The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
The probiotic Bifidobacteria infantis: An assessment of potential antidepressant properties in the rat
Abstract
It is becoming increasingly apparent that probiotics are important to the health of the host. The absence of probiotic bacteria in the gut can have adverse effects not only locally in the gut, but has also been shown to affect central HPA and monoaminergic activity, features that have been implicated in the aetiology of depression. To evaluate the potential antidepressant properties of probiotics, we tested rats chronically treated with Bifidobacteria infantis in the forced swim test, and also assessed the effects on immune, neuroendocrine and central monoaminergic activity. Sprague-Dawley rats were treated for 14 days with B. infantis. Probiotic administration in naive rats had no effect on swim behaviours on day 3 or day 14 following the commencement of treatment. However, there was a significant attenuation of IFN-gamma, TNF-alpha and IL-6 cytokines following mitogen stimulation (p<0.05) in probiotic-treated rats relative to controls. Furthermore, there was a marked increase in plasma concentrations of tryptophan (p<0.005) and kynurenic acid (p<0.05) in the bifidobacteria-treated rats when compared to controls. Bifidobacteria treatment also resulted in a reduced 5-HIAA concentration in the frontal cortex and a decrease in DOPAC in the amygdaloid cortex. The attenuation of pro-inflammatory immune responses, and the elevation of the serotonergic precursor, tryptophan by bifidobacteria treatment, provides encouraging evidence in support of the proposition that this probiotic may possess antidepressant properties. However, these findings are preliminary and further investigation into the precise mechanisms involved, is warranted.
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“Candidate psychobiotics that beneficially impact on host tryptophan metabolites include Bifidobacterium longum subsp.longum 35624 (previously B. infantis 35624) (Desbonnet et al., 2008) and L. reuteri (Marin et al., 2017).”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Desbonnet et al., 2008
In the citing paper
“When administered to rats, B. infantis results in reduced 5-HIAA (serotonin metabolite) concentrations in the frontal cortex, and a marked increase in blood concentrations of tryptophan and kynurenic acid (224).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [224]
In the citing paper
“An experimental animal model showed that probiotics may reduce pro-inflammatory immune responses and increase levels of the serotonergic precursor tryptophan, thereby ameliorating depressive symptoms [19].”
From Flavonoid-rich orange juice intake and altered gut microbiome in young adults with depressive symptom: a randomized controlled study (2020) · cites this paper as [19]
Citations
Cites
1 retracted
Interferon-gamma: biologic functions and HCV terapy (type I/II) (2 of 2 parts).
Gattoni, A., Parlato, A., Vangieri, B., Bresciani, M., & Derna, R. (2006) · PubMed · Cited by 107
RetractedInterleukin-10 and the Interleukin-10 Receptor
Moore, K. W., de Waal Malefyt, R., Coffman, R. L., & O'Garra, A. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.683 · Cited by 6,737
IL-10 inhibits cytokine production by activated macrophages
Fiorentino, D. F., Zlotnik, A., Mosmann, T. R., Howard, M., & O’Garra, A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.11.3815 · Cited by 2,888
Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis
Herman, J. P., & Cullinan, W. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10069-2 · Cited by 2,270
O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448
Harmsen, H. J. M., Wildeboer-Veloo, A. C. M., Raangs, G. C., Wagendorp, A. A., Klijn, N., BINDELS, J. G., & Welling, G. W. (2000) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200001000-00019 · Cited by 1,326
Relationship between interferon‐γ, indoleamine 2,3‐dioxygenase, and tryptophan catabolism
Taylor, M. W., & Feng, G. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.11.1907934 · Cited by 1,060
Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter
Owens, M. J., & Nemeroff, C. B. (1994) · Clinical Chemistry · doi:10.1093/clinchem/40.2.288 · Cited by 932
Amat, J., Baratta, M. V., Paul, E., Bland, S. T., Watkins, L. R., & Maier, S. F. (2005) · Nature Neuroscience · doi:10.1038/nn1399 · Cited by 931
The macrophage theory of depression
Smith, R. S. (1991) · Medical Hypotheses · doi:10.1016/0306-9877(91)90272-z · Cited by 931
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Items 101–138 of 138
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Microbiome and nutrition in autism spectrum disorder: Current knowledge and research needs
Berding, K., & Donovan, S. M. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw048 · Cited by 146
Choi, C. H., Jo, S. Y., Park, H. J., Chang, S. K., Byeon, J.-S., & Myung, S.-J. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e318204593e · Cited by 144
“Bifidobacteria infantis attenuates the production of proinflammatory cytokines and increased plasma levels of tryptophan in animals.(33) Probiotics also inhibit the release of adrenocorticotropic hormone and corticosterone,(40) and provoke behavioral alterations by releasing soluble factors.”
