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Glucostatic Mechanism of Regulation of Food Intake
Abstract
THE regulation of energy intake is fundamental to all homeostatic mechanisms. Yet this basic process has received less attention than many of the physiologic regulations that it makes possible.Before this century, three theories were advanced to account for the phenomenon of hunger. The theories of peripheral origin (Haller, Erasmus Darwin, Johannes Müller and Weber) held that the taking of food resulted from the stimulation either of all afferent nerves by some change in the tissues or of a strictly local group of sensory nerves, mainly in the stomach. The theory of central origin (Magendie, Tidewald and Milne-Edwards) postulated that . . .
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Citations
Cites
Urges to eat and drink in rats.
Adolph, E. F. (1947) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1947.151.1.110 · Cited by 449
Cited by
Liquid versus solid carbohydrate: effects on food intake and body weight
DiMeglio, D., & Mattes, R. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801229 · Cited by 882
Mayer, J. (1955) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1955.tb36543.x · Cited by 858
Self-citationHypothalamic sensing of fatty acids
Lam, T. K. T., Schwartz, G. J., & Rossetti, L. (2005) · Nature Neuroscience · doi:10.1038/nn1456 · Cited by 478
The circadian regulation of food intake
Challet, E. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0210-x · Cited by 428
The New Biology and Pharmacology of Glucagon
Müller, T. D., Finan, B., Clemmensen, C., DiMarchi, R. D., & Tschöp, M. H. (2017) · Physiological Reviews · doi:10.1152/physrev.00025.2016 · Cited by 419
High-glycemic Index Foods, Hunger, and Obesity: Is There a Connection?
Roberts, S. B. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.2000.tb01855.x · Cited by 356
Appetite control and energy balance: Impact of exercise
Blundell, J. E., Gibbons, C., Caudwell, P., Finlayson, G., & Hopkins, M. (2015) · Obesity Reviews · doi:10.1111/obr.12257 · Cited by 346
The physiological psychology of hunger: a physiological perspective
Friedman, M. I., & Stricker, E. M. (1976) · Psychological Review · doi:10.1037/0033-295x.83.6.409 · Cited by 334
The energy balance model of obesity: beyond calories in, calories out
Hall, K. D., Farooqi, I. S., Friedman, J. M., Klein, S., Loos, R. J., Mangelsdorf, D. J., O’Rahilly, S., Ravussin, E., Redman, L. M., Ryan, D. H., et al. (2022) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqac031 · Cited by 315
Obesity, A Disorder Of Nutrient Partitioning: The MONA LISA Hypothesis
Bray, G. A. (1991) · The Journal of Nutrition · doi:10.1093/jn/121.8.1146 · Cited by 243
Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation
Li, Y., Schnabl, K., Gabler, S.-M., Willershäuser, M., Reber, J., Karlas, A., Laurila, S., Lahesmaa, M., u Din, M., Bast-Habersbrunner, A., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.016 · Cited by 228
Association of sleep duration with type 2 diabetes and impaired glucose tolerance
Chaput, J.-P., Després, J.-P., Bouchard, C., & Tremblay, A. (2007) · Diabetologia · doi:10.1007/s00125-007-0786-x · Cited by 222
Chaput, J.-P., Després, J.-P., Bouchard, C., Astrup, A., & Tremblay, A. (2009) · Sleep Medicine · doi:10.1016/j.sleep.2008.09.016 · Cited by 209
Bray, G. A. (2023) · Nutrients · doi:10.3390/nu15102254 · Cited by 210
Glycaemic response to foods: Impact on satiety and long-term weight regulation
Bornet, F. R. J., Jardy-Gennetier, A.-E., Jacquet, N., & Stowell, J. (2007) · Appetite · doi:10.1016/j.appet.2007.04.006 · Cited by 182
The physiological control of eating: signals, neurons, and networks
Watts, A. G., Kanoski, S. E., Sanchez-Watts, G., & Langhans, W. (2022) · Physiological Reviews · doi:10.1152/physrev.00028.2020 · Cited by 168
Human eating: evidence for a physiological basis using a modified paradigm
Campfield, L. A., Smith, F. J., Rosenbaum, M., & Hirsch, J. (1996) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00043-e · Cited by 167
The macronutrients, appetite, and energy intake
Carreiro, A. L., Dhillon, J., Gordon, S., Higgins, K. A., Jacobs, A. G., McArthur, B. M., Redan, B. W., Rivera, R. L., Schmidt, L. R., & Mattes, R. D. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-121415-112624 · Cited by 159
Bouret, S., Levin, B. E., & Ozanne, S. E. (2015) · Physiological Reviews · doi:10.1152/physrev.00007.2014 · Cited by 157
The Glucostatic Theory of Appetite Control and the Risk of Obesity and Diabetes
Chaput, J.-P., & Tremblay, A. (2009) · International Journal of Obesity · doi:10.1038/ijo.2008.221 · Cited by 111
Postprandial glycaemic dips predict appetite and energy intake in healthy individuals
Wyatt, P., Berry, S. E., Finlayson, G., O’Driscoll, R., Hadjigeorgiou, G., Drew, D. A., Khatib, H. A., Nguyen, L. H., Linenberg, I., Chan, A. T., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00383-x · Cited by 114
“The notion that blood glucose is involved in appetite was described by Mayer in the ‘glucostatic hypothesis’(16).”
