Cited by 560Circadian rhythm and melatoninSleep and Work-Related FatigueImpact of Light on Environment and Health

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Dose-response relationships for resetting of human circadian clock by light

Boivin, Diane B., Duffy, Jeanne F., Kronauer, Richard E., Czeisler, Charles A.·1996·Nature

Open this paper in CoChat — free account

Abstract

Since the first report in unicells, studies across diverse species have demonstrated that light is a powerful synchronizer which resets, in an intensity-dependent manner, endogenous circadian pacemakers. Although it is recognized that bright light (approximately 7,000 to 13,000 lux) is an effective circadian synchronizer in humans, it is widely believed that the human circadian pacemaker is insensitive to ordinary indoor illumination (approximately 50-300 lux). It has been proposed that the relationship between the resetting effect of light and its intensity follows a compressive nonlinear function, such that exposure to lower illuminances still exerts a robust effect. We therefore undertook a series of experiments which support this hypothesis and report here that light of even relatively low intensity (approximately 180 lux) significantly phase-shifts the human circadian pacemaker. Our results clearly demonstrate that humans are much more sensitive to light than initially suspected and support the conclusion that they are not qualitatively different from other mammals in their mechanism of circadian entrainment.

Integrity signals

Registry

Crossref · 10.1038/379540a0

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Bright Light Induction of Strong (Type 0) Resetting of the Human Circadian Pacemaker
Czeisler, C. A., Kronauer, R. E., Allan, J. S., Duffy, J. F., Jewett, M. E., Brown, E. N., & Ronda, J. M. (1989) · Science · doi:10.1126/science.2734611 · Cited by 946
Self-citation
Bright light resets the human circadian pacemaker independent of the timing of the sleep-wake cycle
Czeisler, C. A., Allan, J. S., Strogatz, S. H., Ronda, J. M., Sánchez, R., Ríos, C. D., Freitag, W. O., Richardson, G. S., & Kronauer, R. E. (1986) · Science · doi:10.1126/science.3726555 · Cited by 770
Self-citation
A human phase-response curve to light
Minors, D. S., Waterhouse, J. M., & Wirz‐Justice, A. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90051-t · Cited by 640
Spectral sensitivity of a novel photoreceptive system mediating entrainment of mammalian circadian rhythms
Takahashi, J. S., DeCoursey, P. J., Bauman, L., & Menaker, M. (1984) · Nature · doi:10.1038/308186a0 · Cited by 528
Human Melatonin Suppression by Light is Intensity Dependent
Mclntyre, I. M., Norman, T. R., Burrows, G. D., & Armstrong, S. M. (1989) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1989.tb00412.x · Cited by 389
Integrated view of resetting a circadian clock
Winfree, A. T. (1970) · Journal of Theoretical Biology · doi:10.1016/0022-5193(70)90075-5 · Cited by 350
Sensitivity and integration in a visual pathway for circadian entrainment in the hamster (Mesocricetus auratus).
Nelson, D. E., & Takahashi, J. S. (1991) · The Journal of Physiology · doi:10.1113/jphysiol.1991.sp018660 · Cited by 316
Light-induced suppression of endogenous circadian amplitude in humans
Jewett, M. E., Kronauer, R. E., & Czeisler, C. A. (1991) · Nature · doi:10.1038/350059a0 · Cited by 253
Self-citation
A PERSISTENT DIURNAL RHYTHM OF LUMINESCENCE IN GONYAULAX POLYEDRA
Hastings, J. W., & Sweeney, B. M. (1958) · Biological Bulletin · doi:10.2307/1539108 · Cited by 249
ENTRAINMENT OF HUMAN ORCADIAN RHYTHMS BY LIGHT-DARK CYCLES: A REASSESSMENT
Czeisler, C. A., Richardson, G. S., Zimmerman, J. C., Moore‐Ede, M. C., & Weitzman, E. D. (1981) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1981.tb08993.x · Cited by 243
Self-citation

