Modulation of circadian clocks by nutrients and food factors
Abstract
Daily activity rhythms that are dominated by internal clocks are called circadian rhythms. A central clock is located in the suprachiasmatic nucleus of the hypothalamus, and peripheral clocks are located in most mammalian peripheral cells. The central clock is entrained by light/dark cycles, whereas peripheral clocks are entrained by feeding cycles. The effects of nutrients on the central and peripheral clocks have been investigated during the past decade and much interaction between them has come to light. For example, a high-fat diet prolongs the period of circadian behavior, a ketogenic diet advances the onset of locomotor activity rhythms, and a high-salt diet advances the phase of peripheral molecular clocks. Moreover, some food factors such as caffeine, nobiletin, and resveratrol, alter molecular and/or behavioral circadian rhythms. Here, we review nutrients and food factors that modulate mammalian circadian clocks from the cellular to the behavioral level.
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Food can regulate various peripheral body clocks and metabolic rhythms and is often referred to as a zeitgeber.
“Food is often referred to as a zeitgeber (14) because of its ability to regulate various peripheral body clocks and metabolic rhythms (2, 15, 16).”
From Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health (2019) · cites this paper as [16]
It may be that chronotype is a consequence of the entraining effect of food constituents or eating patterns on peripheral clocks.
“Furthermore, it may be that chronotype is a consequence of (caused by) the entraining effect of food constituents (16) or eating patterns on the peripheral clocks (15) (Figure 1).”
From Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health (2019) · cites this paper as [16]
Timing of macronutrient intake has been shown to affect the circadian clock in rodent models, with little data from human studies.
“The latter are key issues considering that timing of macronutrient intake has been shown to affect the circadian clock in rodent models, with little data from human studies (16, 134).”
From Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health (2019) · cites this paper as [16]
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Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health
Almoosawi, S., Vingeliene, S., Gachon, F., Voortman, T., Palla, L., Johnston, J. D., Van Dam, R. M., Darimont, C., & Karagounis, L. G. (2019) · Advances in Nutrition · doi:10.1093/advances/nmy070 · Cited by 247 · see citing works
Managing Travel Fatigue and Jet Lag in Athletes: A Review and Consensus Statement
van Rensburg, D. C. J., van Rensburg, A. J., Fowler, P., Bender, A. M., Stevens, D. J., Sullivan, K. O., Fullagar, H. H. K., Alonso, J. M., Biggins, M., Claassen-Smithers, A., et al. (2021) · Sports Medicine · doi:10.1007/s40279-021-01502-0 · Cited by 145 · see citing works
Entrainment of the mouse circadian clock: Effects of stress, exercise, and nutrition
Tahara, Y., & Shibata, S. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.12.026 · Cited by 116 · see citing works
Circadian clock: a regulator of the immunity in cancer
Zhang, Z., Zeng, P., Gao, W., Zhou, Q., Feng, T., & Tian, X. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00721-2 · Cited by 77 · see citing works
How to manage travel fatigue and jet lag in athletes? A systematic review of interventions
van Rensburg, D. C. J., van Rensburg, A. J., Fowler, P., Fullagar, H. H. K., Stevens, D. J., Halson, S. L., Bender, A. M., Vincent, G. E., Claassen-Smithers, A., Dunican, I. C., et al. (2020) · British Journal of Sports Medicine · doi:10.1136/bjsports-2019-101635 · Cited by 79 · see citing works
Angptl8 mediates food-driven resetting of hepatic circadian clock in mice
Chen, S., Feng, M., Zhang, S., Dong, Z., Wang, Y., Zhang, W., & Liu, C. (2019) · Nature Communications · doi:10.1038/s41467-019-11513-1 · Cited by 73 · see citing works
Jakubowicz, D. J., Wainstein, J., Tsameret, S., & Landau, Z. (2021) · Nutrients · doi:10.3390/nu13051558 · Cited by 54 · see citing works
The impact of insomnia on frailty and the hallmarks of aging
Carvalhas-Almeida, C., Cavadas, C., & Álvaro, A. R. (2022) · Aging Clinical and Experimental Research · doi:10.1007/s40520-022-02310-w · Cited by 49 · see citing works
The clock diet: a practical nutritional guide to manage obesity through chrononutrition
Barrea, L., Frías-Toral, E., APRANO, S., CASTELLUCCI, B., PUGLIESE, G., RODRIGUEZ-VEINTIMILLA, D., Vitale, G., GENTILINI, D., COLAO, A., SAVASTANO, S., et al. (2022) · Minerva Medica · doi:10.23736/s0026-4806.21.07207-4 · Cited by 32 · see citing works
