APACHE II-A Severity of Disease Classification System: Reply

Early goal-directed therapy in the treatment of severe sepsis and septic shock

Rivers, E., Nguyen, B., Havstad, S., Ressler, J., Muzzin, A., Knoblich, B., Peterson, E., & Tomlanovich, M. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010307 · Cited by 10,743

Intensive insulin therapy in critically ill patients.

Van den Berghe, G., Wouters, P., Weekers, F., Verwaest, C., Bruyninckx, F., Schetz, M., Vlasselaers, D., Ferdinande, P., Lauwers, P., & Bouillon, R. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011300 · Cited by 9,977

A New Simplified Acute Physiology Score (SAPS II) Based on a European/North American Multicenter Study

Le Gall, J.-R. (1993) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.270.24.2957 · Cited by 7,773

The American-European Consensus Conference On Ards. Definitions, Mechanisms, Relevant Outcomes, And Clinical Trial Coordination

Bernard, G. R., Artigas, A., Brigham, K. L., Carlet, J., Falke, K., Hudson, L., Lamy, M., Legall, J. R., Morris, A., & Spragg, R. (1994) · American journal of respiratory and critical care medicine · doi:10.1164/ajrccm.149.3.7509706 · Cited by 6,746

Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock

Kumar, A., Roberts, D., Wood, K. E., Light, B., Parrillo, J. E., Sharma, S., Suppes, R., Feinstein, D., Zanotti, S., Taiberg, L., et al. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000217961.75225.e9 · Cited by 6,109

A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care

Hébert, P. C., Wells, G., Blajchman, M. A., Marshall, J., Martin, C., Pagliarello, G., Tweeddale, M., Schweitzer, I., & Yetisir, E. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400601 · Cited by 5,187

Intensive versus Conventional Glucose Control in Critically Ill Patients

(2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810625 · Cited by 5,119

The Richmond agitation-sedation scale: validity and reliability in adult intensive care unit patients

Sessler, C. N., Gosnell, M. S., Grap, M. J., Brophy, G. M., O'Neal, P. V., Keane, K. A., Tesoro, E. P., & Elswick, R. K. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2107138 · Cited by 3,695

Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome.

Amato, M. B. P., Barbas, C. S. V., Medeiros, D. M., Magaldi, R. B., Schettino, G. P., Lorenzi-Filho, G., Kairalla, R. A., Deheinzelin, D., Munoz, C., Oliveira, R., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802053380602 · Cited by 3,654

Intensive insulin therapy in the medical ICU

Van den Berghe, G., Wilmer, A., Hermans, G., Meersseman, W., Wouters, P. J., Milants, I., Van Wijngaerden, E., Bobbaers, H., & Bouillon, R. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052521 · Cited by 3,639

Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): A multicentre randomised controlled trial.

Peek, G. J., Mugford, M., Tiruvoipati, R., Wilson, A., Allen, E., Thalanany, M. M., Hibbert, C. L., Truesdale, A., Clemens, F., Cooper, N., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61069-2 · Cited by 3,395

Delirium in Mechanically Ventilated Patients: Validity and Reliability of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU)

Ely, E. W., Inouye, S. K., Bernard, G. R., Gordon, S., Francis, J., May, L., Truman, B., Speroff, T., Gautam, S., Margolin, R., et al. (2001) · JAMA · doi:10.1001/jama.286.21.2703 · Cited by 3,210

Delirium as a Predictor of Mortality in Mechanically Ventilated Patients in the Intensive Care Unit

Ely, E. W. (2004) · JAMA · doi:10.1001/jama.291.14.1753 · Cited by 3,073

Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study

Peiris, J., Chu, C., Cheng, V., Chan, K., Hung, I., Poon, L., Law, K., Tang, B., Hon, T., Chan, C., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13412-5 · Cited by 2,375

One-Year Outcomes in Survivors of the Acute Respiratory Distress Syndrome

Herridge, M. S., Cheung, A. M., Tansey, C. M., Matte-Martyn, A., Diaz-Granados, N., Al-Saidi, F., Cooper, A. B., Guest, C. B., Mazer, C. D., Mehta, S., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022450 · Cited by 2,334

American College of Gastroenterology guideline: management of acute pancreatitis

Tenner, S., Baillie, J., DeWitt, J., & Vege, S. S. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.218 · Cited by 2,327

Comparison of Dopamine and Norepinephrine in the Treatment of Shock

De Backer, D., Biston, P., Devriendt, J., Madl, C., Chochrad, D., Aldecoa, C., Brasseur, A., Defrance, P., Gottignies, P., & Vincent, J.-L. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0907118 · Cited by 1,940

Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock

Russell, J. A., Walley, K. R., Singer, J., Gordon, A. C., Hébert, P. C., Cooper, D. J., Holmes, C. L., Mehta, S., Granton, J. T., Storms, M. M., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa067373 · Cited by 1,924

Acute Physiology and Chronic Health Evaluation (APACHE) IV: Hospital mortality assessment for today’s critically ill patients*

Zimmerman, J. E., Kramer, A. A., McNair, D. S., & Malila, F. M. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000215112.84523.f0 · Cited by 1,764

