. (2011) · Nature Communications · doi:10.1038/ncomms1316 · Cited by 143
The role of astrocyte structural plasticity in regulating neural circuit function and behavior
Lawal, O., Ulloa Severino, F. P., & Eroglu, C. (2022) · Glia · doi:10.1002/glia.24191 · Cited by 142
McCarthy, M. J., Wei, H., Marnoy, Z., Darvish, R. M., McPhie, D. L., Cohen, B. M., & Welsh, D. K. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.90 · Cited by 137
Self-citationDeery, M. J., Maywood, E. S., Chesham, J. E., Sládek, M., Karp, N. A., Green, E. W., Charles, P. D., Reddy, A. B., Kyriacou, C. P., Lilley, K. S., et al. (2009) · Current Biology · doi:10.1016/j.cub.2009.10.024 · Cited by 125
Daily and seasonal adaptation of the circadian clock requires plasticity of the SCN neuronal network
Meijer, J. H., Michel, S., VanderLeest, H. T., & Rohling, J. H. T. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07522.x · Cited by 119
Honma, S., Ono, D., Suzuki, Y., Inagaki, N., Yoshikawa, T., Nakamura, W., & Honma, K.-I. (2012) · Progress in brain research · doi:10.1016/b978-0-444-59427-3.00029-0 · Cited by 59
Strong resetting of the mammalian clock by constant light followed by constant darkness
Chen, R., Seo, D.-O., Bell, E., von Gall, C., & Lee, C. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2191-08.2008 · Cited by 53
Kim, E., Nohara, K., Wirianto, M., Escobedo, G., Lim, J. Y., Morales, R., Yoo, S.-H., & Chen, Z. (2021) · Biomolecules · doi:10.3390/biom11071004 · Cited by 51
“These oscillators are synchronized by the master pacemaker located in the suprachiasmatic nuclei (SCN) in the hypothalamus, primarily functioning to control gene expression and downstream physiological functions throughout the body [16,17].”
BackgroundCo-opting evo-devo concepts for new insights into mechanisms of behavioural diversity
Hoke, K. L., Adkins-Regan, E., Bass, A. H., McCune, A. R., & Wolfner, M. F. (2019) · Journal of Experimental Biology · doi:10.1242/jeb.190058 · Cited by 42
Circadian regulation of cellular physiology
Peek, C. B., Ramsey, K. M., Levine, D. C., Marcheva, B., Perelis, M., & Bass, J. (2015) · Methods in Enzymology · doi:10.1016/bs.mie.2014.10.006 · Cited by 35
McCarthy, M. J., Fernandes, M., Kranzler, H. R., Covault, J. M., & Welsh, D. K. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12106 · Cited by 32
Self-citationCircadian clock-gastrointestinal peptide interaction in peripheral tissues and the brain
Landgraf, D., Neumann, A.-M., & Oster, H. (2017) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2017.10.007 · Cited by 26
Single-cell analysis of circadian dynamics in tissue explants
Lande-Diner, L., Stewart-Ornstein, J., Weitz, C. J., & Lahav, G. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-06-0403 · Cited by 22
Metadata
- Authors
- Liu, A. C., Welsh, D. K., Ko, C. H., Tran, H. G., Zhang, E. E., Priest, A. A., Buhr, E. D., Singer, O., Meeker, K., Verma, I. M., Doyle, F. J., Takahashi, J. S., & Kay, S. A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2007-05
- Volume
- 129
- Issue
- 3
- Pages
- 605-616
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2094589586
- Cited by
- 699
- References
- 7
- FWCI
- 16.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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