Clinical translation of nanomedicines for brain diseases: Current challenges and future directions

Staging of brain pathology related to sporadic Parkinson’s disease

Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777

Engineering precision nanoparticles for drug delivery

Mitchell, M. J., Billingsley, M. M., Haley, R. M., Wechsler, M. E., Peppas, N. A., & Langer, R. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0090-8 · Cited by 7,933

Principles of nanoparticle design for overcoming biological barriers to drug delivery

Blanco, E., Shen, H., & Ferrari, M. (2015) · Nature Biotechnology · doi:10.1038/nbt.3330 · Cited by 7,002

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930

Nanomaterials and nanoparticles: Sources and toxicity

Buzea, C., Pacheco, I. I., & Robbie, K. (2007) · Biointerphases · doi:10.1116/1.2815690 · Cited by 3,789

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.188 · Cited by 3,076

Targeting oxidative stress in disease: Promise and limitations of antioxidant therapy

Forman, H. J., & Zhang, H. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00233-1 · Cited by 2,900

Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date

Bobo, D., Robinson, K. J., Islam, J., Thurecht, K. J., & Corrie, S. R. (2016) · Pharmaceutical Research · doi:10.1007/s11095-016-1958-5 · Cited by 2,586

Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform

Hu, C. J., Zhang, L., Aryal, S., Cheung, C., Fang, R. H., & Zhang, L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106634108 · Cited by 2,466

Strategies and challenges for the next generation of antibody–drug conjugates

Beck, A., Goetsch, L., Dumontet, C., & Corvaïa, N. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.268 · Cited by 2,271

Lipid NanoparticlesFrom Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement

Tenchov, R., Bird, R., Curtze, A. E., & Zhou, Q. (2021) · ACS Nano · doi:10.1021/acsnano.1c04996 · Cited by 2,221

Progress and challenges towards targeted delivery of cancer therapeutics

Rosenblum, D., Joshi, N., Tao, W., Karp, J. M., & Peer, D. (2018) · Nature Communications · doi:10.1038/s41467-018-03705-y · Cited by 2,220

The blood–brain barrier: Structure, regulation and drug delivery

Wu, D., Chen, Q., Chen, X., Han, F., Chen, Z., & Wang, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01481-w · Cited by 1,906

Inorganic Nanoparticles for MRI Contrast Agents

Na, H. B., Song, I. C., & Hyeon, T. (2009) · Advanced Materials · doi:10.1002/adma.200802366 · Cited by 1,811

Hallmarks of neurodegenerative diseases

Wilson, D. M., Cookson, M. R., Van Den Bosch, L., Zetterberg, H., Holtzman, D. M., & Dewachter, I. (2023) · Cell · doi:10.1016/j.cell.2022.12.032 · Cited by 1,789

The human brain in numbers: a linearly scaled-up primate brain

Herculano-Houzel, S. (2009) · Frontiers in Human Neuroscience · doi:10.3389/neuro.09.031.2009 · Cited by 1,778

The connectomics of brain disorders

Fornito, A., Zalesky, A., & Breakspear, M. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3901 · Cited by 1,734

The entry of nanoparticles into solid tumours

Sindhwani, S., Syed, A. M., Ngai, J., Kingston, B. R., Maiorino, L., Rothschild, J., MacMillan, P., Zhang, Y., Rajesh, N. U., Hoang, T., et al. (2020) · Nature Materials · doi:10.1038/s41563-019-0566-2 · Cited by 1,732

Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells

Lewin, M., Carlesso, N., Tung, C., Tang, X. S., Cory, D. G., Scadden, D. T., & Weissleder, R. (2000) · Nature Biotechnology · doi:10.1038/74464 · Cited by 1,716

Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases

Saraiva, C., Praça, C., Ferreira, R., Santos, T., Ferreira, L., & Bernardino, L. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.044 · Cited by 1,609

Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia

Jain, R. K. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.10.006 · Cited by 1,589

12th Annual International Conference on Material Science and Engineering (12th ICMSE)

Wang, K., & Achour, B. (2025) · Trans Tech Publications Ltd. eBooks · doi:10.4028/b-xdtcg5 · Cited by 1,407

The global burden of neurological disorders: translating evidence into policy

Feigin, V. L., Vos, T., Nichols, E., Owolabi, M. O., Carroll, W. M., Dichgans, M., Deuschl, G., Parmar, P., Brainin, M., & Murray, C. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30411-9 · Cited by 1,303

Challenges associated with penetration of nanoparticles across cell and tissue barriers: A review of current status and future prospects

Barua, S., & Mitragotri, S. (2014) · Nano Today · doi:10.1016/j.nantod.2014.04.008 · Cited by 1,288

Challenges and strategies in anti-cancer nanomedicine development: An industry perspective

Hare, J. I., Lammers, T., Ashford, M. B., Puri, S., Storm, G., & Barry, S. T. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.025 · Cited by 1,279

Pathological mechanisms in progressive multiple sclerosis

Mahad, D., Trapp, B. D., & Lassmann, H. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70256-x · Cited by 1,198

Targeted drug delivery strategies for precision medicines

Manzari, M. T., Shamay, Y., Kiguchi, H., Rosen, N., Scaltriti, M., & Heller, D. A. (2021) · Nature Reviews Materials · doi:10.1038/s41578-020-00269-6 · Cited by 1,183

Targeting Strategies for Tissue-Specific Drug Delivery

Zhao, Z., Ukidve, A., Kim, J., & Mitragotri, S. (2020) · Cell · doi:10.1016/j.cell.2020.02.001 · Cited by 1,145

Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine

de Almeida, M. S., Sušnik, E., Drašler, B., Taladriz‐Blanco, P., Petri‐Fink, A., & Rothen‐Rutishauser, B. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01127d · Cited by 1,140

Strategies for delivering therapeutics across the blood–brain barrier

Terstappen, G. C., Meyer, A. H., Bell, R. D., & Zhang, W. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00139-y · Cited by 1,138

Therapeutic Nanoparticles and Their Targeted Delivery Applications

Yetisgin, A. A., Çetinel, S., Zuvin, M., Koşar, A., & Kutlu, Ö. (2020) · Molecules · doi:10.3390/molecules25092193 · Cited by 1,136

Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation

Chehelgerdi, M., Chehelgerdi, M., Allela, O. Q. B., Pecho, R. D. C., Narayanan, J., Rao, D. P., Thamaraikani, T., Vasanthan, M., Viktor, P., Lakshmaiya, N., et al. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01865-0 · Cited by 1,132

Therapeutic efficacy of nanoparticles and routes of administration

Chenthamara, D., Sadhasivam, S., Ramakrishnan, S. G., Krishnaswamy, S., Essa, M. M., Lin, F., & Qoronfleh, M. W. (2019) · Biomaterials Research · doi:10.1186/s40824-019-0166-x · Cited by 1,103

