The molecular logic of endocannabinoid signalling

Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor

Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633

Molecular characterization of a peripheral receptor for cannabinoids

Munro, S., Thomas, K. L., & Abu-Shaar, M. (1993) · Nature · doi:10.1038/365061a0 · Cited by 5,092

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011

Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB 1 Receptor Knockout Mice

Ledent, C. A., Valverde, O., Cossu, G., Petitet, F., Aubert, J.-F., Beslot, F., Böhme, G. A., Impérato, A., Pedrazzini, T., Roques, B. P., et al. (1999) · Science · doi:10.1126/science.283.5400.401 · Cited by 3,628

Drug Addiction, Dysregulation of Reward, and Allostasis

Koob, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00195-0 · Cited by 2,953

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

Mechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N. E., Schatz, A. R., Gopher, A., Almog, S., Martin, B. R., Compton, D. R., et al. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00109-d · Cited by 2,913

Determination and characterization of a cannabinoid receptor in rat brain

Devane, W. A., Dysarz, F. A., Johnson, M. R., Melvin, L. S., & Howlett, A. C. (1988) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09876-1 · Cited by 2,443 · cited 1×

Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish

Gaoni, Y., & Mechoulam, R. (1964) · Journal of the American Chemical Society · doi:10.1021/ja01062a046 · Cited by 2,389

Cannabinoid receptor localization in brain.

Herkenham, M., Lynn, A. B., Little, M. D., Johnson, M. R., Melvin, L. S., de Costa, B. R., & Rice, K. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.5.1932 · Cited by 2,321

2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain

Sugiura, T., Kondo, S., Sukagawa, A., Nakane, S., Shinoda, A., Itoh, K., Yamashita, A., & Waku, K. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2437 · Cited by 2,196

Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms

Citri, A., & Malenka, R. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301559 · Cited by 2,323

The Endocannabinoid System as an Emerging Target of Pharmacotherapy

Pacher, P., Bátkai, S., & Kunos, G. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.2 · Cited by 2,077

Endocannabinoid-Mediated Control of Synaptic Transmission

Kano, M., Ohno‐Shosaku, T., Hashimotodani, Y., Uchigashima, M., & Watanabe, M. (2009) · Physiological Reviews · doi:10.1152/physrev.00019.2008 · Cited by 1,595

Psychobiotics: A novel class of psychotropic

Dinan, T. G., Stanton, C., & Cryan, J. F. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.001 · Cited by 1,287

A Comprehensive Profile of Brain Enzymes that Hydrolyze the Endocannabinoid 2-Arachidonoylglycerol

Blankman, J. L., Simon, G. M., & Cravatt, B. F. (2007) · Chemistry & Biology · doi:10.1016/j.chembiol.2007.11.006 · Cited by 1,177

Endocannabinoid Signaling and Synaptic Function

Castillo, P. E., Younts, T. J., Chávez, A. E., & Hashimotodani, Y. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.020 · Cited by 1,191

The endocannabinoid system and its therapeutic exploitation

Marzo, V. D., Bifulco, M., & Petrocellis, L. D. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1495 · Cited by 1,090

Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia

Leweke, F. M., Piomelli, D., Pahlisch, F., Muhl, D., Gerth, C. W., Hoyer, C., Klosterkötter, J., Hellmich, M., & Koethe, D. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.15 · Cited by 1,059

The tempted brain eats: Pleasure and desire circuits in obesity and eating disorders

Berridge, K. C., Ho, C.-Y., Richard, J. M., & DiFeliceantonio, A. G. (2010) · Brain Research · doi:10.1016/j.brainres.2010.04.003 · Cited by 873

The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance

Pagotto, U., Marsicano, G., Cota, D., Lutz, B., & Pasquali, R. (2005) · Endocrine Reviews · doi:10.1210/er.2005-0009 · Cited by 891

Prevention of Alzheimer's Disease Pathology by Cannabinoids: Neuroprotection Mediated by Blockade of Microglial Activation

Ramírez, B. G., Blázquez, C., del Pulgar, T. G., Guzmán, M., & CEBALLOS, M. L. D. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4540-04.2005 · Cited by 801

ENDOCANNABINOID-MEDIATED SYNAPTIC PLASTICITY IN THE CNS

Chevaleyre, V., Takahashi, K. A., & Castillo, P. E. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112834 · Cited by 829

