Reduced glutamate in the anterior cingulate cortex in depression: an in vivo proton magnetic resonance spectroscopy study

A cholinergic-adrenergic hypothesis of mania and depression

Janowsky, D., Davis, J., El-Yousef, M. K., & Sekerke, H. J. (1972) · The Lancet · doi:10.1016/s0140-6736(72)93021-8 · Cited by 1,134

Changes in regional cerebral blood flow on recovery from depression

Bench, C. J., Frackowiak, R. S. J., & Dolan, R. J. (1995) · Psychological Medicine · doi:10.1017/s0033291700036151 · Cited by 351

The role of the cingulate gyrus in depression: From functional anatomy to neurochemistry

Ebert, D., & Ebmeier, K. P. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00320-7 · Cited by 170

Towards a glutamate hypothesis of depression

Sanacora, G., Treccani, G., & Popoli, M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.07.036 · Cited by 1,036

Deep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression

Schlaepfer, T. E., Cohen, M. X., Frick, C., Kosel, M., Brodesser, D., Axmacher, N., Joe, A. Y., Kreft, M., Lenartz, D., & Sturm, V. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301408 · Cited by 1,027

Reduced Prefrontal Glutamate/Glutamine and γ-Aminobutyric Acid Levels in Major Depression Determined Using Proton Magnetic Resonance Spectroscopy

Hasler, G., van der Veen, J. W., Tumonis, T., Meyers, N., Shen, J., & Drevets, W. C. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.2.193 · Cited by 846

Limbic-frontal circuitry in major depression: a path modeling metanalysis

Seminowicz, D. A., Mayberg, H. S., McIntosh, A. R., Goldapple, K., Kennedy, S., Segal, Z., & Rafi-Tari, S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.01.015 · Cited by 710

In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice

Cryan, J. F., & Mombereau, C. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001457 · Cited by 616

Astrocyte Pathology in Major Depressive Disorder: Insights from Human Postmortem Brain Tissue

Rajkowska, G., & Stockmeier, C. (2013) · Current Drug Targets · doi:10.2174/13894501113149990156 · Cited by 603

Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission?

Steiner, J., Walter, M., Gos, T., Guillemin, G. J., Bernstein, H.-G., Sarnyai, Z., Mawrin, C., Brisch, R., Bielau, H., zu Schwabedissen, L., et al. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-94 · Cited by 568

Postpartum depression: Etiology, treatment and consequences for maternal care

Brummelte, S., & Galea, L. A. M. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.08.008 · Cited by 567

Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments

Krystal, J. H., Sanacora, G., Blumberg, H., Anand, A., Charney, D. S., Marek, G., Epperson, C. N., Goddard, A., & Mason, G. F. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001021 · Cited by 553

Effects of early adverse experiences on brain structure and function: clinical implications

Kaufman, J., Plotsky, P. M., Nemeroff, C. B., & Charney, D. S. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00998-7 · Cited by 508

A Randomized Controlled Trial of Intranasal Ketamine in Major Depressive Disorder

Lapidus, K. A. B., Levitch, C. F., Perez, A. M., Brallier, J. W., Parides, M. K., Soleimani, L., Feder, A., Iosifescu, D. V., Charney, D. S., & Murrough, J. W. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.03.026 · Cited by 480

Glutamate and Gamma-Aminobutyric Acid Systems in the Pathophysiology of Major Depression and Antidepressant Response to Ketamine

Lener, M. S., Niciu, M. J., Ballard, E. D., Park, M., Park, L. T., Nugent, A. C., & Zarate, C. A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.05.005 · Cited by 468

Glutamate abnormalities in obsessive compulsive disorder: neurobiology, pathophysiology, and treatment

Pittenger, C., Bloch, M. H., & Williams, K. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.09.006 · Cited by 426

Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression

Feyissa, A. M., Chandran, A., Stockmeier, C. A., & Karolewicz, B. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.10.005 · Cited by 421

Glutamate and Depression: Clinical and Preclinical Studies

PAUL, I. A., & SKOLNICK, P. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.016 · Cited by 408

Global Brain Gene Expression Analysis Links Glutamatergic and GABAergic Alterations to Suicide and Major Depression

Sequeira, A., Mamdani, F., Ernst, C., Vawter, M. P., Bunney, W. E., Lebel, V., Rehal, S., Klempan, T., Gratton, A., Benkelfat, C., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006585 · Cited by 388

