Cited by 764RNA Interference and Gene DeliveryNanoparticle-Based Drug DeliveryDendrimers and Hyperbranched Polymers

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Nanodelivery of nucleic acids

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Mendes, Bárbara B., Conniot, João, Avital, Aviram, Yao, Dongbao, Jiang, Xingya, Zhou, Xiang, Sharf-Pauker, Noga, Xiao, Yuling, Adir, Omer, Liang, Haojun, Shi, Jinjun, Schroeder, Avi, Conde, João·2022·Nature Reviews Methods Primers

DOI 10.1038/s43586-022-00104-yPMC PMC9038125

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Abstract

There is growing need for a safe, efficient, specific and non-pathogenic means for delivery of gene therapy materials. Nanomaterials for nucleic acid delivery offer an unprecedented opportunity to overcome these drawbacks; owing to their tunability with diverse physico-chemical properties, they can readily be functionalized with any type of biomolecules/moieties for selective targeting. Nucleic acid therapeutics such as antisense DNA, mRNA, small interfering RNA (siRNA) or microRNA (miRNA) have been widely explored to modulate DNA or RNA expression Strikingly, gene therapies combined with nanoscale delivery systems have broadened the therapeutic and biomedical applications of these molecules, such as bioanalysis, gene silencing, protein replacement and vaccines. Here, we overview how to design smart nucleic acid delivery methods, which provide functionality and efficacy in the layout of molecular diagnostics and therapeutic systems. It is crucial to outline some of the general design considerations of nucleic acid delivery nanoparticles, their extraordinary properties and the structure-function relationships of these nanomaterials with biological systems and diseased cells and tissues.

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Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
Vos, T., Lim, S. S., Abbafati, C., Abbas, K. M., Abbasi, M., Abbasifard, M., Abbasi-Kangevari, M., Abbastabar, H., Abd-Allah, F., Abdelalim, A., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30925-9 · Cited by 19,358
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., & Charpentier, E. (2012) · Science · doi:10.1126/science.1225829 · Cited by 17,116
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
Polack, F. P., Thomas, S. J., Kitchin, N., Absalon, J., Gurtman, A., Lockhart, S., Perez, J. L., Pérez Marc, G., Moreira, E. D., Zerbini, C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2034577 · Cited by 14,592
Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019
Roth, G. A., Mensah, G. A., Johnson, C. O., Addolorato, G., Ammirati, E., Baddour, L. M., Barengo, N. C., Beaton, A. Z., Benjamin, E. J., Benziger, C. P., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.11.010 · Cited by 11,449
Engineering precision nanoparticles for drug delivery
Mitchell, M. J., Billingsley, M. M., Haley, R. M., Wechsler, M. E., Peppas, N. A., & Langer, R. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0090-8 · Cited by 7,933
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015
Forouzanfar, M. H., Afshin, A., Alexander, L. T., Anderson, H. R., Bhutta, Z. A., Biryukov, S., Brauer, M., Burnett, R., Cercy, K., Charlson, F. J., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31679-8 · Cited by 7,698
Stimuli-responsive nanocarriers for drug delivery
Mura, S., Nicolas, J., & Couvreur, P. (2013) · Nature Materials · doi:10.1038/nmat3776 · Cited by 6,289
mRNA vaccines — a new era in vaccinology
Pardi, N., Hogan, M. J., Porter, F. W., & Weissman, D. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.243 · Cited by 4,667
Renal clearance of quantum dots
Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476
Selective Colorimetric Detection of Polynucleotides Based on the Distance-Dependent Optical Properties of Gold Nanoparticles
Elghanian, R., Storhoff, J. J., Mucic, R. C., Letsinger, R. L., & Mirkin, C. A. (1997) · Science · doi:10.1126/science.277.5329.1078 · Cited by 4,399
Direct Gene Transfer into Mouse Muscle in Vivo
Wolff, J. A., Malone, R. W., Williams, P., Chong, W., Acsadi, G., Jani, A., & Felgner, P. L. (1990) · Science · doi:10.1126/science.1690918 · Cited by 4,173
Lipid nanoparticles for mRNA delivery
Hou, X., Zaks, T., Langer, R., & Dong, Y. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00358-0 · Cited by 4,076
The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems
Albanese, A., Tang, P. S., & Chan, W. C. W. (2012) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071811-150124 · Cited by 3,633
Delivering nanomedicine to solid tumors
Jain, R. K., & Stylianopoulos, T. (2010) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.139 · Cited by 3,265
Nanoparticles with Raman Spectroscopic Fingerprints for DNA and RNA Detection
Cao, Y. C., Jin, R. M., & Mirkin, C. A. (2002) · Science · doi:10.1126/science.297.5586.1536 · Cited by 2,977
Cellular uptake of nanoparticles: Journey inside the cell
Behzadi, S., Serpooshan, V., Tao, W., Hamaly, M. A., Alkawareek, M. Y., Dreaden, E. C., Brown, D., Alkilany, A. M., Farokhzad, O. C., & Mahmoudi, M. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00636a · Cited by 2,859
Influence of tumour micro-environment heterogeneity on therapeutic response
Junttila, M. R., & de Sauvage, F. J. (2013) · Nature · doi:10.1038/nature12626 · Cited by 2,694
Design and development of polymers for gene delivery
Pack, D. W., Hoffman, A. S., Pun, S., & Stayton, P. S. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1775 · Cited by 2,568
Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
Cabral, H., Matsumoto, Y., Mizuno, K., Chen, Q., Murakami, M., Kimura, M., Terada, Y., Kano, M. R., Miyazono, K., Uesaka, M., et al. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.166 · Cited by 2,429
Nanoparticle-Based Bio-Bar Codes for the Ultrasensitive Detection of Proteins
Nam, J., Thaxton, C. S., & Mirkin, C. A. (2003) · Science · doi:10.1126/science.1088755 · Cited by 2,414
Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing
Cheng, Q., Wei, T., Farbiak, L., Johnson, L. T., Dilliard, S. A., & Siegwart, D. J. (2020) · Nature Nanotechnology · doi:10.1038/s41565-020-0669-6 · Cited by 2,383
Characterization techniques for nanoparticles: comparison and complementarity upon studying nanoparticle properties
Mourdikoudis, S., Pallares, R. M., & Thanh, N. T. K. (2018) · Nanoscale · doi:10.1039/c8nr02278j · Cited by 2,328
Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019
Kocarnik, J., Compton, K., Dean, F. E., Fu, W., Gaw, B., Harvey, J. D., Henrikson, H. J., Lu, D., Pennini, A., Xu, R., et al. (2021) · JAMA Oncology · doi:10.1001/jamaoncol.2021.6987 · Cited by 2,200
Human organoids: model systems for human biology and medicine
Kim, J., Koo, B.-K., & Knoblich, J. A. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0259-3 · Cited by 2,187
Advances in oligonucleotide drug delivery
Roberts, T. C., Langer, R., & Wood, M. J. A. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0075-7 · Cited by 2,121
Dynamic light scattering: a practical guide and applications in biomedical sciences
Stetefeld, J., McKenna, S. A., & Patel, T. R. (2016) · Biophysical Reviews · doi:10.1007/s12551-016-0218-6 · Cited by 2,058
Scanometric DNA array detection with nanoparticle probes.