Gitaí, D. L. G., de Andrade, T. G., dos Santos, Y. D. R., Attaluri, S., & Shetty, A. K. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.01.004 · Cited by 31 · see citing works
Cui, Y., Yin, Y., Li, S., Wu, Z., Xie, Y., Qian, Q., Yang, H., & Li, X. (2022) · Food & Function · doi:10.1039/d1fo04116a · Cited by 28 · see citing works
Lifetime coffee consumption, pineal gland volume, and sleep quality in late life
Park, J., Han, J. W., Lee, J. R., Byun, S., Suh, S. W., Kim, T., Yoon, I. Y., & Kim, K. W. (2018) · SLEEP · doi:10.1093/sleep/zsy127 · Cited by 27 · see citing works
Statistical mechanics of clock gene networks underlying circadian rhythms
Sun, L., Dong, A., Griffin, C. H., & Wu, R. (2021) · Applied Physics Reviews · doi:10.1063/5.0029993 · Cited by 26 · see citing works
Naturally-derived chronobiotics in chrononutrition
Dufoo‐Hurtado, E., Wall‐Medrano, A., & Campos-Vega, R. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.11.020 · Cited by 24 · see citing works
Circadian regulation of transporter expression and implications for drug disposition
Pácha, J., Balounová, K., & Soták, M. (2020) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2021.1868438 · Cited by 22 · see citing works
Mortaş, H., Bilici, S., Öztürk, H., & Karakan, T. (2022) · Chronobiology International · doi:10.1080/07420528.2022.2044349 · Cited by 21 · see citing works
Fukuda, T., Haraguchi, A., Takahashi, M., Nakaoka, T., Fukazawa, M., Okubo, J., Ozaki, M., Kanatome, A., Ohya, R., Miura, Y., et al. (2018) · Chronobiology International · doi:10.1080/07420528.2018.1490315 · Cited by 15 · see citing works
Kim, S. M., Jeon, Y., Jang, J. Y., & Lee, H. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01554-3 · Cited by 14 · see citing works
Ruben, M. D., Hogenesch, J. B., & Smith, D. F. (2019) · Neurologic Clinics · doi:10.1016/j.ncl.2019.03.004 · Cited by 13 · see citing works
Resveratrol Induces the Fasting State and Alters Circadian Metabolism in Hepatocytes
Chatam, O., Chapnik, N., & Froy, O. (2022) · Plant Foods for Human Nutrition · doi:10.1007/s11130-022-00954-7 · Cited by 12 · see citing works
Jakubowicz, D. J., Matz, Y., Landau, Z., Rosenblum, R. C., Twito, O., Wainstein, J., & Tsameret, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212355 · Cited by 12 · see citing works
Caffeine and rheumatoid arthritis: A complicated relationship
Ingegnoli, F., Cavalli, S., Giudice, L., & Caporali, R. F. (2022) · Autoimmunity Reviews · doi:10.1016/j.autrev.2022.103117 · Cited by 11 · see citing works
Ketogenic Diet Affects Sleep Architecture in C57BL/6J Wild Type and Fragile X Mice
Westmark, P. R., Gholston, A. K., Swietlik, T. J., Maganti, R. K., & Westmark, C. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914460 · Cited by 11 · see citing works
Modulation of cellular circadian clocks by triterpenoids
Suzuki, C., Fukumitsu, S., & Oike, H. (2020) · Phytochemistry · doi:10.1016/j.phytochem.2020.112539 · Cited by 10 · see citing works
Effects of circadian iron administration on iron bioavailability and biological rhythm in pigs
Dong, Z., Li, L., Zhang, Y., Guo, L., Wu, X., Yin, Y., & Wan, D. (2020) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.10897 · Cited by 10 · see citing works
Cheng, H., Liu, Z., Wu, G., Ho, C., Li, D., & Xie, Z. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104370 · Cited by 9 · see citing works
Westmark, P. R., Swietlik, T. J., Runde, E., Corsiga, B., Nissan, R., Boeck, B., Granger, R., Jennings, E., Nebbia, M., Thauwald, A., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126679 · Cited by 8 · see citing works
Wang, C., Almoosawi, S., & Palla, L. (2019) · Nutrients · doi:10.3390/nu11102476 · Cited by 8 · see citing works
Zhang, Z., Liu, B., & Ding, S. (2025) · The FASEB Journal · doi:10.1096/fj.202501289r · Cited by 7 · see citing works
The skeletal muscle circadian clock: current insights
Nakao, R., Nikawa, T., & Oishi, K. (2017) · ChronoPhysiology and Therapy · doi:10.2147/cpt.s116569 · Cited by 7 · see citing works
The impact of biological clock and sex hormones on the risk of disease
Furtado, A., Costa, D. R. B., Lemos, M. C., Cavaco, J. E. B., Santos, C. R. A., & Quintela, T. (2023) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2023.03.004 · Cited by 7 · see citing works
Relationship Between the Cortisol-Estradiol Phase Difference and Affect in Women
Butler, K. G. (2018) · Journal of Circadian Rhythms · doi:10.5334/jcr.154 · Cited by 6 · see citing works
Paragliola, R. M., Marchetti, M., Montagna, C., Corsello, S. M., & Peluso, G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262211230 · Cited by 7 · see citing works
