Cited by 2,120Neural dynamics and brain functionSchizophrenia research and treatmentNeuroscience and Neuropharmacology Research

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Abnormal neural oscillations and synchrony in schizophrenia

Uhlhaas, Peter J., Singer, Wolf·2010·Nature Reviews Neuroscience

DOI 10.1038/nrn2774

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Abstract

Converging evidence from electrophysiological, physiological and anatomical studies suggests that abnormalities in the synchronized oscillatory activity of neurons may have a central role in the pathophysiology of schizophrenia. Neural oscillations are a fundamental mechanism for the establishment of precise temporal relationships between neuronal responses that are in turn relevant for memory, perception and consciousness. In patients with schizophrenia, the synchronization of beta- and gamma-band activity is abnormal, suggesting a crucial role for dysfunctional oscillations in the generation of the cognitive deficits and other symptoms of the disorder. Dysfunctional oscillations may arise owing to anomalies in the brain's rhythm-generating networks of GABA (gamma-aminobutyric acid) interneurons and in cortico-cortical connections.

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“In principle, the pathophysiology of AVH thus predict impaired EEG synchronisation during sensory processing in patient s with AVH, as shown in a series of studies (Kwon et al., 1999; Gallinat et al., 2004; Uhlhaas et al., 2008; Uhlhaas and Singer, 2010; Engel et al., 2013).”
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Authors: Uhlhaas, P. J., & Singer, W.
Affiliations: Goethe University Frankfurt (DE)
Corresponding author: Uhlhaas, Peter J.
ORCID: Uhlhaas, Peter J.
Singer, Wolf
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2010-02
Volume: 11
Issue: 2
Pages: 100-113
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn2774
OpenAlex: W2095060637
Cited by: 2,120
References: 166
Citations by year: 2026: 141 · 2025: 142 · 2024: 105 · 2023: 118 · 2022: 121 · 2021: 153 · 2020: 143 · 2019: 128 · 2018: 118 · 2017: 117 · 2016: 140 · 2015: 157 · 2014: 133 · 2013: 138 · 2012: 121
FWCI: 9.35
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: schizophrenia, neural oscillations, neuronal synchronization, beta oscillations, gamma oscillations, GABAergic interneurons, corticocortical connections, cognitive impairment, pathophysiology
MeSH terms: Animals, Biological Clocks, Cortical Synchronization, Humans, Nerve Net, Neurons, Schizophrenia

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Abnormal neural oscillations and synchrony in schizophrenia

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