Emerging role of glutamate in the pathophysiology of major depressive disorder

Hashimoto, K. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.05.005 · Cited by 381

Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression

Bernard, R., Kerman, I. A., Thompson, R. C., Jones, E. G., Bunney, W. E., Barchas, J. D., Schatzberg, A. F., Myers, R. M., Akil, H., & Watson, S. J. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.44 · Cited by 372

Glutamatergic neurometabolite levels in major depressive disorder: a systematic review and meta-analysis of proton magnetic resonance spectroscopy studies

Moriguchi, S., Takamiya, A., Noda, Y., Horita, N., Wada, M., Tsugawa, S., Plitman, E., Sano, Y., Tarumi, R., ElSalhy, M., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0252-9 · Cited by 357

Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression

Koike, H., Iijima, M., & Chaki, S. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.05.035 · Cited by 346

Correlation between plasma levels of glutamate, alanine and serine with severity of depression

Mitani, H., Shirayama, Y., Yamada, T., Maeda, K., Ashby, C. R., & Kawahara, R. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.03.036 · Cited by 332

Riluzole augmentation in treatment-resistant obsessive-compulsive disorder: An open-label trial

Coric, V., Taskiran, S., Pittenger, C., Wasylink, S., Mathalon, D. H., Valentine, G., Saksa, J., Wu, Y.-T., Gueorguieva, R., Sanacora, G., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.043 · Cited by 314

Kynurenine pathway in depression: a systematic review and meta-analysis

Ogyu, K., Kubo, K., Noda, Y., Iwata, Y., Tsugawa, S., Omura, Y., Wada, M., Tarumi, R., Plitman, E., Moriguchi, S., et al. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.03.023 · Cited by 301

Interoceptive dysfunction: Toward an integrated framework for understanding somatic and affective disturbance in depression

Harshaw, C. (2015) · Psychological Bulletin · doi:10.1037/a0038101 · Cited by 302

Neurobiological and clinical effects of the antidepressant tianeptine

Kasper, S., & McEwen, B. S. (2008) · CNS Drugs · doi:10.2165/00023210-200822010-00002 · Cited by 302

An excitatory synapse hypothesis of depression

Thompson, S. M., Kallarackal, A. J., Kvarta, M. D., Van Dyke, A. M., LeGates, T. A., & Cai, X. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.03.003 · Cited by 265

Discovering imaging endophenotypes for major depression

Hasler, G., & Northoff, G. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.23 · Cited by 274

Glutamatergic and resting state functional connectivity correlates of severity in major depression - the role of pregenual anterior cingulate cortex and anterior insula

Horn (2010) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2010.00033 · Cited by 276

Association testing of the positional and functional candidate gene SLC1A1/EAAC1 in early-onset obsessive-compulsive disorder

Dickel, D. E., Veenstra-VanderWeele, J., Cox, N. J., Wu, X., Fischer, D. J., Van Etten-Lee, M., Himle, J. A., Leventhal, B. L., Cook, E. H., & Hanna, G. L. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.7.778 · Cited by 274

Human astrocytes in the diseased brain

Dossi, E., Vasile, F., & Rouach, N. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.02.001 · Cited by 250

The role of the brain reward system in depression

Naranjo, C. A., Tremblay, L. K., & Busto, U. E. (2001) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(01)00156-7 · Cited by 245

Reduced Anterior Cingulate Glutamatergic Concentrations in Childhood OCD and Major Depression Versus Healthy Controls

ROSENBERG, D. R., MIRZA, Y., RUSSELL, A., TANG, J., SMITH, J. M., BANERJEE, S. P., BHANDARI, R., ROSE, M., IVEY, J., BOYD, C., et al. (2004) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000132812.44664.2d · Cited by 246

Region and state specific glutamate downregulation in major depressive disorder: a meta-analysis of 1H-MRS findings.

Luykx, J. J., Laban, K. G., van den Heuvel, M. P., Boks, M. P. M., Mandl, R. C. W., Kahn, R. S., & Bakker, S. C. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.05.014 · Cited by 235

Biomarkers in bipolar disorder: a positional paper from the international society for bipolar disorders biomarkers task force.

