The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Activity-dependent scaling of quantal amplitude in neocortical neurons
Abstract
Information is stored in neural circuits through long-lasting changes in synaptic strengths. Most studies of information storage have focused on mechanisms such as long-term potentiation and depression (LTP and LTD), in which synaptic strengths change in a synapse-specific manner. In contrast, little attention has been paid to mechanisms that regulate the total synaptic strength of a neuron. Here we describe a new form of synaptic plasticity that increases or decreases the strength of all of a neuron's synaptic inputs as a function of activity. Chronic blockade of cortical culture activity increased the amplitude of miniature excitatory postsynaptic currents (mEPSCs) without changing their kinetics. Conversely, blocking GABA (gamma-aminobutyric acid)-mediated inhibition initially raised firing rates, but over a 48-hour period mESPC amplitudes decreased and firing rates returned to close to control values. These changes were at least partly due to postsynaptic alterations in the response to glutamate, and apparently affected each synapse in proportion to its initial strength. Such 'synaptic scaling' may help to ensure that firing rates do not become saturated during developmental changes in the number and strength of synaptic inputs, as well as stabilizing synaptic strengths during Hebbian modification and facilitating competition between synapses.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“There is compelling evidence from experiments in neuronal cultures that central neurons are able to maintain average firing rates around a homeostatic set point.”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Turrigiano et al. 1998
In the citing paper
“One such mechanism is synaptic scaling, which allows neurons to detect changes in their own firing rates through a set of calcium-dependent sensors that then regulate receptor trafficking to increase or decrease the accumulation of glutamate receptors at synaptic sites.”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Turrigiano et al. 1998
In the citing paper
“When cortical or hippocampal neurons are induced to fire more than normal, over many hours firing returns to baseline levels, and similarly, if neuronal firing is reduced over time, neurons compensate and again firing is restored (Fig. 1A) (Turrigiano et al. 1998;Burrone et al. 2002).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Turrigiano et al. 1998
In the citing paper
“Synaptic scaling was first identified in cultured neocortical neurons, where it was observed that perturbing network activity generated compensatory changes in synaptic strength that were in the right direction to restore average firing rates to baseline values (Turrigiano et al. 1998).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Turrigiano et al. 1998
In the citing paper
“by measuring minis arising from many synapses onto the same neuron, it was observed that modulating network activity induced uniform increases or decreases in the entire mini amplitude distribution, in effect scaling postsynaptic strength up or down (Turrigiano et al. 1998;Desai et al. 2002;Gainey et al. 2009).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Turrigiano et al. 1998
In the citing paper
“Interestingly, the same manipulation (activity blockade using TTX or AMPAR antagonists) that only affects mini amplitude in young cultures (Turrigiano et al. 1998;Wierenga et al. 2005) can also induce changes in mini frequency and in presynaptic release probability in older neuronal cultures (Wierenga et al. 2006), through a process that involves postsynaptic hyperpolarization and a drop in”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Turrigiano et al. 1998
In the citing paper
“Synaptic scaling has now been shown in a variety of central neurons both in vitro and in vivo, including neocortical and hippocampal pyramidal neurons and spinal neurons (O'Brien et al. 1998;Turrigiano et al. 1998;Desai et al. 2002;Stellwagen and Malenka 2006;Goel and Lee 2007;Kim and Tsien 2008;Knogler et al. 2010).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Turrigiano et al. 1998
In the citing paper
“Although in neocortical networks the net effects of changes in excitation and inhibition appear to be homeostatic (Rutherford et al. 1998;Turrigiano et al. 1998;Maffei et al. 2004), different classes of inhibitory synapse are regulated differently by lowered activity.”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Turrigiano et al. 1998
In the citing paper
“In response to chronic hyperactivity or hypoactivity, neurons can engage homeostatic scaling-down or scaling-up respectively, in which the strength of excitatory synapses on a neuron is globally modified to maintain neuronal activity in a physiological range (O'Brien et al., 1998, Turrigiano et al., 1998, Turrigiano, 2008).”
From The AMPA Receptor Code of Synaptic Plasticity (2018) · cites this paper as Turrigiano et al., 1998
In the citing paper
“Sample sizes were initially determined based on prior work using social interaction54,65 and intrinsic physiology62, no formal statistical methods were used to pre-determine sample sizes.”
