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Two Distinct Pathways for Cyclooxygenase-2 Protein Degradation

Mbonye, U. R., Yuan, C., Harris, C. E., Sidhu, R. S., Song, I., Arakawa, T., & Smith, W. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710137200 · Cited by 114

PTGS2 (COX-2) −765G > C Promoter Variant Reduces Risk of Colorectal Adenoma among Nonusers of Nonsteroidal Anti-inflammatory Drugs

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Differential Allosteric Regulation of Prostaglandin H Synthase 1 and 2 by Arachidonic Acid

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Structural bases of hydrogen tunneling in enzymes: progress and puzzles

Liang, Z., & Klinman, J. P. (2004) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2004.10.008 · Cited by 113

Structural and Functional Characterization of HQL-79, an Orally Selective Inhibitor of Human Hematopoietic Prostaglandin D Synthase

Aritake, K., Kado, Y., Tsuyoshi Inoue, A., Miyano, M., & Urade, Y. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m506431200 · Cited by 111

Molecular Cloning and Expression of Human Prostacyclin Synthase

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The 2.0Å Resolution Crystal Structure of Prostaglandin H2 Synthase-1: Structural Insights into an Unusual Peroxidase

Gupta, K., Selinsky, B. S., Kaub, C. J., Katz, A. K., & Loll, P. J. (2003) · Journal of Molecular Biology · doi:10.1016/j.jmb.2003.10.073 · Cited by 111

The 19-amino Acid Cassette of Cyclooxygenase-2 Mediates Entry of the Protein into the Endoplasmic Reticulum-associated Degradation System

Mbonye, U. R., Wada, M., Rieke, C. J., Tang, H.-Y., DeWitt, D. L., & Smith, W. L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608281200 · Cited by 110

Inhibitors of the Microsomal Prostaglandin E2 Synthase-1 as Alternative to Non Steroidal Anti-Inflammatory Drugs (NSAIDs) – A Critical Review

Koeberle, A., & Werz, O. (2009) · Current Medicinal Chemistry · doi:10.2174/092986709789578178 · Cited by 110

Glucocorticoid protects rodent hearts from ischemia/reperfusion injury by activating lipocalin-type prostaglandin D synthase–derived PGD2 biosynthesis

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Selective Inhibition of Prostaglandin Endoperoxide Synthase-1 (Cyclooxygenase-1) by Valerylsalicylic Acid

Bhattacharyya, D. K., Lecomte, M., Dunn, J., Morgans, D. J., & Smith, W. L. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.1130 · Cited by 109

Crystal Structure of Human Prostaglandin F Synthase (AKR1C3),

Komoto, J., Yamada, T., Watanabe, K., & Takusagawa, F. (2004) · Biochemistry · doi:10.1021/bi036046x · Cited by 109

Heme spin states and peroxide-induced radical species in prostaglandin H synthase.

Kulmacz, R. J., Tsai, A., & Palmer, G. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)60993-7 · Cited by 108

Dimerization of the Human Receptors for Prostacyclin and Thromboxane Facilitates Thromboxane Receptor-mediated cAMP Generation

Wilson, S. J., Roche, A. M., Kostetskaia, E., & Smyth, E. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405002200 · Cited by 108

Identification of Mu-Class Glutathione Transferases M2-2 and M3-3 as Cytosolic Prostaglandin E Synthases in the Human Brain

Beuckmann, C. T., Fujimori, K., Urade, Y., & Hayaishi, O. (2000) · Neurochemical Research · doi:10.1023/a:1007579507804 · Cited by 106

Prostaglandin H synthase: Resolved and unresolved mechanistic issues

Tsai, A., & Kulmacz, R. J. (2009) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2009.08.019 · Cited by 106

Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase

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Perineuronal Oligodendrocytes Protect against Neuronal Apoptosis through the Production of Lipocalin-Type Prostaglandin D Synthase in a Genetic Demyelinating Model

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Lipocalin-Type Prostaglandin D Synthase in Human Male Reproductive Organs and Seminal Plasma1

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Studies on pig muscle aldose reductase. Kinetic mechanism and evidence for a slow conformational change upon coenzyme binding.

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Identification of a Novel Prostaglandin F2α Synthase in Trypanosoma brucei

Kubata, B. K., Duszenko, M., Kabututu, Z. P., Rawer, M., Szallies, A., Fujimori, K., Inui, T., Nozaki, T., Yamashita, K., Horii, T., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.9.1327 · Cited by 105

Purification and characterization of membrane-bound prostaglandin E synthase from bovine heart

Watanabe, K., Kurihara, K., & Suzuki, T. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(99)00084-0 · Cited by 103

Structural characteristics of prostaglandin synthetase from sheep vesicular gland.

Roth, G. J., Siok, C. J., & Ozols, J. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86029-5 · Cited by 102

15-deoxy-Δ12,14-PGJ2: endogenous PPARγ ligand or minor eicosanoid degradation product?

Powell, W. S. (2003) · Journal of Clinical Investigation · doi:10.1172/jci19796 · Cited by 100

In situ click chemistry generation of cyclooxygenase-2 inhibitors

Bhardwaj, A., Kaur, J., Wuest, M., & Wuest, F. (2017) · Nature Communications · doi:10.1038/s41467-016-0009-6 · Cited by 7,448

The Concise Guide to PHARMACOLOGY 2013/14: Enzymes

Alexander, S. P. H., Benson, H. E., Faccenda, E., Pawson, A. J., Sharman, J. L., Spedding, M., Peters, J. A., Harmar, A. J., & Collaborators, C. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12451 · Cited by 425

Cannflavins—From plant to patient: A scoping review

Erridge, S., Mangal, N., Salazar, O., Pacchetti, B., & Sodergren, M. H. (2020) · Fitoterapia · doi:10.1016/j.fitote.2020.104712 · Cited by 45

Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition?

Esh, C. J., Chrismas, B. C. R., Mauger, A. R., & Taylor, L. (2021) · Pharmacology Research & Perspectives · doi:10.1002/prp2.835 · Cited by 38

Lactobacillus rhamnosus GG increases cyclooxygenase-2 expression and prostaglandin E2 secretion in colonic myofibroblasts via a MyD88-dependent mechanism during homeostasis

Uribe, G., Villéger, R., Bressollier, P., Dillard, R. N., Worthley, D. L., Wang, T. C., Powell, D. W., Urdaci, M. C., & Pinchuk, I. V. (2018) · Cellular Microbiology · doi:10.1111/cmi.12871 · Cited by 28