Frey, B. N., Andreazza, A. C., Houenou, J., Jamain, S., Goldstein, B. I., Frye, M. A., Leboyer, M., Berk, M., Malhi, G. S., Lopez-Jaramillo, C., et al. (2013) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413478217 · Cited by 234

Review of 1H magnetic resonance spectroscopy findings in major depressive disorder: A meta-analysis

Yildiz-Yesiloglu, A., & Ankerst, D. P. (2006) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2005.12.004 · Cited by 232

Network beyond IDO in psychiatric disorders: Revisiting neurodegeneration hypothesis

Myint, A.-M., & Kim, Y.-K. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.08.008 · Cited by 230

Glial and glutamatergic markers in depression, alcoholism, and their comorbidity

Miguel-Hidalgo, J. J., Waltzer, R., Whittom, A. A., Austin, M. C., Rajkowska, G., & Stockmeier, C. A. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.06.003 · Cited by 218

Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study

Arnold, P., Rosenberg, D., Mundo, E., Tharmalingam, S., Kennedy, J., & Richter, M. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1847-1 · Cited by 202

Anterior Cingulate Cortexγ-Aminobutyric Acid in Depressed Adolescents: Relationship to Anhedonia

Gabbay, V. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.131 · Cited by 201

Fast-acting antidepressant activity of ketamine: Highlights on brain serotonin, glutamate, and GABA neurotransmission in preclinical studies

Pham, T. H., & Gardier, A. M. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.02.017 · Cited by 186

Gray matter volume in major depressive disorder: A meta-analysis of voxel-based morphometry studies

Lai, C.-H. (2013) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2012.06.006 · Cited by 191

Regionally specific alterations in functional connectivity of the anterior cingulate cortex in major depressive disorder

Davey, C. G., Harrison, B. J., Yücel, M., & Allen, N. B. (2012) · Psychological Medicine · doi:10.1017/s0033291712000323 · Cited by 176

Glutamatergic Neurotransmission: Pathway to Developing Novel Rapid-Acting Antidepressant Treatments

Kadriu, B., Musazzi, L., Henter, I. D., Graves, M., Popoli, M., & Zarate, C. A. (2019) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy094 · Cited by 165

Substance P receptor antagonist and clomipramine prevent stress-induced alterations in cerebral metabolites, cytogenesis in the dentate gyrus and hippocampal volume

van der Hart, M. G. C., Czéh, B., de Biurrun, G., Michaelis, T., Watanabe, T., Natt, O., Frahm, J., & Fuchs, E. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001130 · Cited by 158

Neuropathology of suicide: Recent findings and future directions

Lutz, P.-E., Mechawar, N., & Turecki, G. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.141 · Cited by 158

The change in plasma GABA, glutamine and glutamate levels in fluoxetine- or S-citalopram-treated female patients with major depression

Küçükibrahimoğlu, E., Saygın, M. Z., Çalışkan, M., Kaplan, O. K., Ünsal, C., & Gören, M. Z. (2009) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-009-0650-7 · Cited by 155

Indirect evidence of selective glial involvement in glutamate-based mechanisms of mood regulation in depression: Meta-analysis of absolute prefrontal neuro-metabolic concentrations

Arnone, D., Mumuni, A. N., Jauhar, S., Condon, B., & Cavanagh, J. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.04.016 · Cited by 150

Effect of Acamprosate on Magnetic Resonance Spectroscopy Measures of Central Glutamate in Detoxified Alcohol-Dependent Individuals: A Randomized Controlled Experimental Medicine Study

Umhau, J. C., Momenan, R., Schwandt, M. L., Singley, E., Lifshitz, M., Doty, L., Adams, L. J., Vengeliene, V., Spanagel, R., Zhang, Y., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.125 · Cited by 144

A pilot in vivo proton magnetic resonance spectroscopy study of amino acid neurotransmitter response to ketamine treatment of major depressive disorder

Milak, M. S., Proper, C. J., Mulhern, S. T., Parter, A. L., Kegeles, L. S., Ogden, R. T., Mao, X., Rodriguez, C. I., Oquendo, M. A., Suckow, R. F., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.83 · Cited by 144

Is subcortical–cortical midline activity in depression mediated by glutamate and GABA? A cross-species translational approach

Alcaro, A., Panksepp, J., Witczak, J., Hayes, D. J., & Northoff, G. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.11.023 · Cited by 144

Novel Glutamatergic Modulators for the Treatment of Mood Disorders: Current Status

Henter, I. D., Park, L. T., & Zarate, C. A. (2021) · CNS Drugs · doi:10.1007/s40263-021-00816-x · Cited by 142