BackgroundBarrio, C., Arias-Sánchez, S., & Martín-Monzón, I. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105640 · Cited by 143
Strasser, B., Geiger, D., Schauer, M., Gostner, J., Gatterer, H., Burtscher, M., & Fuchs, D. (2016) · Nutrients · doi:10.3390/nu8110752 · Cited by 142
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Park, M., Choi, J., & Lee, H.-J. (2020) · Nutrients · doi:10.3390/nu12061815 · Cited by 139
The role of the microbiome in the neurobiology of social behaviour
Sarkar, A., Harty, S., Johnson, K. V. ‐., Moeller, A. H., Carmody, R. N., Lehto, S. M., Erdman, S. E., Dunbar, R. I. M., & Burnet, P. W. J. (2020) · Biological Reviews · doi:10.1111/brv.12603 · Cited by 135
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Gao, K., Pi, Y., Mu, C., Peng, Y., Huang, Z., & Zhu, W. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14333 · Cited by 119
Medina-Rodriguez, E. M., Madorma, D., O’Connor, G., Mason, B. L., Han, D., Deo, S. K., Oppenheimer, M., Nemeroff, C. B., Trivedi, M. H., Daunert, S., et al. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.19090960 · Cited by 110
Raygan, F., Ostadmohammadi, V., Bahmani, F., & Asemi, Z. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.02.007 · Cited by 112
Tran, N., Zhebrak, M., Yacoub, C., Pelletier, J., & Hawley, D. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.04.043 · Cited by 104
Abbas, Z., Yakoob, J., Jafri, W., Ahmad, Z., Azam, Z., Usman, M. W., Shamim, S., & Islam, M. (2014) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000000094 · Cited by 102
The connection between microbiome and schizophrenia
Golofast, B., & Vales, K. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.011 · Cited by 92
Luk, B., Veeraragavan, S., Engevik, M., Balderas, M., Major, A., Runge, J., Luna, R. A., & Versalovic, J. (2018) · PLOS ONE · doi:10.1371/journal.pone.0196510 · Cited by 90
Sun, Y., Geng, W., Pan, Y., Wang, J., Xiao, P., & Wang, Y. (2019) · Food & Function · doi:10.1039/c8fo02096e · Cited by 89
Gut microbiota regulates key modulators of social behavior
Parashar, A., & Udayabanu, M. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.11.002 · Cited by 88
Bested, A. C., Logan, A. C., & Selhub, E. M. (2013) · Gut Pathogens · doi:10.1186/1757-4749-5-4 · Cited by 84
Systematic review of evidence to support the theory of psychobiotics
Romijn, A. R., & Rucklidge, J. J. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuv025 · Cited by 81
The microbiome-gut-brain axis: implications for schizophrenia and antipsychotic induced weight gain
Kanji, S., Fonseka, T. M., Marshe, V. S., Sriretnakumar, V., Hahn, M. K., & Müller, D. J. (2018) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-017-0820-z · Cited by 79
The gut microbiome in anorexia nervosa: relevance for nutritional rehabilitation
Ruusunen, A., Rocks, T., Jacka, F., & Loughman, A. (2019) · Psychopharmacology · doi:10.1007/s00213-018-5159-2 · Cited by 74
Effects of Bifidobacterium infantis 35624 on Post-Inflammatory Visceral Hypersensitivity in the Rat
Johnson, A. C., Greenwood-Van Meerveld, B., & McRorie, J. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-011-1730-y · Cited by 76
Antibiotics and mental health: the good, the bad and the ugly
Dinan, K., & Dinan, T. (2022) · Journal of Internal Medicine · doi:10.1111/joim.13543 · Cited by 69
Self-citationFarhangi, M. A., Javid, A. Z., Sarmadi, B., Karimi, P., & Dehghan, P. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2017.06.005 · Cited by 68
Salami, M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.613120 · Cited by 67
Kelly, J. R., Keane, V. O., Cryan, J. F., Clarke, G., & Dinan, T. G. (2019) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2019.04.006 · Cited by 65
Self-citationLyte, M., Chapel, A., Lyte, J. M., Ai, Y., Proctor, A., Jane, J.-L., & Phillips, G. J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146406 · Cited by 62
Carbuhn, A. F., Reynolds, S. M., Campbell, C. W., Bradford, L. A., Deckert, J. A., Kreutzer, A., & Fry, A. C. (2018) · Sports · doi:10.3390/sports6040116 · Cited by 56
Alzheimer’s disease and gut microbiota: does trimethylamine N-oxide (TMAO) play a role?