Taton, T. A., Mirkin, C., & Letsinger, R. L. (2000) · Science · doi:10.1126/science.289.5485.1757 · Cited by 2,057
The Effect of Nanoparticle Size on In Vivo Pharmacokinetics and Cellular Interaction
Hoshyar, N., Gray, S., Han, H., & Bao, G. (2016) · Nanomedicine · doi:10.2217/nnm.16.5 · Cited by 1,990
Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake
Walkey, C. D., Olsen, J. B., Guo, H., Emili, A., & Chan, W. C. W. (2012) · Journal of the American Chemical Society · doi:10.1021/ja2084338 · Cited by 1,926
Immunological properties of engineered nanomaterials
Dobrovolskaia, M. A., & McNeil, S. E. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.223 · Cited by 1,823
CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis
Gillmore, J. D., Gane, E., Taubel, J., Kao, J., Fontana, M., Maitland, M. L., Seitzer, J., O’Connell, D., Walsh, K. R., Wood, K., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2107454 · Cited by 1,801
Delivery materials for siRNA therapeutics
Kanasty, R., Dorkin, J. R., Vegas, A., & Anderson, D. (2013) · Nature Materials · doi:10.1038/nmat3765 · Cited by 1,800
Active targeting schemes for nanoparticle systems in cancer therapeutics
Byrne, J. D., Betancourt, T., & Brannon‐Peppas, L. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.08.005 · Cited by 1,762
The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs
Akinc, A., Maier, M. A., Manoharan, M., Fitzgerald, K., Jayaraman, M., Barros, S., Ansell, S., Du, X., Hope, M. J., Madden, T. D., et al. (2019) · Nature Nanotechnology · doi:10.1038/s41565-019-0591-y · Cited by 1,636
mRNA vaccines for infectious diseases: principles, delivery and clinical translation
Chaudhary, N., Weissman, D., & Whitehead, K. A. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00283-5 · Cited by 1,555
Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo
Zuris, J. A., Thompson, D. B., Shu, Y., Guilinger, J. P., Bessen, J. L., Hu, J. H., Maeder, M. L., Joung, J. K., Chen, Z.-Y., & Liu, D. R. (2015) · Nature Biotechnology · doi:10.1038/nbt.3081 · Cited by 1,460
Gene therapy comes of age
Dunbar, C. E., High, K. A., Joung, J. K., Kohn, D. B., Ozawa, K., & Sadelain, M. (2018) · Science · doi:10.1126/science.aan4672 · Cited by 1,410
Viral vector platforms within the gene therapy landscape
Bulcha, J. T., Wang, Y., Ma, H., Tai, P. W. L., & Gao, G. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00487-6 · Cited by 1,404
RNAi-mediated gene silencing in non-human primates
Zimmermann, T. S., Lee, A. C. H., Akinc, A., Bramlage, B., Bumcrot, D., Fedoruk, M. N., Harborth, J., Heyes, J. A., Jeffs, L. B., John, M., et al. (2006) · Nature · doi:10.1038/nature04688 · Cited by 1,357
A Colorimetric Lead Biosensor Using DNAzyme-Directed Assembly of Gold Nanoparticles
Liu, J., & Lu, Y. (2003) · Journal of the American Chemical Society · doi:10.1021/ja034775u · Cited by 1,350
Tumour heterogeneity in the clinic
Bedard, P. L., Hansen, A. R., Ratain, M. J., & Siu, L. L. (2013) · Nature · doi:10.1038/nature12627 · Cited by 1,231
The chemical evolution of oligonucleotide therapies of clinical utility
Khvorova, A., & Watts, J. K. (2017) · Nature Biotechnology · doi:10.1038/nbt.3765 · Cited by 1,216
Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs
Morrissey, D. V., Lockridge, J. A., Shaw, L., Blanchard, K. S., Jensen, K., Breen, W., Hartsough, K. C., Machemer, L., Radka, S. F., Jadhav, V., et al. (2005) · Nature Biotechnology · doi:10.1038/nbt1122 · Cited by 1,175
Spherical Nucleic Acids
Cutler, J. I., Auyeung, E., & Mirkin, C. A. (2012) · Journal of the American Chemical Society · doi:10.1021/ja209351u · Cited by 1,151
Overcoming cellular barriers for RNA therapeutics
Dowdy, S. F. (2017) · Nature Biotechnology · doi:10.1038/nbt.3802 · Cited by 1,139
Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery
Kowalski, P. S., Rudra, A., Miao, L., & Anderson, D. G. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.02.012 · Cited by 1,127
Organs-on-chips: into the next decade
Low, L. A., Mummery, C., Berridge, B. R., Austin, C. P., & Tagle, D. A. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0079-3 · Cited by 1,029
Biomanufacturing of organ-specific tissues with high cellular density and embedded vascular channels
Skylar‐Scott, M. A., Uzel, S. G. M., Nam, L. L., Ahrens, J. H., Truby, R. L., Damaraju, S., & Lewis, J. A. (2019) · Science Advances · doi:10.1126/sciadv.aaw2459 · Cited by 985
Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine
Donahue, N. D., Acar, H., & Wilhelm, S. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.04.008 · Cited by 985
Fast Colorimetric Sensing of Adenosine and Cocaine Based on a General Sensor Design Involving Aptamers and Nanoparticles
Liu, J., & Lu, Y. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200502589 · Cited by 959
Physicochemical characteristics of nanoparticles affect circulation, biodistribution, cellular internalization, and trafficking
Duan, X., & Li, Y. (2013) · Small · doi:10.1002/smll.201201390 · Cited by 926
Gene therapy clinical trials worldwide to 2017: An update
Ginn, S. L., Amaya, A. K., Alexander, I. E., Edelstein, M., & Abedi, M. R. (2018) · The Journal of Gene Medicine · doi:10.1002/jgm.3015 · Cited by 903
The EPR effect and beyond: Strategies to improve tumor targeting and cancer nanomedicine treatment efficacy
Shi, Y., van der Meel, R., Chen, X., & Lammers, T. (2020) · Theranostics · doi:10.7150/thno.49577 · Cited by 868
Engineering circular RNA for potent and stable translation in eukaryotic cells
Wesselhoeft, R. A., Kowalski, P. S., & Anderson, D. G. (2018) · Nature Communications · doi:10.1038/s41467-018-05096-6 · Cited by 853
Polymersomes
Discher, D. E., & Ahmed, F. (2006) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.8.061505.095838 · Cited by 844
Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer’s disease
Georganopoulou, D. G., Chang, L., Nam, J.-M., Thaxton, C. S., Mufson, E. J., Klein, W. L., & Mirkin, C. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409336102 · Cited by 835
In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles
Arami, H., Khandhar, A., Liggitt, D., & Krishnan, K. M. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00541h · Cited by 830