Flagged first, then by citations

Show all 24 references

Research works printed but not linked: 11

Van Cauter, E. et al. Am. J. Physiol. 266, E953–E963 (1994).
Honma, K. & Honma, S. Jap. J. Psych. Neurol. 42, 167–168 (1988).
Kronauer, R. E. Sleep Res. (abstract) 16, 621 (1987).
Klerman, E. B., Dijk, D.-J., Kronauer, R. E. & Czeisler, C. A. Am. J. Physiol. 39, R271–R282 (1996).
Kronauer, R. E., Duffy, J. F. & Czeisler, C. A. Sleep Res. 22, 626 (1993).
Allan, J. S., Czeisler, C. A., Duffy, J. F. & Kronauer, R. E. 154th Ann. A.A.A.S. Meeting 208, 101 (1988).
Campbell, S. S., Dawson, D. & Zulley, J. Sleep 16, 638–640 (1993).
Czeisler, C. A. et al. Sleep Res. (abstract) 24, 505 (1995).
Gaddy, J. R., Rollag, M. D. & Brainard, G. C. J. clin. Endocrin. Metab. 77, 1398–1401 (1993).
Wehr, T. A., Giesen, H. A., Moul, D. E., Turner, E. H. & Schwartz, P. J. Am J. Physiol. 269, 173–178 (1995).
Honma, K.-I. et al. Am. J. Physiol. 268, R528–R535 (1995).

