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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
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“p-IRE1 splices XBP1 mRNA to generate the transcription factor sXBP that enhances chaperones and genes expression involved in ER expansion, ERAD, autophagy, and cytoprotection, also reducing ER load through a RIDD-dependent mRNA degradation [325].”
BackgroundMannan, M. A.-U., Shadrick, W. R., Biener, G., Shin, B.-S., Anshu, A., Raicu, V., Frick, D. N., & Dey, M. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.02.036 · Cited by 18
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Dabsan, S., Zur, G., Abu-Freha, N., Sofer, S., Grossman-Haham, I., Gilad, A., & Igbaria, A. (2025) · eLife · doi:10.7554/elife.102658 · Cited by 10
Ranjan, K. (2020) · Gastrointestinal Disorders · doi:10.3390/gidisord2030024 · Cited by 6
Structural dynamics of IRE1 and its interaction with unfolded peptides
Spinetti, E., Ścibisz, G., Karagöz, G. E., & Covino, R. (2026) · eLife · doi:10.7554/elife.106716
Metadata
- Authors
- Calfon, M., Zeng, H., Urano, F., Till, J. H., Hubbard, S. R., Harding, H. P., Clark, S. G., & Ron, D.
- Venue
- Nature
- Published
- 2002-01-03
- Volume
- 415
- Issue
- 6867
- Pages
- 92-96
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1986737010
- Cited by
- 2,820
- References
- 3
- FWCI
- 27.31
- Type
- journal article
- Language
- en
- Open access
- closed
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