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Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus
Open accessAbstract
Staphylococcus aureus is an important opportunistic pathogen and persistently colonizes about 20% of the human population. Its surface is 'decorated' with proteins that are covalently anchored to the cell wall peptidoglycan. Structural and functional analysis has identified four distinct classes of surface proteins, of which microbial surface component recognizing adhesive matrix molecules (MSCRAMMs) are the largest class. These surface proteins have numerous functions, including adhesion to and invasion of host cells and tissues, evasion of immune responses and biofilm formation. Thus, cell wall-anchored proteins are essential virulence factors for the survival of S. aureus in the commensal state and during invasive infections, and targeting them with vaccines could combat S. aureus infections.
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“Beyond mechanical adhesion, ClfB modulates host inflammatory responses by interfering with complement activation.”
From Staphylococcus aureus: A Review of the Pathogenesis and Virulence Mechanisms (2025) · cites this paper as [49]
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“This dual function—adhesion and immune evasion—explains why ClfB-knockout strains trigger stronger neutrophil recruitment [49].”
From Staphylococcus aureus: A Review of the Pathogenesis and Virulence Mechanisms (2025) · cites this paper as [49]
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“These investigations have identified key virulence factors, such as MSCRAMMs, which mediate bacterial adherence to host tissues and serve as the critical first step in establishing infection [49].”
From Staphylococcus aureus: A Review of the Pathogenesis and Virulence Mechanisms (2025) · cites this paper as [49]
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Self-citationWalsh, E. J., O'Brien, L. M., Liang, X., Höök, M., & Foster, T. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408713200 · Cited by 119
Self-citationKeane, F. M., Loughman, T., Valtulina, V., Brennan, M., Speziale, P., & Foster, T. J. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05552.x · Cited by 119
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Fibronectin-binding proteins of Gram-positive cocci
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Self-citationSharp, J. A., Echague, C. G., Hair, P. S., Ward, M. D., Nyalwidhe, J. O., Geoghegan, J. A., Foster, T. J., & Cunnion, K. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038407 · Cited by 116
Self-citationSeo, H. S., Mu, R., Kim, B. J., Doran, K. S., & Sullam, P. M. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002947 · Cited by 114
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Geoghegan, J. A., Monk, I. R., O’Gara, J. P., & Foster, T. J. (2013) · Journal of Bacteriology · doi:10.1128/jb.02128-12 · Cited by 111
Self-citationAnderson, A. S., Miller, A. A., Donald, R. G. K., Scully, I. L., Nanra, J. S., Cooper, D., & Jansen, K. U. (2012) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.21872 · Cited by 108
Staphylococcus aureus protein A activates TACE through EGFR‐dependent signaling
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Self-citationClarke, S. R., Andre, G., Walsh, E. J., Dufrêne, Y. F., Foster, T. J., & Foster, S. J. (2009) · Infection and Immunity · doi:10.1128/iai.01304-08 · Cited by 105
Self-citationStructural basis for Zn 2+ -dependent intercellular adhesion in staphylococcal biofilms
Conrady, D. G., Wilson, J. J., & Herr, A. B. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208134110 · Cited by 105
Host- and microbe determinants that may influence the success of S. aureus colonization
Johannessen, M., Sollid, J. E., & Hanssen, A.-M. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00056 · Cited by 105
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Self-citationSarathy, V. V., Liang, X., Horndahl, J. K., Ganesh, V. K., Smeds, E., Foster, T. J., & Höök, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.214981 · Cited by 103
Self-citationGenetic manipulation of Staphylococci—breaking through the barrier
Monk, I. R. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00049 · Cited by 101
Ganesh, V. K., Barbu, E. M., Deivanayagam, C. C. S., Le, B. V., Anderson, A. S., Matsuka, Y. V., Lin, S. L., Foster, T. J., Narayana, S. V. L., & Höök, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.217414 · Cited by 99
Self-citationFlick, M. J., Du, X., Prasad, J. M., Raghu, H., Palumbo, J. S., Smeds, E., Höök, M., & Degen, J. L. (2013) · Blood · doi:10.1182/blood-2012-09-453894 · Cited by 95