Anterior Cingulate Glutamate–Glutamine Levels Predict Symptom Severity in Women With Obsessive–Compulsive Disorder

Yücel, M., Wood, S. J., Wellard, R. M., Harrison, B. J., Fornito, A., Pujol, J., Velakoulis, D., & Pantelis, C. (2008) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670802050546 · Cited by 130

Ventromedial prefrontal spectroscopic abnormalities over the course of depression: A comparison among first episode, remitted recurrent and chronic patients

Portella, M. J., de Diego-Adeliño, J., Gómez-Ansón, B., Morgan-Ferrando, R., Vives, Y., Puigdemont, D., Pérez-Egea, R., Ruscalleda, J., Álvarez, E., & Pérez, V. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.08.010 · Cited by 127

The Impact of Gabapentin Administration on Brain GABA and Glutamate Concentrations: A 7T 1H-MRS Study

Cai, K., Nanga, R. P., Lamprou, L., Schinstine, C., Elliott, M., Hariharan, H., Reddy, R., & Epperson, C. N. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.142 · Cited by 128

Magnetic resonance imaging and spectroscopy reveal differential hippocampal changes in anhedonic and resilient subtypes of the chronic mild stress rat model

Delgado y Palacios, R., Campo, A., Henningsen, K., Verhoye, M., Poot, D., Dijkstra, J., Van Audekerke, J., Benveniste, H., Sijbers, J., Wiborg, O., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.014 · Cited by 113

Inter-hemispheric asymmetry of motor corticospinal excitability in major depression studied by transcranial magnetic stimulation

Lefaucheur, J. P., Lucas, B., Andraud, F., Hogrel, J. Y., Bellivier, F., Del Cul, A., Rousseva, A., Leboyer, M., & Paillère-Martinot, M. L. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2007.03.001 · Cited by 103

Glutamine deficiency in the prefrontal cortex increases depressive-like behaviours in male mice

Lee, Y., Son, H., Kim, G., Kim, S., Lee, D. H., Roh, G. S., Kang, S. S., Cho, G. J., Choi, W. S., & Kim, H. J. (2013) · Journal of Psychiatry & Neuroscience · doi:10.1503/jpn.120024 · Cited by 94

Correlation of Glutamate Levels in the Anterior Cingulate Cortex With Self-reported Impulsivity in Patients With Borderline Personality Disorder and Healthy Controls

Hoerst, M., Weber-Fahr, W., Tunc-Skarka, N., Ruf, M., Bohus, M., Schmahl, C., & Ende, G. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.93 · Cited by 97

Ketamine-Associated Brain Changes: A Review of the Neuroimaging Literature

Ionescu, D. F., Felicione, J. M., Gosai, A., Cusin, C., Shin, P., Shapero, B. G., & Deckersbach, T. (2018) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000179 · Cited by 91

Anterior cingulate neurochemistry in social anxiety disorder: 1H-MRS at 4???Tesla

Phan, K. L., Fitzgerald, D. A., Cortese, B. M., Seraji-Bozorgzad, N., Tancer, M. E., & Moore, G. J. (2005) · NeuroReport · doi:10.1097/00001756-200502080-00024 · Cited by 95

Abnormality in glutamine–glutamate cycle in the cerebrospinal fluid of cognitively intact elderly individuals with major depressive disorder: a 3-year follow-up study

Hashimoto, K., Bruno, D., Nierenberg, J., Marmar, C. R., Zetterberg, H., Blennow, K., & Pomara, N. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.8 · Cited by 90

An update on the role of glutamate in the pathophysiology of depression

Mitchell, N. D., & Baker, G. B. (2010) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2009.01529.x · Cited by 91

Functional and Structural Remodeling of Glutamate Synapses in Prefrontal and Frontal Cortex Induced by Behavioral Stress

Musazzi, L., Treccani, G., & Popoli, M. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00060 · Cited by 83

Assessing the role of cingulate cortex in bipolar disorder: Neuropathological, structural and functional imaging data

Fountoulakis, K. N., Giannakopoulos, P., Kövari, E., & Bouras, C. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.04.005 · Cited by 84

Creatine for the Treatment of Depression

Kious, B. M., Kondo, D. G., & Renshaw, P. F. (2019) · Biomolecules · doi:10.3390/biom9090406 · Cited by 74