Nanoparticle processing: Understanding and controlling aggregation

Shrestha, S., Wang, B., & Dutta, P. K. (2020) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2020.102162 · Cited by 959

Minireview: Nanoparticles and the Immune System

Zolnik, B. S., González-Fernández, A., Sadrieh, N., & Dobrovolskaia, M. A. (2010) · Endocrinology · doi:10.1210/en.2009-1082 · Cited by 914

Machine Learning in Drug Discovery: A Review

Dara, S., Dhamercherla, S., Jadav, S. S., Babu, C. M., & Ahsan, M. J. (2021) · Artificial Intelligence Review · doi:10.1007/s10462-021-10058-4 · Cited by 893

Liposome composition in drug delivery design, synthesis, characterization, and clinical application

Large, D. E., Abdelmessih, R. G., Fink, E. A., & Auguste, D. T. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113851 · Cited by 886

Biomimetic peptide self-assembly for functional materials

Levin, A., Hakala, T. A., Schnaider, L., Bernardes, G. J. L., Gazit, E., & Knowles, T. P. J. (2020) · Nature Reviews Chemistry · doi:10.1038/s41570-020-0215-y · Cited by 879

Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics

Mi, P. (2020) · Theranostics · doi:10.7150/thno.38069 · Cited by 874

Local drug delivery strategies for cancer treatment: Gels, nanoparticles, polymeric films, rods, and wafers

Wolinsky, J. B., Colson, Y. L., & Grinstaff, M. W. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.11.031 · Cited by 848

In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles

Arami, H., Khandhar, A., Liggitt, D., & Krishnan, K. M. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00541h · Cited by 830

Nanomedicine: Principles, Properties, and Regulatory Issues

Soares, S., Sousa, J., Pais, A. A. C. C., & Vitorino, C. (2018) · Frontiers in Chemistry · doi:10.3389/fchem.2018.00360 · Cited by 795

Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers

Fang, J., Islam, W., & Maeda, H. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.005 · Cited by 757

Passive, active and endogenous organ-targeted lipid and polymer nanoparticles for delivery of genetic drugs

Dilliard, S. A., & Siegwart, D. J. (2023) · Nature Reviews Materials · doi:10.1038/s41578-022-00529-7 · Cited by 744

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody

Yuan, F., Chen, Y., Dellian, M., Safabakhsh, N., Ferrara, N., & Jain, R. K. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14765 · Cited by 719

Emerging combination strategies with phototherapy in cancer nanomedicine

Xie, Z., Fan, T., An, J., Choi, W., Duo, Y., Ge, Y., Zhang, B., Nie, G., Xie, N., Zheng, T., et al. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00215a · Cited by 718

Current hurdles to the translation of nanomedicines from bench to the clinic

Đorđević, S., Gonzalez, M. M., Conejos‐Sánchez, I., Carreira, B., Pozzi, S., Acúrcio, R. C., Satchi‐Fainaro, R., Florindo, H. F., & Vicent, M. J. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-01024-2 · Cited by 715

Overcoming the Blood–Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases

Furtado, D., Björnmalm, M., Ayton, S., Bush, A. I., Kempe, K., & Caruso, F. (2018) · Advanced Materials · doi:10.1002/adma.201801362 · Cited by 708

Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke

Knowland, D., Arac, A., Sekiguchi, K. J., Hsu, M., Lutz, S. E., Perrino, J., Steinberg, G. K., Barres, B. A., Nimmerjahn, A., & Agalliu, D. (2014) · Neuron · doi:10.1016/j.neuron.2014.03.003 · Cited by 703

Principles in the design of ligand-targeted cancer therapeutics and imaging agents

Srinivasarao, M., Galliford, C. V., & Low, P. S. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4519 · Cited by 687

Function and therapeutic value of astrocytes in neurological diseases

Lee, H.-G., Wheeler, M. A., & Quintana, F. J. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00390-x · Cited by 662

Safe Nanoparticles: Are We There Yet?

Najahi‐Missaoui, W., Arnold, R. D., & Cummings, B. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010385 · Cited by 618

Nanomaterial-based blood-brain-barrier (BBB) crossing strategies

Xie, J., Shen, Z., Anraku, Y., Kataoka, K., & Chen, X. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119491 · Cited by 604

Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo

Chen, F., Wang, G., Griffin, J. I., Brenneman, B., Banda, N. K., Holers, V. M., Backos, D. S., Wu, L., Moghimi, S. M., & Simberg, D. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2016.269 · Cited by 599

Delivery of Molecular and Nanoscale Medicine to Tumors: Transport Barriers and Strategies

Chauhan, V. P., Stylianopoulos, T., Boucher, Y., & Jain, R. K. (2011) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-061010-114300 · Cited by 597

Lipid Nanoparticles for Drug Delivery

Xu, L., Wang, X., Liu, Y., Yang, G., Falconer, R. J., & Zhao, C. (2021) · Advanced NanoBiomed Research · doi:10.1002/anbr.202100109 · Cited by 588

Microglia and Central Nervous System–Associated Macrophages—From Origin to Disease Modulation

Prinz, M., Masuda, T., Wheeler, M. A., & Quintana, F. J. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-093019-110159 · Cited by 584

Amyloid-β-independent regulators of tau pathology in Alzheimer disease

van der Kant, R., Goldstein, L. S. B., & Ossenkoppele, R. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0240-3 · Cited by 580

Animal models of neurodegenerative diseases

Dawson, T. M., Golde, T. E., & Lagier-Tourenne, C. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0236-8 · Cited by 576

Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis

Morad, G., Carman, C. V., Hagedorn, E. J., Perlin, J. R., Zon, L. I., Mustafaoğlu, N., Park, T., Ingber, D. E., Daisy, C. C., & Moses, M. A. (2019) · ACS Nano · doi:10.1021/acsnano.9b04397 · Cited by 572

Lipid-Based Nanoparticles in the Clinic and Clinical Trials: From Cancer Nanomedicine to COVID-19 Vaccines

Thi, T. T. H., Suys, E. J. A., Lee, J. S., Nguyen, D. H., Park, K. D., & Truong, N. P. (2021) · Vaccines · doi:10.3390/vaccines9040359 · Cited by 551

Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson’s disease

Qu, M., Lin, Q., Huang, L., Fu, Y., Wang, L., He, S., Fu, Y., Yang, S., Zhang, Z., Zhang, L., et al. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.08.035 · Cited by 543

Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor

Wiley, D. T., Webster, P. C., Gale, A., & Davis, M. E. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307152110 · Cited by 535