From Insular cortex mediates approach and avoidance responses to social affective stimuli (2018) · cites this paper as [62]
Citations
Cites
Bienenstock, E., Cooper, L., & Munro, P. (1982) · The Journal of Neuroscience · doi:10.1523/jneurosci.02-01-00032.1982 · Cited by 2,896
Liao, D., Hessler, N. A., & Malinow, R. (1995) · Nature · doi:10.1038/375400a0 · Cited by 1,365
Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation
Barria, A., Muller, D., Derkach, V., Griffith, L. C., & Soderling, T. R. (1997) · Science · doi:10.1126/science.276.5321.2042 · Cited by 1,049
Impulse activity and the patterning of connections during cns development
Shatz, C. J. (1990) · Neuron · doi:10.1016/0896-6273(90)90333-b · Cited by 766
A study of supersensitivity in denervated mammalian skeletal muscle
Axelsson, J., & Thesleff, S. (1959) · The Journal of Physiology · doi:10.1113/jphysiol.1959.sp006233 · Cited by 732
A Physiological Mechanism for Hebb's Postulate of Learning
Stent, G. S. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.4.997 · Cited by 710
Mechanisms Underlying Long-Term Potentiation of Synaptic Transmission
Madison, D. V., Malenka, R. C., & Nicoll, R. A. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.002115 · Cited by 617
Maturation of a Central Glutamatergic Synapse
Wu, G.-Y., Malinow, R., & Cline, H. T. (1996) · Science · doi:10.1126/science.274.5289.972 · Cited by 546
Linden, D. J., & Connor, J. A. (1995) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.18.030195.001535 · Cited by 519
The formation and maturation of synapses in the visual cortex of the rat. II. Quantitative analysis
Blue, M. E., & Parnavelas, J. G. (1983) · Journal of Neurocytology · doi:10.1007/bf01181531 · Cited by 506
Flagged first, then by citations
Research works printed but not linked: 2
- Hebb, D. O. The Organization of Behavior: a Neurophysiological Theory (Wiley, New York, 1949).
- Axelsson, J. & Thesleff, S. Astudy of supersensitivity in denervated mammalian skeletal muscle. J.Physiol. (Lond.) 149, 178–193 (1957).
Cited by
Sorted by citations
Faisal, A. A., Selen, L. P. J., & Wolpert, D. M. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2258 · Cited by 2,883
Competitive Hebbian learning through spike-timing-dependent synaptic plasticity
Song, S., Miller, K. D., & Abbott, L. F. (2000) · Nature Neuroscience · doi:10.1038/78829 · Cited by 2,794
AMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588
Homeostatic plasticity in the developing nervous system
Turrigiano, G. G., & Nelson, S. B. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1327 · Cited by 2,485
Self-citationSynaptic Plasticity: Multiple Forms, Functions, and Mechanisms
Citri, A., & Malenka, R. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301559 · Cited by 2,323
Synaptic plasticity: taming the beast
Abbott, L. F., & Nelson, S. B. (2000) · Nature Neuroscience · doi:10.1038/81453 · Cited by 2,263
Self-citationThe induction of pain: an integrative review
Millan, M. J. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00048-3 · Cited by 1,774
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Engert, F., & Bonhoeffer, T. (1999) · Nature · doi:10.1038/19978 · Cited by 1,412
Synaptic scaling mediated by glial TNF-α
Stellwagen, D., & Malenka, R. C. (2006) · Nature · doi:10.1038/nature04671 · Cited by 1,715
Abbott, L. F., & Regehr, W. G. (2004) · Nature · doi:10.1038/nature03010 · Cited by 1,684
APP Processing and Synaptic Function
Kamenetz, F., Tomita, T., Hsieh, H., Seabrook, G., Borchelt, D., Iwatsubo, T., Sisodia, S., & Malinow, R. (2003) · Neuron · doi:10.1016/s0896-6273(03)00124-7 · Cited by 1,644
The self-tuning neuron: synaptic scaling of excitatory synapses
Turrigiano, G. G. (2008) · Cell · doi:10.1016/j.cell.2008.10.008 · Cited by 1,533
Self-citationVariability, compensation and homeostasis in neuron and network function
Marder, E., & Goaillard, J.-M. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1949 · Cited by 1,212
Rate, Timing, and Cooperativity Jointly Determine Cortical Synaptic Plasticity
Sjöström, P. J., Turrigiano, G. G., & Nelson, S. B. (2001) · Neuron · doi:10.1016/s0896-6273(01)00542-6 · Cited by 1,174
Self-citationAMPA receptor trafficking at excitatory synapses
Bredt, D. S., & Nicoll, R. A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00640-8 · Cited by 1,150
Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity
You, X., Vlatkovic, I., Babic, A., Will, T., Epstein, I., Tushev, G., Akbalik, G., Wang, M., Glock, C., Quedenau, C., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3975 · Cited by 1,149
Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function
Turrigiano, G. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005736 · Cited by 1,139
Self-citationPlaque-independent disruption of neural circuits in Alzheimer’s disease mouse models
Hsia, A. Y., Masliah, E., McConlogue, L., Yu, G.-Q., Tatsuno, G., Hu, K., Kholodenko, D., Malenka, R. C., Nicoll, R. A., & Mucke, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3228 · Cited by 1,123
Reinsertion or Degradation of AMPA Receptors Determined by Activity-Dependent Endocytic Sorting
Ehlers, M. D. (2000) · Neuron · doi:10.1016/s0896-6273(00)00129-x · Cited by 1,096
Similar network activity from disparate circuit parameters
Prinz, A. A., Bucher, D., & Marder, E. (2004) · Nature Neuroscience · doi:10.1038/nn1352 · Cited by 1,091
Polychronization: Computation with Spikes
Izhikevich, E. M. (2005) · Neural Computation · doi:10.1162/089976606775093882 · Cited by 1,082
Schaette, R., & McAlpine, D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2156-11.2011 · Cited by 1,049
The cell biology of synaptic plasticity: AMPA receptor trafficking
Shepherd, J. D., & Huganir, R. L. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123516 · Cited by 978
Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system
Ehlers, M. D. (2003) · Nature Neuroscience · doi:10.1038/nn1013 · Cited by 977
From the genetic architecture to synaptic plasticity in autism spectrum disorder
Bourgeron, T. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3992 · Cited by 975
AMPARs and Synaptic Plasticity: The Last 25 Years
Huganir, R. L., & Nicoll, R. A. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.025 · Cited by 968
Dendritic Protein Synthesis, Synaptic Plasticity, and Memory
Sutton, M. A., & Schuman, E. M. (2006) · Cell · doi:10.1016/j.cell.2006.09.014 · Cited by 938
Kreitzer, A. C., & Regehr, W. G. (2001) · Neuron · doi:10.1016/s0896-6273(01)00246-x · Cited by 899
The AMPA Receptor Code of Synaptic Plasticity
Diering, G. H., & Huganir, R. L. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.018 · Cited by 844
Homeostatic plasticity in neuronal networks: the more things change, the more they stay the same
Turrigiano, G. G. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01341-1 · Cited by 840
Self-citationDendritic Spine Pathology: Cause or Consequence of Neurological Disorders?
Fiala, J. C., Spacek, J., & Harris, K. M. (2002) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00158-3 · Cited by 811
Plasticity in the intrinsic excitability of cortical pyramidal neurons
Desai, N. S., Rutherford, L. C., & Turrigiano, G. G. (1999) · Nature Neuroscience · doi:10.1038/9165 · Cited by 806
Self-citationThe role of the GluR2 subunit in AMPA receptor function and synaptic plasticity
Isaac, J. T. R., Ashby, M. C., & McBain, C. J. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.001 · Cited by 802
Regulation of AMPA receptors during synaptic plasticity
Song, I., & Huganir, R. L. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02270-1 · Cited by 798
Astrocyte roles in traumatic brain injury
Burda, J. E., Bernstein, A. M., & Sofroniew, M. V. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.03.020 · Cited by 791
Diversity and Dynamics of Dendritic Signaling
Häusser, M., Spruston, N., & Stuart, G. J. (2000) · Science · doi:10.1126/science.290.5492.739 · Cited by 783
Arc/Arg3.1 Mediates Homeostatic Synaptic Scaling of AMPA Receptors
Shepherd, J. D., Rumbaugh, G., Wu, J., Chowdhury, S., Plath, N., Kuhl, D., Huganir, R. L., & Worley, P. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.034 · Cited by 779
AMPA receptor regulation during synaptic plasticity in hippocampus and neocortex
Lee, H., & Kirkwood, A. (2011) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2011.06.007 · Cited by 772
Dendritic Excitability and Synaptic Plasticity
Sjöström, P. J., Rancz, E. A., Roth, A., & Häusser, M. (2008) · Physiological Reviews · doi:10.1152/physrev.00016.2007 · Cited by 740
Stable Hebbian Learning from Spike Timing-Dependent Plasticity
van Rossum, M. C. W., Bi, G., & Turrigiano, G. G. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08812.2000 · Cited by 722
Self-citationRegulatory mechanisms of AMPA receptors in synaptic plasticity
Derkach, V. A., Oh, M. C., Guire, E. S., & Soderling, T. R. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2055 · Cited by 708
How does nature program neuron types?
