CoChat
Sign Up
Cited by 376Gambling Behavior and TreatmentsNeural and Behavioral Psychology StudiesObsessive-Compulsive Spectrum Disorders

Cue-Induced Brain Activity in Pathological Gamblers

Open access
Crockford, David N., Goodyear, Bradley, Edwards, Jodi, Quickfall, Jeremy, el-Guebaly, Nady·2005·Biological Psychiatry
DOI 10.1016/j.biopsych.2005.04.037
Open this paper in CoChat — free account

Abstract

Background Previous studies using functional magnetic resonance imaging (fMRI) have identified differential brain activity in healthy subjects performing gambling tasks and in pathological gambling (PG) subjects when exposed to motivational and emotional predecessors for gambling as well as during gambling or response inhibition tasks. The goal of the present study was to determine if PG subjects exhibit differential brain activity when exposed to visual gambling cues. Methods Ten male DSM-IV-TR PG subjects and 10 matched healthy control subjects underwent fMRI during visual presentations of gambling-related video alternating with video of nature scenes. Results Pathological gambling subjects and control subjects exhibited overlap in areas of brain activity in response to the visual gambling cues; however, compared with control subjects, PG subjects exhibited significantly greater activity in the right dorsolateral prefrontal cortex (DLPFC), including the inferior and medial frontal gyri, the right parahippocampal gyrus, and left occipital cortex, including the fusiform gyrus. Pathological gambling subjects also reported a significant increase in mean craving for gambling after the study. Post hoc analyses revealed a dissociation in visual processing stream (dorsal vs. ventral) activation by subject group and cue type. Conclusions These findings may represent a component of cue-induced craving for gambling or conditioned behavior that could underlie pathological gambling.

Integrity signals

Registry

Crossref · 10.1016/j.biopsych.2005.04.037

Cites

65 of 65 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • All addictive behaviors share a final common pathway: dopaminergic pathways from the ventral tegmental area of the thalamus projecting to the nucleus accumbens.

    “toutes les conduites addictives ont pour voie finale commune les voies dopaminergiques issues du noyau tegmental ventral du thalamus se projetant sur le nucleus accumbens.”

    From Avant-propos : Les addictions sans drogues (2008) · cites this paper as [3]

  • The reward system involved in addictive behaviors includes the thalamus, amygdala, nucleus accumbens, and prefrontal cortex for all addictive behaviors.

    “Le système de récompense impliqué dans les conduites addictives comprend pour l'ensemble des conduites addictives le thalamus, l'amygdale, le nucleus accumbens et le cortex préfrontal [3, 9].”

    From Avant-propos : Les addictions sans drogues (2008) · cites this paper as [3]

Cites

Flagged first, then by citations

1 of the 66 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Crockford, D. N., Goodyear, B., Edwards, J., Quickfall, J., & el-Guebaly, N.
Affiliations
University of Calgary (CA)
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2005-11
Volume
58
Issue
10
Pages
787-795
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2005.04.037
OpenAlex
W2083386892
Cited by
375
References
66
Citations by year
2026: 7 · 2025: 6 · 2024: 3 · 2023: 12 · 2022: 12 · 2021: 17 · 2020: 55 · 2019: 16 · 2018: 22 · 2017: 15 · 2016: 22 · 2015: 18 · 2014: 29 · 2013: 25 · 2012: 29
FWCI
12.00
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Libraries and Cultural Resources (University of Calgary) (submittedVersion)
  • Libraries and Cultural Resources (University of Calgary)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Keywords
gambling addiction, gambling cues, cue-induced craving, dorsolateral prefrontal cortex, parahippocampal gyrus, fusiform gyrus, visual processing streams, dorsal and ventral visual streams, conditioned behavior, brain activity
MeSH terms
Adult, Brain, Brain Mapping, Cerebral Cortex, Cues, Gambling, Humans, Disruptive, Impulse Control, and Conduct Disorders, Magnetic Resonance Imaging, Male, Middle Aged, Motivation, Reward, Videotape Recording, Visual Perception, Behavior, Addictive, Prefrontal Cortex, Imaging, Three-Dimensional

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review