Crosstalk between Components of Circadian and Metabolic Cycles in Mammals

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Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

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The mammalian circadian timing system: organization and coordination of central and peripheral clocks

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Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus

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PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues

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Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock

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The Orphan Nuclear Receptor REV-ERBα Controls Circadian Transcription within the Positive Limb of the Mammalian Circadian Oscillator

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A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells

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Resetting central and peripheral circadian oscillators in transgenic rats

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Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

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MYC on the Path to Cancer

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Cellular and molecular mechanisms of metformin: an overview

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The two‐process model of sleep regulation: a reappraisal

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Circadian physiology of metabolism

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Bile acid signaling in metabolic disease and drug therapy

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Timing to perfection: the biology of central and peripheral circadian clocks

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A smartphone app reveals erratic diurnal eating patterns in humans that can be modulated for health benefits

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Time for food: the intimate interplay between nutrition, metabolism, and the circadian clock

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Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

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Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease

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Circadian Gene Bmal1 Regulates Diurnal Oscillations of Ly6C hi Inflammatory Monocytes

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SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

Chang, H.-C., & Guarente, L. (2013) · Cell · doi:10.1016/j.cell.2013.05.027 · Cited by 615

Genetics of Circadian Rhythms in Mammalian Model Organisms

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The human circadian metabolome

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Homeostasis in intestinal epithelium is orchestrated by the circadian clock and microbiota cues transduced by TLRs

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A two-way street: reciprocal regulation of metabolism and signalling

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Circadian clock control of endocrine factors

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The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome

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Identification of Small Molecule Activators of Cryptochrome

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Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling

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Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock

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Functions of autophagy in normal and diseased liver

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Circadian Clocks and Feeding Time Regulate the Oscillations and Levels of Hepatic Triglycerides

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Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness

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Time-Restricted Eating to Prevent and Manage Chronic Metabolic Diseases

Chaix, A., Manoogian, E. N. C., Melkani, G. C., & Panda, S. (2019) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082018-124320 · Cited by 424

Seven sirtuins for seven deadly diseases ofaging

Morris, B. J. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.10.525 · Cited by 386

Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice

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Effect of ethanol on lipid metabolism

You, M., & Arteel, G. E. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2018.10.037 · Cited by 357

Time-restricted eating for the prevention and management of metabolic diseases

Manoogian, E. N. C., Chow, L. S., Taub, P. R., Laferrère, B., & Panda, S. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnab027 · Cited by 344

Systems Chronotherapeutics

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Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics

Schmitt, K., Grimm, A., Dallmann, R., Oettinghaus, B., Restelli, L. M., Witzig, M., Ishihara, N., Mihara, K., Ripperger, J. A., Albrecht, U., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.01.011 · Cited by 346

Circadian control of glucose metabolism

Kalsbeek, A., la Fleur, S., & Fliers, E. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.03.002 · Cited by 338

Multiple Functions and Regulation of Mammalian Peroxiredoxins

Rhee, S. G., & Kil, I. S. (2017) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060815-014431 · Cited by 325

Circadian Clock Control of Liver Metabolic Functions

Reinke, H., & Asher, G. (2016) · Gastroenterology · doi:10.1053/j.gastro.2015.11.043 · Cited by 321

Autophagy and mitophagy in the context of doxorubicin-induced cardiotoxicity

Koleini, N., & Kardami, E. (2017) · Oncotarget · doi:10.18632/oncotarget.16944 · Cited by 308

Meal timing and obesity: interactions with macronutrient intake and chronotype

Xiao, Q., Garaulet, M., & Scheer, F. A. J. L. (2019) · International Journal of Obesity · doi:10.1038/s41366-018-0284-x · Cited by 285

bHLH-PAS proteins in cancer

Bersten, D. C., Sullivan, A. E., Peet, D. J., & Whitelaw, M. L. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3621 · Cited by 267

Circadian Clocks and Metabolism

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Relationship between Duration of Sleep and Hypertension in Adults: A Meta-Analysis

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MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells

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Daily eating patterns and their impact on health and disease

Zarrinpar, A., Chaix, A., & Panda, S. (2016) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.11.007 · Cited by 263

