Cited by 2,574Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeural dynamics and brain function

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Getting Formal with Dopamine and Reward

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Schultz, Wolfram·2002·Neuron

DOI 10.1016/s0896-6273(02)00967-4

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Abstract

Recent neurophysiological studies reveal that neurons in certain brain structures carry specific signals about past and future rewards. Dopamine neurons display a short-latency, phasic reward signal indicating the difference between actual and predicted rewards. The signal is useful for enhancing neuronal processing and learning behavioral reactions. It is distinctly different from dopamine's tonic enabling of numerous behavioral processes. Neurons in the striatum, frontal cortex, and amygdala also process reward information but provide more differentiated information for identifying and anticipating rewards and organizing goal-directed behavior. The different reward signals have complementary functions, and the optimal use of rewards in voluntary behavior would benefit from interactions between the signals. Addictive psychostimulant drugs may exert their action by amplifying the dopamine reward signal.

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A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388
Self-citation
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346
A theory of Pavlovian conditioning : Variations in the effectiveness of reinforcement and nonreinforcement
Rescorla, R. A. (1972) · Medical Entomology and Zoology · Cited by 7,268
Cognitive, social, and physiological determinants of emotional state.
Schachter, S., & Singer, J. (1962) · Psychological Review · doi:10.1037/h0046234 · Cited by 6,223
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564
Self-citation
Untitled work
(1996) · Cited by 3,692
Neuronlike adaptive elements that can solve difficult learning control problems
Barto, A. G., Sutton, R. S., & Anderson, C. W. (1983) · IEEE Transactions on Systems Man and Cybernetics · doi:10.1109/tsmc.1983.6313077 · Cited by 3,325
A theory of cerebellar cortex
Marr, D. (1969) · The Journal of Physiology · doi:10.1113/jphysiol.1969.sp008820 · Cited by 3,253
The Cerebellum as a Neuronal Machine
Eccles, J. C., Ito, M., & Szentágothai, J. (1967) · Springer eBooks · doi:10.1007/978-3-662-13147-3 · Cited by 3,229
A model for Pavlovian learning: Variations in the effectiveness of conditioned but not of unconditioned stimuli.
Pearce, J. M., & Hall, G. (1980) · Psychological Review · doi:10.1037/0033-295x.87.6.532 · Cited by 3,023
A theory of attention: Variations in the associability of stimuli with reinforcement
Mackintosh, N. J. (1975) · Psychological Review · doi:10.1037/h0076778 · Cited by 2,733
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
Giros, B., Jaber, M., Jones, S. R., Wightman, R. M., & Caron, M. G. (1996) · Nature · doi:10.1038/379606a0 · Cited by 2,476
A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Burns, R. S., Chiueh, C. C., Markey, S. P., Ebert, M. H., Jacobowitz, D. M., & Kopin, I. J. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.14.4546 · Cited by 2,149
A framework for mesencephalic dopamine systems based on predictive Hebbian learning
Montague, P., Dayan, P., & Sejnowski, T. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-05-01936.1996 · Cited by 2,066
The formation of learning sets.
Harlow, H. F. (1949) · Psychological Review · doi:10.1037/h0062474 · Cited by 1,959
A neostriatal habit learning system in humans
Knowlton, B. J., Mangels, J. A., & Squire, L. R. (1996) · Science · doi:10.1126/science.273.5280.1399 · Cited by 1,777
Neural correlates of decision variables in parietal cortex
Platt, M. L., & Glimcher, P. W. (1999) · Nature · doi:10.1038/22268 · Cited by 1,721
Effects of crossmodal divided attention on late ERP components. II. Error processing in choice reaction tasks
Falkenstein, M., Hohnsbein, J., Hoormann, J., & Blanke, L. (1991) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(91)90062-9 · Cited by 1,706
Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey
Brozoski, T. J., Brown, R. M., Rosvold, H. E., & Goldman, P. S. (1979) · Science · doi:10.1126/science.112679 · Cited by 1,500
Toward a modern theory of adaptive networks: Expectation and prediction.
Sutton, R. S., & Barto, A. G. (1981) · Psychological Review · doi:10.1037/0033-295x.88.2.135 · Cited by 1,450
D1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory
Sawaguchi, T., & Goldman-Rakic, P. S. (1991) · Science · doi:10.1126/science.1825731 · Cited by 1,364
Relative reward preference in primate orbitofrontal cortex
Tremblay, L., & Schultz, W. (1999) · Nature · doi:10.1038/19525 · Cited by 1,314
Self-citation
Responses of monkey dopamine neurons to reward and conditioned stimuli during successive steps of learning a delayed response task
Schultz, W., Apicella, P., & Ljungberg, T. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-03-00900.1993 · Cited by 1,291
Self-citation
Models of Information Processing in the Basal Ganglia
(1994) · doi:10.7551/mitpress/4708.001.0001 · Cited by 1,190
Neurobehavioural mechanisms of reward and motivation
Robbins, T. W., & Everitt, B. J. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80077-8 · Cited by 1,187
Long-Term Depression
Ito, M. (1989) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.12.030189.000505 · Cited by 1,167
Dopamine neurons report an error in the temporal prediction of reward during learning
Hollerman, J. R., & Schultz, W. (1998) · Nature Neuroscience · doi:10.1038/1124 · Cited by 1,161
Self-citation
Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons
Ungless, M. A., Whistler, J. L., Malenka, R. C., & Bonci, A. (2001) · Nature · doi:10.1038/35079077 · Cited by 1,106
Differential effect of stress on in vivo dopamine release in striatum, nucleus accumbens, and medial frontal cortex
Abercrombie, E. D., Keefe, K. A., DiFrischia, D. S., & Zigmond, M. J. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb09224.x · Cited by 1,106
Neurobiology of addiction
Wise, R. A. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80079-1 · Cited by 1,072
Nonrepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli
Aston‐Jones, G., & Bloom, F. E. (1981) · Journal of Neuroscience · doi:10.1523/jneurosci.01-08-00887.1981 · Cited by 1,072
The neural network of the basal ganglia as revealed by the study of synaptic connections of identified neurones
Smith, A. D., & Bolam, J. P. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90106-k · Cited by 1,040
Dopamine responses comply with basic assumptions of formal learning theory
Waelti, P., Dickinson, A., & Schultz, W. (2001) · Nature · doi:10.1038/35083500 · Cited by 1,018
Self-citation
Motivational control of goal-directed action
Dickinson, A., & Balleine, B. (1994) · Animal Learning & Behavior · doi:10.3758/bf03199951 · Cited by 995
Responses of monkey dopamine neurons during learning of behavioral reactions
Ljungberg, T., Apicella, P., & Schultz, W. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.67.1.145 · Cited by 987
Self-citation
Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events
Horvitz, J. C. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00019-1 · Cited by 967
Contemporary Animal Learning Theory.
