Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

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Molecular and cellular insights into T cell exhaustion

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T cell exhaustion

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Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

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Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

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Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

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Tumor antigen–specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired

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CD4+ T cell help in cancer immunology and immunotherapy

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Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates

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A transcriptionally and functionally distinct PD-1(+) CD8(+) T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

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Metabolic Regulation of T Lymphocytes

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An anti-CD3 antibody, teplizumab, in relatives at risk for type 1 diabetes

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VEGF-A modulates expression of inhibitory checkpoints on CD8+ T cells in tumors

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TOX is a critical regulator of tumour-specific T cell differentiation

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CD8+ T cell differentiation and dysfunction in cancer

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Redefining Chronic Viral Infection

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Commensal bacteria calibrate the activation threshold of innate antiviral immunity

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The epigenetic landscape of T cell exhaustion

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Systemic Immunity Is Required for Effective Cancer Immunotherapy

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c-Jun overexpression in CAR T cells induces exhaustion resistance

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The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells

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NR4A transcription factors limit CAR T cell function in solid tumours

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Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion

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Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

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Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

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Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients

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PD-1 signaling in primary T cells

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Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease

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Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis

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T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment

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TCF-1-centered transcriptional network drives an effector versus exhausted CD8 T cell-fate decision

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Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention

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T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection

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Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

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Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen

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Immune escape to PD-L1/PD-1 blockade: seven steps to success (or failure)

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Single-cell genomics unveils critical regulators of Th17 cell pathogenicity

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Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen

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Origin and differentiation of human memory CD8 T cells after vaccination

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Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer

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Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer

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Reversing T-cell Dysfunction and Exhaustion in Cancer

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Induction of T-cell immunity overcomes complete resistance to PD-1 and CTLA-4 blockade and improves survival in pancreatic carcinoma

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Effector CD8 T cells dedifferentiate into long-lived memory cells

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Role of the PD-1 pathway in the immune response

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The emerging role of epigenetic therapeutics in immuno-oncology

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NFATc1 Regulates PD-1 Expression upon T Cell Activation

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Bat3 promotes T cell responses and autoimmunity by repressing Tim-3-mediated cell death and exhaustion

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An ex vivo tumor fragment platform to dissect response to PD-1 blockade in cancer

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Exhaustion and senescence: two crucial dysfunctional states of T cells in the tumor microenvironment

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CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1

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Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation

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CD19 CAR T cell product and disease attributes predict leukemia remission durability

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Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis

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Metabolism in T cell activation and differentiation

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Impaired death receptor signaling in leukemia causes antigen-independent resistance by inducing CAR T-cell dysfunction

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Phosphotyrosine-Dependent Coupling of Tim-3 to T-Cell Receptor Signaling Pathways

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Therapeutic cancer vaccines: Are we there yet?

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Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity

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Partial exhaustion of CD8 T cells and clinical response to teplizumab in new-onset type 1 diabetes

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Age-Associated B Cells: A T-bet–Dependent Effector with Roles in Protective and Pathogenic Immunity

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VEGF-A drives TOX-dependent T cell exhaustion in anti–PD-1–resistant microsatellite stable colorectal cancers

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In vivo discovery of immunotherapy targets in the tumour microenvironment

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Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition

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Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming

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Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies

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TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance

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Molecular profiling of cytomegalovirus-induced human CD8+ T cell differentiation

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Maternal Antibiotic Treatment Impacts Development of the Neonatal Intestinal Microbiome and Antiviral Immunity

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Blockade of PD‐1 or p38 MAP kinase signaling enhances senescent human CD8+ T‐cell proliferation by distinct pathways

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PD-1/PD-L1 blockade enhances T-cell activity and antitumor efficacy of imatinib in gastrointestinal stromal tumors

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Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted

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Detecting Tumor Antigen-Specific T Cells via Interaction-Dependent Fucosyl-Biotinylation

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Functional Heterogeneity of CD4+ Tumor-Infiltrating Lymphocytes With a Resident Memory Phenotype in NSCLC

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Signaling pathways in aged T cells – A reflection of T cell differentiation, cell senescence and host environment

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Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15Rα complexes

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