Cited by 237Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesRegulation of Appetite and Obesity

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NOW vs LATER brain circuits: implications for obesity and addiction

Volkow, Nora D., Baler, Ruben D.·2015·Trends in Neurosciences

DOI 10.1016/j.tins.2015.04.002

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Abstract

Balancing behaviors that provide a reward NOW versus behaviors that provide an advantage LATER is critical for survival. We propose a model in which dopamine (DA) can favor NOW processes through phasic signaling in reward circuits or LATER processes through tonic signaling in control circuits. At the same time, through its modulation of the orbitofrontal cortex, which processes salience attribution, DA also enables shifting from NOW to LATER, while its modulation of the insula, which processes interoceptive information, influences the probability of selecting NOW vs LATER actions on the basis of an individual's physiological state. Disruptions along these circuits contribute to diverse pathologies, including obesity and addiction.

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Authors: Volkow, N. D., & Baler, R. D.
Affiliations: National Institutes of Health (US)
Corresponding author: Volkow, Nora D.
ORCID: Volkow, Nora D.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2015-06
Volume: 38
Issue: 6
Pages: 345-352
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2015.04.002
OpenAlex: W1584054336
Cited by: 237
References: 134
Citations by year: 2026: 10 · 2025: 12 · 2024: 16 · 2023: 13 · 2022: 20 · 2021: 25 · 2020: 30 · 2019: 24 · 2018: 27 · 2017: 28 · 2016: 21 · 2015: 8
FWCI: 3.37
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: delay discounting, dopamine signaling, phasic dopamine, tonic dopamine, reward systems, orbitofrontal cortex, insula, interoception, salience attribution, impulsivity, obesity, addiction
MeSH terms: Animals, Brain, Dopamine, Humans, Neural Pathways, Obesity, Behavior, Addictive, Substance-Related Disorders, Delay Discounting

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