Abrahamson, D. (1981) · Europe PMC (PubMed Central) · Cited by 945
Contemporary Animal Learning Theory
LoLordo, V. M., & Dickinson, A. (1982) · The American Journal of Psychology · doi:10.2307/1422669 · Cited by 890
Brain Reward Circuitry
Wise, R. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)00965-0 · Cited by 881
A cellular mechanism of reward-related learning
Reynolds, J. N. J., Hyland, B. I., & Wickens, J. R. (2001) · Nature · doi:10.1038/35092560 · Cited by 879
Tyrosine hydroxylase-immunoreactive boutons in synaptic contact with identified striatonigral neurons, with particular reference to dendritic spines
Freund, T. F., Powell, J. F., & Smith, A. D. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90294-x · Cited by 875
Impulse activity of locus coeruleus neurons in awake rats and monkeys is a function of sensory stimulation and arousal
Foote, S. L., Aston-Jones, G., & Bloom, F. E. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.5.3033 · Cited by 857
The orbitofrontal cortex: Neuronal activity in the behaving monkey
Thorpe, S. J., Rolls, E. T., & Maddison, S. (1983) · Experimental Brain Research · doi:10.1007/bf00235545 · Cited by 836
Preferential activation of midbrain dopamine neurons by appetitive rather than aversive stimuli
Mirenowicz, J., & Schultz, W. (1996) · Nature · doi:10.1038/379449a0 · Cited by 829
Self-citation
TD-Gammon, a Self-Teaching Backgammon Program, Achieves Master-Level Play
Tesauro, G. J. (1994) · Neural Computation · doi:10.1162/neco.1994.6.2.215 · Cited by 821
Addictive Drugs and Brain Stimulation Reward
Wise, R. A. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.001535 · Cited by 792
The orbitofrontal cortex
Rolls, E. T. (1996) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1996.0128 · Cited by 755
Long-term potentiation of excitatory inputs to brain reward areas by nicotine
Mansvelder, H. D., & McGehee, D. S. (2000) · Neuron · doi:10.1016/s0896-6273(00)00042-8 · Cited by 720
Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas
Mansvelder, H. D., Keath, J. R., & McGehee, D. S. (2002) · Neuron · doi:10.1016/s0896-6273(02)00625-6 · Cited by 701
Reward expectancy in primate prefrental neurons
Watanabe, M. (1996) · Nature · doi:10.1038/382629a0 · Cited by 684 · cited 4×
“…and amounts of food and Given the central importance of rewards for survival, reproduction, and competitive gains, it may not be sur-liquid rewards (Watanabe, 1996; Leon and Shadlen, 1999; Tremblay and Schultz, 1999; Hassani et al., 2001) prising that several specialized and only partly…”
Influential
Long-term synaptic depression in the striatum: physiological and pharmacological characterization
Calabresi, P., Maj, R., Pisani, A., Mercuri, N. B., & Bernardi, G. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-11-04224.1992 · Cited by 682
Nonlinear relationship between impulse flow and dopamine released by rat midbrain dopaminergic neurons as studied by in vivo electrochemistry
Gonon, F. G. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90307-7 · Cited by 676
Purkinje cell activity during motor learning
Gilbert, P. F. C., & Thach, W. T. (1977) · Brain Research · doi:10.1016/0006-8993(77)90997-0 · Cited by 657
Role for Cingulate Motor Area Cells in Voluntary Movement Selection Based on Reward
Shima, K., & Tanji, J. (1998) · Science · doi:10.1126/science.282.5392.1335 · Cited by 645
Expectation of reward modulates cognitive signals in the basal ganglia
Kawagoe, R., Takikawa, Y., & Hikosaka, O. (1998) · Nature Neuroscience · doi:10.1038/1625 · Cited by 643
Locus coeruleus neurons in monkey are selectively activated by attended cues in a vigilance task
Aston-Jones, G., Rajkowski, J., Kubiak, P., & Alexinsky, T. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-07-04467.1994 · Cited by 637
Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys
Murphy, B. L., Arnsten, A. F., Goldman-Rakic, P. S., & Roth, R. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1325 · Cited by 590
Functional properties of monkey caudate neurons. III. Activities related to expectation of target and reward
Hikosaka, O., Sakamoto, M., & Usui, S. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.4.814 · Cited by 579
Presynaptic regulation of neurotransmitter release in the brain: Facts and hypothesis
Chesselet, M.-F. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90058-7 · Cited by 577
Cortical remodelling induced by activity of ventral tegmental dopamine neurons
Bao, S., Chan, V. T., & Merzenich, M. M. (2001) · Nature · doi:10.1038/35083586 · Cited by 569
Neuromodulatory actions of dopamine in the neostriatum are dependent upon the excitatory amino acid receptor subtypes activated.
