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Nanoparticles and innate immunity: new perspectives on host defence

Boraschi, Diana, Italiani, Paola, Palomba, Roberto, Decuzzi, Paolo, Duschl, Albert, Fadeel, Bengt, Moghimi, S. Moein·2017·Seminars in Immunology
DOI 10.1016/j.smim.2017.08.013
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Abstract

The innate immune system provides the first line of defence against foreign microbes and particulate materials. Engineered nanoparticles can interact with the immune system in many different ways. Nanoparticles may thus elicit inflammation with engagement of neutrophils, macrophages and other effector cells; however, it is important to distinguish between acute and chronic inflammation in order to identify the potential hazards of nanoparticles for human health. Nanoparticles may also interact with and become internalised by dendritic cells, key antigen-presenting cells of the immune system, where a better understanding of these processes could pave the way for improved vaccination strategies. Nanoparticle characteristics such as size, shape and deformability also influence nanoparticle uptake by a plethora of immune cells and subsequent immune responses. Furthermore, the corona of adsorbed biomolecules on nanoparticle surfaces should not be neglected. Complement activation represents a special case of regulated and dynamic corona formation on nanoparticles with important implications in clearance and safety. Additionally, the inadvertent binding of bacterial lipopolysaccharide to nanoparticles is important to consider as this may skew the outcome and interpretation of immunotoxicological studies. Here, we discuss nanoparticle interactions with different cell types and soluble mediators belonging to the innate immune system.

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Metadata

Authors
Boraschi, D., Italiani, P., Palomba, R., Decuzzi, P., Duschl, A., Fadeel, B., & Moghimi, S. M.
Venue
Seminars in Immunology
Publisher
Elsevier BV
Published
2017-12
Volume
34
Pages
33-51
ISSN
1044-5323
DOI
10.1016/j.smim.2017.08.013
Cited by
310
References
32
Language
en
Licence
Funders
  • European Commission (GA 602461, GA 696656)
  • Associazione Italiana per la Ricerca sul Cancro (GA 17664)
  • Horizon 2020 Framework Programme (GA 671881)
  • European Research Council (FP7/2007-2013 / ERC GA 616695)
  • Ministero dell’Istruzione, dell’Università e della Ricerca
  • Stiftelsen för Miljöstrategisk Forskning

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