The blood-brain barrier and immune function and dysfunction

Banks, W. A., & Erickson, M. A. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.031 · Cited by 523

RAGE, LRP-1, and amyloid-beta protein in Alzheimer’s disease

Donahue, J. E., Flaherty, S. L., Johanson, C. E., Duncan, J. A., Silverberg, G. D., Miller, M. C., Tavares, R., Yang, W., Wu, Q., Sabo, E., et al. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0115-3 · Cited by 519

“Combo” nanomedicine: Co-delivery of multi-modal therapeutics for efficient, targeted, and safe cancer therapy

Kemp, J. A., Shim, M. S., Heo, C. Y., & Kwon, Y. J. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.10.019 · Cited by 518

Role of animal models in biomedical research: a review

Mukherjee, P., Roy, S., Ghosh, D., & Nandi, S. K. (2022) · Laboratory Animal Research · doi:10.1186/s42826-022-00128-1 · Cited by 510

Inorganic nanomaterials with rapid clearance for biomedical applications

Wang, X., Zhong, X., Li, J., Liu, Z., & Cheng, L. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00461h · Cited by 509

Clinical translation of nanomedicines: Challenges, opportunities, and keys

Younis, M. A., Tawfeek, H. M., Abdellatif, A. A. H., Abdel-Aleem, J. A., & Harashima, H. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114083 · Cited by 506

Targeting and Crossing the Blood-Brain Barrier with Extracellular Vesicles

Saint-Pol, J., Gosselet, F., Duban-Deweer, S., Pottiez, G., & Karamanos, Y. (2020) · Cells · doi:10.3390/cells9040851 · Cited by 503

Protein nanoparticles in drug delivery: animal protein, plant proteins and protein cages, albumin nanoparticles

Kianfar, E. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00896-3 · Cited by 484

Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products

Ibrahim, M. Y., Ramadan, E., Elsadek, N. E., Emam, S. E., Shimizu, T., Ando, H., Ishima, Y., El-Garhy, O. H., Sarhan, H. A., Hussein, A. K., et al. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.09.031 · Cited by 481

Overcoming blood–brain barrier transport: Advances in nanoparticle-based drug delivery strategies

Ding, S., Khan, A. I., Cai, X., Song, Y., Lyu, Z., Du, D., Dutta, P., & Lin, Y. (2020) · Materials Today · doi:10.1016/j.mattod.2020.02.001 · Cited by 468

Biocompatible Polymer Nanoparticles for Drug Delivery Applications in Cancer and Neurodegenerative Disorder Therapies

Calzoni, E., Cesaretti, A., Polchi, A., Michele, A. D., Tancini, B., & Emiliani, C. (2019) · Journal of Functional Biomaterials · doi:10.3390/jfb10010004 · Cited by 468

Nanoparticles in Drug Delivery: From History to Therapeutic Applications

Afzal, O., Altamimi, A. S. A., Nadeem, M. S., Alzarea, S. I., Almalki, W. H., Tariq, A., Mubeen, B., Murtaza, B. N., Iftikhar, S., Riaz, N., et al. (2022) · Nanomaterials · doi:10.3390/nano12244494 · Cited by 468

Nanomedicine scale-up technologies: feasibilities and challenges

Paliwal, R., Babu, R. J., & Palakurthi, S. (2014) · AAPS PharmSciTech · doi:10.1208/s12249-014-0177-9 · Cited by 466

Delivery of nitric oxide with a nanocarrier promotes tumour vessel normalization and potentiates anti-cancer therapies

Sung, Y., Jin, P.-R., Chu, L., Hsu, F., Wang, M.-R., Chang, C. S., Chiou, S.-J., Qiu, J.-T. T., Gao, D.-Y., Lin, C.-C., et al. (2019) · Nature Nanotechnology · doi:10.1038/s41565-019-0570-3 · Cited by 459

Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme

Wolburg, H., Wolburg‐Buchholz, K., Kraus, J., Rascher-Eggstein, G., Liebner, S., Hamm, S., Duffner, F., Grote, E.-H., Risau, W., & Engelhardt, B. (2003) · Acta Neuropathologica · doi:10.1007/s00401-003-0688-z · Cited by 454

Delivering the power of nanomedicine to patients today

Germain, M., Caputo, F., Metcalfe, S. M., Tosi, G., Spring, K., Åslund, A., Pottier, A., Schiffelers, R. M., Ceccaldi, A., & Schmid, R. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.07.007 · Cited by 435

Biomimetic and Bioinspired Synthesis of Nanomaterials/Nanostructures

Zan, G., & Wu, Q. (2016) · Advanced Materials · doi:10.1002/adma.201503215 · Cited by 434

The current state of animal models in research: A review

Robinson, N. B., Krieger, K., Khan, F., Huffman, W., Chang, M., Naik, A., Ruan, Y., Hameed, I., Krieger, K. H., Girardi, L. N., et al. (2019) · International Journal of Surgery · doi:10.1016/j.ijsu.2019.10.015 · Cited by 432

Crossing the Blood–Brain Barrier: Recent Advances in Drug Delivery to the Brain

Patel, M. M., & Patel, B. M. (2017) · CNS Drugs · doi:10.1007/s40263-016-0405-9 · Cited by 430

Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier

Vieira, D., & Gamarra, L. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s117210 · Cited by 427

Mammalian Retrovirus-like Protein PEG10 Packages Its Own MRNA and Can Be Pseudotyped for MRNA Delivery

Segel, M., Lash, B., Song, J., Ladha, A., Liu, C. C., Jin, X., Mekhedov, S. L., Macrae, R. K., Koonin, E. V., & Zhang, F. (2021) · Science · doi:10.1126/science.abg6155 · Cited by 423

Red blood cells: Supercarriers for drugs, biologicals, and nanoparticles and inspiration for advanced delivery systems

Villa, C. H., Anselmo, A. C., Mitragotri, S., & Muzykantov, V. R. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.02.007 · Cited by 404

Simultaneous Blood–Brain Barrier Crossing and Protection for Stroke Treatment Based on Edaravone-Loaded Ceria Nanoparticles

Bao, Q., Hu, P., Xu, Y., Cheng, T., Wei, C., Pan, L., & Shi, J. (2018) · ACS Nano · doi:10.1021/acsnano.8b01994 · Cited by 391

The need for new approaches in CNS drug discovery: Why drugs have failed, and what can be done to improve outcomes

Gribkoff, V. K., & Kaczmarek, L. K. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.03.021 · Cited by 379

Functionalized Nanomaterials Capable of Crossing the Blood–Brain Barrier

Zha, S., Liu, H., Li, H., Li, H., Wong, K.-L., & All, A. H. (2024) · ACS Nano · doi:10.1021/acsnano.3c10674 · Cited by 378

