Cited by 37,077Bioinformatics and Genomic NetworksGenomics and Phylogenetic StudiesMicrobial Metabolic Engineering and Bioproduction

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KEGG: Kyoto Encyclopedia of Genes and Genomes

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Kanehisa, M.·2000·Nucleic Acids Research

DOI 10.1093/nar/28.1.27PMC PMC102409

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Abstract

KEGG (Kyoto Encyclopedia of Genes and Genomes) is a knowledge base for systematic analysis of gene functions, linking genomic information with higher order functional information. The genomic information is stored in the GENES database, which is a collection of gene catalogs for all the completely sequenced genomes and some partial genomes with up-to-date annotation of gene functions. The higher order functional information is stored in the PATHWAY database, which contains graphical representations of cellular processes, such as metabolism, membrane transport, signal transduction and cell cycle. The PATHWAY database is supplemented by a set of ortholog group tables for the information about conserved subpathways (pathway motifs), which are often encoded by positionally coupled genes on the chromosome and which are especially useful in predicting gene functions. A third database in KEGG is LIGAND for the information about chemical compounds, enzyme molecules and enzymatic reactions. KEGG provides Java graphics tools for browsing genome maps, comparing two genome maps and manipulating expression maps, as well as computational tools for sequence comparison, graph comparison and path computation. The KEGG databases are daily updated and made freely available (http://www. genome.ad.jp/kegg/).

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Authors: Kanehisa, M.
Affiliations: Kyoto University (JP)
Corresponding author: Kanehisa, M.
ORCID: Kanehisa, M.
Venue: Nucleic Acids Research
Publisher: Oxford University Press (OUP)
Published: 2000-01-01
Volume: 28
Issue: 1
Pages: 27-30
ISSN: 0305-1048 (ISSN-L)
1362-4962
DOI: 10.1093/nar/28.1.27
PMC: PMC102409
OpenAlex: W4294216483
Cited by: 37,077
References: 2
Citations by year: 2026: 3223 · 2025: 4679 · 2024: 4901 · 2023: 4461 · 2022: 4132 · 2021: 3288 · 2020: 2270 · 2019: 1699 · 2018: 1295 · 2017: 1242 · 2016: 1160 · 2015: 1008 · 2014: 729 · 2013: 600 · 2012: 519
FWCI: 15.42
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Nucleic Acids Research (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Institute for Chemical Research, Kyoto University
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Keywords: KEGG, gene function annotation, metabolic pathways, orthogroups, gene function prediction, chemical compounds, enzymatic reactions, genome annotation, sequence comparison, graph comparison, path computation
MeSH terms: Animals, Humans, Japan, Proteins, Gene Expression, Databases, Factual, Information Storage and Retrieval, Genome

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