Sorted by citations

Sleep Patterns and Predictors of Disturbed Sleep in a Large Population of College Students
Lund, H. G., Reider, B. D., Whiting, A. B., & Prichard, J. R. (2010) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2009.06.016 · Cited by 1,907
Stability, precision, and near-24-hour period of the human circadian pacemaker
Czeisler, C. A., Duffy, J. F., Shanahan, T. L., Brown, E. N., Mitchell, J. F., Rimmer, D. W., Ronda, J. M., Silva, E. J., Allan, J. S., Emens, J. S., et al. (1999) · Science · doi:10.1126/science.284.5423.2177 · Cited by 1,705
Self-citation
Insufficient Sleep in Adolescents and Young Adults: An Update on Causes and Consequences
Owens, J., ADOLESCENT SLEEP WORKING GROUP, COMMITTEE ON ADOLESCENCE, Au, R., Carskadon, M., Millman, R., Wolfson, A., Braverman, P. K., Adelman, W. P., Breuner, C. C., et al. (2014) · Pediatrics · doi:10.1542/peds.2014-1696 · Cited by 1,413
An action spectrum for melatonin suppression: evidence for a novel non‐rod, non‐cone photoreceptor system in humans
Thapan, K., Arendt, J., & Skene, D. J. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.t01-1-00261.x · Cited by 1,320
Sensitivity of the human circadian pacemaker to nocturnal light: melatonin phase resetting and suppression
Zeitzer, J. M., Dijk, D., Kronauer, R. E., Brown, E. N., & Czeisler, C. A. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00695.x · Cited by 1,175
Self-citation
Sleep, circadian rhythms, and delayed phase in adolescence
Crowley, S. J., Acebo, C., & Carskadon, M. A. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2006.12.002 · Cited by 1,127
High Sensitivity of Human Melatonin, Alertness, Thermoregulation, and Heart Rate to Short Wavelength Light
Cajochen, C., Münch, M., Kobialka, S., Kräuchi, K., Steiner, R., Oelhafen, P., Orgül, S., & Wirz-Justice, A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0957 · Cited by 939
Shift Work Sleep Disorder: Prevalence and Consequences Beyond that of Symptomatic Day Workers
Drake, C. L., Roehrs, T., Richardson, G., Walsh, J. K., & Roth, T. (2004) · Sleep · doi:10.1093/sleep/27.8.1453 · Cited by 860
Rhythms of life: circadian disruption and brain disorders across the lifespan
Logan, R. W., & McClung, C. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0088-y · Cited by 713
Dose-response relationship for light intensity and ocular and electroencephalographic correlates of human alertness
Cajochen, C., Zeitzer, J. M., Czeisler, C. A., & Dijk, D.-J. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00236-9 · Cited by 653
Self-citation
Circadian Rhythm Sleep Disorders: Part I, Basic Principles, Shift Work and Jet Lag Disorders
Sack, R. L., Auckley, D., Auger, R. R., Carskadon, M. A., Wright, K. P., Vitiello, M. V., & Zhdanova, I. V. (2007) · Sleep · doi:10.1093/sleep/30.11.1460 · Cited by 650
Sex difference in the near-24-hour intrinsic period of the human circadian timing system
Duffy, J. F., Cain, S. W., Chang, A., Phillips, A. J. K., Münch, M. Y., Gronfier, C., Wyatt, J. K., Dijk, D., Wright, K. P., & Czeisler, C. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010666108 · Cited by 601
Self-citation
Light activates the adrenal gland: Timing of gene expression and glucocorticoid release
Ishida, A., Mutoh, T., Ueyama, T., Bando, H., Masubuchi, S., Nakahara, D., Tsujimoto, G., & Okamura, H. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.009 · Cited by 589
Exposure to Room Light before Bedtime Suppresses Melatonin Onset and Shortens Melatonin Duration in Humans
Gooley, J. J., Chamberlain, K., Smith, K. A., Khalsa, S. B. S., Rajaratnam, S. M. W., Van Reen, E., Zeitzer, J. M., Czeisler, C. A., & Lockley, S. W. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2098 · Cited by 565
Self-citation
Disturbance of the Circadian System in Shift Work and Its Health Impact
Boivin, D. B., Boudreau, P., & Kosmadopoulos, A. (2021) · Journal of Biological Rhythms · doi:10.1177/07487304211064218 · Cited by 580
Self-citation
Depression scores associate with chronotype and social jetlag in a rural population
