Cited by 175Fatty Acid Research and HealthLipid metabolism and biosynthesisLipid Membrane Structure and Behavior

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Lipids in psychiatric disorders and preventive medicine

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Schneider, Miriam, Levant, Beth, Reichel, Martin, Gulbins, Erich, Kornhuber, Johannes, Müller, Christian P.·2017·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2016.06.002

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Abstract

Psychiatric disorders like mood disorders, schizophrenia, or drug addiction affect a sizeable proportion of the human population and severely compromise quality of life. Therefore, measures to prevent the manifestation, and treatments to ameliorate the symptoms, of these disorders are in high demand. Brain lipids determine the localization and function of proteins in the cell membrane of neurons. Lipids may also act as neurotransmitters or other signalling molecules. The lipid composition of the brain can be influenced by nutrition, environmental factors, and by behavioural activity. Thus, lipids represent a target for preventive medicine of psychiatric disorders. Here we review how brain lipids contribute to normal behaviour and to major psychiatric disorders with the focus on phospholipids/fatty acids, sphingolipids, and endocannabinoids. Accumulating evidence suggests a crucial role for membrane forming and signalling lipids in the brain in the etiopathologies of depression, bipolar disorders, schizophrenia, and drug addiction. Lipids also represent potential preventive interventions for these psychiatric disorders by either targeted dietary supplementation or pharmacological manipulation of lipid regulating enzymes.

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See all 175

Authors: Schneider, M., Levant, B., Reichel, M., Gulbins, E., Kornhuber, J., & Müller, C. P.
Affiliations: Heidelberg University (DE)
University of Kansas Medical Center (US)
Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
University of Duisburg-Essen (DE)
Corresponding author: Müller, Christian P.
ORCID: Schneider, Miriam
Levant, Beth
Reichel, Martin
Gulbins, Erich
Kornhuber, Johannes
Müller, Christian P.
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2017-05
Volume: 76
Issue: Pt B
Pages: 336-362
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2016.06.002
OpenAlex: W2421177106
Cited by: 175
References: 474
Citations by year: 2026: 14 · 2025: 12 · 2024: 23 · 2023: 20 · 2022: 20 · 2021: 17 · 2020: 24 · 2019: 16 · 2018: 15 · 2017: 12
FWCI: 2.02
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: German National Science Foundation (KO 947/15-1, GU 335/29-1, MU 2789/8-1, FOR926)
Interdisciplinary Center for Clinical Research Erlangen
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
Keywords: brain lipids, mental illness, depression, bipolar disorder, schizophrenia, drug addiction, phospholipids, fatty acids, sphingolipids, endocannabinoids, lipid signaling, membrane lipids, dietary supplementation, lipid metabolism enzymes
MeSH terms: Mental Disorders, Brain, Humans, Lipids, Quality of Life

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