Extracellular vesicles: A bright star of nanomedicine

Wu, P., Zhang, B., Ocansey, D. K. W., Xu, W., & Qian, H. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2020.120467 · Cited by 368

A first-in-human phase 0 clinical study of RNA interference–based spherical nucleic acids in patients with recurrent glioblastoma

Kumthekar, P., Ko, C. H., Paunesku, T., Dixit, K., Sonabend, A. M., Bloch, O. G., Tate, M. C., Schwartz, M. A., Zuckerman, L., Lezon, R., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abb3945 · Cited by 368

High-sensitivity nanosensors for biomarker detection

Swierczewska, M., Liu, G., Lee, S., & Chen, X. S. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15238f · Cited by 364

Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude

Brenner, J. S., Pan, D. C., Myerson, J. W., Marcos-Contreras, O. A., Villa, C. H., Patel, P., Hekierski, H., Chatterjee, S., Tao, J.-Q., Parhiz, H., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05079-7 · Cited by 363

Current approaches of nanomedicines in the market and various stage of clinical translation

Shan, X., Gong, X., Li, J., Wen, J., Li, Y., & Zhang, Z. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.02.025 · Cited by 354

Development of Pharmaceutical Nanomedicines: From the Bench to the Market

Halwani, A. A. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14010106 · Cited by 353

ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function

Sharma, A., Lyashchenko, A. K., Lü, L., Nasrabady, S. E., Elmaleh, M., Mendelsohn, M. M., Nemes, A., Tapia, J. C., Mentis, G. Z., & Shneider, N. A. (2016) · Nature Communications · doi:10.1038/ncomms10465 · Cited by 351

Focused ultrasound-mediated drug delivery through the blood–brain barrier

Burgess, A., Shah, K., Hough, O., & Hynynen, K. (2015) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2015.1028369 · Cited by 332

Human disease models in drug development

Loewa, A., Feng, J. J., & Hedtrich, S. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00063-3 · Cited by 331

Systemic Review of Biodegradable Nanomaterials in Nanomedicine

Su, S., & Kang, P. M. (2020) · Nanomaterials · doi:10.3390/nano10040656 · Cited by 330

Blood-Brain Delivery Methods Using Nanotechnology

Teleanu, D. M., Chircov, C., Grumezescu, A. M., Volceanov, A., & Teleanu, R. I. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10040269 · Cited by 325

The Promise of Nanotechnology in Personalized Medicine

Alghamdi, M. A., Fallica, A. N., Virzì, N. F., Kesharwani, P., Pittalà, V., & Greish, K. F. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12050673 · Cited by 324

Zwitterionic gel encapsulation promotes protein stability, enhances pharmacokinetics, and reduces immunogenicity

Zhang, P., Sun, F., Tsao, C., Liu, S., Jain, P. R., Sinclair, A., Hung, H., Bai, T., Wu, K., & Jiang, S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1512465112 · Cited by 323

The Importance of Animal Models in Biomedical Research: Current Insights and Applications

Domínguez-Oliva, A., Hernández-Ávalos, I., Martı́nez-Burnes, J., Olmos-Hernández, A. S., Verduzco-Mendoza, A., & Mota‐Rojas, D. (2023) · Animals · doi:10.3390/ani13071223 · Cited by 322

Macrophage cell membrane-based nanoparticles: a new promising biomimetic platform for targeted delivery and treatment

Wu, Y., Wan, S., Yang, S., Hu, H., Zhang, C., Lai, J., Zhou, J., Chen, W., Tang, X., Luo, J., et al. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01746-6 · Cited by 314

Challenges in design and characterization of ligand-targeted drug delivery systems

Muro, S. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.05.052 · Cited by 312

Blood-brain barrier–penetrating siRNA nanomedicine for Alzheimer’s disease therapy

Zhou, Y., Zhu, F., Liu, Y., Zheng, M., Wang, Y., Zhang, D., Anraku, Y., Zou, Y., Li, J., Wu, H., et al. (2020) · Science Advances · doi:10.1126/sciadv.abc7031 · Cited by 304

PLGA-Based Nanomedicine: History of Advancement and Development in Clinical Applications of Multiple Diseases

Alsaab, H. O., Alharbi, F., Al-Hibs, A. S., Alanazi, N. B., Alshehri, B. Y., Saleh, M. A., Alshehri, F. S., Algarni, M. A., Almugaiteeb, T., Uddin, M. N., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14122728 · Cited by 304

Controlling the biodistribution and clearance of nanomedicines

Cabral, H., Li, J., Miyata, K., & Kataoka, K. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00138-1 · Cited by 303

Transferrin Receptor Ligand-Targeted Toxin Conjugate (Tf-CRM107) for Therapy of Malignant Gliomas

Weaver, M. W., & Laske, D. W. (2003) · Journal of Neuro-Oncology · doi:10.1023/a:1026246500788 · Cited by 302

Neurotoxicity of Silica Nanoparticles: Brain Localization and Dopaminergic Neurons Damage Pathways

Wu, J., Wang, C., Sun, J., & Xue, Y. (2011) · ACS Nano · doi:10.1021/nn103530b · Cited by 286

Increased brain uptake of targeted nanoparticles by adding an acid-cleavable linkage between transferrin and the nanoparticle core

Clark, A. J., & Davis, M. E. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1517048112 · Cited by 284

Nanomedicine in the diagnosis and therapy of neurodegenerative disorders

Kabanov, A. V., & Gendelman, H. E. (2007) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2007.05.014 · Cited by 279

Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells

Sarin, H., Kanevsky, A. S., Wu, H., Brimacombe, K. R., Fung, S. H., Sousa, A. A., Auh, S., Wilson, C. M., Sharma, K., Aronova, M. A., et al. (2008) · Journal of Translational Medicine · doi:10.1186/1479-5876-6-80 · Cited by 279

Clinical overview on Lipoplatin™: a successful liposomal formulation of cisplatin

Boulikas, T. (2009) · Expert Opinion on Investigational Drugs · doi:10.1517/13543780903114168 · Cited by 277

Glioblastoma Therapy: Past, Present and Future

Obrador, E., Moreno-Murciano, P., Oriol-Caballo, M., López-Blanch, R., Pineda, B., Gutiérrez-Arroyo, J., Loras, A., Gonzalez-Bonet, L., Martinez-Cadenas, C., Estrela, J., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052529 · Cited by 271

Bio-inspired engineering of cell- and virus-like nanoparticles for drug delivery

Parodi, A., Molinaro, R., Sushnitha, M., Evangelopoulos, M., Martinez, J. O., Arrighetti, N., Corbo, C., & Tasciotti, E. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.09.020 · Cited by 269

Cell membrane coated nanocarriers - an efficient biomimetic platform for targeted therapy