Cepeda, C., Buchwald, N. A., & Levine, M. S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9576 · Cited by 559
A Model of How the Basal Ganglia Generate and Use Neural Signals That Predict Reinforcement
Houk, J. C., Adams, J. L., & Barto, A. G. (1994) · The MIT Press eBooks · doi:10.7551/mitpress/4708.003.0020 · Cited by 554
Cognitive effects of false heart-rate feedback
Valins, S. (1966) · Journal of Personality and Social Psychology · doi:10.1037/h0023791 · Cited by 550
Importance of unpredictability for reward responses in primate dopamine neurons
Mirenowicz, J., & Schultz, W. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.72.2.1024 · Cited by 544
Self-citation
Learning and Computational Neuroscience: Foundations of Adaptive Networks
Gabriel, M., & Moore, J. (1990) · Cited by 518
Prefrontal and cingulate unit activity during timing behavior in the monkey
Niki, H., & Watanabe, M. (1979) · Brain Research · doi:10.1016/0006-8993(79)90328-7 · Cited by 511
Is the short-latency dopamine response too short to signal reward error?
Redgrave, P., Prescott, T. J., & Gurney, K. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01373-3 · Cited by 506
Perspectives on Cognitive Neuroscience
Churchland, P. S., & B, T. J. S. A. (1988) · Science · doi:10.1126/science.3055294 · Cited by 505
Time-Derivative Models of Pavlovian Reinforcement
Sutton, R. S., & Barto, A. G. (1990) · Cited by 501
Spatial Processing in the Monkey Frontal Eye Field. I. Predictive Visual Responses
Umeno, M. M., & Goldberg, M. E. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.78.3.1373 · Cited by 500
D1Receptor Activation Enhances Evoked Discharge in Neostriatal Medium Spiny Neurons by Modulating an L-Type Ca2+Conductance
Hernández‐López, S., Bargas, J., Surmeier, D. J., Reyes, A., & Galarraga, E. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-09-03334.1997 · Cited by 495
Adaptive Critics and the Basal Ganglia
Barto, A. G. (1994) · The MIT Press eBooks · doi:10.7551/mitpress/4708.003.0018 · Cited by 476
Hunger and satiety modify the responses of olfactory and visual neurons in the primate orbitofrontal cortex
Critchley, H., & Rolls, E. T. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.75.4.1673 · Cited by 467
Effect of Expected Reward Magnitude on the Response of Neurons in the Dorsolateral Prefrontal Cortex of the Macaque
Leon, M. I., & Shadlen, M. N. (1999) · Neuron · doi:10.1016/s0896-6273(00)80854-5 · Cited by 449
Anatomical and affinity state comparisons between dopamine D1 and D2 receptors in the rat central nervous system
Richfield, E. K., Penney, J. B., & Young, A. B. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90168-1 · Cited by 448
Dopamine synaptic complex with pyramidal neurons in primate cerebral cortex.
Goldman-Rakic, P. S., Leranth, C., Williams, S. M., Mons, N. E., & Geffard, M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.22.9015 · Cited by 429
Cerebellar complex spikes encode both destinations and errors in arm movements
Kitazawa, S., Kimura, T., & Yin, P.-B. (1998) · Nature · doi:10.1038/33141 · Cited by 401
Nicotinic effects on the firing pattern of midbrain dopamine neurons
GRENHOFF, J., ASTON‐JONES, G., & SVENSSON, T. H. (1986) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1986.tb07988.x · Cited by 399
Dopamine D-1/D-5 Receptor Activation Is Required for Long-Term Potentiation in the Rat Neostriatum In Vitro
Kerr, J. N. D., & Wickens, J. R. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.1.117 · Cited by 395
Performance monitoring by the supplementary eye field
Stuphorn, V., Taylor, T. L., & Schall, J. D. (2000) · Nature · doi:10.1038/35048576 · Cited by 392
Synaptic modification of parallel fibre‐Purkinje cell transmission in in vitro guinea‐pig cerebellar slices.