Levandovski, R., Dantas, G., Fernandes, L. C., Caumo, W., Torres, I., Roenneberg, T., Hidalgo, M. P. L., & Allebrandt, K. V. (2011) · Chronobiology International · doi:10.3109/07420528.2011.602445 · Cited by 527
Entrainment of the human circadian system by light
Duffy, J. F., & Wright, K. P. (2005) · Journal of Biological Rhythms · doi:10.1177/0748730405277983 · Cited by 515
Self-citation
Shift work and cancer risk: potential mechanistic roles of circadian disruption, light at night, and sleep deprivation
Haus, E. L., & Smolensky, M. H. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.08.003 · Cited by 499
Effect of Light on Human Circadian Physiology
Duffy, J. F., & Czeisler, C. A. (2009) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2009.01.004 · Cited by 477
Self-citation
The Effects of Light at Night on Circadian Clocks and Metabolism
Fonken, L. K., & Nelson, R. J. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1051 · Cited by 494
Sleep Deprivation in Critical Illness
Kamdar, B. B., Needham, D. M., & Collop, N. A. (2011) · Journal of Intensive Care Medicine · doi:10.1177/0885066610394322 · Cited by 477
High sensitivity and interindividual variability in the response of the human circadian system to evening light
Phillips, A. J. K., Vidafar, P., Burns, A. C., McGlashan, E. M., Anderson, C., Rajaratnam, S. M. W., Lockley, S. W., & Cain, S. W. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901824116 · Cited by 430
Sleep and Circadian Rhythms in Humans
Czeisler, C. A., & Gooley, J. J. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.064 · Cited by 425
Self-citation
Dim light melatonin onset (DLMO): A tool for the analysis of circadian phase in human sleep and chronobiological disorders
Pandi-Perumal, S. R., Smits, M. G., Spence, W., Srinivasan, V., Cardinali, D. P., Lowe, A. D., & Kayumov, L. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.06.020 · Cited by 416
Sleep timing and quantity in ecological and family context: a nationally representative time-diary study
Adam, E. K., Snell, E. K., & Pendry, P. (2007) · Journal of Family Psychology · doi:10.1037/0893-3200.21.1.4 · Cited by 405
Healthy, natural, efficient and tunable lighting: four-package white LEDs for optimizing the circadian effect, color quality and vision performance
Oh, J. H., Yang, S. J., & Rag, Y. (2014) · Light Science & Applications · doi:10.1038/lsa.2014.22 · Cited by 405
Social influences on mammalian circadian rhythms: animal and human studies
Mistlberger, R. E., & Skene, D. J. (2004) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1017/s1464793103006353 · Cited by 402
Daytime Exposure to Bright Light, as Compared to Dim Light, Decreases Sleepiness and Improves Psychomotor Vigilance Performance
Phipps-Nelson, J., Redman, J. R., Dijk, D.-J., & Rajaratnam, S. M. W. (2003) · Sleep · doi:10.1093/sleep/26.6.695 · Cited by 394
CONTRIBUTION OF CIRCADIAN PHYSIOLOGY AND SLEEP HOMEOSTASIS TO AGE-RELATED CHANGES IN HUMAN SLEEP
Dijk, D., Duffy, J. F., & Czeisler, C. A. (2000) · Chronobiology International · doi:10.1081/cbi-100101049 · Cited by 373
Self-citation
Effects of playing a computer game using a bright display on presleep physiological variables, sleep latency, slow wave sleep and REM sleep
Higuchi, S., Motohashi, Y., Liu, Y., & MAEDA, A. (2005) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2005.00463.x · Cited by 358
The Human Circadian Clock's Seasonal Adjustment Is Disrupted by Daylight Saving Time
Kantermann, T., Juda, M., Merrow, M. W., & Roenneberg, T. (2007) · Current Biology · doi:10.1016/j.cub.2007.10.025 · Cited by 357
Comparisons of the Variability of Three Markers of the Human Circadian Pacemaker
Klerman, E. B., Gershengorn, H. B., Duffy, J. F., & Kronauer, R. E. (2002) · Journal of Biological Rhythms · doi:10.1177/074873002129002474 · Cited by 350
Self-citation
Later endogenous circadian temperature nadir relative to an earlier wake time in older people
Duffy, J. F., Dijk, D., Klerman, E. B., & Czeisler, C. A. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.5.r1478 · Cited by 318
Self-citation
Relationship between Melatonin Rhythms and Visual Loss in the Blind