An endocannabinoid mechanism for stress-induced analgesia

Hohmann, A. G., Suplita, R. L., Bolton, N. M., Neely, M. H., Fegley, D., Mangieri, R., Krey, J. F., Michael Walker, J., Holmes, P. V., Crystal, J. D., et al. (2005) · Nature · doi:10.1038/nature03658 · Cited by 778

Cannabinoid-based drugs as anti-inflammatory therapeutics

Klein, T. W. (2005) · Nature Reviews Immunology · doi:10.1038/nri1602 · Cited by 728

Dendritic Excitability and Synaptic Plasticity

Sjöström, P. J., Rancz, E. A., Roth, A., & Häusser, M. (2008) · Physiological Reviews · doi:10.1152/physrev.00016.2007 · Cited by 740

The Endocannabinoid System Controls Key Epileptogenic Circuits in the Hippocampus

Monory, K., Massa, F., Egertová, M., Eder, M., Blaudzun, H., Westenbroek, R., Kelsch, W., Jacob, W., Marsch, R., Ekker, M., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.006 · Cited by 706

Activation of the peripheral endocannabinoid system in human obesity

Engeli, S., Böhnke, J., Feldpausch, M., Gorzelniak, K., Janke, J., Bátkai, S., Pacher, P., Harvey-White, J., Luft, F. C., Sharma, A. M., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.10.2838 · Cited by 686

Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis

Gobbi, G., Bambico, F. R., Mangieri, R. A., Bortolato, M., Campolongo, P., Solinas, M., Cassano, T., Morgese, M. G., Debonnel, G., Duranti, A., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509591102 · Cited by 692

Cannabinoid physiology and pharmacology: 30 years of progress

Howlett, A. C., Breivogel, C. S., Childers, S. R., Deadwyler, S. A., Hampson, R. E., & Porrino, L. J. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.07.030 · Cited by 608

Mitochondrial CB1 receptors regulate neuronal energy metabolism

Bénard, G., Massa, F., Puente, N., Lourenço, J., Bellocchio, L., Soria-Gómez, E., Matias, I., Delamarre, A., Metna-Laurent, M., Cannich, A., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3053 · Cited by 588

Endocannabinoids Mediate Neuron-Astrocyte Communication

Navarrete, M., & Araque, A. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.029 · Cited by 625

Physiology and pharmacology of striatal neurons

Kreitzer, A. C. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135422 · Cited by 530

Enzymatic pathways that regulate endocannabinoid signaling in the nervous system

Ahn, K., McKinney, M. K., & Cravatt, B. F. (2008) · Chemical Reviews · doi:10.1021/cr0782067 · Cited by 529

Dysregulation of the Peripheral and Adipose Tissue Endocannabinoid System in Human Abdominal Obesity

Blüher, M., Engeli, S., Klöting, N., Berndt, J., Faßhauer, M., Bátkai, S., Pacher, P., Schön, M. R., Jordan, J., & Stümvoll, M. (2006) · Diabetes · doi:10.2337/db06-0812 · Cited by 526

Endocannabinoid signaling as a synaptic circuit breaker in neurological disease

Katona, I., & Freund, T. F. (2008) · Nature Medicine · doi:10.1038/nm.f.1869 · Cited by 579

Molecular Composition of the Endocannabinoid System at Glutamatergic Synapses

Katona, I., Urbán, G. M., Wallace, M., Ledent, C., Jung, K.-M., Piomelli, D., Mackie, K., & Freund, T. F. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0309-06.2006 · Cited by 511

CANNABINOID RECEPTORS AS THERAPEUTIC TARGETS

Mackie, K. (2005) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.46.120604.141254 · Cited by 518

Endocannabinoids potentiate synaptic transmission through stimulation of astrocytes.

Navarrete, M., & Araque, A. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.043 · Cited by 480

Endocannabinoid Signaling and Long-Term Synaptic Plasticity

Heifets, B. D., & Castillo, P. E. (2009) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163149 · Cited by 516

Cerebrospinal Anandamide Levels are Elevated in Acute Schizophrenia and are Inversely Correlated with Psychotic Symptoms

Giuffrida, A., Leweke, F. M., Gerth, C. W., Schreiber, D., Koethe, D., Faulhaber, J., Klosterkötter, J., & Piomelli, D. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300558 · Cited by 481

The Endocannabinoid System and Pain

Guindon, J., & Hohmann, A. (2009) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152709789824660 · Cited by 476

Endocannabinoid Signaling Negatively Modulates Stress-Induced Activation of the Hypothalamic-Pituitary-Adrenal Axis