Sakurai, M. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016881 · Cited by 391
Responses of midbrain dopamine neurons to behavioral trigger stimuli in the monkey
Schultz, W. (1986) · Journal of Neurophysiology · doi:10.1152/jn.1986.56.5.1439 · Cited by 390
Self-citation
Effects of methylphenidate on spatial working memory and planning in healthy young adults
Elliott, R., Sahakian, B. J., Matthews, K., Bannerjea, A., Rimmer, J., & Robbins, T. W. (1997) · Psychopharmacology · doi:10.1007/s002130050284 · Cited by 389
Influence of Reward Expectation on Behavior-Related Neuronal Activity in Primate Striatum
Hollerman, J. R., Tremblay, L., & Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.2.947 · Cited by 380
Self-citation
D1/D5 dopamine receptor activation increases the magnitude of early long-term potentiation at CA1 hippocampal synapses
Otmakhova, N. A., & Lisman, J. E. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-23-07478.1996 · Cited by 377
Rat navigation guided by remote control
Talwar, S. K., Xu, S., Hawley, E. S., Weiss, S. A., Moxon, K. A., & Chapin, J. K. (2002) · Nature · doi:10.1038/417037a · Cited by 372
Dopamine D1 receptor actions in layers V-VI rat prefrontal cortex neurons in vitro: modulation of dendritic-somatic signal integration
Yang, C., & Seamans, J. K. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-05-01922.1996 · Cited by 369
Brain Regions Responsive to Novelty in the Absence of Awareness
Berns, G. S., Cohen, J. D., & Mintun, M. A. (1997) · Science · doi:10.1126/science.276.5316.1272 · Cited by 367
Essential Role of D1 But Not D2 Receptors in the NMDA Receptor-Dependent Long-Term Potentiation at Hippocampal-Prefrontal Cortex SynapsesIn Vivo
Gurden, H., Takita, M., & Jay, T. M. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-22-j0003.2000 · Cited by 366
Dopaminergic A10 neurones are involved in cognitive functions
Simon, H., Scatton, B., & Moal, M. L. (1980) · Nature · doi:10.1038/286150a0 · Cited by 362
Dopamine neurons of the monkey midbrain: contingencies of responses to active touch during self-initiated arm movements
Romo, R., & Schultz, W. (1990) · Journal of Neurophysiology · doi:10.1152/jn.1990.63.3.592 · Cited by 353 · cited 3×
“These data might ward-predicting stimuli (which are tested in separate trials) (Romo and Schultz, 1990; Mirenowicz and Schultz,sugggest that phasic dopamine activations reflect attention-inducing properties of stimuli, including rewards, 1994).”
Self-citation
Dopamine-mediated modulation of odour-evoked amygdala potentials during pavlovian conditioning
Rosenkranz, J. A., & Grace, A. A. (2002) · Nature · doi:10.1038/417282a · Cited by 348
Operant Reward Learning in Aplysia : Neuronal Correlates and Mechanisms
Brembs, B., Lorenzetti, F. D., Reyes, F. D., Baxter, D. A., & Byrne, J. H. (2002) · Science · doi:10.1126/science.1069434 · Cited by 338
Abnormal influences of passive limb movement on the activity of globus pallidus neurons in parkinsonian monkeys
Filion, M., Tremblay, L., & Bédard, P. J. (1988) · Brain Research · doi:10.1016/0006-8993(88)90924-9 · Cited by 337
Dopamine neurons of the monkey midbrain: contingencies of responses to stimuli eliciting immediate behavioral reactions
Schultz, W., & Romo, R. (1990) · Journal of Neurophysiology · doi:10.1152/jn.1990.63.3.607 · Cited by 334 · cited 2×
“…only to the onset of conditioned stimuli and not to their offset, even if stimuli are used whose offsets,Pavlovian or instrumental tasks, such as visual or audi- tory reaction time tasks, spatial delayed response or rather than their onsets, are valid predictors of reward (Schultz and Romo, 1990).”
Self-citation
Single unit activity of locus coeruleus neurons in the freely moving cat
Rasmussen, K., Morilak, D. A., & Jacobs, B. L. (1986) · Brain Research · doi:10.1016/0006-8993(86)90370-7 · Cited by 324
The cerebellum and VOR/OKR learning models
Kawato, M., & Gomi, H. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90008-v · Cited by 323
Interaction of norepinephrine with cerebrocortical activity evoked by stimulation of somatosensory afferent pathways in the rat☆
Waterhouse, B. D., & Woodward, D. J. (1980) · Experimental Neurology · doi:10.1016/0014-4886(80)90159-4 · Cited by 322
Synaptic relationships between dopaminergic afferents and cortical or thalamic input in the sensorimotor territory of the striatum in monkey
Smith, Y., Bennett, B. D., Bolam, J. P., Parent, A., & Sadikot, A. F. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903440102 · Cited by 312
Bee foraging in uncertain environments using predictive hebbian learning
Montague, P. R., Dayan, P., Person, C., & Sejnowski, T. J. (1995) · Nature · doi:10.1038/377725a0 · Cited by 311
Response to Novelty and its Rapid Habituation in Locus Coeruleus Neurons of the Freely Exploring Rat
Vankov, A., Hervé‐Minvielle, A., & Sara, S. J. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb01108.x · Cited by 309
Neuronal activity in monkey striatum related to the expectation of predictable environmental events
Apicella, P., Scarnati, E., Ljungberg, T., & Schultz, W. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.68.3.945 · Cited by 305
Self-citation
Reciprocal Bidirectional Plasticity of Parallel Fiber Receptive Fields in Cerebellar Purkinje Cells and Their Afferent Interneurons
Jörntell, H., & Ekerot, C. ‐. (2002) · Neuron · doi:10.1016/s0896-6273(02)00713-4 · Cited by 302
Prolonged and Extrasynaptic Excitatory Action of Dopamine Mediated by D1 Receptors in the Rat StriatumIn Vivo
Gonon, F. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-15-05972.1997 · Cited by 301
Dopamine reverses the depression of rat corticostriatal synapses which normally follows high-frequency stimulation of cortex In vitro
Wickens, J. R., Begg, A., & Arbuthnott, G. W. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00436-m · Cited by 298
Selective association and conditioning
Kamin, L. J. (1969) · Medical Entomology and Zoology · Cited by 297
A neural network model with dopamine-like reinforcement signal that learns a spatial delayed response task
Suri, R. E., & Schultz, W. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00697-6 · Cited by 294
Self-citation
Abnormal Synaptic Plasticity in the Striatum of Mice Lacking Dopamine D2 Receptors
Calabresi, P., Saiardi, A., Pisani, A., Baik, J., Centonze, D., Mercuri, N. B., Bernardi, G., & Borrelli, E. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-12-04536.1997 · Cited by 289
Characterization of the Dopaminergic Innervation of the Primate Frontal Cortex Using a Dopamine-specific Antibody
Williams, S. M., & Goldman-Rakic, P. S. (1993) · Cerebral Cortex · doi:10.1093/cercor/3.3.199 · Cited by 284 · cited 2×
“Thus, synaptically released frontal cortex (Berger et al., 1988; Williams and Goldman-Rakic, 1993).”
