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Cited by 674

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Miro1 Is a Calcium Sensor for Glutamate Receptor-Dependent Localization of Mitochondria at Synapses

Open access
MacAskill, Andrew F., Rinholm, Johanne E., Twelvetrees, Alison E., Arancibia-Carcamo, I. Lorena, Muir, James, Fransson, Asa, Aspenstrom, Pontus, Attwell, David, Kittler, Josef T.·2009·Neuron
DOI 10.1016/j.neuron.2009.01.030
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Abstract

Energy use, mainly to reverse ion movements in neurons, is a fundamental constraint on brain information processing. Trafficking of mitochondria to locations in neurons where there are large ion fluxes is essential for powering neural function. Mitochondrial trafficking is regulated by Ca2+ entry through ionotropic glutamate receptors, but the underlying mechanism is unknown. We show that the protein Miro1 links mitochondria to KIF5 motor proteins, allowing mitochondria to move along microtubules. This linkage is inhibited by micromolar levels of Ca2+ binding to Miro1. With the EF hand domains of Miro1 mutated to prevent Ca2+ binding, Miro1 could still facilitate mitochondrial motility, but mitochondrial stopping induced by glutamate or neuronal activity was blocked. Activating neuronal NMDA receptors with exogenous or synaptically released glutamate led to Miro1 positioning mitochondria at the postsynaptic side of synapses. Thus, Miro1 is a key determinant of how energy supply is matched to energy usage in neurons.

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Metadata

Authors
MacAskill, A. F., Rinholm, J. E., Twelvetrees, A. E., Arancibia-Carcamo, I. L., Muir, J., Fransson, A., Aspenstrom, P., Attwell, D., & Kittler, J. T.
Venue
Neuron
Publisher
Elsevier BV
Published
2009-02
Volume
61
Issue
4
Pages
541-555
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2009.01.030
OpenAlex
W1993696187
Cited by
674
References
5
FWCI
15.60
Type
journal article
Language
en
Open access
hybrid

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