Circadian Enhancers Coordinate Multiple Phases of Rhythmic Gene Transcription In Vivo

Fang, B., Everett, L. J., Jager, J., Briggs, E. R., Armour, S. M., Feng, D., Roy, A., Gerhart‐Hines, Z., Sun, Z., & Lazar, M. A. (2014) · Cell · doi:10.1016/j.cell.2014.10.022 · Cited by 269

Circadian control of oscillations in mitochondrial rate-limiting enzymes and nutrient utilization by PERIOD proteins

Neufeld-Cohen, A., Robles, M. S., Aviram, R., Manella, G., Adamovich, Y., Ladeuix, B., Nir, D., Rousso-Noori, L., Kuperman, Y., Golik, M., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1519650113 · Cited by 262

The nuclear receptor Rev-erbα controls circadian thermogenic plasticity

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Feeding Rhythms and the Circadian Regulation of Metabolism

Pickel, L., & Sung, H. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.00039 · Cited by 282

Circadian Oscillations of Protein-Coding and Regulatory RNAs in a Highly Dynamic Mammalian Liver Epigenome

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The nuclear receptor REV-ERBα is required for the daily balance of carbohydrate and lipid metabolism

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Macromolecular Assemblies of the Mammalian Circadian Clock

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The circadian clock and liver function in health and disease

Mukherji, A., Bailey, S. M., Staels, B., & Baumert, T. F. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.03.020 · Cited by 246

Circadian timing of metabolism in animal models and humans

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Chronopharmacology: New Insights and Therapeutic Implications

Dallmann, R., Brown, S. A., & Gachon, F. (2013) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-135923 · Cited by 259

SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket

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A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use

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Sweet Sixteenth for ChREBP: Established Roles and Future Goals

Abdul-Wahed, A., Guilmeau, S., & Postic, C. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.07.004 · Cited by 231

Cracking the O-GlcNAc code in metabolism

Ruan, H., Singh, J. P., Li, M., Wu, J., & Yang, X. (2013) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.02.002 · Cited by 224

PPARs Integrate the Mammalian Clock and Energy Metabolism

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Light and the Human Circadian Clock

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Bmal1 and β-Cell Clock Are Required for Adaptation to Circadian Disruption, and Their Loss of Function Leads to Oxidative Stress-Induced β-Cell Failure in Mice

Lee, J., Moulik, M., Fang, Z., Saha, P., Zou, F., Xu, Y., Nelson, D. L., Ma, K., Moore, D. D., & Yechoor, V. K. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01421-12 · Cited by 230

Impact of nutrients on circadian rhythmicity

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Circadian Disruption Changes Gut Microbiome Taxa and Functional Gene Composition

Deaver, J. A., Eum, S. Y., & Toborek, M. J. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00737 · Cited by 218

Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism

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O-GlcNAc Signaling Entrains the Circadian Clock by Inhibiting BMAL1/CLOCK Ubiquitination

Li, M., Ruan, H., Hughes, M. E., Lee, J.-S., Singh, J. P., Jones, S. P., Nitabach, M. N., & Yang, X. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.015 · Cited by 225

Circadian regulation of metabolism

Bailey, S. M., Udoh, U. S., & Young, M. E. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0200 · Cited by 219

mTOR signaling regulates central and peripheral circadian clock function

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Tuning the Mammalian Circadian Clock: Robust Synergy of Two Loops

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Interacting epidemics? Sleep curtailment, insulin resistance, and obesity

Lucassen, E. A., Rother, K. I., & Cizza, G. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06655.x · Cited by 191

Exposure to Light at Night, Nocturnal Urinary Melatonin Excretion, and Obesity/Dyslipidemia in the Elderly: A Cross-Sectional Analysis of the HEIJO-KYO Study

Obayashi, K., Saeki, K., Iwamoto, J., Okamoto, N., Tomioka, K., Nezu, S., Ikada, Y., & Kurumatani, N. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2874 · Cited by 198

(Re)inventing the Circadian Feedback Loop

Brown, S. A., Kowalska, E., & Dallmann, R. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.02.007 · Cited by 191

Homeostasis of Glucose and Lipid in Non-Alcoholic Fatty Liver Disease

Chao, H., Chao, S.-W., Lin, H., Ku, H., & Cheng, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020298 · Cited by 192