Localization of drug reward mechanisms by intracranial injections
Wise, R. A., & Hoffman, D. C. (1992) · Synapse · doi:10.1002/syn.890100307 · Cited by 279
Responses to the Sensory Properties of Fat of Neurons in the Primate Orbitofrontal Cortex
Rolls, E. T., Critchley, H. D., Browning, A. S., Hernadi, I., & Lenard, L. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-04-01532.1999 · Cited by 278
Neural mechanisms in disorders of movement
Crossman, A. R. (1989) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(89)90201-6 · Cited by 276
Modifications of Reward Expectation-Related Neuronal Activity During Learning in Primate Striatum
Tremblay, L., Hollerman, J. R., & Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.2.964 · Cited by 273
Self-citation
Value-dependent selection in the brain: Simulation in a synthetic neural model
Friston, K. J., Tononi, G., Reeke, G. N., Sporns, O., & Edelman, G. M. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90592-4 · Cited by 268
Visual and oculomotor functions of monkey subthalamic nucleus
Matsumura, M., Kojima, J., Gardiner, T. W., & Hikosaka, O. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.67.6.1615 · Cited by 265
Regional and laminar distribution of the dopamine and serotonin innervation in the macaque cerebral cortex: A radioautographic study
Berger, B., Trottier, S., Verney, C., Gaspar, P., & Alvarez, C. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902730109 · Cited by 264
Influence of Expectation of Different Rewards on Behavior-Related Neuronal Activity in the Striatum
Hassani, O. K., Cromwell, H. C., & Schultz, W. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.6.2477 · Cited by 257
Self-citation
EXPERIMENTAL AND HISTOLOGICAL STUDY OF MIDBRAIN DYSKINESIAS
POIRIER, L. J. (1960) · Journal of Neurophysiology · doi:10.1152/jn.1960.23.5.534 · Cited by 255
On the cerebellum and motor learning
Llinás, R., & Welsh, J. P. (1993) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(93)90168-x · Cited by 252
Inhibition of climbing fibres is a signal for the extinction of conditioned eyelid responses
Medina, J. F., Nores, W. L., & Mauk, M. D. (2002) · Nature · doi:10.1038/416330a · Cited by 252
Orbitofrontal cortex is activated during breaches of expectation in tasks of visual attention
Nobre, A. C., Coull, J. T., Frith, C., & Mesulam, M. M. (1999) · Nature Neuroscience · doi:10.1038/4513 · Cited by 249
Relations between movement and single cell discharge in the substantia nigra of the behaving monkey
DeLong, M., Crutcher, M., & Georgopoulos, A. (1983) · The Journal of Neuroscience · doi:10.1523/jneurosci.03-08-01599.1983 · Cited by 247
Neural signals in the monkey ventral striatum related to motivation for juice and cocaine rewards
Bowman, E. M., Aigner, T. G., & Richmond, B. J. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.75.3.1061 · Cited by 246
Noradrenergic Regulation of Synaptic Plasticity in the Hippocampal CA1 Region
Katsuki, H., Izumi, Y., & Zorumski, C. F. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.77.6.3013 · Cited by 244
Use‐dependent changes in synaptic efficacy in rat prefrontal neurons in vitro.
Hirsch, J. C., & Crépel, F. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018159 · Cited by 239
Responses of human frontal cortex to surprising events are predicted by formal associative learning theory
Fletcher, P. C., Anderson, J. M., Shanks, D. R., Honey, R., Carpenter, T. A., Donovan, T., Papadakis, N., & Bullmore, E. T. (2001) · Nature Neuroscience · doi:10.1038/nn733 · Cited by 238
Models of the cerebellum and motor learning
Houk, J. C., Buckingham, J. T., & Barto, A. G. (1997) · Cambridge University Press eBooks · doi:10.1017/cbo9780511666896.006 · Cited by 234
Single cell activity in ventral prefrontal cortex of behaving monkeys
Rosenkilde, C. E., Bauer, R. H., & Fuster, J. M. (1981) · Brain Research · doi:10.1016/0006-8993(81)90160-8 · Cited by 233
Models of the cerebellum and motor learning
Houk, J. C., Buckingham, J. T., & Barto, A. G. (1996) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00081474 · Cited by 231
Interaction of norepinephrine with cerebellar activity evoked by mossy and climbing fibers
Freedman, R., Hoffer, B. J., Woodward, D. J., & Puro, D. G. (1977) · Experimental Neurology · doi:10.1016/0014-4886(77)90175-3 · Cited by 230
The cerebellum and motor learning
Glickstein, M. (1992) · Current Biology · doi:10.1016/0960-9822(92)90096-s · Cited by 230
Nonlinear relationship between impulse flow, dopamine release and dopamine elimination in the rat brainin vivo
Chergui, K., Suaud‐Chagny, M., & Gonon, F. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90465-0 · Cited by 229
Extracellular dopamine in rat striatum following uptake inhibition by cocaine, nomifensine and benztropine
Church, W. H., Justice, J. B., & Byrd, L. D. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90592-9 · Cited by 227
Conditioned responses of monkey locus coeruleus neurons anticipate acquisition of discriminative behavior in a vigilance task
Aston‐Jones, G., Rajkowski, J., & Kubiak, P. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00060-2 · Cited by 227
Perspectives on cognitive neuroscience
(1992) · Choice Reviews Online · doi:10.5860/choice.30-0604 · Cited by 226
Facilitation of instrumental behavior by a Pavlovian appetitive conditioned stimulus.
