The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
BDNF is essential to promote persistence of long-term memory storage
Open accessAbstract
Persistence is a characteristic attribute of long-term memories (LTMs). However, little is known about the molecular mechanisms that mediate this process. We recently showed that persistence of LTM requires a late protein synthesis- and BDNF-dependent phase in the hippocampus. Here, we show that intrahippocampal delivery of BDNF reverses the deficit in memory persistence caused by inhibition of hippocampal protein synthesis. Importantly, we demonstrate that BDNF induces memory persistence by itself, transforming a nonlasting LTM trace into a persistent one in an ERK-dependent manner. Thus, BDNF is not only necessary, but sufficient to induce a late postacquisition phase in the hippocampus essential for persistence of LTM storage.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Neurotrophin signal transduction in the nervous system
Kaplan, D. R., & Miller, F. D. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00092-1 · Cited by 1,944
Learning induces long-term potentiation in the hippocampus
Whitlock, J. R., Heynen, A. J., Shuler, M. G., & Bear, M. F. (2006) · Science · doi:10.1126/science.1128134 · Cited by 1,913
The MAPK cascade is required for mammalian associative learning
Atkins, C. M., Selcher, J. C., Petraitis, J. J., Trzaskos, J. M., & Sweatt, J. D. (1998) · Nature Neuroscience · doi:10.1038/2836 · Cited by 1,083
Independent cellular processes for hippocampal memory consolidation and reconsolidation
Lee, J. L. C., Everitt, B. J., & Thomas, K. L. (2004) · Science · doi:10.1126/science.1095760 · Cited by 825
Dendritic spines and long-term plasticity
Segal, M. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1649 · Cited by 489
Neurotrophins and Time: Different Roles for TrkB Signaling in Hippocampal Long-Term Potentiation
Kang, H., Welcher, A. A., Shelton, D., & Schuman, E. M. (1997) · Neuron · doi:10.1016/s0896-6273(00)80378-5 · Cited by 481
Alonso, M., Medina, J. H., & Pozzo-Miller, L. (2004) · Learning & Memory · doi:10.1101/lm.67804 · Cited by 412
Self-citationOverexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP
Wang, H., Ferguson, G. D., Pineda, V. V., Cundiff, P. E., & Storm, D. R. (2004) · Nature Neuroscience · doi:10.1038/nn1248 · Cited by 244
Long-term potentiation and memory
Morris, R. G. M. (2003) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2002.1230 · Cited by 232
Cited by
The effect of pain on cognitive function: A review of clinical and preclinical research
Moriarty, O., McGuire, B. E., & Finn, D. P. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.01.002 · Cited by 1,122
TrkB signalling pathways in LTP and learning
Minichiello, L. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2738 · Cited by 1,055
Brain-Derived Neurotrophic Factor in Alzheimer’s Disease and Its Pharmaceutical Potential
Gao, L., Zhang, Y., Sterling, K., & Song, W. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00279-0 · Cited by 606
Brain-derived neurotrophic factor levels in schizophrenia: a systematic review with meta-analysis
Green, M. J., Matheson, S. L., Shepherd, A., Weickert, C. S., & Carr, V. J. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.88 · Cited by 453
Mustapic, M., Eitan, E., Werner, J. K., Berkowitz, S. T., Lazaropoulos, M. P., Tran, J., Goetzl, E. J., & Kapogiannis, D. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00278 · Cited by 441
Behavioral tagging is a general mechanism of long-term memory formation
Ballarini, F., Moncada, D., Martinez, M. C., Alen, N., & Viola, H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907078106 · Cited by 301
Epigenetic Regulation of the BDNF Gene: Implications for Psychiatric Disorders
Boulle, F., van den Hove, D. L. A., Jakob, S. B., Rutten, B. P., Hamon, M., van Os, J., Lesch, K.-P., Lanfumey, L., Steinbusch, H. W., & Kenis, G. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.107 · Cited by 282
The neuroprotective roles of BDNF in hypoxic ischemic brain injury
CHEN, A., XIONG, L.-J., TONG, Y., & MAO, M. (2013) · Biomedical Reports · doi:10.3892/br.2012.48 · Cited by 267
BDNF activates mTOR to regulate GluR1 expression required for memory formation