Lockley, S. W., Skene, D. J., Arendt, J., Tabandeh, H., Bird, A. C., & Defrance, R. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.11.4355 · Cited by 312
Human responses to bright light of different durations
Chang, A., Santhi, N., St Hilaire, M., Gronfier, C., Bradstreet, D. S., Duffy, J. F., Lockley, S. W., Kronauer, R. E., & Czeisler, C. A. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.226555 · Cited by 295
Self-citation
Health Consequences of Circadian Disruption in Humans and Animal Models
Evans, J. A., & Davidson, A. J. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00010-5 · Cited by 291
Nonphotic Entrainment in Humans?
Mistlberger, R. E., & Skene, D. J. (2005) · Journal of Biological Rhythms · doi:10.1177/0748730405277982 · Cited by 267
Endophenotypes in bipolar disorder
Lenox, R. H., Gould, T. D., & Manji, H. K. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10360 · Cited by 264
Human circadian phase–response curves for exercise
Youngstedt, S. D., Elliott, J. A., & Kripke, D. F. (2019) · The Journal of Physiology · doi:10.1113/jp276943 · Cited by 263
Illumination levels in nursing home patients: effects on sleep and activity rhythms
Shochat, T., Martin, J., Marler, M., & Ancoli‐Israel, S. (2000) · Journal of Sleep Research · doi:10.1046/j.1365-2869.2000.00221.x · Cited by 262
Heritability of cortisol levels: review and simultaneous analysis of twin studies
Bartels, M., den Berg, M. V., Sluyter, F., Boomsma, D. I., & de Geus, E. J. C. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00003-3 · Cited by 259
Adaptation of Human Pineal Melatonin Suppression by Recent Photic History
Smith, K. A., Schoen, M. W., & Czeisler, C. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032100 · Cited by 256
Self-citation
Intrinsic near-24-h pacemaker period determines limits of circadian entrainment to a weak synchronizer in humans
Wright, K. P., Hughes, R. J., Kronauer, R. E., Dijk, D., & Czeisler, C. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.201530198 · Cited by 260
Self-citation
Influence of sleep-wake and circadian rhythm disturbances in psychiatric disorders.
Boivin, D. B. (2000) · PubMed Central · Cited by 247
Self-citation
Light in the Built Environment: Potential role of Circadian Disruption in Endocrine Disruption and Breast Cancer
Stevens, R. G., & Rea, M. S. (2001) · Cancer Causes & Control · doi:10.1023/a:1011237000609 · Cited by 245
Developing Circadian Rhythmicity in Infants
Rivkees, S. A. (2003) · PEDIATRICS · doi:10.1542/peds.112.2.373 · Cited by 243
Phase‐shifting human circadian rhythms: influence of sleep timing, social contact and light exposure.
Duffy, J. F., Kronauer, R. E., & Czeisler, C. A. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021593 · Cited by 234
Self-citation
Melanopsin as a Sleep Modulator: Circadian Gating of the Direct Effects of Light on Sleep and Altered Sleep Homeostasis in Opn4−/− Mice
Tsai, J. W., Hannibal, J., Hagiwara, G., Colas, D., Ruppert, É., Ruby, N. F., Heller, H. C., Franken, P., & Bourgin, P. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000125 · Cited by 226
A Review of Human Physiological Responses to Light: Implications for the Development of Integrative Lighting Solutions
Vetter, C., Pattison, P. M., Houser, K. W., Herf, M., Phillips, A. J. K., Wright, K. P., Skene, D. J., Brainard, G. C., Boivin, D. B., & Glickman, G. L. (2021) · LEUKOS The Journal of the Illuminating Engineering Society of North America · doi:10.1080/15502724.2021.1872383 · Cited by 243
Self-citation
Women's sleep in health and disease
Dzaja, A., Arber, S., Hislop, J., Kerkhofs, M., Kopp, C., Pollmächer, T., Polo‐Kantola, P., Skene, D. J., Stenuit, P., Tobler, I., et al. (2004) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2004.05.008 · Cited by 227
Aerial survey and spatial analysis of sources of light pollution in Berlin, Germany
Kuechly, H. U., Kyba, C. C. M., Ruhtz, T., Lindemann, C., Wolter, C., Fischer, J., & Hölker, F. (2012) · Remote Sensing of Environment · doi:10.1016/j.rse.2012.08.008 · Cited by 219
