A Unified Nomenclature for Yeast Autophagy-Related Genes

Induction of autophagy and inhibition of tumorigenesis by beclin 1

Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347

Tor-Mediated Induction of Autophagy via an Apg1 Protein Kinase Complex

Kamada, Y., Funakoshi, T., Shintani, T., Nagano, K., Ohsumi, M., & Ohsumi, Y. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.6.1507 · Cited by 1,145

Two Distinct Vps34 Phosphatidylinositol 3–Kinase Complexes Function in Autophagy and Carboxypeptidase Y Sorting in Saccharomyces cerevisiae

Kihara, A., Noda, T., Ishihara, N., & Ohsumi, Y. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.3.519 · Cited by 1,004

Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate

Mizushima, N., Kuma, A., Kobayashi, Y., Yamamoto, A., Matsubae, M., Takao, T., Natsume, T., Ohsumi, Y., & Yoshimori, T. (2003) · Journal of Cell Science · doi:10.1242/jcs.00381 · Cited by 791

New Component of the Vacuolar Class C-Vps Complex Couples Nucleotide Exchange on the Ypt7 Gtpase to Snare-Dependent Docking and Fusion

Wurmser, A. E., Sato, T. K., & Emr, S. D. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.3.551 · Cited by 425

Post-translational Modifications of Three Members of the Human MAP1LC3 Family and Detection of a Novel Type of Modification for MAP1LC3B

He, H., Dang, Y., Dai, F., Guo, Z., Wu, J., She, X., Pei, Y., Chen, Y., Ling, W., Wu, C., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303800200 · Cited by 273

Cvt18/Gsa12 Is Required for Cytoplasm-to-Vacuole Transport, Pexophagy, and Autophagy in Saccharomyces cerevisiae and Pichia pastoris

Guan, J., Stromhaug, P. E., George, M. D., Habibzadegah-Tari, P., Bevan, A., Dunn, W. A., & Klionsky, D. J. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.12.3821 · Cited by 204

Autophagy and the cytoplasm to vacuole targeting pathway both require Aut10p

Barth, H., Meiling-Wesse, K., Epple, U. D., & Thumm, M. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)03016-2 · Cited by 123

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1

Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,897

The role of autophagy during the early neonatal starvation period

Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T., & Mizushima, N. (2004) · Nature · doi:10.1038/nature03029 · Cited by 2,865

Biological Functions of Autophagy Genes: A Disease Perspective

Levine, B., & Kroemer, G. (2019) · Cell · doi:10.1016/j.cell.2018.09.048 · Cited by 2,832

Autophagy Is a Defense Mechanism Inhibiting BCG and Mycobacterium tuberculosis Survival in Infected Macrophages

Gutierrez, M. G., Master, S. S., Singh, S. B., Taylor, G. A., Colombo, M. I., & Deretic, V. (2004) · Cell · doi:10.1016/j.cell.2004.11.038 · Cited by 2,252

In Vivo Analysis of Autophagy in Response to Nutrient Starvation Using Transgenic Mice Expressing a Fluorescent Autophagosome Marker

Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T., & Ohsumi, Y. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-09-0704 · Cited by 2,105

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

Scherz‐Shouval, R., Shvets, E., Fass, E., Shorer, H., Gil, L., & Elazar, Z. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601623 · Cited by 2,101

The machinery of macroautophagy

Feng, Y., He, D., Yao, Z., & Klionsky, D. J. (2014) · Cell Research · doi:10.1038/cr.2013.168 · Cited by 2,083

The pathways of mitophagy for quality control and clearance of mitochondria

Ashrafi, G., & Schwarz, T. L. (2013) · Cell Death & Differentiation · doi:10.1038/cdd.2012.81 · Cited by 1,900

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

Axe, E. L., Walker, S. A., Manifava, M., Chandra, P., Roderick, H. L., Habermann, A., Griffiths, G., & Ktistakis, N. T. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200803137 · Cited by 1,885

FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells.