Arrona Cardoza, P., Spillane, M. B., & Morales Marroquin, E. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuab022 · Cited by 53
Between Dysbiosis, Maternal Immune Activation and Autism: Is There a Common Pathway?
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Arboleya, S., Stanton, C., Ryan, C. A., Dempsey, E., & Ross, P. R. (2016) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-041715-033151 · Cited by 41
Tyagi, P., Tasleem, M., Prakash, S., & Chouhan, G. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109489 · Cited by 42
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Terry, S. M., Barnett, J. A., & Gibson, D. L. (2022) · Journal of Eating Disorders · doi:10.1186/s40337-022-00681-z · Cited by 40
Basso, M., Johnstone, N., Knytl, P., Nauta, A., Groeneveld, A., & Cohen Kadosh, K. (2022) · Nutrients · doi:10.3390/nu14030614 · Cited by 28
Teixeira, A. L., Martins, L. B., Berk, M., & Bauer, M. E. (2022) · Clinical Science · doi:10.1042/cs20211106 · Cited by 22
Wang, H.-X., & Wang, Y.-P. (2016) · Chinese Medical Journal · doi:10.4103/0366-6999.190667 · Cited by 546
Metadata
- Authors
- Desbonnet, L., Garrett, L., Clarke, G., Bienenstock, J., & Dinan, T. G.
- Affiliations
- University College Cork (IE)
- McMaster University (CA)
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 43
- Issue
- 2
- Pages
- 164-174
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W2164685446
- Cited by
- 952
- References
- 71
- Citations by year
- 2026: 24 · 2025: 70 · 2024: 63 · 2023: 83 · 2022: 97 · 2021: 98 · 2020: 99 · 2019: 83 · 2018: 60 · 2017: 59 · 2016: 54 · 2015: 51 · 2014: 35 · 2013: 26 · 2012: 16
- FWCI
- 17.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Funders
- Higher Education Academy
- Science Foundation Ireland
- Wellcome Trust
- Health Research Board
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Bifidobacterium infantis, probiotics, antidepressant effects, depression, forced swim test, inflammatory cytokines, tryptophan, kynurenic acid, serotonin, 5-hydroxyindoleacetic acid, DOPAC, hypothalamic-pituitary-adrenal axis, gut-brain axis, neuroendocrine activity
- MeSH terms
- Animals, Antidepressive Agents, Behavior, Animal, Bifidobacterium, Brain, Chromatography, High Pressure Liquid, Corticosterone, Corticotropin-Releasing Hormone, Depression, Disease Models, Animal, Flow Cytometry, Hypothalamus, Immunoenzyme Techniques, Intestines, Kynurenic Acid, Male, Stress, Psychological, Tryptophan, Vasopressins, Biogenic Monoamines, Polymerase Chain Reaction, Cytokines, Rats, Sprague-Dawley, Probiotics, Rats
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