Lovibond, P. F. (1983) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.9.3.225 · Cited by 225
Dorsal accessory inferior olive activity diminishes during acquisition of the rabbit classically conditioned eyelid response
Sears, L. L., & Steinmetz, J. E. (1991) · Brain Research · doi:10.1016/0006-8993(91)91276-7 · Cited by 224
Plasticity of sensory responses of locus coeruleus neurons in the behaving rat: implications for cognition
Sara, S. J., & Segal, M. (1991) · Progress in brain research · doi:10.1016/s0079-6123(08)63835-2 · Cited by 223
Quantification of the dopamine innervation in adult rat neostriatum
Doucet, G., Descarries, L., & Garcia, S. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90272-1 · Cited by 214
Inhibitory Cerebello-Olivary Projections and Blocking Effect in Classical Conditioning
Kim, J. J., Krupa, D. J., & Thompson, R. F. (1998) · Science · doi:10.1126/science.279.5350.570 · Cited by 212
Response of nucleus accumbens neurons to amygdala stimulation and its modification by dopamine
Yim, C. Y., & Mogenson, G. J. (1982) · Brain Research · doi:10.1016/0006-8993(82)90518-2 · Cited by 210
Reward, Motivation, Cognition: Psychobiology of Mesotelencephalic Dopamine Systems
Fibiger, H. C., & Phillips, A. G. (1986) · Comprehensive physiology · doi:10.1002/cphy.cp010412 · Cited by 206
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonian syndrome in Macaca fascicularis: Which midbrain dopaminergic neurons are lost?
German, D. C., Dubach, M. F., Askari, S., Speciale, S. G., & Bowden, D. M. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90320-x · Cited by 200
Learning of sequential movements by neural network model with dopamine-like reinforcement signal
Suri, R. E., & Schultz, W. (1998) · Experimental Brain Research · doi:10.1007/s002210050467 · Cited by 198
Self-citation
Dopamine facilitates long-term depression of glutamatergic transmission in rat prefrontal cortex
Otani, S., Blond, O., Desce, J. M., & Crépel, F. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00677-5 · Cited by 196
Purkinje cell complex and simple spike changes during a voluntary arm movement learning task in the monkey
Ojakangas, C. L., & Ebner, T. J. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.68.6.2222 · Cited by 190
Integrity of the mesocortical dopaminergic system is necessary for complete expression of in vivo hippocampal–prefrontal cortex long-term potentiation
Gurden, H., Tassin, J., & Jay, T. M. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00395-4 · Cited by 189
The 28th Bartlett Memorial Lecture Causal learning: An associative analysis
Dickinson, A. (2001) · The Quarterly Journal of Experimental Psychology Section B · doi:10.1080/02724990042000010 · Cited by 187
Responses of nigrostriatal dopamine neurons to high-intensity somatosensory stimulation in the anesthetized monkey
Schultz, W., & Romo, R. (1987) · Journal of Neurophysiology · doi:10.1152/jn.1987.57.1.201 · Cited by 184 · cited 1×
“Primary re-insensitive to aversive stimuli, as they show depressions or activations with slower time courses following pain wards elicit neuronal activations during initial learning periods which decrease progressively and are trans-pinch in anesthetized monkeys (Schultz and Romo, 1987).”
Self-citation
Cellular mechanisms of long-term depression in the cerebellum
Linden, D. J., & Connor, J. A. (1993) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(93)90133-j · Cited by 181
Activity of dopamine neurons in the behaving primate
Schultz, W. (1992) · Seminars in Neuroscience · doi:10.1016/1044-5765(92)90011-p · Cited by 178
Self-citation
Electrophysiological and pharmacological evidence for the role of the nucleus accumbens in cocaine self-administration in freely moving rats
Chang, J., Sawyer, S. F., Lee, R., & Woodward, D. J. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-03-01224.1994 · Cited by 177
D1/D5 Dopamine Receptors Inhibit Depotentiation at CA1 Synapses via cAMP-Dependent Mechanism
Otmakhova, N. A., & Lisman, J. E. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-04-01270.1998 · Cited by 176
‘Error’ potentials in limbic cortex (anterior cingulate area 24) of monkeys during motor learning
Gemba, H., Sasaki, K., & Brooks, V. B. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90467-2 · Cited by 176
The primate globus pallidus: neuronal activity related to direction of movement
Mitchell, S. J., Richardson, R. T., Baker, F., & DeLong, M. R. (1987) · Experimental Brain Research · doi:10.1007/bf00249793 · Cited by 175
Modifications of Reward Expectation-Related Neuronal Activity During Learning in Primate Orbitofrontal Cortex
Tremblay, L., & Schultz, W. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.4.1877 · Cited by 172
Self-citation
Dopamine-dependent synaptic plasticity in striatum during in vivo development
Tang, K., Low, M. J., Grandy, D. K., & Lovinger, D. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.3.1255 · Cited by 171
Norepinephrine induces pathway-specific long-lasting potentiation and depression in the hippocampal dentate gyrus.