Zhao, J., Brault, J. J., Schild, A., Cao, P., Sandri, M., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.004 · Cited by 1,489

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

Ganley, I. G., Lam, D. H., Wang, J., Ding, X., Chen, S., & Jiang, X. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900573200 · Cited by 1,447

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

B’chir, W., Maurin, A.-C., Carraro, V., Averous, J., Jousse, C., Muranishi, Y., Parry, L., Stepien, G., Fafournoux, P., & Bruhat, A. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt563 · Cited by 1,162

Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy

Tanida, I., Minematsu-Ikeguchi, N., Ueno, T., & Kominami, E. (2005) · Autophagy · doi:10.4161/auto.1.2.1697 · Cited by 1,108

Control of Macroautophagy by Calcium, Calmodulin-Dependent Kinase Kinase-β, and Bcl-2

Høyer-Hansen, M., Bastholm, L., Szyniarowski, P., Campanella, M., Szabadkai, G., Farkas, T., Bianchi, K., Fehrenbacher, N., Elling, F., Rizzuto, R., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2006.12.009 · Cited by 1,072

Mitophagy: mechanisms, pathophysiological roles, and analysis

Ding, W.-X., & Yin, X.-M. (2012) · bchm · doi:10.1515/hsz-2012-0119 · Cited by 1,032

Potential therapeutic applications of autophagy

Rubinsztein, D. C., Gestwicki, J. E., Murphy, L. O., & Klionsky, D. J. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2272 · Cited by 862

Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes

Young, A. R. J., Chan, E. Y. W., Hu, X. W., Köchl, R., Crawshaw, S. G., High, S., Hailey, D. W., Lippincott-Schwartz, J., & Tooze, S. A. (2006) · Journal of Cell Science · doi:10.1242/jcs.03172 · Cited by 815

Ubiquitination and selective autophagy

Shaid, S., Brandts, C. H., Serve, H., & Dikic, I. (2013) · Cell Death & Differentiation · doi:10.1038/cdd.2012.72 · Cited by 800

Autophagy and aging: The importance of maintaining "clean" cells

Cuervo, A. M., Bergamini, E., Brunk, U. T., Dröge, W., Ffrench, M., & Terman, A. (2005) · Autophagy · doi:10.4161/auto.1.3.2017 · Cited by 792

Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability.

Ding, W.-X., Ni, H.-M., Gao, W., Yoshimori, T., Stolz, D. B., Ron, D., & Yin, X.-M. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.070188 · Cited by 708

A brief history of autophagy from cell biology to physiology and disease

Mizushima, N. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0092-5 · Cited by 696

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin.

Iwata, A., Riley, B. E., Johnston, J. A., & Kopito, R. R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508786200 · Cited by 719

Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

Simonsen, A., Cumming, R. C., Brech, A., Isakson, P., Schubert, D. R., & Finley, K. D. (2008) · Autophagy · doi:10.4161/auto.5269 · Cited by 716

Methods for Monitoring Autophagy from Yeast to Human

Klionsky, D. J., Cuervo, A. M., & Seglen, P. O. (2007) · Autophagy · doi:10.4161/auto.3678 · Cited by 656

Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease

Filimonenko, M., Stuffers, S., Raiborg, C., Yamamoto, A., Malerød, L., Fisher, E. M. C., Isaacs, A., Brech, A., Stenmark, H., & Simonsen, A. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200702115 · Cited by 626

Growth Arrest and Autophagy Are Required for Salivary Gland Cell Degradation in Drosophila

Berry, D. L., & Baehrecke, E. H. (2007) · Cell · doi:10.1016/j.cell.2007.10.048 · Cited by 602

Autophagic Nutrient Recycling in Arabidopsis Directed by the ATG8 and ATG12 Conjugation Pathways

Thompson, A. R., Doelling, J. H., Suttangkakul, A., & Vierstra, R. D. (2005) · Plant Physiology · doi:10.1104/pp.105.060673 · Cited by 574

Induction of Autophagy during Extracellular Matrix Detachment Promotes Cell Survival

Fung, C., Lock, R., Gao, S., Salas, E., & Debnath, J. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-10-1092 · Cited by 558

LC3, an Autophagosome Marker, Can be Incorporated into Protein Aggregates Independent of Autophagy: Caution in the Interpretation of LC3 Localization

Kuma, A., Matsui, M., & Mizushima, N. (2007) · Autophagy · doi:10.4161/auto.4012 · Cited by 555

Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein

Cao, Y., & Klionsky, D. J. (2007) · Cell Research · doi:10.1038/cr.2007.78 · Cited by 541

Autophagy and aging: keeping that old broom working

Cuervo, A. M. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.10.002 · Cited by 527

Autophagy in the liver: functions in health and disease

Ueno, T., & Komatsu, M. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.185 · Cited by 500