Patel, S., Roelke, C. T., Rademacher, D. J., Cullinan, W. E., & Hillard, C. J. (2004) · Endocrinology · doi:10.1210/en.2004-0638 · Cited by 475

Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders

Campos, A. C., Moreira, F. A., Gomes, F. V., Del Bel, E. A., & Guimarães, F. S. (2012) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2011.0389 · Cited by 475

Modulation of inflammation in brain: A matter of fat

Farooqui, A. A., Horrocks, L. A., & Farooqui, T. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04371.x · Cited by 460

The endogenous cannabinoid system protects against colonic inflammation

Massa, F., Marsicano, G., Hermann, H., Cannich, A., Monory, K., Cravatt, B. F., Ferri, G., Sibaev, A., Storr, M., & Lutz, B. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19465 · Cited by 461

Spine Ca2+Signaling in Spike-Timing-Dependent Plasticity

Nevian, T., & Sakmann, B. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1749-06.2006 · Cited by 458

Cannabinoid Receptor Signaling

Howlett, A. C. (2005) · Springer eBooks · doi:10.1007/3-540-26573-2_2 · Cited by 473

The Endocannabinoid Anandamide Protects Neurons during CNS Inflammation by Induction of MKP-1 in Microglial Cells

Eljaschewitsch, E., Witting, A., Mawrin, C., Lee, T., Schmidt, P. M., Wolf, S., Hoertnagl, H., Raine, C. S., Schneider-Stock, R., Nitsch, R., et al. (2006) · Neuron · doi:10.1016/j.neuron.2005.11.027 · Cited by 445

Pharmacological Profile of the Selective FAAH Inhibitor KDS-4103 (URB597)

Piomelli, D., Tarzia, G., Duranti, A., Tontini, A., Mor, M., Compton, T. R., Dasse, O. A., Monaghan, E. P., Parrott, J. A., & Putman, D. (2006) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2006.00021.x · Cited by 451

The emerging functions of endocannabinoid signaling during CNS development

Harkany, T., Guzmán, M., Galve‐Roperh, I., Berghuis, P., Devi, L. A., & Mackie, K. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.12.004 · Cited by 449

Characterization of the Fatty Acid Amide Hydrolase Inhibitor Cyclohexyl Carbamic Acid 3′-Carbamoyl-biphenyl-3-yl Ester (URB597): Effects on Anandamide and Oleoylethanolamide Deactivation

Fegley, D., Gaetani, S., Duranti, A., Tontini, A., Mor, M., Tarzia, G., & Piomelli, D. (2005) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.078980 · Cited by 427

Cannabinoids and the gut: New developments and emerging concepts

Izzo, A. A., & Sharkey, K. A. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.12.005 · Cited by 434

Is lipid signaling through cannabinoid 2 receptors part of a protective system?

Pacher, P., & Mechoulam, R. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.01.001 · Cited by 435

Endocannabinoids and exercise

Dietrich, A., & McDaniel, W. F. (2004) · British Journal of Sports Medicine · doi:10.1136/bjsm.2004.011718 · Cited by 410

THE ENDOCANNABINOID SYSTEM: PHYSIOLOGY AND PHARMACOLOGY

de Fonseca, F. R., del Arco, I., Bermúdez‐Silva, F. J., Bilbao, A., Cippitelli, A., & Navarro, M. (2004) · Alcohol and Alcoholism · doi:10.1093/alcalc/agh110 · Cited by 419

Cannabidiol and Other Cannabinoids Reduce Microglial Activation In Vitro and In Vivo: Relevance to Alzheimer’s Disease

Martín-Moreno, A. M., Reigada, D., Ramírez, B. G., Mechoulam, R., Innamorato, N. G., Cuadrado, A., & CEBALLOS, M. L. D. (2011) · Molecular Pharmacology · doi:10.1124/mol.111.071290 · Cited by 410

Pharmacological Evaluation of Cannabinoid Receptor Ligands in a Mouse Model of Anxiety: Further Evidence for an Anxiolytic Role for Endogenous Cannabinoid Signaling

Patel, S., & Hillard, C. J. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.101287 · Cited by 397

Strategies for Discovering and Derisking Covalent, Irreversible Enzyme Inhibitors

Johnson, D. S., Weerapana, E., & Cravatt, B. F. (2010) · Future Medicinal Chemistry · doi:10.4155/fmc.10.21 · Cited by 387

A neuroscientist's guide to lipidomics

Piomelli, D., Astarita, G., & Rapaka, R. S. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2233 · Cited by 399