Borst, A. (2008) · Frontiers in Neuroscience · doi:10.3389/neuro.01.016.2008 · Cited by 705
Hebb and homeostasis in neuronal plasticity
Turrigiano, G. G., & Nelson, S. B. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00091-x · Cited by 693
Self-citationActivity-Dependent Modulation of Synaptic AMPA Receptor Accumulation
O’Brien, R. J., Kamboj, S., Ehlers, M. D., Rosen, K. R., Fischbach, G. D., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80624-8 · Cited by 688
Too many cooks? Intrinsic and synaptic homeostatic mechanisms in cortical circuit refinement
Turrigiano, G. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153238 · Cited by 671
Self-citationNeuronal Plasticity in Thalamocortical Networks during Sleep and Waking Oscillations
Steriade, M., & Timofeev, I. (2003) · Neuron · doi:10.1016/s0896-6273(03)00065-5 · Cited by 659
BDNF signaling in context: From synaptic regulation to psychiatric disorders
Wang, C. S., Kavalali, E. T., & Monteggia, L. M. (2021) · Cell · doi:10.1016/j.cell.2021.12.003 · Cited by 654
Activity-dependent regulation of inhibitory synapse development by Npas4
Lin, Y., Bloodgood, B. L., Hauser, J. L., Lapan, A. D., Koon, A. C., Kim, T.-K., Hu, L. S., Malik, A. N., & Greenberg, M. E. (2008) · Nature · doi:10.1038/nature07319 · Cited by 639
Sutton, M. A., Ito, H. T., Cressy, P., Kempf, C., Woo, J. C., & Schuman, E. M. (2006) · Cell · doi:10.1016/j.cell.2006.03.040 · Cited by 633
Neocortical LTD via Coincident Activation of Presynaptic NMDA and Cannabinoid Receptors
Sjöström, P. J., Turrigiano, G. G., & Nelson, S. B. (2003) · Neuron · doi:10.1016/s0896-6273(03)00476-8 · Cited by 629
Self-citationProtein palmitoylation in neuronal development and synaptic plasticity
Fukata, Y., & Fukata, M. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2788 · Cited by 625
Altered Electrical Properties inDrosophilaNeurons Developing without Synaptic Transmission
Baines, R., Uhler, J. P., Thompson, A., Sweeney, S. T., & Bate, M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01523.2001 · Cited by 618
Inactivity produces increases in neurotransmitter release and synapse size
Murthy, V. N., Schikorski, T., Stevens, C. F., & Zhu, Y. (2001) · Neuron · doi:10.1016/s0896-6273(01)00500-1 · Cited by 612
The Postsynaptic Organization of Synapses
Sheng, M., & Kim, E. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005678 · Cited by 603
Phenomenological models of synaptic plasticity based on spike timing
Morrison, A., Diesmann, M., & Gerstner, W. (2008) · Biological Cybernetics · doi:10.1007/s00422-008-0233-1 · Cited by 593
Critical periods for experience-dependent synaptic scaling in visual cortex
Desai, N. S., Cudmore, R. H., Nelson, S. B., & Turrigiano, G. G. (2002) · Nature Neuroscience · doi:10.1038/nn878 · Cited by 582
Self-citationRapid, experience-dependent expression of synaptic NMDA receptors in visual cortex in vivo
Quinlan, E. M., Philpot, B. D., Huganir, R. L., & Bear, M. F. (1999) · Nature Neuroscience · doi:10.1038/7263 · Cited by 579
Neuromorphic Electronic Circuits for Building Autonomous Cognitive Systems
Chicca, E., Stefanini, F., Bartolozzi, C., & Indiveri, G. (2014) · Proceedings of the IEEE · doi:10.1109/jproc.2014.2313954 · Cited by 571
Unraveling mechanisms of homeostatic synaptic plasticity
Pozo, K., & Goda, Y. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.028 · Cited by 565
Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization
Lin, J., Ju, W. H., Foster, K. A., Lee, S. H., Ahmadian, G., Wyszynski, M. W., Wang, Y. T., & Sheng, M. (2000) · Nature Neuroscience · doi:10.1038/81814 · Cited by 562
Long-Term Plasticity of Intrinsic Excitability: Learning Rules and MechanismsPreprint
Daoudal, G., & Debanne, D. (2003) · Learning & Memory · doi:10.1101/lm.64103 · Cited by 554
HOMEOSTATIC CONTROL OF NEURAL ACTIVITY: From Phenomenology to Molecular Design
Davis, G. W. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135751 · Cited by 543
Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors
Ju, W. H., Morishita, W., Tsui, J., Gaietta, G. M., Deerinck, T. J., Adams, S., Garner, C. C., Tsien, R. Y., Ellisman, M. H., & Malenka, R. C. (2004) · Nature Neuroscience · doi:10.1038/nn1189 · Cited by 541
Structure, development, and plasticity of dendritic spines
Harris, K. M. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80050-6 · Cited by 523
Gao, R., & Penzes, P. (2015) · Current Molecular Medicine · doi:10.2174/1566524015666150303003028 · Cited by 516
“[39] discovered chronic activity blockade with tetrodotoxin (TTX) and bicuculline increased and decreased the amplitude of miniature excitatory postsynaptic currents (mEPSC) respectively in cultured neurons, while drug washout restored firing rates to control levels.”