A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates
Sabnis, S., Kumarasinghe, E. S., Salerno, T., Mihai, C., Ketova, T., Senn, J. J., Lynn, A., Bulychev, A., McFadyen, I., Chan, J., et al. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.03.010 · Cited by 820
Non Viral Vectors in Gene Therapy- An Overview
Ramamoorth, M. (2015) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2015/10443.5394 · Cited by 806
In situ programming of leukaemia-specific T cells using synthetic DNA nanocarriers
Smith, T. T., Stephan, S. B., Moffett, H. F., McKnight, L. E., Ji, W., Reiman, D., Bonagofski, E., Wohlfahrt, M. E., Pillai, S. P. S., & Stephan, M. T. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2017.57 · Cited by 801
Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs
Kauffman, K. J., Dorkin, J. R., Yang, J. H., Heartlein, M. W., DeRosa, F., Mir, F. F., Fenton, O. S., & Anderson, D. G. (2015) · Nano Letters · doi:10.1021/acs.nanolett.5b02497 · Cited by 796
Minimum information reporting in bio–nano experimental literature
Faria, M., Björnmalm, M., Thurecht, K. J., Kent, S. J., Parton, R. G., Kavallaris, M., Johnston, A. P. R., Gooding, J. J., Corrie, S. R., Boyd, B. J., et al. (2018) · Nature Nanotechnology · doi:10.1038/s41565-018-0246-4 · Cited by 777
Orally delivered thioketal nanoparticles loaded with TNF-α–siRNA target inflammation and inhibit gene expression in the intestines
Wilson, D. S., Dalmasso, G., Wang, L., Sitaraman, S. V., Merlin, D., & Murthy, N. (2010) · Nature Materials · doi:10.1038/nmat2859 · Cited by 758
Selective Naked-Eye Detection of SARS-CoV-2 Mediated by N Gene Targeted Antisense Oligonucleotide Capped Plasmonic Nanoparticles
Moitra, P., Alafeef, M., Dighe, K., Frieman, M. B., & Pan, D. (2020) · ACS Nano · doi:10.1021/acsnano.0c03822 · Cited by 752
Lipid–polymer hybrid nanoparticles as a new generation therapeutic delivery platform: A review
Hadinoto, K., Sundaresan, A., & Cheow, W. S. (2013) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2013.07.002 · Cited by 726
Cellular toxicity of inorganic nanoparticles: Common aspects and guidelines for improved nanotoxicity evaluation
Soenen, S. J., Rivera-Gil, P., Montenegro, J., Parak, W. J., Smedt, S. C. D., & Braeckmans, K. (2011) · Nano Today · doi:10.1016/j.nantod.2011.08.001 · Cited by 718
Different behavior of branched and linear polyethylenimine for gene deliveryin vitro andin vivo
Wightman, L., Kircheis, R., R�ssler, V., Carotta, S., Ruzicka, R., Kursa, M., & Wagner, E. (2001) · The Journal of Gene Medicine · doi:10.1002/jgm.187 · Cited by 702
Dendrimers as Nanocarriers for Nucleic Acid and Drug Delivery in Cancer Therapy
Palmerston Mendes, L., Pan, J., & Torchilin, V. (2017) · Molecules · doi:10.3390/molecules22091401 · Cited by 701
State-of-the-art gene-based therapies: the road ahead
Kay, M. A. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2971 · Cited by 699
Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA
Belliveau, N. M., Huft, J., Lin, P. J., Chen, S., Leung, A. K., Leaver, T. J., Wild, A. W., Lee, J. B., Taylor, R. J., Tam, Y. K., et al. (2012) · Molecular Therapy - Nucleic Acids · doi:10.1038/mtna.2012.28 · Cited by 685
Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR–Cas gene editing
Liu, S., Cheng, Q., Wei, T., Yu, X., Johnson, L. T., Farbiak, L., & Siegwart, D. J. (2021) · Nature Materials · doi:10.1038/s41563-020-00886-0 · Cited by 653
Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering
Billingsley, M. M., Singh, N., Ravikumar, P., Zhang, R., June, C. H., & Mitchell, M. J. (2020) · Nano Letters · doi:10.1021/acs.nanolett.9b04246 · Cited by 636
Accelerated Color Change of Gold Nanoparticles Assembled by DNAzymes for Simple and Fast Colorimetric Pb2+ Detection
Liu, J., & Lu, Y. (2004) · Journal of the American Chemical Society · doi:10.1021/ja046628h · Cited by 635
DNA-based therapeutics and DNA delivery systems: A comprehensive review
Patil, S. D., Rhodes, D. G., & Burgess, D. J. (2005) · The AAPS Journal · doi:10.1208/aapsj070109 · Cited by 631
An ionizable lipid toolbox for RNA delivery
Han, X., Zhang, H., Butowska, K., Swingle, K. L., Alameh, M.-G., Weissman, D., & Mitchell, M. J. (2021) · Nature Communications · doi:10.1038/s41467-021-27493-0 · Cited by 628
Effect of the surface modification, size, and shape on cellular uptake of nanoparticles
Salatin, S., Dizaj, S. M., & Khosroushahi, A. Y. (2015) · Cell Biology International · doi:10.1002/cbin.10459 · Cited by 626
Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells
Holtkamp, S., Kreiter, S., Selmi, A., Simon, P., Koslowski, M., Huber, C., Türeci, O., & Sahin, U. (2006) · Blood · doi:10.1182/blood-2006-04-015024 · Cited by 625
Nucleic Acid Therapeutics Using Polyplexes: A Journey of 50 Years (and Beyond)
Lächelt, U., & Wagner, E. (2015) · Chemical Reviews · doi:10.1021/cr5006793 · Cited by 607
Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo
Chen, F., Wang, G., Griffin, J. I., Brenneman, B., Banda, N. K., Holers, V. M., Backos, D. S., Wu, L., Moghimi, S. M., & Simberg, D. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2016.269 · Cited by 599
Global, regional, and national incidence, prevalence, and mortality of HIV, 1980–2017, and forecasts to 2030, for 195 countries and territories: a systematic analysis for the Global Burden of Diseases, Injuries, and Risk Factors Study 2017
Frank, T. D., Carter, A., Jahagirdar, D., Biehl, M. H., Douwes‐Schultz, D., Larson, S. L., Arora, M. K., Dwyer‐Lindgren, L., Steuben, K. M., Abbastabar, H., et al. (2019) · The Lancet HIV · doi:10.1016/s2352-3018(19)30196-1 · Cited by 592
Single Particle Tracking: From Theory to Biophysical Applications
Shen, H., Tauzin, L. J., Baiyasi, R., Wang, W., Moringo, N. A., Shuang, B., & Landes, C. F. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00815 · Cited by 556
Controlled Vesicle Self-Assembly in Microfluidic Channels with Hydrodynamic Focusing
Jahn, Α., Vreeland, W. N., Gaitan, M., & Locascio, L. E. (2004) · Journal of the American Chemical Society · doi:10.1021/ja0318030 · Cited by 539
The Human Genome Project: Past, Present, and Future
Watson, J. D. (1990) · Science · doi:10.1126/science.2181665 · Cited by 537
Nanoparticle Characterization: What to Measure?