Dash, P., Piras, A. M., & Dash, M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.012 · Cited by 267

Cancer nanomedicine toward clinical translation: Obstacles, opportunities, and future prospects

Zhang, P., Xiao, Y., Sun, X. F., Lin, X., Koo, S., Yaremenko, A. V., Qin, D., Kong, N., Farokhzad, O. C., & Tao, W. (2022) · Med · doi:10.1016/j.medj.2022.12.001 · Cited by 265

The effects of protein corona on in vivo fate of nanocarriers

Xiao, Q., Zoulikha, M., Qiu, M., Teng, C., Lin, C., Li, X., Sallam, M. A., Xu, Q., & He, W. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114356 · Cited by 264

Bioactive inorganic nanomaterials for cancer theranostics

Pei, Z., Lei, H., & Cheng, L. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00352j · Cited by 264

Increased Gold Nanoparticle Retention in Brain Tumors by in Situ Enzyme-Induced Aggregation

Ruan, S., Hu, C., Tang, X., Cun, X., Xiao, W., Shi, K., He, Q., & Gao, H. (2016) · ACS Nano · doi:10.1021/acsnano.6b05070 · Cited by 263

Application of the Nano-Drug Delivery System in Treatment of Cardiovascular Diseases

Deng, Y., Zhang, X., Shen, H., He, Q., Wu, Z., Liao, W., & Yuan, M. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00489 · Cited by 263

Decreased blood–brain barrier P-glycoprotein function in the progression of Parkinson’s disease, PSP and MSA

Bartels, A. L., Willemsen, A., Kortekaas, R., de Jong, B. M., de Vries, R., de Klerk, O., van Oostrom, J. C. H., Portman, A. T., & Leenders, K. L. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0030-y · Cited by 261

Alzheimer's disease; a review of the pathophysiological basis and therapeutic interventions

Abeysinghe, A. A. D. T., Deshapriya, S., & Udawatte, C. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117996 · Cited by 259

Stimulus-responsive sequential release systems for drug and gene delivery

Ahmadi, S., Rabiee, N., Bagherzadeh, M., Elmi, F., Fatahi, Y., Farjadian, F., Baheiraei, N., Nasseri, B., Rabiee, M., Dastjerd, N. T., et al. (2020) · Nano Today · doi:10.1016/j.nantod.2020.100914 · Cited by 256

Key for crossing the BBB with nanoparticles: the rational design

Lombardo, S. M., Schneider, M., Türeli, A. E., & Günday-Türeli, N. (2020) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.11.72 · Cited by 255

Nanomedicine-based commercial formulations: current developments and future prospects

Thapa, R. K., & Kim, J. O. (2022) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-022-00607-6 · Cited by 251

Parkinson disease therapy: current strategies and future research priorities

Stocchi, F., Bravi, D., Emmi, A., & Antonini, A. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-024-01034-x · Cited by 247

Blood-Brain Barrier Dysfunction in CNS Disorders and Putative Therapeutic Targets: An Overview

Archie, S. R., Shoyaib, A. A., & Cucullo, L. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111779 · Cited by 244

STING agonist-loaded, CD47/PD-L1-targeting nanoparticles potentiate antitumor immunity and radiotherapy for glioblastoma

Zhang, P., Rashidi, A., Zhao, J., Silvers, C., Wang, H., Castro, B. A., Ellingwood, A., Han, Y., Lopez‐Rosas, A., Ζαννίκου, Μ., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37328-9 · Cited by 243

A molecular docking study repurposes FDA approved iron oxide nanoparticles to treat and control COVID-19 infection

Abo‐zeid, Y., Ismail, N. S. M., McLean, G. R., & Hamdy, N. Μ. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105465 · Cited by 238

P-selectin-targeted nanocarriers induce active crossing of the blood–brain barrier via caveolin-1-dependent transcytosis

Tylawsky, D. E., Kiguchi, H., Vaynshteyn, J., Gerwin, J. N., Shah, J., Islam, T., Boyer, J. A., Boué, D. R., Snuderl, M., Greenblatt, M. B., et al. (2023) · Nature Materials · doi:10.1038/s41563-023-01481-9 · Cited by 238

MR-guided focused ultrasound enhances delivery of trastuzumab to Her2-positive brain metastases

Meng, Y., Reilly, R. M., Pezo, R. C., Trudeau, M., Sahgal, A., Singnurkar, A., Perry, J., Myrehaug, S. D., Pople, C. B., Davidson, B., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abj4011 · Cited by 236

Cancer nanomedicine: is targeting our target?

Lammers, T., Kiessling, F. M., Ashford, M. B., Hennink, W. E., Crommelin, D. J. A., & Storm, G. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.69 · Cited by 234

Brain penetrating peptides and peptide–drug conjugates to overcome the blood–brain barrier and target CNS diseases

Zhou, X., Smith, Q. R., & Liu, X. (2021) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1695 · Cited by 229

Correlation between mouse age and human age in anti-tumor research: Significance and method establishment

Wang, S., Lai, X., Deng, Y., & Song, Y. (2020) · Life Sciences · doi:10.1016/j.lfs.2019.117242 · Cited by 228

Biomimetic Macrophage Membrane-Camouflaged Nanoparticles Induce Ferroptosis by Promoting Mitochondrial Damage in Glioblastoma

Cao, Z., Liu, X., Zhang, W., Zhang, K., Pan, L., Zhu, M., Qin, H., Zou, C., Wang, W., Zhang, C., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c07555 · Cited by 227

Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor

Hultqvist, G., Syvänen, S., Fang, X. T., Lannfelt, L., & Sehlin, D. (2017) · Theranostics · doi:10.7150/thno.17155 · Cited by 224

ROS‐Responsive Polymeric siRNA Nanomedicine Stabilized by Triple Interactions for the Robust Glioblastoma Combinational RNAi Therapy

Zheng, M., Liu, Y., Wang, Y., Zhang, D., Zou, Y., Ruan, W., Yin, J., Tao, W., Park, J. B., & Shi, B. (2019) · Advanced Materials · doi:10.1002/adma.201903277 · Cited by 220

Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function

Spiteri, A. G., Wishart, C. L., Pamphlett, R., Locatelli, G., & King, N. J. C. (2022) · Acta Neuropathologica · doi:10.1007/s00401-021-02384-2 · Cited by 216

Cell-Penetrating Peptides Selectively Cross the Blood-Brain Barrier In Vivo

Stalmans, S., Bracke, N., Wynendaele, E., Gevaert, B., Peremans, K. Y., Burvenich, C., Polis, I., & Spiegeleer, B. M. J. D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139652 · Cited by 212

