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Tuning of the human left fusiform gyrus to sublexical orthographic structure
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Neuropsychological and neurophysiological evidence point to a role for the left fusiform gyrus in visual word recognition, but the specific nature of this role remains a topic of debate. The aim of this study was to measure the sensitivity of this region to sublexical orthographic structure. We measured blood oxygenation (BOLD) changes in the brain with functional magnetic resonance imaging while fluent readers of English viewed meaningless letter strings. The stimuli varied systematically in their approximation to English orthography, as measured by the probability of occurrence of letters and sequential letter pairs (bigrams) comprising the string. A whole-brain analysis showed a single region in the lateral left fusiform gyrus where BOLD signal increased with letter sequence probability; no other brain region showed this response pattern. The results suggest tuning of this cortical area to letter probabilities as a result of perceptual experience and provide a possible neural correlate for the 'word superiority effect' observed in letter perception research.
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“led to suggestions that learning to read tuned the receptive properties of the underlying neurons to combinations of letters (such as bigrams and trigrams) that are found within familiar words (Cohen and Dehaene, 2004; Binder et al., 2006).”
From A review and synthesis of the first 20years of PET and fMRI studies of heard speech, spoken language and reading (2012) · cites this paper as Binder et al., 2006
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Sorted by citations
Price, C. J. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.04.062 · Cited by 2,159
“Observations that left occipitotemporal activation was observed for pseudowords with increased activation as letter strings became more word-like (Binder et al., 2006) led to suggestions that learning to read tuned the receptive properties of the underlying neurons to combinations of letters (such…”
BackgroundInfluentialThe unique role of the visual word form area in reading
Dehaene, S., & Cohen, L. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.04.003 · Cited by 1,488
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“Binder et al. (2006) recently showed that activation increases monotonically with bigram frequency in the left occipito-temporal region (but not the right), at the usual main peak of the VWFA, indicating a fine tuning to frequent letter combinations.”
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“Previous studies showed that the left fusiform gyrus is responsive to orthographic structure during visual word recognition (Binder et al., 2006), leading researchers to suggest that the role of the left fusiform is to integrate features into elaborate schemes that represent whole words or objects (Starrfelt and Gerla…”
BackgroundThe Interactive Account of ventral occipitotemporal contributions to reading
Price, C. J., & Devlin, J. T. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.04.001 · Cited by 712
Metadata
- Authors
- Binder, J. R., Medler, D. A., Westbury, C. F., Liebenthal, E., & Buchanan, L.
- Affiliations
- Medical College of Wisconsin (US)
- University of Alberta (CA)
- University of Windsor (CA)
- Corresponding author
- Binder, Jeffrey R.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2006-11
- Volume
- 33
- Issue
- 2
- Pages
- 739-748
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC1634933
- OpenAlex
- W2070993882
- Cited by
- 286
- References
- 74
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 9 · 2023: 9 · 2022: 14 · 2021: 15 · 2020: 9 · 2019: 14 · 2018: 16 · 2017: 15 · 2016: 13 · 2015: 26 · 2014: 16 · 2013: 20 · 2012: 21
- FWCI
- 23.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- National Institute of Mental Health (P01MH51358, P01MH051358)
- National Institute of Neurological Disorders and Stroke (R01NS033576, R01 NS33576)
- National Center for Research Resources (M01-RR00058, M01RR000058)
- Topics
- Social Sciences › Psychology › Developmental and Educational Psychology › Reading and Literacy Development
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- fusiform gyrus, visual word recognition, bigrams, word superiority effect, letter perception, perceptual experience, English orthography, BOLD signal
- MeSH terms
- Adult, Brain Mapping, Cerebrovascular Circulation, Educational Status, Female, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Middle Aged, Oxygen, Reference Values
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