Modena, M. M., Rühle, B., Burg, T. P., & Wuttke, S. (2019) · Advanced Materials · doi:10.1002/adma.201901556 · Cited by 537
Zwitterionic‐Coated “Stealth” Nanoparticles for Biomedical Applications: Recent Advances in Countering Biomolecular Corona Formation and Uptake by the Mononuclear Phagocyte System
García, K. P., Zarschler, K., Barbaro, L., Barreto, J. A., O’Malley, W., Spiccia, L., Stephan, H., & Graham, B. (2014) · Small · doi:10.1002/smll.201303540 · Cited by 527
mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases
Maruggi, G., Zhang, C., Li, J., Ulmer, J. B., & Yu, D. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.01.020 · Cited by 507
Non-viral Vectors in Gene Therapy: Recent Development, Challenges, and Prospects
Zu, H., & Gao, D. (2021) · The AAPS Journal · doi:10.1208/s12248-021-00608-7 · Cited by 505
Integrating Artificial Intelligence and Nanotechnology for Precision Cancer Medicine
Adir, O., Poley, M., Chen, G., Froim, S., Krinsky, N., Shklover, J., Shainsky‐Roitman, J., Lammers, T., & Schroeder, A. (2020) · Advanced Materials · doi:10.1002/adma.201901989 · Cited by 496
Self-citation
What Does Nanoparticle Stability Mean?
Phan, H. T., & Haes, A. J. (2019) · The Journal of Physical Chemistry C · doi:10.1021/acs.jpcc.9b00913 · Cited by 487
Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice
McKay, P. F., Hu, K., Blakney, A. K., Samnuan, K., Brown, J. C., Penn, R., Zhou, J., Bouton, C. R., Rogers, P., Polra, K., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17409-9 · Cited by 462
Recent advances in the development of gene delivery systems.
Sung, Y., & Kim, S. (2019) · Biomaterials Research · doi:10.1186/s40824-019-0156-z · Cited by 458
In vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in circulating T cells in vivo
Parayath, N. N., Stephan, S. B., Koehne, A. L., Nelson, P. S., & Stephan, M. T. (2020) · Nature Communications · doi:10.1038/s41467-020-19486-2 · Cited by 457
Local triple-combination therapy results in tumour regression and prevents recurrence in a colon cancer model
Conde, J., Oliva, N., Zhang, Y., & Artzi, N. (2016) · Nature Materials · doi:10.1038/nmat4707 · Cited by 451
Self-citation
Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA
Woodrow, K. A., Cu, Y., Booth, C. J., Saucier-Sawyer, J. K., Wood, M. J., & Saltzman, W. M. (2009) · Nature Materials · doi:10.1038/nmat2444 · Cited by 444
The size of liposomes: a factor which affects their targeting efficiency to tumors and therapeutic activity of liposomal antitumor drugs
Nagayasu, A., Uchiyama, K., & Kiwada, H. (1999) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(99)00041-1 · Cited by 440
The complexity and cost of vaccine manufacturing – An overview
Plotkin, S. A., Robinson, J. M., Cunningham, G., Iqbal, R., & Larsen, S. (2017) · Vaccine · doi:10.1016/j.vaccine.2017.06.003 · Cited by 437
Overcoming Nonviral Gene Delivery Barriers: Perspective and Future
Jones, C. H., Chen, C., Ravikrishnan, A., Rane, S., & Pfeifer, B. A. (2013) · Molecular Pharmaceutics · doi:10.1021/mp400467x · Cited by 430
Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells
Maugeri, M., Nawaz, M., Papadimitriou, A., Angerfors, A., Camponeschi, A., Na, M., Hölttä, M., Skantze, P., Johansson, S., Sundqvist, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12275-6 · Cited by 428
Delivery of oligonucleotides to the liver with GalNAc: From research to registered therapeutic drug.
Debacker, A. J., Voutila, J., Catley, M., Blakey, D., & Habib, N. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.06.015 · Cited by 424
On the role of helper lipids in lipid nanoparticle formulations of siRNA
Kulkarni, J. A., Witzigmann, D., Leung, J., Tam, Y. Y. C., & Cullis, P. R. (2019) · Nanoscale · doi:10.1039/c9nr09347h · Cited by 406
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics
Leppek, K., Byeon, G. W., Kladwang, W., Wayment-Steele, H. K., Kerr, C. H., Xu, A. F., Kim, D. S., Topkar, V. V., Choe, C., Rothschild, D., et al. (2021) · doi:10.1101/2021.03.29.437587 · Cited by 399
Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics
Leppek, K., Byeon, G. W., Kladwang, W., Wayment-Steele, H. K., Kerr, C. H., Xu, A. F., Kim, D. S., Topkar, V. V., Choe, C., Rothschild, D., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28776-w · Cited by 399
Alliance with EPR Effect: Combined Strategies to Improve the EPR Effect in the Tumor Microenvironment
Park, J., Choi, Y., Chang, H., Um, W., Ryu, J. H., & Kwon, I. C. (2019) · Theranostics · doi:10.7150/thno.37198 · Cited by 397
Delivery of drugs, proteins, and nucleic acids using inorganic nanoparticles
Luther, D. C., Huang, R., Jeon, T., Zhang, X., Lee, Y.-W., Nagaraj, H., & Rotello, V. M. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.020 · Cited by 380
Lipid nanoparticle technology for therapeutic gene regulation in the liver
Witzigmann, D., Kulkarni, J. A., Leung, J., Chen, S., Cullis, P. R., & van der Meel, R. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.026 · Cited by 376
Polyethylene Glycol Backfilling Mitigates the Negative Impact of the Protein Corona on Nanoparticle Cell Targeting
Dai, Q., Walkey, C., & Chan, W. C. W. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201309464 · Cited by 373
Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA
Chen, S., Tam, Y. Y. C., Lin, P. J. C., Sung, M. M. H., Tam, Y. K., & Cullis, P. R. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.059 · Cited by 366
Improving mRNA-Based Therapeutic Gene Delivery by Expression-Augmenting 3′ UTRs Identified by Cellular Library Screening
Orlandini von Niessen, A. G., Poleganov, M. A., Rechner, C., Plaschke, A., Kranz, L. M., Fesser, S., Diken, M., Löwer, M., Vallazza, B., Beissert, T., et al. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2018.12.011 · Cited by 365
Multifunctional nanoparticles for brain tumor imaging and therapy
Cheng, Y., Morshed, R. A., Auffinger, B., Tobias, A. L., & Lesniak, M. S. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.09.006 · Cited by 359
Polymeric Nanoparticles in Gene Therapy: New Avenues of Design and Optimization for Delivery Applications
Rai, R., Alwani, S., & Badea, I. (2019) · Polymers · doi:10.3390/polym11040745 · Cited by 350
Nanoparticle ζ -Potentials
Doane, T. L., Chuang, C.-H., Hill, R. J., & Burda, C. (2011) · Accounts of Chemical Research · doi:10.1021/ar200113c · Cited by 349
Manufacturing Considerations for the Development of Lipid Nanoparticles Using Microfluidics
Roces, C. B., Lou, G., Jain, N., Abraham, S., Thomas, A. M., Halbert, G., & Perrie, Y. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12111095 · Cited by 346
Evolution of the nanoparticle corona
Hadjidemetriou, M., & Kostarelos, K. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2017.61 · Cited by 345
Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA
Islam, M. A., Xu, Y., Tao, W., Ubellacker, J. M., Lim, M., Aum, D., Lee, G. Y., Zhou, K., Zope, H., Yu, M., et al. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0284-0 · Cited by 339
Self-citation
Bottom-up design and synthesis of limit size lipid nanoparticle systems with aqueous and triglyceride cores using millisecond microfluidic mixing.