Dahl, D. R., & Sarvey, J. M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.12.4776 · Cited by 171
Mesencephalic dopaminergic unit activity in the behaviorally conditioned rat
Miller, J. D., Sanghera, M. K., & German, D. C. (1981) · Life Sciences · doi:10.1016/0024-3205(81)90231-9 · Cited by 170
Differential reactivity of dopaminergic neurons in the nucleus accumbens in response to different behavioral situations. An in vivo voltammetric study in free moving rats
Louilot, A., Moal, M. L., & Simon, H. (1986) · Brain Research · doi:10.1016/0006-8993(86)90646-3 · Cited by 168
Cerebellar Function in Consolidation of a Motor Memory
Attwell, P. J. E., Cooke, S. F., & Yeo, C. H. (2002) · Neuron · doi:10.1016/s0896-6273(02)00719-5 · Cited by 167
On the Origin of Extracellular Glutamate Levels Monitored in the Basal Ganglia of the Rat by In Vivo Microdialysis
Herrera‐Marschitz, M., You, Z. ‐., Goiny, M., et al. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66041726.x · Cited by 167
Primate striatonigral projections: A comparison of the sensorimotor‐related striatum and the ventral striatum
Lynd‐Balta, E., & Haber, S. N. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903450407 · Cited by 164
Neuronal responses related to the novelty and familiarity of visual stimuli in the substantia innominata, diagonal band of Broca and periventricular region of the primate basal forebrain
Wilson, F. A. W., & Rolls, E. T. (1990) · Experimental Brain Research · doi:10.1007/bf00228852 · Cited by 164
Responses of tonically discharging neurons in the monkey striatum to primary rewards delivered during different behavioral states
Apicella, P., Legallet, E., & Trouche, E. (1997) · Experimental Brain Research · doi:10.1007/pl00005773 · Cited by 162
Topographic distribution of modality-specific amygdalar neurons in alert monkey
Nishijo, H., Ono, T., & Nishino, H. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-10-03556.1988 · Cited by 153
Neural correlates of decisions
Platt, M. L. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00302-1 · Cited by 152
Amphetamine Blocks Long-Term Synaptic Depression in the Ventral Tegmental Area
Jones, S., Gutlerner, J. L., & Kauer, J. A. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-15-05575.2000 · Cited by 151
The electrophysiology of dopamine (D2) receptors: A study of the actions of dopamine on corticostriatal transmission
Brown, J. R., & Arbuthnott, G. W. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90138-0 · Cited by 138
Continuousin vivo monitoring of evoked dopamine release in the rat nucleus accumbens by amperometry
Dugast, C., Suaud‐Chagny, M., & Gonon, F. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90466-9 · Cited by 138
The activity of pars compacta neurons of the monkey substantia nigra in relation to motor activation
Schultz, W., Ruffieux, A., & Aebischer, P. (1983) · Experimental Brain Research · doi:10.1007/bf00237874 · Cited by 136
Self-citation
The performance on learning tasks of patients in the early stages of Parkinson's disease
Canavan, A. G. M., Passingham, R. E., Marsden, C. D., Quinn, N., Wyke, M., & Polkey, C. E. (1989) · Neuropsychologia · doi:10.1016/0028-3932(89)90167-x · Cited by 133
Firing patterns of nucleus accumbens neurons during cocaine self-administration in rats
Carelli, R. M., King, V. C., Hampson, R. E., & Deadwyler, S. A. (1993) · Brain Research · doi:10.1016/0006-8993(93)90557-4 · Cited by 130
Neuronal responses related to reinforcement in the primate basal forebrain
Wilson, F. A. W., & Rolls, E. T. (1990) · Brain Research · doi:10.1016/0006-8993(90)90546-n · Cited by 130
Reward-Predicting and Reward-Detecting Neuronal Activity in the Primate Supplementary Eye Field
Amador, N., Schlag-Rey, M., & Schlag, J. D. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.4.2166 · Cited by 128
Responses of monkey midbrain dopamine neurons during delayed alternation performance
Ljungberg, T., Apicella, P., & Schultz, W. (1991) · Brain Research · doi:10.1016/0006-8993(91)90816-e · Cited by 128
Self-citation
Memory for temporal order and conditional associative-learning in patients with Parkinson's disease
Vriezen, E. R., & Moscovitch, M. (1990) · Neuropsychologia · doi:10.1016/0028-3932(90)90044-o · Cited by 124
Nucleus basalis of Meynert neuronal activity during a delayed response task in monkey
Richardson, R. T., & DeLong, M. R. (1986) · Brain Research · doi:10.1016/0006-8993(86)91529-5 · Cited by 122
Neuronal activity in the ventral tegmental area (VTA) during motivated bar press feeding in the monkey
Nishino, H., Ono, T., Muramoto, K., Fukuda, M., & Sasaki, K. (1987) · Brain Research · doi:10.1016/0006-8993(87)91021-3 · Cited by 120
Learning and memory is reflected in the responses of reinforcement- related neurons in the primate basal forebrain
Wilson, F., & Rolls, E. T. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-04-01254.1990 · Cited by 120
Dopamine Modulates Excitability of Spiny Neurons in the Avian Basal Ganglia
Ding, L., & Perkel, D. J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-12-05210.2002 · Cited by 119
Increased dopamine release in vivo in nucleus accumbens and caudate nucleus of the rat during drinking: A microdialysis study
Young, A. M. J., Joseph, M. H., & Gray, J. A. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90275-7 · Cited by 111