Cellular abnormalities in depression: evidence from postmortem brain tissue

Stockmeier, C. A., & Rajkowska, G. (2004) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2004.6.2/cstockmeier · Cited by 67

Prefrontal cortical GABA abnormalities are associated with reduced hippocampal volume in major depressive disorder

Abdallah, C. G., Jackowski, A., Sato, J. R., Mao, X., Kang, G., Cheema, R., Coplan, J. D., Mathew, S. J., & Shungu, D. C. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.04.025 · Cited by 67

Lack of effect of ketamine on cortical glutamate and glutamine in healthy volunteers: a proton magnetic resonance spectroscopy study

Taylor, M. J., Tiangga, E. R., Mhuircheartaigh, R. N., & Cowen, P. J. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881111405359 · Cited by 66

Evidence for increased glutamatergic cortical facilitation in children and adolescents with major depressive disorder

Croarkin, P. E., Nakonezny, P. A., Husain, M. M., Melton, T., Buyukdura, J. S., Kennard, B. D., Emslie, G. J., Kozel, F. A., & Daskalakis, Z. J. (2013) · JAMA Psychiatry · doi:10.1001/2013.jamapsychiatry.24 · Cited by 65

Linking atypical depression and insulin resistance-related disorders via low-grade chronic inflammation: Integrating the phenotypic, molecular and neuroanatomical dimensions

Sen, Z. D., Danyeli, L. V., Woelfer, M., Lamers, F., Wagner, G., Sobanski, T., & Walter, M. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.12.020 · Cited by 65

Morphological Brain Changes in Depression: Can Antidepressants Reverse Them?

Miguel-Hidalgo, J. J., & Rajkowska, G. (2002) · CNS Drugs · doi:10.2165/00023210-200216060-00001 · Cited by 64

Spectroscopic correlates of antidepressant response to sleep deprivation and light therapy: A 3.0 Tesla study of bipolar depression

Benedetti, F., Calabrese, G., Bernasconi, A., Cadioli, M., Colombo, C., Dallaspezia, S., Falini, A., Radaelli, D., Scotti, G., & Smeraldi, E. (2009) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2008.08.004 · Cited by 53

Region-specific glutamate changes in patients with unipolar depression

Grimm, S., Luborzewski, A., Schubert, F., Merkl, A., Kronenberg, G., Colla, M., Heuser, I., & Bajbouj, M. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.04.018 · Cited by 52

Proton magnetic resonance spectroscopy of N-acetyl aspartate in first depressive episode and chronic major depressive disorder: A systematic review and meta-analysis

Saccaro, L. F., Tassone, M., Tozzi, F., & Rutigliano, G. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.03.150 · Cited by 42

Reduced metabotropic glutamate receptor 5 in the Flinders Sensitive Line of rats, an animal model of depression: an autoradiographic study

Kovačević, T., Skelin, I., Minuzzi, L., Rosa-Neto, P., & Diksic, M. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2012.01.010 · Cited by 41

The Role of Glutamine Homeostasis in Emotional and Cognitive Functions

Baek, J. H., Park, H., Kang, H., Kim, R., Kang, J. S., & Kim, H. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021302 · Cited by 35

Glutamate and GABA contributions to medial prefrontal cortical activity to emotion: Implications for mood disorders

Stan, A. D., Schirda, C. V., Bertocci, M. A., Bebko, G. M., Kronhaus, D. M., Aslam, H. A., LaBarbara, E. J., Tanase, C., Lockovich, J. C., Pollock, M. H., et al. (2014) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2014.05.016 · Cited by 35

Examining SLV-323, a novel NK1 receptor antagonist, in a chronic psychosocial stress model for depression

Czéh, B., Pudovkina, O., van der Hart, M. G. C., Simon, M., Heilbronner, U., Michaelis, T., Watanabe, T., Frahm, J., & Fuchs, E. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2184-8 · Cited by 33

Beyond NMDA Receptors: A Narrative Review of Ketamine’s Rapid and Multifaceted Mechanisms in Depression Treatment

Antos, Z., Żukow, X., Bursztynowicz, L., & Jakubów, P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413658 · Cited by 21

Announcing the first novel class of rapid-onset antidepressants in clinical practice

Fasipe, O., Akhideno, P., Owhin, O., & Ibiyemi-Fasipe, O. (2019) · Journal of Medical Sciences · doi:10.4103/jmedsci.jmedsci_36_19 · Cited by 6