Diminished Melatonin Secretion in the Elderly Caused by Insufficient Environmental Illumination1
Mishima, K., Okawa, M., Shimizu, T., & Hishikawa, Y. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.1.7097 · Cited by 218
Daily exercise facilitates phase delays of circadian melatonin rhythm in very dim light
Barger, L. K., Wright, K. P., Hughes, R. J., & Czeisler, C. A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00397.2003 · Cited by 218
Self-citation
Nonphotic entrainment of the human circadian pacemaker
Klerman, E. B., Rimmer, D. W., Dijk, D., Kronauer, R. E., Rizzo, J. F., & Czeisler, C. A. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.4.r991 · Cited by 217
Self-citation
Working on atypical schedules
Boivin, D. B., Tremblay, G. M., & James, F. O. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2007.03.015 · Cited by 214
Self-citation
Efficacy of a single sequence of intermittent bright light pulses for delaying circadian phase in humans
Gronfier, C., Wright, K. P., Kronauer, R. E., Jewett, M. E., & Czeisler, C. A. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00385.2003 · Cited by 212
Self-citation
Interactive Mathematical Models of Subjective Alertness and Cognitive Throughput in Humans
Jewett, M. E., & Kronauer, R. E. (1999) · Journal of Biological Rhythms · doi:10.1177/074873099129000920 · Cited by 212
Self-citation
Sleep and recovery from critical illness and injury: A review of theory, current practice, and future directions*
Friese, R. S. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181643f29 · Cited by 206
Circadian Adaptation to Night-Shift Work by Judicious Light and Darkness Exposure
Boivin, D. B., & James, F. O. (2002) · Journal of Biological Rhythms · doi:10.1177/0748730402238238 · Cited by 205
Self-citation
Human circadian rhythms: physiological and therapeutic relevance of light and melatonin
Skene, D. J., & Arendt, J. (2006) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/000456306778520142 · Cited by 210
Effects of earplugs and eye masks on nocturnal sleep, melatonin and cortisol in a simulated intensive care unit environment
Hu, R.-F., Jiang, X.-Y., Zeng, Y.-M., Chen, X.-Y., & Zhang, Y.-H. (2010) · Critical Care · doi:10.1186/cc8965 · Cited by 198
Sleep, hormones, and circadian rhythms throughout the menstrual cycle in healthy women and women with premenstrual dysphoric disorder
Shechter, A., & Boivin, D. B. (2010) · International Journal of Endocrinology · doi:10.1155/2010/259345 · Cited by 194
Self-citation
Quantifying Human Circadian Pacemaker Response to Brief, Extended, and Repeated Light Stimuli over the Phototopic Range
Kronauer, R. E., Forger, D. B., & Jewett, M. E. (1999) · Journal of Biological Rhythms · doi:10.1177/074873099129001073 · Cited by 187
Self-citation
Sleep-Wake as a Biological Rhythm
Lavie, P. (2001) · Annual Review of Psychology · doi:10.1146/annurev.psych.52.1.277 · Cited by 186
How to use light and dark to produce circadian adaptation to night shift work
Eastman, C. I., & Martin, S. K. (1999) · Annals of Medicine · doi:10.3109/07853899908998783 · Cited by 180
Phase-advance shifts of human circadian pacemaker are accelerated by daytime physical exercise
Miyazaki, T., Hashimoto, S., Masubuchi, S., Honma, S., & Honma, K. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.1.r197 · Cited by 178
Melatonin as a biomarker of circadian dysregulation
Mirick, D. K., & Davis, S. (2008) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0605 · Cited by 176
Effects of one night's sleep deprivation on anaerobic performance the following day
Souissi, N., Sesboüé, B., Gauthier, A., Larue, J., & Davenne, D. (2003) · European Journal of Applied Physiology · doi:10.1007/s00421-003-0793-7 · Cited by 175
Sleep-Facilitating Effect of Exogenous Melatonin in Healthy Young Men and Women Is Circadian-Phase Dependent
Wyatt, J. K., Dijk, D., Cecco, A. R.-D., Ronda, J. M., & Czeisler, C. A. (2006) · SLEEP · doi:10.1093/sleep/29.5.609 · Cited by 177
Self-citation
Revised Limit Cycle Oscillator Model of Human Circadian Pacemaker