Exposure to copper oxide nanoparticles triggers oxidative stress and endoplasmic reticulum (ER)-stress induced toxicology and apoptosis in male rat liver and BRL-3A cell

Liu, H., Lai, W., Liu, X., Yang, H., Fang, Y., Tian, L., Li, K., Nie, H., Zhang, W., Shi, Y., et al. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.123349 · Cited by 212

Grand challenges in nanomedicine

Wu, L., Wang, D., & Li, Z. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110302 · Cited by 210

Nanotechnology-based strategies for siRNA brain delivery for disease therapy

Zheng, M., Tao, W., Zou, Y., Farokhzad, O. C., & Shi, B. (2018) · Trends in biotechnology · doi:10.1016/j.tibtech.2018.01.006 · Cited by 210

Genetically engineered cell membrane–coated nanoparticles for targeted delivery of dexamethasone to inflamed lungs

Park, J. H., Jiang, Y., Zhou, J., Gong, H., Mohapatra, A., Heo, J., Gao, W., Fang, R. H., & Zhang, L. (2021) · Science Advances · doi:10.1126/sciadv.abf7820 · Cited by 209

Clinical translation of gold nanoparticles

Zhang, R., Kiessling, F. M., Lammers, T., & Pallares, R. M. (2022) · Drug Delivery and Translational Research · doi:10.1007/s13346-022-01232-4 · Cited by 208

Vascular Targeting of Nanocarriers: Perplexing Aspects of the Seemingly Straightforward Paradigm

Howard, M. D., Zern, B. J., Anselmo, A. C., Shuvaev, V. V., Mitragotri, S., & Muzykantov, V. R. (2014) · ACS Nano · doi:10.1021/nn500136z · Cited by 204

Brain Co‐Delivery of Temozolomide and Cisplatin for Combinatorial Glioblastoma Chemotherapy

Zou, Y., Wang, Y., Xu, S., Liu, Y., Yin, J., Lovejoy, D. B., Zheng, M., Liang, X., Park, J. B., Efremov, Y. M., et al. (2022) · Advanced Materials · doi:10.1002/adma.202203958 · Cited by 204

Age-Associated Changes in the Immune System and Blood–Brain Barrier Functions

Erickson, M. A., & Banks, W. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071632 · Cited by 203

Apolipoprotein E Peptide-Directed Chimeric Polymersomes Mediate an Ultrahigh-Efficiency Targeted Protein Therapy for Glioblastoma

Jiang, Y., Zhang, J., Meng, F., & Zhong, Z. (2018) · ACS Nano · doi:10.1021/acsnano.8b05265 · Cited by 201

Artificial intelligence to bring nanomedicine to life

Serov, N., & Vinogradov, V. V. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114194 · Cited by 200

Current Strategies to Enhance Delivery of Drugs across the Blood–Brain Barrier

Teleanu, R. I., Preda, M. D., Niculescu, A.-G., Vladâcenco, O., Radu, C. I., Grumezescu, A. M., & Teleanu, D. M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14050987 · Cited by 200

A nitric-oxide driven chemotactic nanomotor for enhanced immunotherapy of glioblastoma

Chen, H., Li, T., Liu, Z., Tang, S., Tong, J., Tao, Y., Zhao, Z., Li, N., Mao, C., Shen, J., et al. (2023) · Nature Communications · doi:10.1038/s41467-022-35709-0 · Cited by 198

Smart Nanotherapeutic Targeting of Tumor Vasculature

Li, Z., Di, C., Li, S., Yang, X., & Nie, G. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00283 · Cited by 196

Intranasal Delivery of Nanoformulations: A Potential Way of Treatment for Neurological Disorders

Islam, S. U., Shehzad, A., Ahmed, M. B., & Lee, Y. S. (2020) · Molecules · doi:10.3390/molecules25081929 · Cited by 193

Human Models Are Needed for Studying Human Neurodevelopmental Disorders

Zhao, X., & Bhattacharyya, A. (2018) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2018.10.009 · Cited by 192

Phase I Study of GRN1005 in Recurrent Malignant Glioma

Drappatz, J., Brenner, A., Wong, E. T., Eichler, A., Schiff, D., Groves, M. D., Mikkelsen, T., Rosenfeld, S., Sarantopoulos, J., Meyers, C. A., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-2481 · Cited by 190

Novel Therapeutic Approaches for Alzheimer’s Disease: An Updated Review

Yu, T.-W., Lane, H., & Lin, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158208 · Cited by 190

Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance

Wang, Y., Jiang, Y., Wei, D., Singh, P., Yu, Y., Lee, T., Zhang, L., Mandl, H. K., Piotrowski-Daspit, A. S., Chen, X., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00728-7 · Cited by 190

Shared mechanisms across the major psychiatric and neurodegenerative diseases

Wingo, T. S., Liu, Y., Gerasimov, E. S., Vattathil, S. M., Wynne, M. E., Liu, J., Lori, A., Faundez, V., Bennett, D. A., Seyfried, N. T., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31873-5 · Cited by 190

Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood–brain barrier

Marcos-Contreras, O. A., Greineder, C. F., Kiseleva, R. Y., Parhiz, H., Walsh, L. R., Zuluaga‐Ramirez, V., Myerson, J. W., Hood, E. D., Villa, C. H., Tombácz, I., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1912012117 · Cited by 187

Intrathecal drug delivery in the era of nanomedicine

Fowler, M. J., Cotter, J. D., Knight, B. E., Sevick-Muraca, E. M., Sandberg, D. I., & Sirianni, R. W. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.02.006 · Cited by 187

Combined intracavitary thermotherapy with iron oxide nanoparticles and radiotherapy as local treatment modality in recurrent glioblastoma patients

Grauer, O. M., Jaber, M., Heß, K., Weckesser, M., Schwindt, W., Maring, S., Wölfer, J., & Stummer, W. (2018) · Journal of Neuro-Oncology · doi:10.1007/s11060-018-03005-x · Cited by 186

Poly(carboxybetaine) nanomaterials enable long circulation and prevent polymer-specific antibody production

Yang, W. M., Liu, S., Bai, T., Keefe, A. J., Zhang, L., Ella‐Menye, J., Li, Y., & Jiang, S. (2014) · Nano Today · doi:10.1016/j.nantod.2014.02.004 · Cited by 186

Dysfunction of the blood–brain barrier in Alzheimer's disease: Evidence from human studies

Kurz, C., Walker, L., Rauchmann, B., & Perneczky, R. (2022) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12782 · Cited by 183

Correlation between Ferumoxytol Uptake in Tumor Lesions by MRI and Response to Nanoliposomal Irinotecan in Patients with Advanced Solid Tumors: A Pilot Study