Addressing Circadian Disruptions in Visually Impaired Paralympic Athletes
Anderson, T., Adams, W. M., Burns, G. T., Post, E. G., Baumann, S., Clark, E., Cogan, K. D., & Finnoff, J. T. (2024) · International Journal of Sports Physiology and Performance · doi:10.1123/ijspp.2023-0267 · Cited by 4 · see citing works
Molecular Mechanisms of Chronobiotics as Functional Foods
Dufoo‐Hurtado, E., Wall‐Medrano, A., & Campos-Vega, R. (2022) · Wiley eBooks · doi:10.1002/9781119804055.ch3 · Cited by 4 · see citing works
Rodrigues, P. R. M., Monteiro, L. S., de Vasconcelos, T. M., Alves, I. A., Yokoo, E. M., Sichieri, R., & Pereira, R. A. (2024) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph21111403 · Cited by 3 · see citing works
Tsameret, S., Jakubowicz, D. J., Landau, Z., Wainstein, J., Ganz, T., Raz, I., Chapnik, N., & Froy, O. (2021) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2021.108941 · Cited by 3 · see citing works
Spermidine resets circadian clock phase in NIH3T3 cells
Yang, D., Oike, H., Furuse, M., & Yasuo, S. (2021) · Biomedical Research · doi:10.2220/biomedres.42.221 · Cited by 3 · see citing works
Hara, A., & Satake, A. (2021) · Journal of Mathematical Biology · doi:10.1007/s00285-021-01645-8 · Cited by 3 · see citing works
Plasma Activated Water in Enhancing Food Safety and Quality: A Comprehensive Review
Srivastava, S., Akbar, U., Mondol, M. S. A., Dash, K. K., Junaid, P. M., Manzoor, M., Khan, S. A., & Dar, A. H. (2025) · Plasma Chemistry and Plasma Processing · doi:10.1007/s11090-025-10601-z · Cited by 2 · see citing works
Eberli, N., Colas, L., & Gimalac, A. (2024) · Journal of Chinese Integrative Medicine · doi:10.1016/j.joim.2024.02.002 · Cited by 2 · see citing works
Dalvi, M., & Medithi, S. (2024) · Biological Rhythm Research · doi:10.1080/09291016.2024.2333296 · Cited by 2 · see citing works
Circadian rhythms, physical activity and longevity
Nasso, R., Pagliara, V., Ascione, A., Masullo, M., & Arcone, R. (2019) · Summer Conferences of Sports Science · doi:10.14198/jhse.2019.14.proc5.11 · Cited by 2 · see citing works
Chrononutritional Modulation of Sleep and the Circadian Clock by Amino Acids
Yasuo, S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816658-1.00037-5 · Cited by 1 · see citing works
Biological clock vs Social clock conflict in Adolescents
Verma, P., Yadav, A., Rani, S., & Malik, S. (2021) · Journal of Applied and Natural Science · doi:10.31018/jans.v13i1.2571 · Cited by 1 · see citing works
Silva, G. H., Leite, A. M. Z. D. S., Guinho, G. A. S., Tiburcio, J. W. D. L., Teles, E. D. L. S., Gonçalves, D. M. M., Santos, J. C. F., de Medeiros, L. S., Faustino, A. G., da Silva, M. C., et al. (2024) · Brazilian Journal of Implantology and Health Sciences · doi:10.36557/2674-8169.2024v6n1p1139-1160 · Cited by 1 · see citing works
Could chronotype be a risk factor for unhealthy eating and prediabetes?
Çelen, M., & İnce, N. (2024) · Biological Rhythm Research · doi:10.1080/09291016.2024.2361676 · Cited by 1 · see citing works
Oike, H. (2021) · KAGAKU TO SEIBUTSU · doi:10.1271/kagakutoseibutsu.59.75
Hara, A., & Satake, A. (2022) · Mathematics for industry · doi:10.1007/978-981-19-1154-5_7
Liver clock: Malalignment and entrainment therapeutics
Sharma, S., Pandey, S., & Mishra, A. K. (2026) · World Journal of Gastrointestinal Pharmacology and Therapeutics · doi:10.4292/wjgpt.v17.i1.112588
Sun, M., 潘焕新, Yang, G., Zhang, Y., Li, J., Li, X., & Zhu, W. (2026) · Toxics · doi:10.3390/toxics14100893
- Authors
- Oike, H.
- Affiliations
- National Agriculture and Food Research Organization (JP)
- Corresponding author
- Oike, Hideaki
- ORCID
- Oike, Hideaki
- Venue
- Bioscience Biotechnology and Biochemistry
- Publisher
- Informa UK Limited
- Published
- 2017-05-04
- Volume
- 81
- Issue
- 5
- Pages
- 863-870
- ISSN
- 0916-8451 (ISSN-L)
- 1347-6947
- OpenAlex
- W2581646467
- Cited by
- 53
- References
- 91
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 8 · 2023: 3 · 2022: 8 · 2021: 10 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 3
- FWCI
- 0.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Bioscience Biotechnology and Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (KAKENHI Challenging Exploratory Research (16K12746, KAKENHI Young Scientists A (25702005))
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- circadian clock, circadian rhythm, nutrients, food factors, feeding rhythm, suprachiasmatic nucleus, peripheral clocks, high-fat diet, ketogenic diet, high-salt diet, caffeine, nobiletin, resveratrol, locomotor activity rhythm, clock period, clock phase
- MeSH terms
- Animals, Food, Humans, Circadian Clocks
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