Protein Homeostasis and Aging: the importance of exquisite quality control

Koga, H., Kaushik, S., & Cuervo, A. M. (2011) · Ageing research reviews · doi:10.1016/j.arr.2010.02.001 · Cited by 476

The Atg1-Atg13 Complex Regulates Atg9 and Atg23 Retrieval Transport from the Pre-Autophagosomal Structure

Reggiori, F., Tucker, K. A., Stromhaug, P. E., & Klionsky, D. J. (2004) · Developmental Cell · doi:10.1016/s1534-5807(03)00402-7 · Cited by 476

The endoplasmic reticulum–mitochondria connection: One touch, multiple functions

Marchi, S., Patergnani, S., & Pinton, P. (2014) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.10.015 · Cited by 475

Biogenesis and Cargo Selectivity of Autophagosomes

Weidberg, H., Shvets, E., & Elazar, Z. (2011) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-052709-094552 · Cited by 466

siRNA Screening of the Kinome Identifies ULK1 as a Multidomain Modulator of Autophagy

Chan, E. Y. W., Kir, S., & Tooze, S. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703663200 · Cited by 422

Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells

Scarlatti, F., Maffei, R., Beau, I., Codogno, P., & Ghidoni, R. (2008) · Cell Death & Differentiation · doi:10.1038/cdd.2008.51 · Cited by 412

NF-κB Activation Represses Tumor Necrosis Factor-α-induced Autophagy

Djavaheri-Mergny, M., Amelotti, M., Mathieu, J., Besançon, F., Bauvy, C., Souquère, S., Pierron, G., & Codogno, P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602097200 · Cited by 407

Diverse Cellular Roles of Autophagy

Morishita, H., & Mizushima, N. (2019) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100818-125300 · Cited by 376

Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila

Juhász, G., Érdi, B., Sass, M., & Neufeld, T. P. (2007) · Genes & Development · doi:10.1101/gad.1600707 · Cited by 396

Autophagosome Biogenesis in Primary Neurons Follows an Ordered and Spatially Regulated Pathway

Maday, S., & Holzbaur, E. L. F. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.06.001 · Cited by 372

Autophagy and Alzheimer’s Disease: From Molecular Mechanisms to Therapeutic Implications

Uddin, M. S., Stachowiak, A., Mamun, A. A., Tzvetkov, N. T., Takeda, S., Atanasov, A. G., Bergantin, L. B., Abdel-Daim, M. M., & Stankiewicz, A. M. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00004 · Cited by 395

Ceramide-mediated Macroautophagy Involves Inhibition of Protein Kinase B and Up-regulation of Beclin 1

Scarlatti, F., Bauvy, C., Ventruti, A., Sala, G., Cluzeaud, F., Vandewalle, A., Ghidoni, R., & Codogno, P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313561200 · Cited by 388

Adaptation of Hansenula polymorpha to methanol: a transcriptome analysis

van Zutphen, T., Baerends, R. J., Susanna, K. A., de Jong, A., Kuipers, O. P., Veenhuis, M., & van der Klei, I. J. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-1 · Cited by 350

HsAtg4B/HsApg4B/Autophagin-1 Cleaves the Carboxyl Termini of Three Human Atg8 Homologues and Delipidates Microtubule-associated Protein Light Chain 3- and GABAA Receptor-associated Protein-Phospholipid Conjugates

Tanida, I., Sou, Y.-S., Ezaki, J., Minematsu-Ikeguchi, N., Ueno, T., & Kominami, E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401461200 · Cited by 334

The Cvt pathway as a model for selective autophagy

Lynch-Day, M. A., & Klionsky, D. J. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.02.013 · Cited by 329

Autophagosome-Lysosome Fusion

Lőrincz, P., & Juhász, G. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.10.028 · Cited by 328

Chaperone-mediated autophagy in aging and disease

Massey, A. C., Zhang, C., & Cuervo, A. M. (2006) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(05)73007-6 · Cited by 315

The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1

Vicencio, J. M., Ortiz, C., Criollo, A., Jones, A. W. E., Kepp, O., Galluzzi, L., Joza, N., Vitale, I., Morselli, E., Tailler, M., et al. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2009.34 · Cited by 289

Microtubules Support Production of Starvation-induced Autophagosomes but Not Their Targeting and Fusion with Lysosomes