Ramanathan, R. K., Korn, R. L., Raghunand, N., Sachdev, J. C., Newbold, R. G., Jameson, G., Fetterly, G. J., Prey, J., Klinz, S. G., Kim, J., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-1990 · Cited by 183

Cell membrane-derived vesicles for delivery of therapeutic agents

Le, Q.-V., Lee, J., Lee, H., Shim, G., & Oh, Y.-K. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.01.020 · Cited by 181

An iRGD-conjugated prodrug micelle with blood-brain-barrier penetrability for anti-glioma therapy

Lu, L., Zhao, X., Fu, T., Li, K., He, Y., Luo, Z. Y., Dai, L., Zeng, R., & Cai, K. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119666 · Cited by 180

Oxidative stress and potential effects of metal nanoparticles: A review of biocompatibility and toxicity concerns

Wang, Y., Lee, Y., Chou, C., Chang, Y., Liu, W., & Chiu, H. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.123617 · Cited by 179

Single siRNA Nanocapsules for Effective siRNA Brain Delivery and Glioblastoma Treatment

Zou, Y., Sun, X., Wang, Y., Yan, C., Liu, Y., Li, J., Zhang, D., Zheng, M., Chung, R. S., & Shi, B. (2020) · Advanced Materials · doi:10.1002/adma.202000416 · Cited by 178

Genetically Engineered Cell Membrane Nanovesicles for Oncolytic Adenovirus Delivery: A Versatile Platform for Cancer Virotherapy

Lv, P., Liu, X., Chen, X., Liu, C., Zhang, Y., Chu, C., Wang, J., Wang, X., Chen, X. S., & Liu, G. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b00145 · Cited by 178

Approved Nanomedicine against Diseases

Jia, Y., Jiang, Y., He, Y., Zhang, W., Zou, J., Magar, K. T., Boucetta, H., Teng, C., & He, W. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030774 · Cited by 178

Precision drug delivery to the central nervous system using engineered nanoparticles

Gao, J., Xia, Z. J., Gunasekar, S., Jiang, C., Karp, J. M., & Joshi, N. (2024) · Nature Reviews Materials · doi:10.1038/s41578-024-00695-w · Cited by 173

Theranostic AGuIX nanoparticles as radiosensitizer: A phase I, dose-escalation study in patients with multiple brain metastases (NANO-RAD trial)

Verry, C., Dufort, S., Villa, J., Gavard, M., Iriart, C., Grand, S., Charles, J., Chovelon, B., Cracowski, J.-L., Quesada, J.-L., et al. (2021) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2021.04.021 · Cited by 173

Blood–brain-barrier-crossing lipid nanoparticles for mRNA delivery to the central nervous system

Wang, C., Xue, Y., Markovic, T., Li, H., Wang, S., Zhong, Y., Du, S., Zhang, Y., Hou, X., Yu, Y., et al. (2025) · Nature Materials · doi:10.1038/s41563-024-02114-5 · Cited by 171

Recent Preclinical and Clinical Progress in Liposomal Doxorubicin

Aloss, K., & Hamar, P. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030893 · Cited by 171

Convection-enhanced drug delivery for glioblastoma: a review

D’Amico, R. S., Aghi, M. K., Vogelbaum, M. A., & Bruce, J. N. (2021) · Journal of Neuro-Oncology · doi:10.1007/s11060-020-03408-9 · Cited by 169

Targeted Delivery of Nano-Therapeutics for Major Disorders of the Central Nervous System

Gao, H., Pang, Z., & Jiang, X. (2013) · Pharmaceutical Research · doi:10.1007/s11095-013-1122-4 · Cited by 167

Shape effect in active targeting of nanoparticles to inflamed cerebral endothelium under static and flow conditions

da Silva‐Candal, A., Brown, T. D., Krishnan, V., López-Loureiro, I., Ávila-Gómez, P., Pusuluri, A., Pérez, A. C., Correa‐Paz, C., Hervella, P., Castillo, J., et al. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.07.026 · Cited by 167

FDA’s Poly (Lactic-Co-Glycolic Acid) Research Program and Regulatory Outcomes

Wang, Y., Qin, B., Xia, G., & Choi, S. H. (2021) · The AAPS Journal · doi:10.1208/s12248-021-00611-y · Cited by 167

Modulating the antibody density changes the uptake and transport at the blood-brain barrier of both transferrin receptor-targeted gold nanoparticles and liposomal cargo

Johnsen, K. B., Bak, M., Melander, F., Thomsen, M. S., Burkhart, A., Kempen, P. J., Andresen, T. L., & Moos, T. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.01.005 · Cited by 164

Overview of Current Drug Delivery Methods Across the Blood–Brain Barrier for the Treatment of Primary Brain Tumors

Haumann, R., Videira, J. C., Kaspers, G. J. L., van Vuurden, D. G., & Hulleman, E. (2020) · CNS Drugs · doi:10.1007/s40263-020-00766-w · Cited by 163

Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle

Thorek, D. L. J., Ulmert, D., Diop, N.-F. M., Lupu, M. E., Doran, M. G., Huang, R., Abou, D. S., Larson, S. M., & Grimm, J. (2014) · Nature Communications · doi:10.1038/ncomms4097 · Cited by 163

Blood–brain barrier dysfunction in multiple sclerosis: causes, consequences, and potential effects of therapies

Zierfuss, B., Larochelle, C., & Prat, A. (2023) · The Lancet Neurology · doi:10.1016/s1474-4422(23)00377-0 · Cited by 162

Regulating Nanomedicine – Can the FDA Handle It?

Bawa, R. (2011) · Current Drug Delivery · doi:10.2174/156720111795256156 · Cited by 162

Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles

Johnsen, K. B., Bak, M., Kempen, P. J., Melander, F., Burkhart, A., Thomsen, M. S., Nielsen, M. S., Moos, T., & Andresen, T. L. (2018) · Theranostics · doi:10.7150/thno.25228 · Cited by 161

High‐Throughput Continuous Flow Production of Nanoscale Liposomes by Microfluidic Vertical Flow Focusing

Hood, R. R., & DeVoe, D. L. (2015) · Small · doi:10.1002/smll.201501345 · Cited by 156

Recent Advancements of Nanomedicine in Neurodegenerative Disorders Theranostics

Mukherjee, S., Madamsetty, V. S., Bhattacharya, D., Roy Chowdhury, S., Paul, M. K., & Mukherjee, A. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202003054 · Cited by 152

Recent Advances in Nanomaterials-Based Targeted Drug Delivery for Preclinical Cancer Diagnosis and Therapeutics

Tiwari, H., Rai, N., Singh, S., Gupta, P., Verma, A. K., Singh, A. K., Kajal, Salvi, P., Singh, S. K., & Gautam, V. (2023) · Bioengineering · doi:10.3390/bioengineering10070760 · Cited by 151

