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Cited by 1,533

The DOI matches its Crossref record; 143 of the 143 references it cites were found in a registry or an index.

Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus

Open access
Foster, Timothy J., Geoghegan, Joan A., Ganesh, Vannakambadi K., Höök, Magnus·2014·Nature Reviews Microbiology

Abstract

Staphylococcus aureus is an important opportunistic pathogen and persistently colonizes about 20% of the human population. Its surface is 'decorated' with proteins that are covalently anchored to the cell wall peptidoglycan. Structural and functional analysis has identified four distinct classes of surface proteins, of which microbial surface component recognizing adhesive matrix molecules (MSCRAMMs) are the largest class. These surface proteins have numerous functions, including adhesion to and invasion of host cells and tissues, evasion of immune responses and biofilm formation. Thus, cell wall-anchored proteins are essential virulence factors for the survival of S. aureus in the commensal state and during invasive infections, and targeting them with vaccines could combat S. aureus infections.

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Crossref · 10.1038/nrmicro3161

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Metadata

Authors
Foster, T. J., Geoghegan, J. A., Ganesh, V. K., & Höök, M.
Venue
Nature Reviews Microbiology
Published
2013-12-16
Volume
12
Issue
1
Pages
49-62
ISSN
  • 1740-1526 (ISSN-L)
  • 1740-1534
OpenAlex
W1973675012
Cited by
1,533
References
143
FWCI
11.84
Type
journal article
Language
en
Open access
green

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