Targeting the correct HDAC(s) to treat cognitive disorders

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Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

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Mammalian Sirtuins: Biological Insights and Disease Relevance

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An operational definition of epigenetics: Figure 1.

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The Deacetylase HDAC6 Regulates Aggresome Formation and Cell Viability in Response to Misfolded Protein Stress

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HDAC6 Regulates Hsp90 Acetylation and Chaperone-Dependent Activation of Glucocorticoid Receptor

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Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation

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A novel pathway regulates memory and plasticity via SIRT1 and miR-134

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Class II Histone Deacetylases Act as Signal-Responsive Repressors of Cardiac Hypertrophy

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Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

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Chromatin Acetylation, Memory, and LTP Are Impaired in CBP+/− Mice

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Overlooking the Obvious: A Meta-analytic Comparison of Digit Symbol Coding Tasks and Other Cognitive Measures in Schizophrenia

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Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation

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CBP Histone Acetyltransferase Activity Is a Critical Component of Memory Consolidation

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Histone Deacetylase 4 Controls Chondrocyte Hypertrophy during Skeletogenesis

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Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation

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Mice with Truncated MeCP2 Recapitulate Many Rett Syndrome Features and Display Hyperacetylation of Histone H3

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Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression

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Inhibition of Histone Deacetylase 6 Acetylates and Disrupts the Chaperone Function of Heat Shock Protein 90

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HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo

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Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

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Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

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Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

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Epigenetics: A Historical Overview

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The Aging Brain

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Multiple roles of HDAC inhibition in neurodegenerative conditions

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MicroRNA-206 Delays ALS Progression and Promotes Regeneration of Neuromuscular Synapses in Mice

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Essential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity

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Gene expression changes in the course of normal brain aging are sexually dimorphic

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Antidepressant Actions of Histone Deacetylase Inhibitors

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Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

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Histone Deacetylase 5 Epigenetically Controls Behavioral Adaptations to Chronic Emotional Stimuli

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Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3- 3-dependent cellular localization

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Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally

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Antidepressant-Like Effects of the Histone Deacetylase Inhibitor, Sodium Butyrate, in the Mouse

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Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

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Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders

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Histone Deacetylase 7 Maintains Vascular Integrity by Repressing Matrix Metalloproteinase 10

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ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS

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Cognitive impairment in major depression

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A summary of the FDA-NIMH-MATRICS workshop on clinical trial design for neurocognitive drugs for schizophrenia

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S-nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons

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Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents

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Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model

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Expression and function of orphan nuclear receptor TLX in adult neural stem cells

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DNA Methylation in the Human Cerebral Cortex Is Dynamically Regulated throughout the Life Span and Involves Differentiated Neurons

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Histone deacetylase 8 in neuroblastoma tumorigenesis

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Histone deacetylase 6 interacts with the microtubule‐associated protein tau

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Deletion of Histone Deacetylase 3 Reveals Critical Roles in S Phase Progression and DNA Damage Control

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Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice

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Distribution of histone deacetylases 1–11 in the rat brain

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Identification of Novel Isoform-Selective Inhibitors within Class I Histone Deacetylases

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ERK/MAPK regulates hippocampal histone phosphorylation following contextual fear conditioning

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Evolution of the Aging Brain Transcriptome and Synaptic Regulation

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Transgenic mice expressing a truncated form of CREB-binding protein (CBP) exhibit deficits in hippocampal synaptic plasticity and memory storage

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HDAC6 is a target for protection and regeneration following injury in the nervous system

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Histone deacetylase inhibitors: discovery and development as anticancer agents

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Cognitive functioning in patients with schizophrenia and bipolar disorder: A quantitative review

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A meta-analysis and critical review of the effects of conventional neuroleptic treatment on cognition in schizophrenia: opening a closed book

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Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development

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Neuronal activity‐dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5

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The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice

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Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity

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HDAC6 deacetylation of tubulin modulates dynamics of cellular adhesions

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Epigenetic regulation in the pathophysiology of Alzheimer's disease

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Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice

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