BackgroundImpaired Spatial Learning after Saturation of Long-Term Potentiation
Moser, E. I., Krobert, K. A., Moser, M.-B., & Morris, R. G. M. (1998) · Science · doi:10.1126/science.281.5385.2038 · Cited by 505
Adaptation to Synaptic Inactivity in Hippocampal Neurons
Thiagarajan, T. C., Lindskog, M., & Tsien, R. W. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.037 · Cited by 496
Morris, R., Moser, E. I., Riedel, G., Martin, S. J., Sandin, J., Day, M., & O’Carroll, C. (2003) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2002.1264 · Cited by 493
Burrone, J., O'Byrne, M., & Murthy, V. N. (2002) · Nature · doi:10.1038/nature01242 · Cited by 487
Phillips, C. (2017) · Neural Plasticity · doi:10.1155/2017/7260130 · Cited by 480
Dopamine: The Neuromodulator of Long-Term Synaptic Plasticity, Reward and Movement Control
Speranza, L., di Porzio, U., Viggiano, D., Donato, A. D., & Volpicelli, F. (2021) · Cells · doi:10.3390/cells10040735 · Cited by 472
Cytokines and brain excitability
Galic, M. A., Riazi, K., & Pittman, Q. J. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.12.002 · Cited by 462
The Impact of Studying Brain Plasticity
Mateos‐Aparicio, P., & Moreno, A. R. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00066 · Cited by 465
An integrative model of tinnitus based on a central gain controlling neural sensitivity
Noreña, A. J. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.11.003 · Cited by 460
Plasticity of Cortical Excitatory-Inhibitory Balance
Froemke, R. C. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-034002 · Cited by 458
A history of spike-timing-dependent plasticity
Markram, H. (2011) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2011.00004 · Cited by 454
Synaptic activity at calcium-permeable AMPA receptors induces a switch in receptor subtype
Liu, S. J., & Cull-Candy, S. G. (2000) · Nature · doi:10.1038/35013064 · Cited by 452
Rutherford, L. C., Nelson, S. B., & Turrigiano, G. G. (1998) · Neuron · doi:10.1016/s0896-6273(00)80563-2 · Cited by 451
Self-citationRole of ampa receptor endocytosis in synaptic plasticity
Carroll, R. C., Beattie, E. C., von Zastrow, M., & Malenka, R. C. (2001) · Nature Reviews Neuroscience · doi:10.1038/35072500 · Cited by 448
Rapid Synaptic Scaling Induced by Changes in Postsynaptic Firing
Ibata, K., Sun, Q., & Turrigiano, G. G. (2008) · Neuron · doi:10.1016/j.neuron.2008.02.031 · Cited by 446
Self-citationAuditory plasticity and hyperactivity following cochlear damage
Salvi, R., Wang, J., & Ding, D. (2000) · Hearing Research · doi:10.1016/s0378-5955(00)00136-2 · Cited by 443
The origin of spontaneous activity in developing networks of the vertebrate nervous system
O'Donovan, M. J. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80012-9 · Cited by 439
Postnatal synaptic potentiation: delivery of GluR4-containing AMPA receptors by spontaneous activity
Zhu, J. J., Esteban, J. A., Hayashi, Y., & Malinow, R. (2000) · Nature Neuroscience · doi:10.1038/80614 · Cited by 437
Emerging concepts in the physiological basis of dystonia
Quartarone, A., & Hallett, M. (2013) · Movement Disorders · doi:10.1002/mds.25532 · Cited by 432
Marom, S., & Shahaf, G. (2002) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583501003742 · Cited by 432
Selective reconfiguration of layer 4 visual cortical circuitry by visual deprivation
Maffei, A., Nelson, S. B., & Turrigiano, G. G. (2004) · Nature Neuroscience · doi:10.1038/nn1351 · Cited by 415
Self-citationLearning in Networks of Cortical Neurons