High-speed chronoamperometric measurements of mesolimbic and nigrostriatal dopamine release associated with repeated daily stress
Doherty, M. D., & Gratton, A. P. (1992) · Brain Research · doi:10.1016/0006-8993(92)91639-v · Cited by 108
A Predictive Reinforcement Model of Dopamine Neurons for Learning Approach Behavior
Contreras-Vidal, J. L., & Schultz, W. (1999) · Journal of Computational Neuroscience · doi:10.1023/a:1008862904946 · Cited by 107
Self-citation
Dopaminergic Synapses Mediate Neuronal Changes in an Analogue of Operant Conditioning
Nargeot, R., Baxter, D. A., Patterson, G. W., & Byrne, J. H. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.4.1983 · Cited by 104
Uptake of Dopamine Released by Impulse Flow in the Rat Mesolimbic and Striatal Systems In Vivo
Suaud‐Chagny, M., Dugast, C., Chergui, K., Msghina, M., & Gonon, F. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65062603.x · Cited by 103
Context-dependent responses of primate nucleus basalis neurons in a go/no-go task
Richardson, R., & DeLong, M. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-08-02528.1990 · Cited by 97
A quantitative correlation between single unit activity and fluorescence intensity of dopamine neurones in zona compacta of substantia nigra, as demonstrated under the influence of nicotine and physostigmine
LICHTENSTEIGER, W., Felix, D., Lienhart, R., & Hefti, F. F. (1976) · Brain Research · doi:10.1016/0006-8993(76)90558-8 · Cited by 96
Phasic Firing Time Locked to Cocaine Self-Infusion and Locomotion: Dissociable Firing Patterns of Single Nucleus Accumbens Neurons in the Rat
Peoples, L. L., Gee, F., Bibi, R., & West, M. O. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-18-07588.1998 · Cited by 76
Associative learning in degenerative neostriatal disorders: Contrasts in explicit and implicit remembering between Parkinson's and huntington's diseases
Sprengelmeyer, R., Canavan, A. G. M., Lange, H. W., & Hömberg, V. (1995) · Movement Disorders · doi:10.1002/mds.870100110 · Cited by 72
The appropriateness of behavioral responses coded in post-trial activity of primate prefrontal units
Watanabe, M. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90450-3 · Cited by 64
Influence of the predicted time of stimuli eliciting movements on responses of tonically active neurons in the monkey striatum
Sardo, P., Ravel, S., Legallet, E., & Apicella, P. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00068.x · Cited by 60
Elements of the Intrinsic Organization and Information Processing in the Neostriatum
Groves, P. M., Garcia-Munoz, M., Linder, J. C., Manley, M. S., Martone, M. E., & Young, S. J. (1994) · The MIT Press eBooks · doi:10.7551/mitpress/4708.003.0007 · Cited by 59
Chronic administration of (+)-amphetamine alters the reactivity of midbrain dopaminergic neurons to prefrontal cortex stimulation in the rat
Tong, Z.-Y., Overton, P. G., & Clark, D. T. (1995) · Brain Research · doi:10.1016/0006-8993(94)01439-o · Cited by 56
Long-term potentiation in rat prefrontal slices facilitated by phased application of dopamine
Blond, O., Crépel, F., & Otani, S. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01291-8 · Cited by 52
Responses of rat pallidum cells to cortex stimulation and effects of altered dopaminergic activity
Toan, D. L., & Schultz, W. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90070-3 · Cited by 49
Self-citation
Blocking observed in human eyelid conditioning.
Martin, I., & Levey, A. B. (1991) · PubMed · Cited by 40
Noradrenergic enhancement of GABA-induced input resistance changes in layer V regular spiking pyramidal neurons of rat somatosensory cortex
Sessler, F. M., Liu, W., Kirifides, M. L., Mouradian, R., Lin, R. C. S., & Waterhouse, B. D. (1995) · Brain Research · doi:10.1016/0006-8993(95)00060-4 · Cited by 39
Learning admittance mappings for force-guided assembly
Gullapalli, V., Barto, A. G., & Grupen, R. A. (2002) · Proceedings - IEEE International Conference on Robotics and Automation/Proceedings · doi:10.1109/robot.1994.351117 · Cited by 37
Low-dose amphetamine elevates movement-related firing of rat striatal neurons
West, M. O., Peoples, L. L., Michael, A. J., Chapin, J. K., & Woodward, D. J. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01215-2 · Cited by 33

Research works printed but not linked: 1

Andén, 1966, A quantitative study on the nigro-neostriatal dopamine neurons. Acta physiol, Scand., 67, 306

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Authors: Schultz, W.
Affiliations: University of Fribourg (CH)
Corresponding author: Schultz, Wolfram
ORCID: Schultz, Wolfram
Venue: Neuron
Publisher: Elsevier BV
Published: 2002-10
Volume: 36
Issue: 2
Pages: 241-263
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(02)00967-4
OpenAlex: W1998152406
Cited by: 2,574
References: 208
Citations by year: 2026: 22 · 2025: 56 · 2024: 101 · 2023: 46 · 2022: 54 · 2021: 76 · 2020: 94 · 2019: 87 · 2018: 91 · 2017: 88 · 2016: 117 · 2015: 113 · 2014: 146 · 2013: 130 · 2012: 138
FWCI: 8.71
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3942 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust (095495)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: dopamine, reward signals, prediction error, striatum, frontal cortex, amygdala, goal-directed behavior, stimulant use disorder
MeSH terms: Animals, Brain, Dopamine, Humans, Neurons, Reward, Illicit Drugs

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