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Personality and substance use disorders: A prospective study.
Abstract
The personality systems of Cloninger (as measured by the Tridimensional Personality Questionnaire [TPQ]) and Eysenck (as measured by the Eysenck Personality Questionnaire [EPQ]) both have been linked to substance use and abuse. The current study examined the predictive utility of both systems for substance use disorder (SUD) diagnoses, both cross-sectionally and prospectively. Participants (N = 489 at baseline) completed the EPQ and TPQ and were assessed via structured diagnostic interview at baseline and 6 years later (N = 457 at follow-up). Both the EPQ and TPQ scales demonstrated bivariate cross-sectional and prospective associations with SUDs. Within each system, those dimensions marking a broad impulsive sensation-seeking or behavioral disinhibition trait were the best predictors prospectively, although the 2 systems were differentially sensitive to specific diagnoses. These relations remained significant even with autoregressivity, other concurrent SUD diagnoses, and multiple personality dimensions statistically controlled.
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“For example, disinhibition has been linked to impulsive substance use [15], while negative affectivity may contribute to emotion-driven consumption [16].”
From The link of adverse childhood experiences and attachment to maladaptive personality traits in adults diagnosed with substance use disorder (2025) · cites this paper as [15]
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“Although the alpha level for EPQ-P was rather low, it was largely consistent with that reported in previous research (e.g., Sher, Bartholow, & Wood, 2000).”
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“, 1998), and prospectively predicts development of impulsive-compulsive behaviours and addiction (Sher et al., 2000; Cyders and Smith, 2008).”
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“…some personality traits or psychiatric disorders are more specifically associated with vulnerability to use (Zuckerman 1986; Franques et al. 2000; Sher et al. 2000; Terracciano et al. 2008) or to addiction (Swendsen and Le Moal 2011), thereby rendering even more complex the relationships between…”
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Schilling, C., Kühn, S., Romanowski, A., Schubert, F., Kathmann, N., & Gallinat, J. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.07.058 · Cited by 124
“…been described as a central symptom domain in major psychiatric disorders, for instance attention-deficit/hyperactivity disorder (ADHD; Solanto et al., 2009), substance abuse (Sher et al., 2000), borderline personality disorder (Berlin et al., 2005) and suicidal behavior (Dougherty et al., 2004).”
BackgroundHerting, M. M., Schwartz, D., Mitchell, S. H., & Nagel, B. J. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01244.x · Cited by 122
“…linking impulsivity in youth with more frequent and heavier alcohol use and greater likelihood of developing a use disorder (Kirisci et al., 2007; Sher et al., 2000; Tarter et al., 2007), our findings may also attest to the role of trait impulsivity as a viable risk factor for future alcohol…”
Impulsivity and methamphetamine use
Semple, S. J., Zians, J., Grant, I., & Patterson, T. L. (2005) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2005.05.001 · Cited by 117
Moderators of the association between peer and target adolescent substance use
Marschall-Lévesque, S., Ryan, N. C., Vitaro, F., & Séguin, J. R. (2013) · Addictive Behaviors · doi:10.1016/j.addbeh.2013.09.025 · Cited by 121
Vassileva, J., & Conrod, P. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2018.0137 · Cited by 118
Collegiate heavy drinking prospectively predicts change in sensation seeking and impulsivity.
Quinn, P. D., Stappenbeck, C. A., & Fromme, K. (2011) · Journal of Abnormal Psychology · doi:10.1037/a0023159 · Cited by 119
“In addition to drinking, these traits reliably predict a variety of other negative outcomes, including poorer academic performance (Duckworth & Seligman, 2005) and greater likelihood of risky behaviors such as illicit drug abuse (Sher et al., 2000), unprotected sex (Hoyle, Fejfar, & Miller, 2000), and gambling (Slutsk…”
BackgroundCongdon, E. L., & Canli, T. (2005) · Behavioral and Cognitive Neuroscience Reviews · doi:10.1177/1534582305285980 · Cited by 109
Dopamine receptors in the learning, memory and drug reward circuitry
Dalley, J. W., & Everitt, B. J. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.01.002 · Cited by 115
Oshri, A., Rogosch, F. A., & Cicchetti, D. (2012) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2012.715366 · Cited by 112
“Among older youth, Sher, Bartholow, and Wood (2000) tested the predictive utility of two personality systems (Cloninger and Eysenck) from late adolescence to early adulthood.”
BackgroundThe Effect of Parental Alcohol and Drug Disorders on Adolescent Personality
Elkins, I. J., McGue, M. K., Malone, S., & Iacono, W. G. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.4.670 · Cited by 105
Big-five personality domains predict internal drinking motives in young adults
Mezquita, L., Stewart, S. H., & Ruipérez, M. Á. (2010) · Personality and Individual Differences · doi:10.1016/j.paid.2010.03.043 · Cited by 112
Genetic susceptibility to substance dependence
Hiroi, N., & Agatsuma, S. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001622 · Cited by 107
Weiland, B. J., Welsh, R. C., Yau, W. W., Zucker, R. A., Zubieta, J., & Heitzeg, M. M. (2012) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2012.08.019 · Cited by 105
Littlefield, A. K., Sher, K. J., & Steinley, D. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01224.x · Cited by 103
“P A A uthor M anuscript cross-sectionally (e.g., Bennett et al., 1999; McGue et al., 1997; Trull et al., 2004) and longitudinally (e.g., Caspi et al., 1998; Elkins et al., 2006; Schuckit, 1998; Sher et al., 2000).”
BackgroundSelf-citationBrunelle, C., Assaad, J., Barrett, S. P., Ávila, C., Conrod, P., Tremblay, R. E., & Pihl, R. O. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000117859.23567.2e · Cited by 93
“Interestingly, animal and human studies have demonstrated that those with a high interest in exploring their environment tend to be more sensitive to drug-induced reward and to use more alcohol and stimulant drugs (Dellu et al., 1996; Hooks and Kalivas, 1994; Sher et al., 2000; Zuckerman and Kuhlman, 2000).”
BackgroundJones, H. A., & Lejuez, C. W. (2005) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.13.3.259 · Cited by 92
Risk and learning in impulsive and nonimpulsive patients with Parkinson's disease
Djamshidian, A., Jha, A., O’Sullivan, S. S., Silveira‐Moriyama, L., Jacobson, C., Brown, P., Lees, A. J., & Averbeck, B. B. (2010) · Movement Disorders · doi:10.1002/mds.23247 · Cited by 90
“In contrast PD1ICB patients have a behavioral profile characterized by increased impulsiveness or novelty seeking(28) similar to subjects prone to substance abuse and behavioral addictions.(30) Overall, PD1ICB patients showed a trend to be more risk prone relative to normal PD, which did not reach significance.”
BackgroundLlorente‐Berzal, A., Fuentes, S., Gagliano, H., López‐Gallardo, M., Armario, A., Viveros, M., & Nadal, R. A. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00318.x · Cited by 90
Sizoo, B. B., van den Brink, W., Eenige, M. G.-V., & van der Gaag, R. J. (2009) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0b013e3181a61dd0 · Cited by 88
“…character profiles, for example, that the groups with SUD would present with higher novelty seeking scores and self transcendence scores than those without SUD, based on personality studies in groups with SUD (Martinotti et al., 2006; Moran et al., 2006; Sher et al., 2000; Spalletta et al., 2007).”
Grekin, E. R., & Sher, K. J. (2006) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.14.3.329 · Cited by 88
Self-citationLatent Structure of the Davis Interpersonal Reactivity Index in Methadone Maintenance Patients
Alterman, A. I., McDermott, P. A., Cacciola, J. S., & Rutherford, M. J. (2003) · Journal of Psychopathology and Behavioral Assessment · doi:10.1023/a:1025936213110 · Cited by 86
“High scores on the N and P scales have been associated with substance abuse ( Sher, Bartholow, & Wood, 2000 ).”
BackgroundA meta-analysis of temperament in axis I psychiatric disorders
Miettunen, J., & Raevuori, A. (2011) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2011.03.008 · Cited by 85
“Compared with the control group, this meta-analysis failed to establish a frequently observed association of elevated NS in alcohol use disorders, derived from crosssectional and longitudinal studies as well as from experimental human and animal studies in various types of substance abuse [118].”
ResultQuality of life and personality disorders in heroin abusers
Fassino, S., Daga, G. A., Delsedime, N., Rogna, L., & Boggio, S. (2004) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2004.04.005 · Cited by 85
“, 2004) together with other temperament alterations (Ball et al., 1997, 1998; Conway et al., 2003; Gerdner et al., 2002; Gomez-Peretta De Mateo et al., 2002; Howard et al., 1997; Sher et al., 2000; Van Ammers et al., 1997; Vukov et al., 1995; Wills et al., 1998, 1999).”
BackgroundMethodResultInfluentialPersonality correlates of Iowa Gambling Task performance in healthy adolescents
Hooper, C. J., Luciana, M. M., Wahlstrom, D., Conklin, H. M., & Yarger, R. S. (2007) · Personality and Individual Differences · doi:10.1016/j.paid.2007.09.021 · Cited by 84
Big-Five personality domains predict drinking motives
Theakston, J. A., Stewart, S. H., Dawson, M. Y., Knowlden-Loewen, S. A. B., & Lehman, D. R. (2004) · Personality and Individual Differences · doi:10.1016/j.paid.2003.11.007 · Cited by 83
Sussman, S. Y., McCuller, W. J., & Dent, C. W. (2003) · Addictive Behaviors · doi:10.1016/s0306-4603(02)00222-8 · Cited by 83
Deroche‐Gamonet, V., & Piazza, P. V. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.07.014 · Cited by 79
Jahng, S., Trull, T. J., Wood, P. K., Tragesser, S. L., Tomko, R. L., Grant, J. D., Bucholz, K. K., & Sher, K. J. (2011) · Journal of Abnormal Psychology · doi:10.1037/a0023539 · Cited by 80
Self-citation
Metadata
- Authors
- Sher, K. J., Bartholow, B. D., & Wood, M. D.
- Affiliations
- University of Missouri (US)
- Venue
- Journal of Consulting and Clinical Psychology
- Published
- 2000
- Volume
- 68
- Issue
- 5
- Pages
- 818-829
- ISSN
- 0022-006X (ISSN-L)
- 1939-2117
- OpenAlex
- W1991864809
- Cited by
- 483
- References
- 107
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 7 · 2023: 15 · 2022: 12 · 2021: 9 · 2020: 35 · 2019: 12 · 2018: 21 · 2017: 11 · 2016: 27 · 2015: 18 · 2014: 26 · 2013: 34 · 2012: 33
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Consulting and Clinical Psychology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R37 AA7231, P50AA011998, P50 AA 11998, R37AA007231)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Clinical Psychology › Personality Traits and Psychology
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Keywords
- personality traits, substance use disorders, substance abuse, Eysenck Personality Questionnaire, Tridimensional Personality Questionnaire, impulsivity, sensation seeking, behavioral disinhibition, prospective prediction, autoregressive effects
- MeSH terms
- Adolescent, Adult, Cross-Sectional Studies, Female, Follow-Up Studies, Humans, Impulsive Behavior, Inhibition, Psychological, Male, Personality Disorders, Personality Inventory, Predictive Value of Tests, Prospective Studies, Risk-Taking, Sensitivity and Specificity, Logistic Models, Substance-Related Disorders
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