Nanomaterial-based contrast agents

Hsu, J. C., Tang, Z., Eremina, O. E., Sofias, A. M., Lammers, T., Lovell, J. F., Zavaleta, C. L., Cai, W., & Cormode, D. P. (2023) · Nature Reviews Methods Primers · doi:10.1038/s43586-023-00211-4 · Cited by 151

Opening of the Blood–Brain Barrier Using Low-Intensity Pulsed Ultrasound Enhances Responses to Immunotherapy in Preclinical Glioma Models

Sabbagh, A., Beccaria, K., Ling, X., Marisetty, A., Ott, M., Caruso, H. G., Barton, E. A., Kong, L.-Y., Fang, D., Latha, K., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-3760 · Cited by 150

Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies

Colombo, M., Fiandra, L., Alessio, G., Mazzucchelli, S., Nebuloni, M., Palma, C. D., Kantner, K., Pelaz, B., Rotem, R., Corsi, F., et al. (2016) · Nature Communications · doi:10.1038/ncomms13818 · Cited by 149

Drug delivery strategies to enhance the permeability of the blood–brain barrier for treatment of glioma

Zhang, F., Xu, C., & Liu, C. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s79592 · Cited by 147

Drug Delivery and Targeting to the Brain Through Nasal Route: Mechanisms, Applications and Challenges

Kashyap, K., & Shukla, R. (2019) · Current Drug Delivery · doi:10.2174/1567201816666191029122740 · Cited by 147

Activation of endothelial Wnt/β-catenin signaling by protective astrocytes repairs BBB damage in ischemic stroke

Song, S., Huang, H., Guan, X., Fiesler, V. M., Bhuiyan, M. I. H., Liu, R., Jalali, S., Hasan, M. N., Tai, A., Chattopadhyay, A., et al. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101963 · Cited by 146

Nanomedicine for brain cancer

Quader, S., Kataoka, K., & Cabral, H. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114115 · Cited by 146

Brain-targeted intranasal delivery of dopamine with borneol and lactoferrin co-modified nanoparticles for treating Parkinson’s disease

Tang, S.-N., Wang, A.-P., Yan, X., Chu, L., Yang, X., Song, Y., Sun, K.-X., Yu, X., Liu, R.-X., Wu, Z., et al. (2019) · Drug Delivery · doi:10.1080/10717544.2019.1636420 · Cited by 144

Polymeric Nanoparticles for Nasal Drug Delivery to the Brain: Relevance to Alzheimer's Disease

Rabiee, N., Ahmadi, S., Afshari, R., Khalaji, S., Rabiee, M., Bagherzadeh, M., Fatahi, Y., Dinarvand, R., Tahriri, M., Tayebi, L., et al. (2020) · Advanced Therapeutics · doi:10.1002/adtp.202000076 · Cited by 144

Claudin-1-Dependent Destabilization of the Blood–Brain Barrier in Chronic Stroke

Sladojević, N., Stamatovic, S. M., Johnson, A., Choi, J. H. K., Hu, A., Dithmer, S., Blasig, I. E., Keep, R. F., & Andjelkovic, A. V. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1432-18.2018 · Cited by 142

Neurocognitive and somatic stabilization in pediatric patients with severe Mucopolysaccharidosis Type I after 52 weeks of intravenous brain-penetrating insulin receptor antibody-iduronidase fusion protein (valanafusp alpha): an open label phase 1-2 trial

Giugliani, R., Giugliani, L., Poswar, F. D. O., Donis, K. C., Corte, A. D., Schmidt, M., Boado, R. J., Nestrašil, I., Nguyen, C., Chen, S., et al. (2018) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-018-0849-8 · Cited by 140

Dual-targeted nanomedicines for enhanced tumor treatment

Zhu, Y., Feijén, J., & Zhong, Z. (2018) · Nano Today · doi:10.1016/j.nantod.2017.12.007 · Cited by 139

Stimuli-responsive nanoplatforms for central nervous system disorders: integrating delivery, modulation, and imaging

Chen, Y., Ding, Y., Lin, H., & Shi, J. (2026) · Chemical Society Reviews · doi:10.1039/d5cs01323b · Cited by 9

Biomaterials and Nanoparticle-Based Therapeutics in Neurodegenerative Diseases: Bridging the Gap Between Innovation and Translation

Panchal, D., Solanki, D., Solanki, R., Yadav, A. K., Bhatia, D. D., & Yadav, P. K. (2026) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6c00245 · Cited by 6

Artificial intelligence-assisted lipid nanoparticles formulation in drug delivery for precision therapy

Huang, C., Zuo, W., Xiao, J., Xiong, C., Zhu, L., Su, Y., & Zhan, M. (2026) · Materials Today Advances · doi:10.1016/j.mtadv.2026.100800 · Cited by 5

Nanoparticles in Therapy and Diagnosis: A Comprehensive Review of Mechanisms, Applications, and Translational Challenges

Tiwary, P., Oswal, K., Varghese, R., & Gupta, P. K. (2026) · Journal of Nanotheranostics · doi:10.3390/jnt7020011 · Cited by 4

Advances in Strategies to Transport Nanoparticles Across the Blood–Brain Barrier for Drug Delivery into the Brain for the Treatment of Alzheimer’s Disease

Silva, R., Monteiro, J., Ramalho, M. J., Andrade, S., Loureiro, J. A., & Pereira, M. C. (2026) · Pharmaceuticals · doi:10.3390/ph19050685 · Cited by 2

Nanoparticulate Drug Delivery Systems to Overcome the Blood–Brain Barrier

Tagami, T., Taki, M., & Ozeki, T. (2015) · Methods in pharmacology and toxicology · doi:10.1007/978-1-4939-3121-7_17 · Cited by 7

Nanoparticle-Based Drug Delivery Across the Blood–Brain Barrier: Current In Vivo Evidence, Translational Challenges, and Future Perspectives

Al‐allaq, A. A., Hassan, H. A., Hidayet, H. M., Abdulhakeem, A. A., & Ahmad, Z. A.-A. Q. (2026) · Micro · doi:10.3390/micro6030065 · Cited by 1

Brain Targeting Nanomedicines: Pitfalls and Promise

Käkinen, A., Jiang, Y., Davis, T. P., Teesalu, T., & Saarma, M. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s454553 · Cited by 26

Getting into the Brain: Are We in Yet or Just Knocking at the Door?

Nagpal, K., Singh, D., Bhatia, A., & Kumar, P. (2021) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.2021038918 · Cited by 4

NANOMEDICINE IN TARGETED DRUG DELIVERY FOR NEUROLOGICAL DISORDERS

Sehgal, P. (2017) · Innovations in Pharmacy Planet