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Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin
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Citations
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“…phospho-LRP6 directly binds and inhibits GSK3 (Cselenyi et al. 2008; Piao et al. 2008; Wu et al. 2009) and since only GSK3 in the active conformation can bind to Axin (Ikeda et al. 1998), it is expected that Wnt signaling reduces the physical interaction 6 GENES & DEVELOPMENT between GSK3 and Axin.”
BackgroundInfluentialEarly Embryonic Death in Mice Lacking the β-Catenin-Binding Protein Duplin
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Metadata
- Authors
- Ikeda, S.
- Venue
- The EMBO Journal
- Published
- 1998-03-02
- Volume
- 17
- Issue
- 5
- Pages
- 1371-1384
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- OpenAlex
- W2132475598
- Cited by
- 1,246
- References
- 2
- FWCI
- 28.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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