Biochemistry and pharmacology of endovanilloids

Starowicz, K., Nigam, S., & Marzo, V. D. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.01.005 · Cited by 381

The Chronic Effects of Cannabis on Memory in Humans: A Review

Solowij, N., & Battisti, R. A. (2008) · Current Drug Abuse Reviews · doi:10.2174/1874473710801010081 · Cited by 388

Endocannabinoid Hedonic Hotspot for Sensory Pleasure: Anandamide in Nucleus Accumbens Shell Enhances ‘Liking’ of a Sweet Reward

Mahler, S. V., Smith, K. S., & Berridge, K. C. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301376 · Cited by 377

Subcellular Arrangement of Molecules for 2-Arachidonoyl-Glycerol-Mediated Retrograde Signaling and Its Physiological Contribution to Synaptic Modulation in the Striatum

Uchigashima, M., Narushima, M., Fukaya, M., Katona, I., Kano, M., & Watanabe, M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0448-07.2007 · Cited by 375

A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme

Guzmán, M., Duarte, M. C. L. F., Blázquez, C., Ravina, J., Rosa, M. C., Galve‐Roperh, I., Sánchez, C., Velasco, G., & González‐Feria, L. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603236 · Cited by 366

Antidepressant‐like effects of cannabidiol in mice: possible involvement of 5‐HT1Areceptors

Zanelati, T., Biojone, C., Moreira, F., Guimarães, F., & Joca, S. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00521.x · Cited by 366

Cannabinoid CB2 receptor: a new target for controlling neural cell survival?

Fernández‐Ruíz, J., Romero, J., Velasco, G., Tolón, R. M., Ramos, J. A., & Guzmán, M. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.11.001 · Cited by 362

Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice

Marsch, R., Foeller, E., Rammes, G., Bunck, M., Kössl, M., Holsboer, F., Zieglgänsberger, W., Landgraf, R., Lutz, B., & Wotjak, C. T. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3303-06.2007 · Cited by 359

Review article: The impact of obesity on reproduction in women with polycystic ovary syndrome

Pasquali, R., Gambineri, A., & Pagotto, U. (2006) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.00990.x · Cited by 359

Reverse gateways? Frequent cannabis use as a predictor of tobacco initiation and nicotine dependence

Patton, G. C., Coffey, C., Carlin, J. B., Sawyer, S. M., & Lynskey, M. T. (2005) · Addiction · doi:10.1111/j.1360-0443.2005.01220.x · Cited by 356

The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells

Carracedo, A., Lorente, M., Egia, A., Blázquez, C., Garcia, S., Giroux, V., Malicet, C., Villuendas, R., Gironella, M., González‐Feria, L., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.03.005 · Cited by 361

TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus

Chávez, A. E., Chiu, C. Q., & Castillo, P. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2684 · Cited by 348

The Endocannabinoid System: Drug Targets, Lead Compounds, and Potential Therapeutic Applications

Lambert, D. M., & Fowler, C. J. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm058183t · Cited by 354

CB1 Receptor Signaling in the Brain: Extracting Specificity from Ubiquity

Busquets-García, A., Bains, J. S., & Marsicano, G. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.206 · Cited by 365

Cannabinoids and neuroinflammation

Walter, L. M., & Stella, N. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705667 · Cited by 341

Cannabinoids, opioids and eating behavior: The molecular face of hedonism?

Cota, D., Tschöp, M. H., Horvath, T. L., & Levine, A. S. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.10.004 · Cited by 330

The neurobiology of social play and its rewarding value in rats

Vanderschuren, L. J. M. J., Achterberg, E. J. M., & Trezza, V. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.025 · Cited by 329

Oleoylethanolamide Stimulates Lipolysis by Activating the Nuclear Receptor Peroxisome Proliferator-activated Receptor α (PPAR-α)

Guzmán, M., Lo Verme, J., Fu, J., Oveisi, F., Blázquez, C., & Piomelli, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404087200 · Cited by 328

Localization of Diacylglycerol Lipase-α around Postsynaptic Spine Suggests Close Proximity between Production Site of an Endocannabinoid, 2-Arachidonoyl-glycerol, and Presynaptic Cannabinoid CB1 Receptor

Yoshida, T., Fukaya, M., Uchigashima, M., Miura, E., Kamiya, H., Kano, M., & Watanabe, M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0054-06.2006 · Cited by 334

The endocannabinoid system drives neural progenitor proliferation

Aguado, T., Monory, K., Palazuelos, J., Stella, N., Cravatt, B. F., Lutz, B., Marsicano, G., Kokaia, Z., Guzmán, M., & Galve‐Roperh, I. (2005) · The FASEB Journal · doi:10.1096/fj.05-3995fje · Cited by 335

