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Somatosensory and auditory convergence in the lateral nucleus of the amygdala.
Abstract
Previous studies have shown that the lateral nucleus of the amygdala (AL) is essential in auditory fear conditioning and that neurons in the AL respond to auditory stimuli. The goals of the present study were to determine whether neurons in the AL are also responsive to somatosensory stimuli and, if so, whether single neurons in the AL respond to both auditory and somatosensory stimulation. Single-unit activity was recorded in the AL in anesthetized rats during the presentation of acoustic (clicks) and somatosensory (footshock) stimuli. Neurons in the dorsal subdivision of the AL responded to both somatosensory and auditory stimuli, whereas neurons in the ventrolateral AL responded only to somatosensory stimuli and neurons in the ventromedial AL did not respond to either stimuli. These findings indicate that the dorsal AL is a site of auditory and somatosensory convergence and may therefore be a locus of convergence of conditioned and unconditioned stimuli in auditory fear conditioning.
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Several lines of indirect evidence support the idea that this plasticity occurs as a result of a Hebbian mechanism through which depolarization of LA pyramidal neurons by the shock US coincident with weaker activation of the same cells by auditory CS inputs results in fear learning.
“Several lines of indirect evidence support the idea that this plasticity occurs as a result of a Hebbian mechanism through which depolarization of LA pyramidal neurons by the shock US coincident with weaker activation of the same cells by auditory CS inputs results in fear learning (8–18).”
From Optical activation of lateral amygdala pyramidal cells instructs associative fear learning (2010) · cites this paper as [13]
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Metadata
- Authors
- Romanski, L. M., Clugnet, M.-C., Bordi, F., & LeDoux, J. E.
- Affiliations
- Yale University (US)
- New York University (US)
- Venue
- Behavioral Neuroscience
- Published
- 1993
- Volume
- 107
- Issue
- 3
- Pages
- 444-450
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2092568693
- Cited by
- 446
- References
- 37
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 10 · 2023: 12 · 2022: 12 · 2021: 12 · 2020: 19 · 2019: 12 · 2018: 15 · 2017: 12 · 2016: 19 · 2015: 17 · 2014: 24 · 2013: 15 · 2012: 16
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH 46516, R01MH046516, MH38774)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- lateral amygdala, auditory fear conditioning, single-unit activity, footshock, acoustic stimuli
- MeSH terms
- Amygdala, Animals, Attention, Brain Mapping, Conditioning, Classical, Evoked Potentials, Auditory, Evoked Potentials, Somatosensory, Fear, Male, Neural Pathways, Neurons, Nociceptors, Rats, Sprague-Dawley, Rats
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