Early versus late parenteral nutrition in critically ill adults

Casaer, M. P., Mesotten, D., Hermans, G., Wouters, P. J., Schetz, M., Meyfroidt, G., Van Cromphaut, S., Ingels, C., Meersseman, P., Muller, J., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1102662 · Cited by 1,696

Loss of Independence in Activities of Daily Living in Older Adults Hospitalized with Medical Illnesses: Increased Vulnerability with Age

Covinsky, K. E., Palmer, R. M., Fortinsky, R. H., Counsell, S. R., Stewart, A. L., Kresevic, D., Burant, C. J., & Landefeld, C. S. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51152.x · Cited by 1,670

Critically Ill Patients With 2009 Influenza A(H1N1) Infection in Canada

Kumar, A. (2009) · JAMA · doi:10.1001/jama.2009.1496 · Cited by 1,425

Ventilation Strategy Using Low Tidal Volumes, Recruitment Maneuvers, and High Positive End-Expiratory Pressure for Acute Lung Injury and Acute Respiratory Distress Syndrome: A Randomized Controlled Trial

Meade, M. O., Cook, D. J., Guyatt, G. H., Slutsky, A. S., Arabi, Y. M., Cooper, D. J., Davies, A. R., Hand, L. E., Zhou, Q., Thabane, L., et al. (2008) · JAMA · doi:10.1001/jama.299.6.637 · Cited by 1,370

Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial

Besselink, M. G., van Santvoort, H. C., Buskens, E., Boermeester, M. A., van Goor, H., Timmerman, H. M., Nieuwenhuijs, V. B., Bollen, T. L., van Ramshorst, B., Witteman, B. J., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60207-x · Cited by 1,367

Price of Adaptation—Allostatic Load and Its Health Consequences: MacArthur Studies of Successful Aging

Seeman, T. E. (1997) · Archives of Internal Medicine · doi:10.1001/archinte.1997.00440400111013 · Cited by 1,368

Pneumonia and Respiratory Failure from Swine-Origin Influenza A (H1N1) in Mexico

Perez-Padilla, R., de la Rosa-Zamboni, D., Ponce de Leon, S., Hernandez, M., Quiñones-Falconi, F., Bautista, E., Ramirez-Venegas, A., Rojas-Serrano, J., Ormsby, C. E., Corrales, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0904252 · Cited by 1,325

Delaying the Empiric Treatment of Candida Bloodstream Infection until Positive Blood Culture Results Are Obtained: a Potential Risk Factor for Hospital Mortality

Morrell, M., Fraser, V. J., & Kollef, M. H. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.9.3640-3645.2005 · Cited by 1,286

Effect of prone positioning on the survival of patients with acute respiratory failure.

Gattinoni, L., Tognoni, G., Pesenti, A., Taccone, P., Mascheroni, D., Labarta, V., Malacrida, R., Di Giulio, P., Fumagalli, R., Pelosi, P., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010043 · Cited by 1,271

Big Data In Health Care: Using Analytics To Identify And Manage High-Risk And High-Cost Patients

Bates, D. W., Saria, S., Ohno-Machado, L., Shah, A., & Escobar, G. (2014) · Health Affairs · doi:10.1377/hlthaff.2014.0041 · Cited by 1,235

Medical Futility: Its Meaning and Ethical Implications

Schneiderman, L. J., Jecker, N. S., & Jonsen, A. R. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-112-12-949 · Cited by 1,215

DALI: Defining Antibiotic Levels in Intensive Care Unit Patients: Are Current -Lactam Antibiotic Doses Sufficient for Critically Ill Patients?

Roberts, J. A., Paul, S. K., Akova, M., Bassetti, M., De Waele, J. J., Dimopoulos, G., Kaukonen, K.-M., Koulenti, D., Martin, C., Montravers, P., et al. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu027 · Cited by 1,090

Impact of delayed transfer of critically ill patients from the emergency department to the intensive care unit.

Chalfin, D. B., Trzeciak, S., Likourezos, A., Baumann, B. M., & Dellinger, R. P. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000266585.74905.5a · Cited by 1,022

A Randomized Trial Comparing Fluconazole with Amphotericin B for the Treatment of Candidemia in Patients without Neutropenia

Rex, J. H., Bennett, J. E., Sugar, A. M., Pappas, P. G., van der Horst, C. M., Edwards, J. E., Washburn, R. G., Scheld, W. M., Karchmer, A. W., Dine, A. P., et al. (1994) · New England Journal of Medicine · doi:10.1056/nejm199411173312001 · Cited by 1,039

Early exercise in critically ill patients enhances short-term functional recovery*

Burtin, C., Clerckx, B., Robbeets, C., Ferdinande, P., Langer, D., Troosters, T., Hermans, G., Decramer, M., & Gosselink, R. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181a38937 · Cited by 1,032

Risk Factors for Gastrointestinal Bleeding in Critically Ill Patients

Cook, D. J., Fuller, H. D., Guyatt, G. H., Marshall, J. C., Leasa, D., Hall, R., Winton, T. L., Rutledge, F., Todd, T., Roy, P., et al. (1994) · New England Journal of Medicine · doi:10.1056/nejm199402103300601 · Cited by 1,010