Zhigaltsev, I. V., Belliveau, N. M., Hafez, I. M., Leung, A. K. K., Huft, J., Hansen, C., & Cullis, P. (2012) · Langmuir · doi:10.1021/la204833h · Cited by 330
Durable anticancer immunity from intratumoral administration of IL-23, IL-36γ, and OX40L mRNAs
Hewitt, S. L., Bai, A., Bailey, D., Ichikawa, K., Zielinski, J., Karp, R., Apte, A., Arnold, K., Zacharek, S. J., Iliou, M. S., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aat9143 · Cited by 316
Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53 -deficient cancers to mTOR inhibition
Kong, N., Tao, W., Ling, X., Wang, J., Xiao, Y., Shi, S., Ji, X., Shajii, A., Gan, S. T., Kim, N. Y., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw1565 · Cited by 314
Self-citation
High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing
Sago, C. D., Lokugamage, M. P., Paunovska, K., Vanover, D. A., Monaco, C. M., Shah, N. N., Gamboa Castro, M., Anderson, S. E., Rudoltz, T. G., Lando, G. N., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811276115 · Cited by 313
Simplifying the synthesis of dendrimers: accelerated approaches
Walter, M. V., & Malkoch, M. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35062a · Cited by 310
Gene therapy for neurological disorders: progress and prospects
Deverman, B. E., Ravina, B. M., Bankiewicz, K. S., Paul, S. M., & Sah, D. W. Y. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.110 · Cited by 306
Systemic delivery of factor IX messenger RNA for protein replacement therapy
Ramaswamy, S., Tonnu, N., Tachikawa, K., Limphong, P., Vega, J. B., Karmali, P. P., Chivukula, P., & Verma, I. M. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1619653114 · Cited by 301
The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019
Alvarez, E. M., Force, L. M., Xu, R., Compton, K., Lu, D., Henrikson, H. J., Kocarnik, J., Harvey, J. D., Pennini, A., Dean, F. E., et al. (2021) · The Lancet Oncology · doi:10.1016/s1470-2045(21)00581-7 · Cited by 293
Self-assembled RNA-triple-helix hydrogel scaffold for microRNA modulation in the tumour microenvironment
Conde, J., Oliva, N., Atilano, M., Song, H. S., & Artzi, N. (2015) · Nature Materials · doi:10.1038/nmat4497 · Cited by 283
Self-citation
A Review of Patisiran (ONPATTRO®) for the Treatment of Polyneuropathy in People with Hereditary Transthyretin Amyloidosis
Urits, I., Swanson, D., Swett, M. C., Patel, A., Berardino, K., Amgalan, A., Berger, A. A., Kassem, H., Kaye, A. D., & Viswanath, O. (2020) · Neurology and Therapy · doi:10.1007/s40120-020-00208-1 · Cited by 282
Development and Clinical Translation of Approved Gene Therapy Products for Genetic Disorders
Shahryari, A., Jazi, M. S., Mohammadi, S., Nikoo, H. R., Nazari, Z., Hosseini, E. S., Burtscher, I., Mowla, S. J., & Lickert, H. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00868 · Cited by 271
CRISPR/Cas9-Mediated Genome Editing as a Therapeutic Approach for Leber Congenital Amaurosis 10
Ruan, G.-X., Barry, E., Yu, D., Lukason, M., Cheng, S. H., & Scaria, A. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2016.12.006 · Cited by 270
Principles for designing an optimal mRNA lipid nanoparticle vaccine
Kon, E., Elia, U., & Peer, D. (2022) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2021.09.016 · Cited by 269
Cancer‐Targeting Nanoparticles for Combinatorial Nucleic Acid Delivery
Vaughan, H. J., Green, J. J., & Tzeng, S. Y. (2019) · Advanced Materials · doi:10.1002/adma.201901081 · Cited by 259
Reactivation of the tumor suppressor PTEN by mRNA nanoparticles enhances antitumor immunity in preclinical models
Lin, Y., Wang, Y., Ding, J., Jiang, A., Wang, J., Yu, M., Blake, S., Liu, S., Bieberich, C. J., Farokhzad, O. C., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.aba9772 · Cited by 259
Self-citation
siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice
Tao, W., Yurdagul, A., Kong, N., Li, W., Wang, X., Doran, A. C., Feng, C., Wang, J., Islam, M. A., Farokhzad, O. C., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay1063 · Cited by 258
Self-citation
Genome Editing with mRNA Encoding ZFN, TALEN, and Cas9
Zhang, H., Zhang, Y., & Yin, H. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.01.014 · Cited by 256
Delivery of mRNA vaccine with a lipid-like material potentiates antitumor efficacy through Toll-like receptor 4 signaling
Zhang, H., You, X., Wang, X., Cui, L., Wang, Z., Xu, F., Li, M., Yang, Z., Liu, J., Huang, P., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2005191118 · Cited by 252
Surface Charge Controls the Suborgan Biodistributions of Gold Nanoparticles
Elci, S. G., Jiang, Y. Y., Yan, B., Kim, S. T., Saha, K., Moyano, D. F., Tonga, G. Y., Jackson, L. C., Rotello, V. M., & Vachet, R. W. (2016) · ACS Nano · doi:10.1021/acsnano.6b02086 · Cited by 250
Erratum: Gene therapy for neurological disorders: progress and prospects
Deverman, B. E., Ravina, B. M., Bankiewicz, K. S., Paul, S. M., & Sah, D. W. Y. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.158 · Cited by 248
On the issue of transparency and reproducibility in nanomedicine
Leong, H. S., Butler, K. S., Brinker, C. J., Azzawi, M., Conlan, R. S., Dufès, C., Owen, A., Rannard, S. P., Scott, C., Chen, C., et al. (2019) · Nature Nanotechnology · doi:10.1038/s41565-019-0496-9 · Cited by 244
Factors Relating to the Biodistribution & Clearance of Nanoparticles & Their Effects on In Vivo Application
Wei, Y., Li, Q., Zhou, C., & Zhan, Q. (2018) · Nanomedicine · doi:10.2217/nnm-2018-0040 · Cited by 243
Dual Targeted Immunotherapy via In Vivo Delivery of Biohybrid RNAi‐Peptide Nanoparticles to Tumor‐Associated Macrophages and Cancer Cells
Conde, J., Bao, C., Tan, Y., Cui, D., Edelman, E. R., Azevedo, H. S., Byrne, H. J., Artzi, N., & Tian, F. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201501283 · Cited by 242
Self-citation