Jewett, M. E., Forger, D. B., & Kronauer, R. E. (1999) · Journal of Biological Rhythms · doi:10.1177/074873049901400608 · Cited by 171
Self-citation
Amplitude Reduction and Phase Shifts of Melatonin, Cortisol and Other Circadian Rhythms after a Gradual Advance of Sleep and Light Exposure in Humans
Dijk, D.-J., Duffy, J. F., Silva, E. J., Shanahan, T. L., Boivin, D. B., & Czeisler, C. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030037 · Cited by 170
Self-citation
InP colloidal quantum dots for visible and near-infrared photonics
Almeida, G., Ubbink, R. F., Stam, M., du Fossé, I., & Houtepen, A. J. (2023) · Nature Reviews Materials · doi:10.1038/s41578-023-00596-4 · Cited by 170
Light and Diurnal Cycle Affect Human Heart Rate: Possible Role for the Circadian Pacemaker
Scheer, F. A. J. L., van Doornen, L. J. P., & Buijs, R. M. (1999) · Journal of Biological Rhythms · doi:10.1177/074873099129000614 · Cited by 170
Human circadian pacemaker is sensitive to light throughout subjective day without evidence of transients
Jewett, M. E., Rimmer, D. W., Duffy, J. F., Klerman, E. B., Kronauer, R. E., & Czeisler, C. A. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.273.5.r1800 · Cited by 168
Self-citation
Exercise as a synchroniser of human circadian rhythms: an update and discussion of the methodological problems
Atkinson, G., Edwards, B., Reilly, T., & Waterhouse, J. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-006-0361-z · Cited by 167
Alerting effects of light are sensitive to very short wavelengths
Revell, V. L., Arendt, J., Fogg, L., & Skene, D. J. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.01.032 · Cited by 173
Circadian disrupting exposures and breast cancer risk: a meta-analysis
He, C., Anand, S. T., Ebell, M. H., Vena, J. E., & Robb, S. W. (2015) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-014-0986-x · Cited by 165
Profile of 24-h Light Exposure and Circadian Phase of Melatonin Secretion in Night Workers
Dumont, M., Benhaberou-Brun, D., & Paquet, J. (2001) · Journal of Biological Rhythms · doi:10.1177/074873001129002178 · Cited by 162
Can light make us bright? Effects of light on cognition and sleep
Chellappa, S. L., Gordijn, M. C. M., & Cajochen, C. (2011) · Progress in brain research · doi:10.1016/b978-0-444-53817-8.00007-4 · Cited by 157
The Role of Daylight for Humans: Gaps in Current Knowledge
Münch, M. Y., Wirz‐Justice, A., Brown, S. A., Kantermann, T., Martiny, K., Stefani, O., Vetter, C., Wright, K. P., Wulff, K., & Skene, D. J. (2020) · Clocks & Sleep · doi:10.3390/clockssleep2010008 · Cited by 168
Access to Electric Light Is Associated with Shorter Sleep Duration in a Traditionally Hunter-Gatherer Community
de la Iglesia, H. O., Fernández-Duque, E., Golombek, D. A., Lanza, N., Duffy, J. F., Czeisler, C. A., & Valeggia, C. R. (2015) · Journal of Biological Rhythms · doi:10.1177/0748730415590702 · Cited by 156
Self-citation
Rest-Activity Patterns of Premature Infants Are Regulated by Cycled Lighting
Rivkees, S. A., Mayes, L., Jacobs, H., & Gross, I. (2004) · Pediatrics · doi:10.1542/peds.113.4.833 · Cited by 155
Circadian regulation of human sleep and age-related changes in its timing, consolidation and EEG characteristics
Dijk, D., & Duffy, J. F. (1999) · Annals of Medicine · doi:10.3109/07853899908998789 · Cited by 155
Self-citation
Preflight Adjustment to Eastward Travel:3 Days of Advancing Sleep with and without Morning Bright Light
Burgess, H. J., Crowley, S. J., Gazda, C. J., Fogg, L., & Eastman, C. I. (2003) · Journal of Biological Rhythms · doi:10.1177/0748730403253585 · Cited by 154
Venom Proteomes of Closely RelatedSistrurusRattlesnakes with Divergent Diets
Sanz, L., Gibbs, H. L., Mackessy, S. P., & Calvete, J. J. (2006) · Journal of Proteome Research · doi:10.1021/pr0602500 · Cited by 151
Endogenous Circadian Rhythm of Pulmonary Function in Healthy Humans
Spengler, C. M., & Shea, S. A. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.3.9911107 · Cited by 147
Plasticity of the Intrinsic Period of the Human Circadian Timing System
Scheer, F. A. J. L., Wright, K. P., Kronauer, R. E., & Czeisler, C. A. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000721 · Cited by 146