Self-citationWalsh, E. J., Miajlović, H., Gorkun, O. V., & Foster, T. J. (2008) · Microbiology · doi:10.1099/mic.0.2007/010868-0 · Cited by 90
Self-citationStaphylococcal biofilm-forming protein has a contiguous rod-like structure
Gruszka, D. T., Wojdyla, J. A., Bingham, R. J., Turkenburg, J. P., Manfield, I. W., Steward, A., Leech, A., Geoghegan, J. A., Foster, T. J., Clarke, J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119456109 · Cited by 89
Self-citationSdrF, a Staphylococcus epidermidis Surface Protein, Binds Type I Collagen
Arrecubieta, C., Lee, M., Macey, A., Foster, T. J., & Lowy, F. D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610940200 · Cited by 89
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Self-citationStaphylococcus aureus clumping factor B mediates biofilm formation in the absence of calcium
Abraham, N. M., & Jefferson, K. K. (2012) · Microbiology · doi:10.1099/mic.0.057018-0 · Cited by 84
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Self-citationSavolainen, K., Paulin, L. G., Westerlund‐Wikström, B., Foster, T. J., Korhonen, T. K., & Kuusela, P. (2001) · Infection and Immunity · doi:10.1128/iai.69.5.3013-3020.2001 · Cited by 79
Self-citationJosefsson, E., O'Connell, D. W., Foster, T. J., Durussel, I., & Cox, J. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.47.31145 · Cited by 78
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Fibronectin-binding protein B variation in Staphylococcus aureus
Burke, F. M., McCormack, N., Rindi, S., Speziale, P., & Foster, T. J. (2010) · BMC Microbiology · doi:10.1186/1471-2180-10-160 · Cited by 75
Self-citationIsdA Protects Staphylococcus aureus against the Bactericidal Protease Activity of Apolactoferrin
Clarke, S. R., & Foster, S. J. (2008) · Infection and Immunity · doi:10.1128/iai.01530-07 · Cited by 75
Immune evasion by Staphylococcus aureus conferred by iron-regulated surface determinant protein IsdH
Visai, L., Yanagisawa, N., Josefsson, E., Tarkowski, A., Pezzali, I., Rooijakkers, S. H. M., Foster, T. J., & Speziale, P. (2009) · Microbiology · doi:10.1099/mic.0.025684-0 · Cited by 73
Self-citationβ-Neurexin Is a Ligand for the Staphylococcus aureus MSCRAMM SdrC
Barbu, E. M., Ganesh, V. K., Gurusiddappa, S., MacKenzie, R. C., Foster, T. J., Südhof, T. C., & Höök, M. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000726 · Cited by 73
Self-citationRoberts, G. A., Houston, P. J., White, J. H., Chen, K., Stephanou, A. S., Cooper, L. P., Dryden, D. T. F., & Lindsay, J. A. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt535 · Cited by 71
Crystal Structures Reveal the Multi-Ligand Binding Mechanism of Staphylococcus aureus ClfB
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Self-citationEnzymatic properties of Staphylococcus aureus adenosine synthase (AdsA)
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Self-citationSequence diversity in the A domain of Staphylococcus aureusfibronectin-binding protein A
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Molecular mechanisms of Staphylococcus aureus nasopharyngeal colonization
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An IgG-binding protein A homolog in Staphylococcus hyicus
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Staphylococcus aureus biofilms: recent developments in biofilm dispersal
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Staphylococcus aureus host interactions and adaptation
Howden, B. P., Giulieri, S. G., Wong Fok Lung, T., Baines, S. L., Sharkey, L. K., Lee, J. Y. H., Hachani, A., Monk, I. R., & Stinear, T. P. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-023-00852-y · Cited by 689
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“The SasG fibrils have been proposed to represent amechanism bywhich individual bacteria can become linked together during the attachment phase of biofilm formation (Geoghegan et al. 2010; Foster et al. 2014).”
BackgroundMethodInfluentialMasters, E. A., Trombetta, R. P., de Mesy Bentley, K. L., Boyce, B. F., Gill, A. L., Gill, S. R., Nishitani, K., Ishikawa, M., Morita, Y., Ito, H., et al. (2019) · Bone Research · doi:10.1038/s41413-019-0061-z · Cited by 575
Metadata
- Authors
- Foster, T. J., Geoghegan, J. A., Ganesh, V. K., & Höök, M.
- Venue
- Nature Reviews Microbiology
- Published
- 2013-12-16
- Volume
- 12
- Issue
- 1
- Pages
- 49-62
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W1973675012
- Cited by
- 1,533
- References
- 143
- FWCI
- 11.84
- Type
- journal article
- Language
- en
- Open access
- green
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