Lipidoid-Coated Iron Oxide Nanoparticles for Efficient DNA and siRNA delivery
Jiang, S., Eltoukhy, A. A., Love, K. T., Langer, R., & Anderson, D. G. (2013) · Nano Letters · doi:10.1021/nl304287a · Cited by 239
Design of Multifunctional Gold Nanoparticles for In Vitro and In Vivo Gene Silencing
Conde, J., Ambrosone, A., Sanz, V., Hernández, Y., Marchesano, V., Tian, F., Child, H., Berry, C. C., Ibarra, M. R., Baptista, P. V., et al. (2012) · ACS Nano · doi:10.1021/nn3030223 · Cited by 236
Self-citation
Polymeric vehicles for nucleic acid delivery
Piotrowski-Daspit, A. S., Kauffman, A. C., Bracaglia, L. G., & Saltzman, W. M. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.014 · Cited by 230
Colorimetric Screening of DNA‐Binding Molecules with Gold Nanoparticle Probes
Han, M. S., Lytton‐Jean, A. K. R., Oh, B., Heo, J., & Mirkin, C. A. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200504277 · Cited by 229
Ionizable lipid nanoparticles encapsulating barcoded mRNA for accelerated in vivo delivery screening
Guimarães, P. P. G., Zhang, R., Spektor, R., Tan, M., Chung, A., Billingsley, M. M., El-Mayta, R. D., Riley, R., Wang, L., Wilson, J. M., et al. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.10.028 · Cited by 224
A Combinatorial Library of Lipid Nanoparticles for RNA Delivery to Leukocytes
Ramishetti, S., Hazan‐Halevy, I., Palakuri, R., Chatterjee, S., Naidu, G. S., Dammes, N., Freilich, I., Shmuel, L. K., Danino, D., & Peer, D. (2020) · Advanced Materials · doi:10.1002/adma.201906128 · Cited by 220
Adjuvant-pulsed mRNA vaccine nanoparticle for immunoprophylactic and therapeutic tumor suppression in mice
Islam, M. A., Jamie, R., Reesor, E., Zope, H. R., Tao, W., Lim, M., Ding, J., Chen, Y., Aduluso, D., Zetter, B. R., et al. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120431 · Cited by 220
Self-citation
Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators
Conniot, J., Scomparin, A., Peres, C., Yeini, E., Pozzi, S., Matos, A. I., Kleiner, R., Moura, L. I. F., Zupančič, E., Viana, A. S., et al. (2019) · Nature Nanotechnology · doi:10.1038/s41565-019-0512-0 · Cited by 217
Self-citation
Quantitative self-assembly prediction yields targeted nanomedicines
Shamay, Y., Shah, J., Işık, M., Mizrachi, A., Leibold, J., Tschaharganeh, D. F., Roxbury, D., Budhathoki-Uprety, J., Nawaly, K., Sugarman, J. L., et al. (2018) · Nature Materials · doi:10.1038/s41563-017-0007-z · Cited by 216
Clinical Evidence Supporting Early Treatment Of Patients With Spinal Muscular Atrophy: Current Perspectives
Dangouloff, T., & Servais, L. (2019) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s172291 · Cited by 211
International Collaboration to Ensure Equitable Access to Vaccines for COVID‐19: The ACT‐Accelerator and the COVAX Facility
Eccleston-Turner, M., & Upton, H. (2021) · Milbank Quarterly · doi:10.1111/1468-0009.12503 · Cited by 210
Stabilized plasmid–lipid particles containing PEG-diacylglycerols exhibit extended circulation lifetimes and tumor selective gene expression
Ambegia, E., Ansell, S. M., Cullis, P. R., Heyes, J. A., Palmer, L., & MacLachlan, I. (2005) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2005.02.001 · Cited by 208
Peptide Vectors for the Nonviral Delivery of Nucleic Acids
Hoyer, J., & Neundorf, I. (2012) · Accounts of Chemical Research · doi:10.1021/ar2002304 · Cited by 205
The Effect of Nanoparticle Polyethylene Glycol Surface Density on Ligand-Directed Tumor Targeting Studiedin Vivoby Dual Modality Imaging
Hak, S., Helgesen, E., Hektoen, H. H., Huuse, E. M., Jarzyna, P. A., Mulder, W. J. M., Haraldseth, O., & Davies, C. D. L. (2012) · ACS Nano · doi:10.1021/nn301630n · Cited by 204
DNA-controlled dynamic colloidal nanoparticle systems for mediating cellular interaction
Ohta, S., Glancy, D., & Chan, W. C. W. (2016) · Science · doi:10.1126/science.aad4925 · Cited by 204
Exploration of the nanomedicine-design space with high-throughput screening and machine learning
Yamankurt, G., Berns, E. J., Xue, A., Lee, A., Bagheri, N., Mrksich, M., & Mirkin, C. A. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0351-1 · Cited by 203
Role of Lipid-Based and Polymer-Based Non-Viral Vectors in Nucleic Acid Delivery for Next-Generation Gene Therapy
Wahane, A. V., Waghmode, A., Kapphahn, A., Dhuri, K., Gupta, A., & Bahal, R. (2020) · Molecules · doi:10.3390/molecules25122866 · Cited by 202
In vivo imaging of oligonucleotides with positron emission tomography
Tavitian, B., Terrazzino, S., Kühnast, B., Marzabal, S., Stettler, O., Dollé, F., Deverre, J.-R., Jobert, A., Hinnen, F., Bendriem, B., et al. (1998) · Nature Medicine · doi:10.1038/nm0498-467 · Cited by 200
Hollow Mesoporous Zirconia Nanocapsules for Drug Delivery
Tang, S., Huang, X., Chen, X., & Zheng, N. (2010) · Advanced Functional Materials · doi:10.1002/adfm.201000647 · Cited by 198
Polymersomes for Therapeutic Delivery of Protein and Nucleic Acid Macromolecules: From Design to Therapeutic Applications
Iqbal, S., Blenner, M., Alexander-Bryant, A. A., & Larsen, J. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.9b01754 · Cited by 194
Rational designs of in vivo CRISPR-Cas delivery systems
Xu, C., Chen, G., Luo, Y., Zhang, Y., Zhao, G., Lu, Z.-D., Czarna, A., Gu, Z., & Wang, J. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.11.005 · Cited by 187
Local microRNA delivery targets Palladin and prevents metastatic breast cancer
Gilam, A., Conde, J., Weissglas‐Volkov, D., Oliva, N., Friedman, E., Artzi, N., & Shomron, N. (2016) · Nature Communications · doi:10.1038/ncomms12868 · Cited by 185
Self-citation
Access to cancer medicines deemed essential by oncologists in 82 countries: an international, cross-sectional survey
Fundytus, A. M., Sengar, M., Lombe, D. C., Hopman, W. M., Jalink, M., Gyawali, B., Trapani, D., Roitberg, F., de Vries, E. G. E., Moja, L., et al. (2021) · The Lancet Oncology · doi:10.1016/s1470-2045(21)00463-0 · Cited by 183
