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Cited by 221Treatment of Major DepressionNeural and Behavioral Psychology StudiesAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

Executive dysfunction predicts nonresponse to fluoxetine in major depression

Dunkin, Jennifer J, Leuchter, Andrew F, Cook, Ian A, Kasl-Godley, Julia E, Abrams, Michelle, Rosenberg-Thompson, Susan·2000·Journal of Affective Disorders
DOI 10.1016/s0165-0327(99)00157-3
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Abstract

Background Functional brain imaging studies of major depression have consistently revealed hypometabolism or hypoperfusion in specific regions of the prefrontal cortex and basal ganglia. Studies of cognitive functioning in major depression have suggested that some but not all subjects exhibit cognitive deficits that are consistent with frontal-subcortical dysfunction, although the reasons for this heterogeneity are unclear. In this study, we explored this heterogeneity among depressed subjects by examining the relationship between cognitive functioning and treatment outcome.Method Subjects with major depression were administered a complete neuropsychological test battery prior to treatment with fluoxetine.Results There were no significant differences between responders and nonresponders to fluoxetine in terms of age, educational achievement, number of past episodes of depression, and estimated premorbid IQ. However, nonresponders performed significantly worse than responders on several pretreatment measures of executive functioning, after controlling for baseline group differences in depression severity.Limitations The results are based on a small sample of primarily female subjects, resulting in low statistical power and less generalizability to samples of male subjects with depression.Conclusions The findings suggest that subtle prefrontal dysfunction in subjects with major depression may be predictive of poor response with particular medications. Assessment of the executive functions may play a particular role in pretreatment identification of subjects likely to respond to specific medications.

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Metadata

Authors
Dunkin, J. J., Leuchter, A. F., Cook, I. A., Kasl-Godley, J. E., Abrams, M., & Rosenberg-Thompson, S.
Affiliations
University of California, Los Angeles (US)
Corresponding author
Dunkin, Jennifer J
ORCID
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
2000-10
Volume
60
Issue
1
Pages
13-23
ISSN
0165-0327 (ISSN-L)
DOI
10.1016/s0165-0327(99)00157-3
OpenAlex
W2047261130
Cited by
221
References
54
Citations by year
2026: 2 · 2025: 3 · 2024: 8 · 2023: 4 · 2022: 8 · 2021: 9 · 2020: 7 · 2019: 3 · 2018: 13 · 2017: 9 · 2016: 12 · 2015: 16 · 2014: 6 · 2013: 20 · 2012: 11
FWCI
1.73
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Affective Disorders (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01mh040705-13)
  • National Institute of Mental Health (R01MH40705)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
major depressive disorder, executive dysfunction, fluoxetine, treatment non-response, cognitive impairment, prefrontal cortex, treatment outcome prediction, neuropsychological assessment, antidepressant response
MeSH terms
Adult, Cognition Disorders, Major Depressive Disorder, Double-Blind Method, Female, Fluoxetine, Humans, Male, Neuropsychological Tests, Predictive Value of Tests, Severity of Illness Index, Single-Blind Method, Treatment Failure, Selective Serotonin Reuptake Inhibitors, Prefrontal Cortex

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