BackgroundSugars, energy metabolism, and body weight control
Saris, W. H. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.4.850s · Cited by 102
Jarvis, P. R. E., Cardin, J. L., Nisevich-Bede, P. M., & McCarter, J. P. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155640 · Cited by 86
Food Cues and Obesity: Overpowering Hormones and Energy Balance Regulation
Belfort-DeAguiar, R., & Seo, D. (2018) · Current Obesity Reports · doi:10.1007/s13679-018-0303-1 · Cited by 84
White, N. M. (1986) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(86)90030-8 · Cited by 79
Levin, B. E. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00763-1 · Cited by 79
Hansen, T. T., Astrup, A., & Sjödin, A. (2021) · Nutrients · doi:10.3390/nu13093193 · Cited by 77
Glucose sensing and the pathogenesis of obesity and type 2 diabetes
Thorens, B. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.208 · Cited by 78
Hopkins, M., King, N. A., & Blundell, J. E. (2010) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e32833e343b · Cited by 76
Insulin and glucagon as determinants of body weight set point and microregulation in rats
de Castro, J. M., Paullin, S. K., & DeLugas, G. M. (1978) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077485 · Cited by 74
Chaput, J.-P., Tremblay, A., Rimm, E. B., Bouchard, C., & Ludwig, D. S. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.2.303 · Cited by 73
The physiology and pathophysiology of the neural control of the counterregulatory response
Beall, C., Ashford, M. L., & McCrimmon, R. J. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00531.2011 · Cited by 63
Role of Neuronal Glucosensing in the Regulation of Energy Homeostasis
Levin, B. E., Kang, L., Sanders, N. M., & Dunn-Meynell, A. A. (2006) · Diabetes · doi:10.2337/db06-s016 · Cited by 54
Insights into the constellating drivers of satiety impacting dietary patterns and lifestyle
Rakha, A., Mehak, F., Shabbir, M. A., Arslan, M., Ranjha, M. M. A. N., Ahmed, W., Socol, C. T., Rusu, A. V., Hassoun, A., & Aadil, R. M. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1002619 · Cited by 52
About unsuspected potential determinants of obesity
Tremblay, A., & Chaput, J.-P. (2008) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h08-038 · Cited by 45
Chandler-Laney, P. C., Morrison, S. A., Goree, L. L. T., Ellis, A. C., Casazza, K., Desmond, R., & Gower, B. A. (2014) · Appetite · doi:10.1016/j.appet.2014.04.031 · Cited by 24
Wedick, N. M., Snijder, M. B., Dekker, J. M., Heine, R. J., Stehouwer, C. D. A., Nijpels, G., & van Dam, R. M. (2009) · Obesity · doi:10.1038/oby.2008.666 · Cited by 18
Metadata
- Authors
- Mayer, J.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1953-07-02
- Volume
- 249
- Issue
- 1
- Pages
- 13-16
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2334369162
- Cited by
- 666
- References
- 1
- FWCI
- 7.12
- Type
- journal article
- Language
- en
- Open access
- closed
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