Self-citation
Lighting, sleep and circadian rhythm: An intervention study in the intensive care unit
Engwall, M., Fridh, I., Johansson, L., Bergbom, I., & Lindahl, B. (2015) · Intensive and Critical Care Nursing · doi:10.1016/j.iccn.2015.07.001 · Cited by 146
Sleep in the Intensive Care Unit
Pulak, L. M., & Jensen, L. A. (2014) · Journal of Intensive Care Medicine · doi:10.1177/0885066614538749 · Cited by 154
History of the Development of Sleep Medicine in the United States
Shepard, J., Buysse, D. J., Chesson, A. L., Dement, W. C., Goldberg, R., Guilleminault, C., Harris, C., Iber, C., Mignot, E. J.-M., Mitler, M. M., et al. (2005) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.26298 · Cited by 150
Disruption of Circadian Rhythms: A Crucial Factor in the Etiology of Depression
Salgado‐Delgado, R., Osorio, A. T., Saderi, N., & Escobar, C. (2011) · Depression Research and Treatment · doi:10.1155/2011/839743 · Cited by 148
Seasonal and Diurnal Patterns of Human Illumination Under Natural Conditions
Hubert, M., Dumont, M., & Paquet, J. (1998) · Chronobiology International · doi:10.3109/07420529808998670 · Cited by 144
Jet-lag
Waterhouse, J. M., Reilly, T. P., & Atkinson, G. (1997) · The Lancet · doi:10.1016/s0140-6736(97)07569-7 · Cited by 144
Dynamic resetting of the human circadian pacemaker by intermittent bright light
Rimmer, D. W., Boivin, D. B., Shanahan, T. L., Kronauer, R. E., Duffy, J. F., & Czeisler, C. A. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.5.r1574 · Cited by 139
Self-citation
Efficacy of bright light and sleep/darkness scheduling in alleviating circadian maladaptation to night work
Horowitz, T. S., Cade, B. E., Wolfe, J. M., & Czeisler, C. A. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.2.e384 · Cited by 133
Self-citation
Direct Effects of Light on Alertness, Vigilance, and the Waking Electroencephalogram in Humans Depend on Prior Light History
Chang, A.-M., Scheer, F. A. J. L., Czeisler, C. A., & Aeschbach, D. (2013) · Sleep · doi:10.5665/sleep.2894 · Cited by 131
Self-citation
Melatonin and Human Chronobiology
Lewy, A. J. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.055 · Cited by 129
Sleeping on a problem: the impact of sleep disturbance on intensive care patients - a clinical review
Delaney, L., van Haren, F. M. P., & López, V. (2015) · Annals of Intensive Care · doi:10.1186/s13613-015-0043-2 · Cited by 129
Novel Approaches for Assessing Circadian Rhythmicity in Humans: A Review
Dijk, D., & Duffy, J. F. (2020) · Journal of Biological Rhythms · doi:10.1177/0748730420940483 · Cited by 138
Self-citation
Non-24-Hour Sleep-Wake Syndrome in a Sighted Man: Circadian Rhythm Studies and Efficacy of Melatonin Treatment
McArthur, A. J., Lewy, A. J., & Sack, R. L. (1996) · SLEEP · doi:10.1093/sleep/19.7.544 · Cited by 127

Authors: Boivin, D. B., Duffy, J. F., Kronauer, R. E., & Czeisler, C. A.
Affiliations: Brigham and Women's Hospital (US)
ORCID: Boivin, Diane B.
Duffy, Jeanne F.
Czeisler, Charles A.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1996-02
Volume: 379
Issue: 6565
Pages: 540-542
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/379540a0
OpenAlex: W2072214097
Cited by: 559
References: 24
Citations by year: 2026: 12 · 2025: 14 · 2024: 10 · 2023: 12 · 2022: 32 · 2021: 24 · 2020: 25 · 2019: 25 · 2018: 13 · 2017: 16 · 2016: 20 · 2015: 18 · 2014: 20 · 2013: 14 · 2012: 24
FWCI: 7.84
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Physical Sciences › Environmental Science › Global and Planetary Change › Impact of Light on Environment and Health
Keywords: circadian clock, light exposure, phase shift, circadian entrainment, light intensity, dose-response relationship, indoor lighting, photosensitivity
MeSH terms: Adult, Body Temperature, Circadian Rhythm, Dose-Response Relationship, Radiation, Humans, Light, Male

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Dose-response relationships for resetting of human circadian clock by light

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks