A Drosophila model of Parkinson's disease

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Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease

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Parkin functions as an E2-dependent ubiquitin– protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

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Tauopathy in Drosophila : Neurodegeneration Without Neurofibrillary Tangles

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Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

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Expanding insights of mitochondrial dysfunction in Parkinson's disease

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Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

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α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

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Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53 → Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice

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Parkinson’s disease: genetics and pathogenesis

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Parkin ubiquitinates the α-synuclein–interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

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Repression of α-synuclein expression and toxicity by microRNA-7

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Parkinson-Like Neurodegeneration Induced by Targeted Overexpression of α-Synuclein in the Nigrostriatal System

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The art and design of genetic screens: Drosophila melanogaster

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β-Amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease

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A Role for α-Synuclein in the Regulation of Dopamine Biosynthesis

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Remote Control of Behavior through Genetically Targeted Photostimulation of Neurons

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Effects of α-Synuclein Immunization in a Mouse Model of Parkinson’s Disease

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The fold of α-synuclein fibrils

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Failure of the ubiquitin-proteasome system in Parkinson’s disease

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RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk

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Differential neuropathological alterations in transgenic mice expressing α‐synuclein from the platelet‐derived growth factor and Thy‐1 promoters

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Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

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Parkinson’s disease induced pluripotent stem cells with triplication of the α-synuclein locus

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α-synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease

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Clearance of α-Synuclein Oligomeric Intermediates via the Lysosomal Degradation Pathway

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Pre‐fibrillar α‐synuclein variants with impaired β‐structure increase neurotoxicity in Parkinson's disease models

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Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila

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β-Synuclein Inhibits α-Synuclein Aggregation

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α‐Synuclein metabolism and aggregation is linked to ubiquitin‐independent degradation by the proteasome

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Behavioral and Neurochemical Effects of Wild-Type and Mutated Human α-Synuclein in Transgenic Mice

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Lack of Nigral Pathology in Transgenic Mice Expressing Human α-Synuclein Driven by the Tyrosine Hydroxylase Promoter

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TOR-Mediated Cell-Cycle Activation Causes Neurodegeneration in a Drosophila Tauopathy Model

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GSK-3β inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila

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Genetic modifiers of tauopathy in Drosophila

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Neurological and Neurodegenerative Alterations in a Transgenic Mouse Model Expressing Human α-Synuclein under Oligodendrocyte Promoter: Implications for Multiple System Atrophy

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Molecular pathogenesis of Parkinson's disease

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α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton

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ER stress inhibits neuronal death by promoting autophagy

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Proteolytic stress: A unifying concept for the etiopathogenesis of Parkinson’s disease

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Sodium butyrate improves locomotor impairment and early mortality in a rotenone-induced Drosophila model of Parkinson's disease

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Lewy Body Pathology in Alzheimer's Disease

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Inhibition of GSK-3 Ameliorates Aβ Pathology in an Adult-Onset Drosophila Model of Alzheimer's Disease

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DeepFly3D, a deep learning-based approach for 3D limb and appendage tracking in tethered, adult Drosophila

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On the mechanism of internalization of α‐synuclein into microglia: roles of ganglioside GM1 and lipid raft

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Could a loss of α‐synuclein function put dopaminergic neurons at risk?

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Sensitivity to MPTP is not increased in Parkinson's disease‐associated mutant α‐synuclein transgenic mice: RAPID COMMUNICATION

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General aspects of neurodegeneration

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Disease model organism for Parkinson disease: Drosophila melanogaster

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Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons

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Parkinsons Disease and other α-Synucleinopathies

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Pathogenic mechanisms of prion protein, amyloid-β and α-synuclein misfolding: the prion concept and neurotoxicity of protein oligomers

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A calcineurin- and NFAT-dependent pathway is involved in -synuclein-induced degeneration of midbrain dopaminergic neurons

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Cycles of Aberrant Synaptic Sprouting and Neurodegeneration in Alzheimer's and Dementia with Lewy Bodies

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Interactions between Tau and α-synuclein augment neurotoxicity in a Drosophila model of Parkinson's disease

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The interrelationship of proteasome impairment and oligomeric intermediates in neurodegeneration

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Standardized extract of Withania somnifera (Ashwagandha) markedly offsets rotenone-induced locomotor deficits, oxidative impairments and neurotoxicity in Drosophila melanogaster

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Drosophila Fip200 is an essential regulator of autophagy that attenuates both growth and aging

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Genetic Defects and Pro-inflammatory Cytokines in Parkinson's Disease

Magnusen, A. F., Hatton, S. L., Rani, R., & Pandey, M. K. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.636139 · Cited by 47

Parp mutations protect from mitochondrial toxicity in Alzheimer’s disease

Yu, Y., Fedele, G., Celardo, I., Loh, S. H. Y., & Martins, L. M. (2021) · Cell Death & Disease · doi:10.1038/s41419-021-03926-y · Cited by 46

Supplementation of Spirulina ( Arthrospira platensis ) Improves Lifespan and Locomotor Activity in Paraquat-Sensitive DJ-1β Δ93 Flies, a Parkinson's Disease Model in Drosophila melanogaster

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Paraquat and iron exposure as possible synergistic environmental risk factors in Parkinson’s disease

Andersen, J. K. (2003) · Neurotoxicity Research · doi:10.1007/bf03033150 · Cited by 40

Dopamine Modulates Serotonin Innervation in the Drosophila Brain

Niens, J., Reh, F., Çoban, B., Cichewicz, K., Eckardt, J., Liu, Y.-T., Hirsh, J., & Riemensperger, T. D. (2017) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2017.00076 · Cited by 38

The GATOR1 Complex Regulates Metabolic Homeostasis and the Response to Nutrient Stress in Drosophila melanogaster

Wei, Y., Reveal, B., Cai, W., & Lilly, M. A. (2016) · G3 Genes|Genomes|Genetics · doi:10.1534/g3.116.035337 · Cited by 31

Endophilin-B regulates autophagy during synapse development and neurodegeneration

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Bioinformatic Approaches Used in Modelling Human Tremor

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Senolytic and senomorphic secondary metabolites as therapeutic agents in Drosophila melanogaster models of Parkinson’s disease

Miller, S. J., Darji, R. Y., Walaieh, S., Lewis, J. A., & Logan, R. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1271941 · Cited by 16

The Drosophila melanogaster as Genetic Model System to Dissect the Mechanisms of Disease that Lead to Neurodegeneration in Adrenoleukodystrophy

Bülow, M. H., Parsons, B. D., & Di Cara, F. (2020) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-030-60204-8_11 · Cited by 8