Protein adsorption onto nanoparticles induces conformational changes: Particle size dependency, kinetics, and mechanisms
Satzer, P., Švec, F., Sekot, G., & Jungbauer, A. (2015) · Engineering in Life Sciences · doi:10.1002/elsc.201500059 · Cited by 181
Oligonucleotide therapies for disorders of the nervous system
Khorkova, O., & Wahlestedt, C. (2017) · Nature Biotechnology · doi:10.1038/nbt.3784 · Cited by 179
Overcoming Gene-Delivery Hurdles: Physiological Considerations for Nonviral Vectors
Hill, A. B., Chen, M., Chen, C., Pfeifer, B. A., & Jones, C. H. (2015) · Trends in biotechnology · doi:10.1016/j.tibtech.2015.11.004 · Cited by 166
mRNA-based SARS-CoV-2 vaccine candidate CVnCoV induces high levels of virus-neutralising antibodies and mediates protection in rodents
Rauch, S., Roth, N., Schwendt, K., Fotin-Mleczek, M., Mueller, S. O., & Petsch, B. (2021) · npj Vaccines · doi:10.1038/s41541-021-00311-w · Cited by 165
A Multifunctional Peptide‐Conjugated AIEgen for Efficient and Sequential Targeted Gene Delivery into the Nucleus
Cheng, Y., Sun, C., Liu, R., Yang, J., Dai, J., Zhai, T., Lou, X., & Xia, F. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201901527 · Cited by 161
Analyzing 2000 in Vivo Drug Delivery Data Points Reveals Cholesterol Structure Impacts Nanoparticle Delivery
Paunovska, K., Gil, C. J., Lokugamage, M. P., Sago, C. D., Sato, M., Lando, G. N., Gamboa Castro, M., Bryksin, A. V., & Dahlman, J. E. (2018) · ACS Nano · doi:10.1021/acsnano.8b03640 · Cited by 160
BBB pathophysiology–independent delivery of siRNA in traumatic brain injury
Li, W., Qiu, J., Li, X.-L., Aday, S., Zhang, J., Conley, G., Xu, J., Joseph, J., Lan, H., Langer, R., et al. (2021) · Science Advances · doi:10.1126/sciadv.abd6889 · Cited by 160
Synthesis and surface modification of mesoporous silica nanoparticles and its application as carriers for sustained drug delivery
Ahmadi, E., Dehghannejad, N., Hashemikia, S., Ghasemnejad, M., & Tabebordbar, H. (2013) · Drug Delivery · doi:10.3109/10717544.2013.838715 · Cited by 149
Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies
Colombo, M., Fiandra, L., Alessio, G., Mazzucchelli, S., Nebuloni, M., Palma, C. D., Kantner, K., Pelaz, B., Rotem, R., Corsi, F., et al. (2016) · Nature Communications · doi:10.1038/ncomms13818 · Cited by 149
Effect of base modifications on structure, thermodynamic stability, and gene silencing activity of short interfering RNA
Kubiak, K., Sochacka, E., Kaźmierczak-Barańska, J., Maszewska, M., Janicka, M., Nowak, G., & Nawrot, B. (2007) · RNA · doi:10.1261/rna.538907 · Cited by 147
Nanoparticles to Knockdown Osteoporosis-Related Gene and Promote Osteogenic Marker Expression for Osteoporosis Treatment
Mora‐Raimundo, P., Lozano, D., Manzano, M., & Vallet‐Regí, M. (2019) · ACS Nano · doi:10.1021/acsnano.9b00241 · Cited by 146
Nanoparticles for nucleic acid delivery: Applications in cancer immunotherapy
Mukalel, A. J., Riley, R., Zhang, R., & Mitchell, M. J. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.04.040 · Cited by 143
Degradable polymer-coated gold nanoparticles for co-delivery of DNA and siRNA
Bishop, C. J., Tzeng, S. Y., & Green, J. J. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.09.020 · Cited by 142
Low‐pH‐sensitive poly(ethylene glycol) (PEG)‐stabilized plasmid nanolipoparticles: effects of PEG chain length, lipid composition and assembly conditions on gene delivery
Li, W., Huang, Z. R., MacKay, J. A., Grube, S., & Szoka, F. C. (2004) · The Journal of Gene Medicine · doi:10.1002/jgm.634 · Cited by 140
Implantable hydrogel embedded dark-gold nanoswitch as a theranostic probe to sense and overcome cancer multidrug resistance
Conde, J., Oliva, N., & Artzi, N. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421229112 · Cited by 139
Self-citation
Nanomaterials for Therapeutic RNA Delivery
Han, X., Mitchell, M. J., & Nie, G. (2020) · Matter · doi:10.1016/j.matt.2020.09.020 · Cited by 139
Clinical Impact of Laboratory Implementation of Verigene BC-GN Microarray-Based Assay for Detection of Gram-Negative Bacteria in Positive Blood Cultures
Walker, T., Dumadag, S., Lee, C. J., Lee, S. H., Bender, J. M., Abbott, J. C., & She, R. C. (2016) · Journal of Clinical Microbiology · doi:10.1128/jcm.00376-16 · Cited by 137
The Effect of Size and Shape of RNA Nanoparticles on Biodistribution
Jasinski, D. L., Li, H., & Guo, P. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.12.018 · Cited by 137
Design of Polymeric Gene Carriers for Effective Intracellular Delivery
Lai, W., & Wong, W. (2018) · Trends in biotechnology · doi:10.1016/j.tibtech.2018.02.006 · Cited by 128
Optimization of non-coding regions for a non-modified mRNA COVID-19 vaccine
Gebre, M. S., Rauch, S., Roth, N., Yu, J., Chandrashekar, A., Mercado, N. B., He, X., Liu, J., McMahan, K., Martinot, A., et al. (2022) · Nature · doi:10.1038/s41586-021-04231-6 · Cited by 127
Nanoparticle-Assisted Targeted Delivery of Eye-Specific Genes to Eyes Significantly Improves the Vision of Blind Mice In Vivo
Rajala, A., Wang, Y., Zhu, Y., Ranjo‐Bishop, M., Ma, J., Mao, C., & Rajala, R. V. S. (2014) · Nano Letters · doi:10.1021/nl502275s · Cited by 121
Cryo‐electron microscopy and cryo‐electron tomography of nanoparticles
Stewart, P. L. (2016) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1417 · Cited by 120
Endothelial siRNA delivery in nonhuman primates using ionizable low–molecular weight polymeric nanoparticles
Khan, O. F., Kowalski, P. S., Doloff, J. C., Tsosie, J. K., Bakthavatchalu, V., Winn, C. B., Haupt, J. L., Jamiel, M., Langer, R., & Anderson, D. G. (2018) · Science Advances · doi:10.1126/sciadv.aar8409 · Cited by 120
Let’s talk about lipid nanoparticles
(2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00281-4 · Cited by 119