Shahaf, G., & Marom, S. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-22-08782.2001 · Cited by 403
O’Donnell, J., Zeppenfeld, D., McConnell, E., Pena, S., & Nedergaard, M. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0818-x · Cited by 399
Synaptic Signaling by All-Trans Retinoic Acid in Homeostatic Synaptic Plasticity
Aoto, J., Nam, C. I., Poon, M. M., Ting, P., & Chen, L. (2008) · Neuron · doi:10.1016/j.neuron.2008.08.012 · Cited by 397
Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons
Liao, D., Zhang, X., O’Brien, R., Ehlers, M., & Huganir, R. L. (1999) · Nature Neuroscience · doi:10.1038/4540 · Cited by 396
Opp, M. R. (2005) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.01.002 · Cited by 393
Molecular mechanisms of epilepsy
Staley, K. J. (2015) · Nature Neuroscience · doi:10.1038/nn.3947 · Cited by 387
Mechanisms Underlying the Rapid Induction and Sustained Expression of Synaptic Homeostasis
Frank, C. A., Kennedy, M. J., Goold, C. P., Marek, K. W., & Davis, G. W. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.029 · Cited by 384
Jones, E. G. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.1 · Cited by 380
Synaptic Dynamics in Analog VLSI
Bartolozzi, C., & Indiveri, G. (2007) · Neural Computation · doi:10.1162/neco.2007.19.10.2581 · Cited by 377
The role of AMPA receptors in postsynaptic mechanisms of synaptic plasticity
Chater, T. E., & Goda, Y. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00401 · Cited by 377
Network Homeostasis and State Dynamics of Neocortical Sleep
Watson, B. O., Levenstein, D., Greene, J. P., Gelinas, J. N., & Buzsáki, G. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.036 · Cited by 375
Neocortical seizures: initiation, development and cessation
Timofeev, I., & Steriade, M. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.08.051 · Cited by 374
Functional Convergence of Neurons Generated in the Developing and Adult Hippocampus
Laplagne, D. A., Esposito, M. S., Piatti, V. C., Morgenstern, N. A., Zhao, C., van Praag, H., Gage, F. H., & Schinder, A. F. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040409 · Cited by 373
Montgomery, S. L., & Bowers, W. J. (2011) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9287-2 · Cited by 372
Metadata
- Authors
- Turrigiano, G. G., Leslie, K. R., Desai, N. S., Rutherford, L. C., & Nelson, S. B.
- Affiliations
- Brandeis University (US)
- Corresponding author
- Turrigiano, Gina G.
- Venue
- Nature
- Published
- 1998-02
- Volume
- 391
- Issue
- 6670
- Pages
- 892-896
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1514853588
- Semantic Scholar
- a2bfdaf93cc88c5d56c9b08b910e2e9e1fcfed40
- Cited by
- 2,226
- References
- 30
- Citations by year
- 2026: 53 · 2025: 96 · 2024: 86 · 2023: 76 · 2022: 91 · 2021: 107 · 2020: 110 · 2019: 89 · 2018: 101 · 2017: 97 · 2016: 74 · 2015: 115 · 2014: 91 · 2013: 118 · 2012: 84
- FWCI
- 18.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- synaptic scaling, miniature excitatory postsynaptic currents, neocortical neurons, synaptic plasticity, GABAergic inhibition, glutamate response, firing rate, Hebbian learning, synaptic competition, long-term potentiation and depression, cortical development
- MeSH terms
- Animals, Bicuculline, Cells, Cultured, Membrane Potentials, Synaptic Transmission, Neuronal Plasticity, Tetrodotoxin, Visual Cortex, 2-Amino-5-phosphonovalerate, Receptors, N-Methyl-D-Aspartate, Pyramidal Cells, alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid, Excitatory Amino Acid Antagonists, Glutamic Acid, GABA Antagonists, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