Fass, E., Shvets, E., Degani, I., Hirschberg, K., & Elazar, Z. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607031200 · Cited by 286

Atg11 Links Cargo to the Vesicle-forming Machinery in the Cytoplasm to Vacuole Targeting Pathway

Yorimitsu, T., & Klionsky, D. J. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-11-1035 · Cited by 280

Autophagy is an immediate macrophage response to Legionella pneumophila

Amer, A. O., & Swanson, M. S. (2005) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00509.x · Cited by 279

Chapter 10 Monitoring Autophagy by Electron Microscopy in Mammalian Cells

Ylä‐Anttila, P., Vihinen, H., Jokitalo, E., & Eskelinen, E. (2009) · Methods in Enzymology · doi:10.1016/s0076-6879(08)03610-0 · Cited by 257

Regulation of autophagy by phosphatidylinositol 3‐phosphate

Burman, C., & Ktistakis, N. T. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.01.011 · Cited by 234

Regulation of Autophagy by Sphingosine Kinase 1 and Its Role in Cell Survival during Nutrient Starvation

Lavieu, G., Scarlatti, F., Sala, G., Carpentier, S., Levade, T., Ghidoni, R., Botti, J., & Codogno, P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m506182200 · Cited by 225

Increased autophagy in transgenic mice with a G93A mutant SOD1 gene

Morimoto, N., Nagai, M., Ohta, Y., Miyazaki, K., Kurata, T., Morimoto, M., Murakami, T., Takehisa, Y., Ikeda, Y., Kamiya, T., et al. (2007) · Brain Research · doi:10.1016/j.brainres.2007.06.045 · Cited by 223

The Pancreatitis-induced Vacuole Membrane Protein 1 Triggers Autophagy in Mammalian Cells

Ropolo, A., Grasso, D., Pardo, R., Sacchetti, M. L., Archange, C., Re, A. L., Seux, M., Nowak, J., Gonzalez, C. D., Iovanna, J. L., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706956200 · Cited by 223

Pexophagy: The Selective Autophagy of Peroxisomes

Dunn, Jr., Cregg, J. M., Kiel, J. A. K. W., Klei, I. J. V. D., Oku, M., Sakai, Y., Sibirny, A. A., Stasyk, O. V., & Veenhuis, M. (2005) · Autophagy · doi:10.4161/auto.1.2.1737 · Cited by 222

Autophagy mediates pharmacological lifespan extension by spermidineand resveratrol

Morselli, E., Galluzzi, L., Kepp, O., Criollo, A., Maiuri, M. C., Tavernarakis, N., Madeo, F., & Kroemer, G. (2009) · Aging · doi:10.18632/aging.100110 · Cited by 213

Autophagic Stress in Neuronal Injury and Disease

Chu, C. T. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000229233.75253.be · Cited by 211

Macroautophagy inhibition sensitizes tamoxifen-resistant breast cancer cells and enhances mitochondrial depolarization

Qadir, M. A., Kwok, B., Dragowska, W. H., To, K. H., Le, D., Bally, M. B., & Gorski, S. M. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-007-9873-4 · Cited by 201

Autophagy, ageing and apoptosis: The role of oxidative stress and lysosomal iron

Kurz, T., Terman, A., & Brunk, U. T. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.01.013 · Cited by 199

The Autophagy Lysosomal Pathway and Neurodegeneration

Finkbeiner, S. (2020) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a033993 · Cited by 196

In Vivo and in Vitro Reconstitution of Atg8 Conjugation Essential for Autophagy

Ichimura, Y., Imamura, Y., Emoto, K., Umeda, M., Noda, T., & Ohsumi, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405860200 · Cited by 193

AtATG Genes, Homologs of Yeast Autophagy Genes, are Involved in Constitutive Autophagy in Arabidopsis Root Tip Cells

Inoue, Y., Suzuki, T., Hattori, M., Yoshimoto, K., Ohsumi, Y., & Moriyasu, Y. (2006) · Plant and Cell Physiology · doi:10.1093/pcp/pcl031 · Cited by 189

Atg17 Regulates the Magnitude of the Autophagic Response

Cheong, H., Yorimitsu, T., Reggiori, F., Legakis, J. E., Wang, C.-W., & Klionsky, D. J. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-10-0894 · Cited by 187