Cannabinoids Elicit Antidepressant-Like Behavior and Activate Serotonergic Neurons through the Medial Prefrontal Cortex

Bambico, F. R., Katz, N., Debonnel, G., & Gobbi, G. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1636-07.2007 · Cited by 325

Cannabis, the mind and society: the hash realities

Murray, R. M., Morrison, P. D., Henquet, C., & Forti, M. D. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2253 · Cited by 329

Pregnenolone Can Protect the Brain from Cannabis Intoxication

Vallée, M., Vitiello, S., Bellocchio, L., Hébert-Chatelain, É., Monlezun, S., Martín‐García, E., Kasanetz, F., Baillie, G. L., Panin, F., Cathala, A., et al. (2014) · Science · doi:10.1126/science.1243985 · Cited by 321

Traditional marijuana, high‐potency cannabis and synthetic cannabinoids: increasing risk for psychosis

Murray, R. M., Quigley, H., Quattrone, D., Englund, A., & Forti, M. D. (2016) · World Psychiatry · doi:10.1002/wps.20341 · Cited by 332

Effects of Cannabis on Neurocognitive Functioning: Recent Advances, Neurodevelopmental Influences, and Sex Differences

Crane, N. A., Schuster, R. M., Fusar‐Poli, P., & González, R. (2012) · Neuropsychology Review · doi:10.1007/s11065-012-9222-1 · Cited by 330

Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95–neuroligin

Futai, K., Kim, M. J., Hashikawa, T., Scheiffele, P., Sheng, M., & Hayashi, Y. (2007) · Nature Neuroscience · doi:10.1038/nn1837 · Cited by 310

Long-lasting self-inhibition of neocortical interneurons mediated by endocannabinoids

Bacci, A., Huguenard, J., & Prince, D. (2004) · Nature · doi:10.1038/nature02913 · Cited by 295

Endocannabinoid-Mediated Metaplasticity in the Hippocampus

Chevaleyre, V., & Castillo, P. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.036 · Cited by 303

The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2‐arachidonoylglycerol signalling through cannabinoid receptors

Savinainen, J. R., Saario, S. M., & Laitinen, J. T. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02280.x · Cited by 297

The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain

Donvito, G., Nass, S. R., Wilkerson, J. L., Curry, Z. A., Schurman, L. D., Kinsey, S. G., & Lichtman, A. H. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.204 · Cited by 301

Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies

Maccarrone, M., Guzmán, M., Mackie, K., Doherty, P., & Harkany, T. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3846 · Cited by 298

Inhibition of restraint stress-induced neural and behavioural activation by endogenous cannabinoid signalling

Patel, S., Roelke, C. T., Rademacher, D. J., & Hillard, C. J. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03916.x · Cited by 297

Endocannabinoids in the rat basolateral amygdala enhance memory consolidation and enable glucocorticoid modulation of memory

Campolongo, P., Roozendaal, B., Trezza, V., Hauer, D., Schelling, G., McGaugh, J. L., & Cuomo, V. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900835106 · Cited by 294

Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum

Maccarrone, M., Rossi, S., Bari, M., Chiara, V. D., Fezza, F., Musella, A., Gasperi, V., Prosperetti, C., Bernardi, G., Finazzi‐Agrò, A., et al. (2008) · Nature Neuroscience · doi:10.1038/nn2042 · Cited by 306

Cannabinoid receptors as novel targets for the treatment of melanoma

Blázquez, C., Carracedo, A., Barrado, L., Real, P. J., Fernández-Luna, J. L., Velasco, G., Malumbres, M., & Guzmán, M. (2006) · The FASEB Journal · doi:10.1096/fj.06-6638fje · Cited by 293

Daily Cannabis Smoking as a Risk Factor for Progression of Fibrosis in Chronic Hepatitis C *

Hézode, C., Roudot‐Thoraval, F., NGUYEN, S. V., Grenard, P., Julien, B., Zafrani, E., Pawlotsky, J., Dhumeaux, D., Lotersztajn, S., & Mallat, A. (2005) · Hepatology · doi:10.1002/hep.20733 · Cited by 292

A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD)

Peng, J., Fan, M., An, C., Ni, F., Huang, W., & Luo, J. (2022) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13710 · Cited by 315