Disassembly of polyethylenimine-DNA particles in vitro: Implications for polyethylenimine-mediated DNA delivery
Bertschinger, M., Backliwal, G., Schertenleib, A., Jordan, M., Hacker, D. L., & Wurm, F. M. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.09.006 · Cited by 115
From COVID-19 to Cancer mRNA Vaccines: Moving From Bench to Clinic in the Vaccine Landscape
Chakraborty, C., Sharma, A. R., Bhattacharya, M., & Lee, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.679344 · Cited by 114
Elucidation of the physicochemical properties and potency of siRNA-loaded small-sized lipid nanoparticles for siRNA delivery
Sato, Y., Note, Y., Maeki, M., Kaji, N., Baba, Y., Tokeshi, M., & Harashima, H. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.03.019 · Cited by 108
Chemical Reactions of Molecules Promoted and Simultaneously Imaged by the Electron Beam in Transmission Electron Microscopy
Skowron, S. T., Chamberlain, T. W., Biskupek, J., Kaiser, U. A., Besley, E., & Khlobystov, A. N. (2017) · Accounts of Chemical Research · doi:10.1021/acs.accounts.7b00078 · Cited by 105
Targeting Costimulatory Molecules to Improve Antitumor Immunity
Capece, D., Verzella, D., Fischietti, M., Zazzeroni, F., & Alesse, E. (2012) · BioMed Research International · doi:10.1155/2012/926321 · Cited by 103
Multimodal Dispersion of Nanoparticles: A Comprehensive Evaluation of Size Distribution with 9 Size Measurement Methods
Varenne, F., Makky, A., Gaucher, M., Violleau, F., & Vauthier, C. (2016) · Pharmaceutical Research · doi:10.1007/s11095-016-1867-7 · Cited by 103
Efficient Delivery of Antisense Oligonucleotides Using Bioreducible Lipid Nanoparticles In Vitro and In Vivo
Yang, L., Ma, F., Liu, F., Chen, J., Zhao, X., & Xu, Q. (2020) · Molecular Therapy - Nucleic Acids · doi:10.1016/j.omtn.2020.01.018 · Cited by 103
Mapping of Molecular Structure of the Nanoscale Surface in Bionanoparticles
Herda, L. M., Hristov, D. R., Lo Giudice, M. C., Polo, E., & Dawson, K. A. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.6b12297 · Cited by 100
Focusing the research efforts
Schrurs, F., & Lison, D. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.148 · Cited by 99
Characterization of nanoparticles using Atomic Force Microscopy
Rao, A., Schoenenberger, M., Gnecco, E., Glatzel, T., Meyer, E., Brändlin, D., & Scandella, L. (2007) · Journal of Physics Conference Series · doi:10.1088/1742-6596/61/1/192 · Cited by 98
Background, status and future of the Transmission Electron Aberration-corrected Microscope project
Dahmen, U., Erni, R., Radmilovic, V. R., Ksielowski, C., Rossell, M. D., & Denes, P. (2009) · Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences · doi:10.1098/rsta.2009.0094 · Cited by 93
Structural basis of DOTMA for its high intravenous transfection activity in mouse
Ren, T., Song, Y. K., Zhang, G., & Liu, D. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301153 · Cited by 91
Design concepts of polyplex micelles for in vivo therapeutic delivery of plasmid DNA and messenger RNA
Uchida, S., & Kataoka, K. (2019) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36614 · Cited by 90
Targeted Polymersome Delivery of siRNA Induces Cell Death of Breast Cancer Cells Dependent upon Orai3 Protein Expression
Pangburn, T. O., Georgiou, K., Bates, F. S., & Kokkoli, E. (2012) · Langmuir · doi:10.1021/la300874z · Cited by 85
RNA delivery biomaterials for the treatment of genetic and rare diseases
Zhao, W., Hou, X., Vick, O. G., & Dong, Y. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119291 · Cited by 82

Research works printed but not linked: 1

Malaviya, M. & Shiroya, M. Systemic gene delivery using lipid envelope systems and its potential in overcoming challenges. Int. J. Pharm. Drug Anal. 9, 46–55 (2021).

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Authors: Mendes, B. B., Conniot, J., Avital, A., Yao, D., Jiang, X., Zhou, X., Sharf-Pauker, N., Xiao, Y., Adir, O., Liang, H., Shi, J., Schroeder, A., & Conde, J.
Affiliations: Ningbo University (CN)
University of Science and Technology of China (CN)
Brigham and Women's Hospital (US)
Technion – Israel Institute of Technology (IL)
Universidade Nova de Lisboa (PT)
Corresponding author: Liang, Haojun
Shi, Jinjun
Schroeder, Avi
Conde, João
ORCID: Mendes, Bárbara B.
Conniot, João
Avital, Aviram
Yao, Dongbao
Jiang, Xingya
Zhou, Xiang
Xiao, Yuling
Adir, Omer
Liang, Haojun
Shi, Jinjun
Schroeder, Avi
Conde, João
Venue: Nature Reviews Methods Primers
Publisher: Springer Science and Business Media LLC
Published: 2022-04-14
Volume: 2
Issue: 1
ISSN: 2662-8449 (ISSN-L)
DOI: 10.1038/s43586-022-00104-y
PMC: PMC9038125
OpenAlex: W4223968391
Cited by: 719
References: 228
Citations by year: 2026: 166 · 2025: 233 · 2024: 196 · 2023: 103 · 2022: 21
FWCI: 14.40
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Methods Primers (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
Funders: U.S. Department of Veterans Affairs (I01 BX004426)
American Lung Association
Massachusetts General Hospital
National Natural Science Foundation of China (52003264, 21991132, 52033010, 2020YFA0710700, 52021002)
National Institutes of Health
Fundação para a Ciência e a Tecnologia (PTDC/BTM-MAT/4738/2020)
Fundamental Research Funds for the Central Universities
National Heart, Lung, and Blood Institute (R01HL159012, R01HL156362, R01HL137229, R01HL158097, R01HL162367)
National Cancer Institute (R01CA200900)
H2020 European Research Council (848325)
DOD Peer Reviewed Cancer Research Program
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
Keywords: nucleic acid delivery, nanodelivery, gene therapy, nanoparticles, siRNA, microRNA, antisense DNA, mRNA therapeutics, targeted delivery, structure-function relationship, molecular diagnosis, gene silencing, vaccines, protein replacement

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