Circadian metabolism in the light of evolution

Gerhart-Hines, Z., & Lazar, M. A. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1007 · Cited by 178

Shifting eating to the circadian rest phase misaligns the peripheral clocks with the master SCN clock and leads to a metabolic syndrome

Mukherji, A., Kobiita, A., Damara, M., Misra, N., Méziane, H., Champy, M., & Chambon, P. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1519807112 · Cited by 185

Retinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism

Cook, D. N., Kang, H. S., & Jetten, A. M. (2015) · Nuclear Receptor Research · doi:10.11131/2015/101185 · Cited by 181

Circadian Rhythms in the Pathogenesis and Treatment of Fatty Liver Disease

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Retinoic acid-related orphan receptors α and γ: key regulators of lipid/glucose metabolism, inflammation, and insulin sensitivity

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Clock Genes and Clock-Controlled Genes in the Regulation of Metabolic Rhythms

Mazzoccoli, G., Pazienza, V., & Vinciguerra, M. (2012) · Chronobiology International · doi:10.3109/07420528.2012.658127 · Cited by 173

Mitochondrial autophagy and cell survival is regulated by the circadian Clock gene in cardiac myocytes during ischemic stress

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Rhythmic Degradation Explains and Unifies Circadian Transcriptome and Proteome Data

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Circadian rhythms – from genes to physiology and disease

Bollinger, T., & Schibler, U. (2014) · Swiss Medical Weekly · doi:10.4414/smw.2014.13984 · Cited by 152

Circadian Rhythms, Aging, and Life Span in Mammals

Froy, O. (2011) · Physiology · doi:10.1152/physiol.00012.2011 · Cited by 156

Circadian Clock Control by Polyamine Levels through a Mechanism that Declines with Age

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A Novel Protein, CHRONO, Functions as a Core Component of the Mammalian Circadian Clock

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The circadian clock: a framework linking metabolism, epigenetics and neuronal function

Masri, S., & Sassone‐Corsi, P. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3393 · Cited by 161

Hepatic mTORC1 controls locomotor activity, body temperature, and lipid metabolism through FGF21

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Development and Therapeutic Potential of Small-Molecule Modulators of Circadian Systems

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RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo

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Regulation of Circadian Behavioral Output via a MicroRNA-JAK/STAT Circuit

Luo, W., & Sehgal, A. (2012) · Cell · doi:10.1016/j.cell.2011.12.024 · Cited by 147

Eyeless Mexican Cavefish Save Energy by Eliminating the Circadian Rhythm in Metabolism

Moran, D., Softley, R., & Warrant, E. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107877 · Cited by 142

The circadian clock and glucocorticoids – interactions across many time scales

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O-GlcNAcylation, Novel Post-Translational Modification Linking Myocardial Metabolism and Cardiomyocyte Circadian Clock

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Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals

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CLOCK-Controlled Polyphonic Regulation of Circadian Rhythms through Canonical and Noncanonical E-Boxes

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Circadian and sleep disorder in Huntington's disease

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Global and hepatocyte-specific ablation of Bmal1 induces hyperlipidaemia and enhances atherosclerosis

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Entrainment of the mouse circadian clock by sub-acute physical and psychological stress

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Circadian Secretion of the Intestinal Hormone GLP-1 by the Rodent L Cell

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Shifting the feeding of mice to the rest phase creates metabolic alterations, which, on their own, shift the peripheral circadian clocks by 12 hours

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A Fad too Far? Dietary Strategies for the Prevention and Treatment of NAFLD

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NRF2 regulates core and stabilizing circadian clock loops, coupling redox and timekeeping in Mus musculus

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Novel Small-Molecule PGC-1α Transcriptional Regulator With Beneficial Effects on Diabetic db/db Mice

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Crosstalk between metabolism and circadian clocks

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Metabolism control by the circadian clock and vice versa

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Molecular and genetic aspects of interactions of the circadian clock and the energy-producing substrate metabolism in mammals

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Circadian NAD(P)(H) cycles in cell metabolism

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Metabolism as an integral cog in the mammalian circadian clockwork

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