Cited by 9Attention Deficit Hyperactivity DisorderNeural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on Behavior

The neurobehavioral mechanisms of motivational control in attention-deficit/hyperactivity disorder

Ceceli, Ahmet O., Natsheh, Joman Y., Cruz, Daniel, Tricomi, Elizabeth·2020·Cortex

Abstract

Attention-deficit/hyperactivity disorder (ADHD) poses debilitating impairments in the neurobehavioral systems governing reward-related processes-key to the control of motivated behaviors. Individuals with ADHD may rely on a motivational control system that favors cue-driven habits-rooted in the posterior putamen-over caudate and prefrontal cortex-driven goal-directed behaviors. We examined the neurobehavioral correlates of motivational control in ADHD. Twenty-five adults with ADHD and 25 neurotypicals underwent fMRI while training on two stimulus-response-outcome associations. A devaluation procedure followed, whereby they were selectively satiated on one of the snack outcomes, decreasing its value. A subsequent extinction test determined outcome-sensitivity (i.e., whether responses towards devalued snack diminished). Despite behavioral similarities, the ADHD group displayed a distinct neural signature marked by enhanced posterior putamen activation as a function of training. This region also displayed diminished functional connectivity with the dorsal anterior cingulate cortex, which is associated with top-down control. Our whole-brain analysis yielded ADHD-specific posterior putamen and opercular/insular cortex activity over the course of training-regions associated with stimulus-sensitivity and maladaptively rigid behaviors, respectively. Neural comparisons also identified hyper-recruitment of the hippocampus in the ADHD group. These results highlight corticostriatal discrepancies in ADHD, possibly serving as a biomarker of the disorder.

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Crossref · 10.1016/j.cortex.2020.02.009

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Authors
Ceceli, A. O., Natsheh, J. Y., Cruz, D., & Tricomi, E.
Affiliations
  • Rutgers, The State University of New Jersey (US)
  • Kessler Foundation (US)
Corresponding author
Tricomi, Elizabeth
Venue
Cortex
Publisher
Elsevier BV
Published
2020-06
Volume
127
Pages
191-207
ISSN
0010-9452 (ISSN-L)
OpenAlex
W3007888665
Cited by
9
References
109
Citations by year
2026: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1
FWCI
1.10
Type
journal article
Language
en
Open access
closed
Locations
  • Cortex (publishedVersion)
  • PubMed (publishedVersion)
Funders
Rutgers, The State University of New Jersey
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
attention deficit hyperactivity disorder, motivational control, reward processing, posterior putamen, dorsal anterior cingulate cortex, corticostriatal circuits, currency devaluation, outcome sensitivity, extinction, stimulus-response associations, hippocampus, insula, goal-directed behavior, top-down control, neural markers
MeSH terms
Adult, Attention Deficit Disorder with Hyperactivity, Brain, Brain Mapping, Humans, Magnetic Resonance Imaging, Motivation

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