Cited by 857Eating Disorders and BehaviorsRegulation of Appetite and ObesityNeural and Behavioral Psychology Studies

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Widespread reward-system activation in obese women in response to pictures of high-calorie foods

Stoeckel, Luke E., Weller, Rosalyn E., Cook, Edwin W., Twieg, Donald B., Knowlton, Robert C., Cox, James E.·2008·NeuroImage

DOI 10.1016/j.neuroimage.2008.02.031

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Abstract

Behavioral studies have suggested that exaggerated reactivity to food cues, especially those associated with high-calorie foods, may be a factor underlying obesity. This increased motivational potency of foods in obese individuals appears to be mediated in part by a hyperactive reward system. We used a Philips 3T magnet and fMRI to investigate activation of reward-system and associated brain structures in response to pictures of high-calorie and low-calorie foods in 12 obese compared to 12 normal-weight women. A regions of interest (ROI) analysis revealed that pictures of high-calorie foods produced significantly greater activation in the obese group compared to controls in medial and lateral orbitofrontal cortex, amygdala, nucleus accumbens/ventral striatum, medial prefrontal cortex, insula, anterior cingulate cortex, ventral pallidum, caudate, putamen, and hippocampus. For the contrast of high-calorie vs. low-calorie foods, the obese group also exhibited a larger difference than the controls did in all of the same regions of interest except for the putamen. Within-group contrasts revealed that pictures of high-calorie foods uniformly stimulated more activation than low-calorie foods did in the obese group. By contrast, in the control group, greater activation by high-calorie foods was seen only in dorsal caudate, whereas low-calorie foods were more effective than high-calorie foods in the lateral orbitofrontal cortex, medial prefrontal cortex, and anterior cingulate cortex. In summary, compared to normal-weight controls, obese women exhibited greater activation in response to pictures of high-calorie foods in a large number of regions hypothesized to mediate motivational effects of food cues.

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Self-citation

Authors: Stoeckel, L. E., Weller, R. E., Cook, E. W., Twieg, D. B., Knowlton, R. C., & Cox, J. E.
Affiliations: University of Alabama at Birmingham (US)
Corresponding author: Stoeckel, Luke E.
ORCID: Stoeckel, Luke E.
Cook, Edwin W.
Knowlton, Robert C.
Venue: NeuroImage
Publisher: Elsevier BV
Published: 2008-06
Volume: 41
Issue: 2
Pages: 636-647
ISSN: 1053-8119 (ISSN-L)
DOI: 10.1016/j.neuroimage.2008.02.031
OpenAlex: W2074382500
Cited by: 857
References: 122
Citations by year: 2026: 11 · 2025: 19 · 2024: 18 · 2023: 33 · 2022: 47 · 2021: 49 · 2020: 57 · 2019: 47 · 2018: 81 · 2017: 53 · 2016: 59 · 2015: 64 · 2014: 59 · 2013: 57 · 2012: 79
FWCI: 45.19
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: NeuroImage (publishedVersion)
PubMed (publishedVersion)
Funders: Procter and Gamble
University of Alabama at Birmingham
Deutsches Krebsforschungszentrum
National Center for Research Resources (M01RR00032, M01RR000032)
Topics: Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: obesity, food reward, high-calorie foods, food cue reactivity, reward systems, orbitofrontal cortex, amygdala, nucleus accumbens, ventral striatum, medial prefrontal cortex, anterior cingulate cortex, insula, caudate nucleus, putamen, hippocampus, women
MeSH terms: Adult, Brain, Brain Mapping, Cues, Female, Food, Food Preferences, Humans, Magnetic Resonance Imaging, Obesity, Photic Stimulation, Reward

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Widespread reward-system activation in obese women in response to pictures of high-calorie foods

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