Slipczuk, L., Bekinschtein, P., Katche, C., Cammarota, M., Izquierdo, I., & Medina, J. H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006007 · Cited by 246
Self-citationZhang, Z., Liu, X., Schroeder, J. P., Chan, C.-B., Song, M., Yu, S. P., Weinshenker, D., & Ye, K. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.243 · Cited by 242
Form follows function: BDNF and its involvement in sculpting the function and structure of synapses
Zagrebelsky, M., & Korte, M. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.029 · Cited by 241
Higher BDNF serum levels predict slower cognitive decline in Alzheimer's disease patients
Laske, C., Stellos, K., Hoffmann, N., Stransky, E., Straten, G., Eschweiler, G. W., & Leyhe, T. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710001008 · Cited by 180
Lin, Y.-T., Hsieh, T.-Y., Tsai, T.-C., Chen, C.-C., Huang, C.-C., & Hsu, K.-S. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.1896-17.2017 · Cited by 165
Yang, L.-C., Zhang, Q.-G., Zhou, C.-F., Yang, F., Zhang, Y.-D., Wang, R.-M., & Brann, D. W. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009851 · Cited by 163
A Positive Autoregulatory BDNF Feedback Loop via C/EBPβ Mediates Hippocampal Memory Consolidation
Bambah-Mukku, D., Travaglia, A., Chen, D. Y., Pollonini, G., & Alberini, C. M. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.0324-14.2014 · Cited by 145
Joggin’ the Noggin: Towards a Physiological Understanding of Exercise-Induced Cognitive Benefits
Stimpson, N. J., Davison, G., & Javadi, A.-H. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.03.018 · Cited by 134
Yang, F., Chu, X., Yin, M., Liu, X., Yuan, H., Niu, Y., & Fu, L. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.02.005 · Cited by 136
Zheng, Y., Fan, W., Zhang, X., & Dong, E. (2016) · Epigenetics · doi:10.1080/15592294.2016.1146850 · Cited by 111
Gafford, G. M., Parsons, R. G., & Helmstetter, F. J. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.03.023 · Cited by 110
Beck, B., & Pourié, G. (2013) · Nutrition Reviews · doi:10.1111/nure.12045 · Cited by 86
Kofink, D., Boks, M. P. M., Timmers, H. T. M., & Kas, M. J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.03.020 · Cited by 83
Uribe, V., Wong, B. K. Y., Graham, R. K., Cusack, C. L., Skotte, N. H., Pouladi, M. A., Xie, Y., Feinberg, K., Ou, Y., Ouyang, Y., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds005 · Cited by 78
Mello-Carpes, P. B., da Silva de Vargas, L., Gayer, M. C., Roehrs, R., & Izquierdo, I. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.11.014 · Cited by 75
Self-citationFurini, C. R., Rossato, J. I., Bitencourt, L. L., Medina, J. H., Izquierdo, I., & Cammarota, M. (2010) · Hippocampus · doi:10.1002/hipo.20656 · Cited by 72
Vargas-Martínez, F., Uvnäs-Moberg, K., Petersson, M., Olausson, H. A., & Jiménez-Estrada, I. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.10.001 · Cited by 51
Vitaliano, G. D., Kim, J. K., Kaufman, M. J., Adam, C. W., Zeballos, G., Shanmugavadivu, A., Subburaju, S., McLaughlin, J. P., Lukas, S. E., & Vitaliano, F. (2022) · Communications Biology · doi:10.1038/s42003-022-03177-3 · Cited by 48
Cardoner, N., Andero, R., Cano, M., Marin-Blasco, I., Porta-Casteràs, D., Serra-Blasco, M., Via, E., Vicent-Gil, M., & Portella, M. J. (2024) · Current Neuropharmacology · doi:10.2174/1570159x21666230703091435 · Cited by 45
Uysal, N. (2015) · Medical Science Monitor · doi:10.12659/msm.893159 · Cited by 44
Hafycz, J. M., Strus, E., & Naidoo, N. (2022) · Aging Cell · doi:10.1111/acel.13598 · Cited by 34
Unsain, N., Montroull, L. E., & Mascó, D. H. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06342.x · Cited by 32
Ozawa, T., Yamada, K., & Ichitani, Y. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.01.034 · Cited by 31
Metadata
- Authors
- Bekinschtein, P., Cammarota, M., Katche, C., Slipczuk, L., Rossato, J. I., Goldin, A., Izquierdo, I., & Medina, J. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2008-02-19
- Volume
- 105
- Issue
- 7
- Pages
- 2711-2716
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2078945917
- Cited by
- 657
- References
- 9
- FWCI
- 14.77
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