The Epidermal Growth Factor Receptor Antibody Cetuximab Induces Autophagy in Cancer Cells by Downregulating HIF-1α and Bcl-2 and Activating the Beclin 1/hVps34 Complex

Li, X., & Fan, Z. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0157 · Cited by 179

Aberrant Membranes and Double-Membrane Structures Accumulate in the Axons of Atg5-Null Purkinje Cells before Neuronal Death

Nishiyama, J., Miura, E., Mizushima, N., Watanabe, M., & Yuzaki, M. (2007) · Autophagy · doi:10.4161/auto.4964 · Cited by 159

The Actin Cytoskeleton Is Required for Selective Types of Autophagy, but Not Nonspecific Autophagy, in the Yeast Saccharomyces cerevisiae

Reggiori, F., Monastyrska, I., Shintani, T., & Klionsky, D. J. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-07-0629 · Cited by 155

Ultrastructural relationship of the phagophore with surrounding organelles

Biazik, J., Ylä-Anttila, P., Vihinen, H., Jokitalo, E., & Eskelinen, E.-L. (2015) · Autophagy · doi:10.1080/15548627.2015.1017178 · Cited by 149

The C. elegans LC3 Acts Downstream of GABARAP to Degrade Autophagosomes by Interacting with the HOPS Subunit VPS39

Manil-Ségalen, M., Lefebvre, C., Jenzer, C., Trichet, M., Boulogne, C., Satiat-Jeunemaitre, B., & Legouis, R. (2014) · Developmental Cell · doi:10.1016/j.devcel.2013.11.022 · Cited by 144

Cysteine peptidases CPA and CPB are vital for autophagy and differentiation in Leishmania mexicana

Williams, R. A., Tetley, L., Mottram, J. C., & Coombs, G. H. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05274.x · Cited by 140

In Situ Detection of Starvation-induced Autophagy

Martinet, W., De Meyer, G. R. Y., Andries, L., Herman, A. G., & Kockx, M. M. (2006) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.5a6743.2005 · Cited by 139

Autophagy-related and autophagy-regulatory genes are induced in human muscle after ultraendurance exercise

Jamart, C., Benoit, N., Raymackers, J.-M., Kim, H. J., Kim, C. K., & Francaux, M. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-011-2287-3 · Cited by 121

Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body

Juhász, G., Puskás, L. G., Komonyi, O., Érdi, B., Maróy, P., Neufeld, T. P., & Sass, M. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402123 · Cited by 121

Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formation

Mauthe, M., Jacob, A., Freiberger, S., Hentschel, K., Stierhof, Y.-D., Codogno, P., & Proikas-Cezanne, T. (2011) · Autophagy · doi:10.4161/auto.7.12.17802 · Cited by 116

How and why to study autophagy in Drosophila: It’s more than just a garbage chute

Nagy, P., Varga, Á., Kovács, A. L., Takáts, S., & Juhász, G. (2015) · Methods · doi:10.1016/j.ymeth.2014.11.016 · Cited by 115

The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy in C. elegans

Ruck, A., Attonito, J., Garces, K. T., Nuñez, L., Palmisano, N. J., Rubel, Z., Bai, Z., Nguyen, K. C. Q., Sun, L., Grant, B. D., et al. (2011) · Autophagy · doi:10.4161/auto.7.4.14391 · Cited by 115

Molecular Processes that Drive Cigarette Smoke–Induced Epithelial Cell Fate of the Lung

Nyunoya, T., Mebratu, Y., Contreras, A., Delgado, M., Chand, H. S., & Tesfaigzi, Y. (2014) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0348tr · Cited by 110

The pathophysiology of defective proteostasis in the hypothalamus — from obesity to ageing

Cavadas, C., Aveleira, C. A., Souza, G. F. P., & Velloso, L. A. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.107 · Cited by 105

The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease

Fox, J. H., Connor, T., Chopra, V., Dorsey, K., Kama, J. A., Bleckmann, D., Betschart, C., Hoyer, D., Frentzel, S., DiFiglia, M., et al. (2010) · Molecular Neurodegeneration · doi:10.1186/1750-1326-5-26 · Cited by 94

Sequential formation of different layers of dystrophic neurites in Alzheimer’s brains

Sharoar, M. G., Hu, X., Ma, X.-M., Zhu, X., & Yan, R. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0396-2 · Cited by 87

Atg17/FIP200 localizes to perilysosomal Ref(2)P aggregates and promotes autophagy by activation of Atg1 in Drosophila

Nagy, P., Kárpáti, M., Varga, Á., Pircs, K., Venkei, Z., Takáts, S., Varga, K., Érdi, B., Hegedűs, K., & Juhász, G. (2014) · Autophagy · doi:10.4161/auto.27442 · Cited by 79

Autophagy in organelle homeostasis: Peroxisome turnover

Monastyrska, I., & Klionsky, D. J. (2006) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2006.08.004 · Cited by 79

Autophagy-related proteins Beclin-1 and LC3 predict cetuximab efficacy in advanced colorectal cancer.