Cannabinoids Induce Cancer Cell Proliferation via Tumor Necrosis Factor α-Converting Enzyme (TACE/ADAM17)-Mediated Transactivation of the Epidermal Growth Factor Receptor

Hart, S., Fischer, O. M., & Ullrich, A. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3720 · Cited by 292

Autism-Associated Neuroligin-3 Mutations Commonly Disrupt Tonic Endocannabinoid Signaling

Földy, C., Malenka, R. C., & Südhof, T. C. (2013) · Neuron · doi:10.1016/j.neuron.2013.02.036 · Cited by 287

The endocannabinoid system controls food intake via olfactory processes

Gómez, E. S., Bellocchio, L., Reguero, L., Lepousez, G., Martin, C., Bendahmane, M., Ruehle, S., Remmers, F., Desprez, T., Matias, I., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3647 · Cited by 287

The discovery of central monoamine neurons gave volume transmission to the wired brain

Fuxé, K., Dahlström, A. B., JONSSON, G., Marcellino, D. J., Guescini, M., Dam, M., Manger, P. R., & Agnati, L. F. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.10.012 · Cited by 285

5‐HT1Areceptors are involved in the cannabidiol‐induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats

Resstel, L. B. M., Tavares, R. F., Lisboa, S. F. S., Joca, S. R. L., Corrêa, F. M. A., & Guimarães, F. S. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00046.x · Cited by 283

Cannabinoid receptor signaling in progenitor/stem cell proliferation and differentiation

Galve‐Roperh, I., Chiurchiù, V., Díaz-Alonso, J., Bari, M., Guzmán, M., & Maccarrone, M. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2013.05.004 · Cited by 287

Bimodal control of stimulated food intake by the endocannabinoid system

Bellocchio, L., Lafenêtre, P., Cannich, A., Cota, D., Puente, N., Grandes, P., Chaouloff, F., Piazza, P. V., & Marsicano, G. (2010) · Nature Neuroscience · doi:10.1038/nn.2494 · Cited by 282

Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome

Jung, K., Sepers, M. D., Henstridge, C. M., Lassalle, O., Neuhofer, D., Martin, H. G. S., Ginger, M. R., Frick, A., DiPatrizio, N. V., Mackie, K., et al. (2012) · Nature Communications · doi:10.1038/ncomms2045 · Cited by 284

The neurobiology of individual differences in complex behavioral traits

Hariri, A. R. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135335 · Cited by 273

Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors

Moreira, F. A., Kaiser, N., Monory, K., & Lutz, B. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.07.005 · Cited by 288

The endocannabinoid system in obesity and type 2 diabetes

Marzo, V. D. (2008) · Diabetologia · doi:10.1007/s00125-008-1048-2 · Cited by 280

Cannabinoids and Epilepsy

Rosenberg, E. C., Tsien, R. W., Whalley, B. J., & Devinsky, O. (2015) · Neurotherapeutics · doi:10.1007/s13311-015-0375-5 · Cited by 292

Cyclohexylcarbamic Acid 3‘- or 4‘-Substituted Biphenyl-3-yl Esters as Fatty Acid Amide Hydrolase Inhibitors: Synthesis, Quantitative Structure−Activity Relationships, and Molecular Modeling Studies

Mor, M., Rivara, S., Lodola, A., Plazzi, P. V., Tarzia, G., Duranti, A., Tontini, A., Piersanti, G., Kathuria, S., & Piomelli, D. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm031140x · Cited by 277

Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and depression

Moreira, F. A., Grieb, M., & Lutz, B. (2009) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2008.09.003 · Cited by 277

Neuropharmacology of the Endocannabinoid Signaling System-Molecular Mechanisms, Biological Actions and Synaptic Plasticity

Basavarajappa, B. S. (2007) · Current Neuropharmacology · doi:10.2174/157015907780866910 · Cited by 115

The Endocannabinoid System

Basavarajappa, B. S., Yalamanchili, R., Cooper, T. B., & Hungund, B. L. (2008) · Springer eBooks · doi:10.1007/978-0-387-30382-6_14 · Cited by 7

Functional diversity on synaptic plasticity mediated by endocannabinoids

Cachope, R. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0386 · Cited by 37

Endocannabinoids and Synaptic Function in the CNS

Hashimotodani, Y., Ohno‐Shosaku, T., & Kano, M. (2007) · The Neuroscientist · doi:10.1177/1073858406296716 · Cited by 210

Synaptic effects of cannabinoids

Benarroch, E. E. (2014) · Neurology · doi:10.1212/wnl.0000000000001013 · Cited by 25