Guo, G.-F. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i43.4779 · Cited by 74

Atg8 regulates vacuolar membrane dynamics in a lipidation-independent manner in Pichia pastoris

Tamura, N., Oku, M., & Sakai, Y. (2010) · Journal of Cell Science · doi:10.1242/jcs.070045 · Cited by 68

Microtubule-associated protein light chain 3 is involved in melanogenesis via regulation of MITF expression in melanocytes

Yun, W. J., Kim, E.-Y., Park, J.-E., Jo, S. Y., Bang, S. H., Chang, E.-J., & Chang, S. E. (2016) · Scientific Reports · doi:10.1038/srep19914 · Cited by 67

Genetic Modifiers of the Drosophila Blue Cheese Gene Link Defects in Lysosomal Transport With Decreased Life Span and Altered Ubiquitinated-Protein Profiles

Simonsen, A., Cumming, R. C., Lindmo, K., Galaviz, V., Cheng, S., Rusten, T. E., & Finley, K. D. (2007) · Genetics · doi:10.1534/genetics.106.065011 · Cited by 67

Early Secretory Pathway Gene TRS85 is Required for Selective Macroautophagy of Peroxisomes in Yarrowia lipolytica

Nazarko, T. Y., Huang, J., Nicaud, J.-M., Klionsky, D. J., & Sibirny, A. A. (2005) · Autophagy · doi:10.4161/auto.1.1.1512 · Cited by 63

Autophagy and ageing: Insights from invertebrate model organisms

Lionaki, E., Markaki, M., & Tavernarakis, N. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2012.05.001 · Cited by 61

Live-cell imaging ofAspergillus nidulansautophagy: RAB1 dependence, Golgi independence and ER involvement

Pinar, M., Pantazopoulou, A., & Peñalva, M. A. (2013) · Autophagy · doi:10.4161/auto.24483 · Cited by 60

Autophagy genesSmatg8andSmatg4are required for fruiting-body development, vegetative growth and ascospore germination in the filamentous ascomyceteSordaria macrospora

Voigt, O., & Pöggeler, S. (2013) · Autophagy · doi:10.4161/auto.22398 · Cited by 60

Alternative Macroautophagic Pathways

Juenemann, K., & Reits, E. A. (2012) · International Journal of Cell Biology · doi:10.1155/2012/189794 · Cited by 58

Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagy-suppressive toxins

SAMARI, H. R., MØLLER, M. T. N., HOLDEN, L., ASMYHR, T., & SEGLEN, P. O. (2005) · Biochemical Journal · doi:10.1042/bj20040609 · Cited by 58

SNF4Aγ, the Drosophila AMPK γ subunit is required for regulation of developmental and stress-induced autophagy

Lippai, M., Csikós, G., Maróy, P., Lukácsovich, T., Juhász, G., & Sass, M. (2008) · Autophagy · doi:10.4161/auto.5719 · Cited by 56

mTOR Modulates Methamphetamine‐Induced Toxicity through Cell Clearing Systems

Lazzeri, G., Biagioni, F., Fulceri, F., Busceti, C. L., Scavuzzo, M. C., Ippolito, C., Salvetti, A., Lenzi, P., & Fornai, F. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6124745 · Cited by 53

Analyses of Gα-Interacting Protein and Activator of G-Protein-Signaling-3 Functions in Macroautophagy

Pattingre, S., Petiot, A., & Codogno, P. (2004) · Methods in Enzymology · doi:10.1016/s0076-6879(04)90002-x · Cited by 46

Atg9A Protein, an Autophagy-related Membrane Protein, Is Localized in the Neurons of Mouse Brains

Tamura, H., Shibata, M., Koike, M., Sasaki, M., & Uchiyama, Y. (2010) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2010.955690 · Cited by 43