The relationship between nutritional intake and clinical outcomes in critically ill patients: results of an international multicenter observational study

Alberda, C., Gramlich, L., Jones, N., Jeejeebhoy, K., Day, A. G., Dhaliwal, R., & Heyland, D. K. (2009) · Intensive Care Medicine · doi:10.1007/s00134-009-1567-4 · Cited by 975

Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock: The ANDROMEDA-SHOCK Randomized Clinical Trial

Hernández, G., Ospina-Tascón, G. A., Damiani, L. P., Estenssoro, E., Dubin, A., Hurtado, J., Friedman, G., Castro, R., Alegría, L., Teboul, J.-L., et al. (2019) · JAMA · doi:10.1001/jama.2019.0071 · Cited by 946

Interpretable machine learning: Fundamental principles and 10 grand challenges

Rudin, C., Chen, C., Chen, Z., Huang, H., Semenova, L., & Zhong, C. (2022) · Statistics Surveys · doi:10.1214/21-ss133 · Cited by 958

Angiotensin II for the Treatment of Vasodilatory Shock

Khanna, A., English, S. W., Wang, X. S., Ham, K., Tumlin, J., Szerlip, H., Busse, L. W., Altaweel, L., Albertson, T. E., Mackey, C., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1704154 · Cited by 916

A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: the Glucontrol study

Preiser, J.-C., Devos, P., Ruiz-Santana, S., Mélot, C., Annane, D., Groeneveld, J., Iapichino, G., Leverve, X., Nitenberg, G., Singer, P., et al. (2009) · Intensive Care Medicine · doi:10.1007/s00134-009-1585-2 · Cited by 911

Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock

Marik, P. E., Khangoora, V., Rivera, R., Hooper, M. H., & Catravas, J. (2017) · Chest · doi:10.1016/j.chest.2016.11.036 · Cited by 887

Identifying critically ill patients who benefit the most from nutrition therapy: the development and initial validation of a novel risk assessment tool

Heyland, D. K., Dhaliwal, R., Jiang, X., & Day, A. G. (2011) · Critical Care · doi:10.1186/cc10546 · Cited by 863

Critically Ill patients with 2009 influenza A(H1N1) in Mexico

Domínguez-Cherit, G. (2009) · JAMA · doi:10.1001/jama.2009.1536 · Cited by 840

Tidal Volume Reduction for Prevention of Ventilator-induced Lung Injury in Acute Respiratory Distress Syndrome

BROCHARD, L., ROUDOT-THORAVAL, F., ROUPIE, E., DELCLAUX, C., CHASTRE, J., FERNANDEZ-MONDÉJAR, E., CLÉMENTI, E., MANCEBO, J., FACTOR, P., MATAMIS, D., et al. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.6.9801044 · Cited by 800

Interpretable classifiers using rules and Bayesian analysis: Building a better stroke prediction model

Letham, B., Rudin, C., McCormick, T. H., & Madigan, D. (2015) · The Annals of Applied Statistics · doi:10.1214/15-aoas848 · Cited by 766

Two-Year Cognitive, Emotional, and Quality-of-Life Outcomes in Acute Respiratory Distress Syndrome

Hopkins, R. O., Weaver, L. K., Collingridge, D., Parkinson, R. B., Chan, K. J., & Orme, J. F. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200406-763oc · Cited by 759

Effect of a Buffered Crystalloid Solution vs Saline on Acute Kidney Injury Among Patients in the Intensive Care Unit: The SPLIT Randomized Clinical Trial

Young, P., Bailey, M., Beasley, R., Henderson, S., Mackle, D., McArthur, C., McGuinness, S., Mehrtens, J., Myburgh, J., Psirides, A., et al. (2015) · JAMA · doi:10.1001/jama.2015.12334 · Cited by 728

The Underrecognized Epidemic of Low Mobility During Hospitalization of Older Adults

Brown, C. J., Redden, D. T., Flood, K. L., & Allman, R. M. (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02393.x · Cited by 686

Candidemia in a tertiary care hospital: epidemiology, risk factors, and predictors of mortality.

Fraser, V. J., Jones, M., Dunkel, J., Storfer, S., Medoff, G., & Dunagan, W. C. (1992) · Clinical Infectious Diseases · doi:10.1093/clind/15.3.414 · Cited by 679

Depression, post-traumatic stress disorder, and functional disability in survivors of critical illness in the BRAIN-ICU study: a longitudinal cohort study

Jackson, J. C., Pandharipande, P. P., Girard, T. D., Brummel, N. E., Thompson, J. L., Hughes, C. G., Pun, B. T., Vasilevskis, E. E., Morandi, A., Shintani, A. K., et al. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(14)70051-7 · Cited by 673

Severe hypoglycemia in critically ill patients: risk factors and outcomes

Krinsley, J. S., & Grover, A. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000282073.98414.4b · Cited by 671

Risk Factors for Candidal Bloodstream Infections in Surgical Intensive Care Unit Patients: The NEMIS Prospective Multicenter Study

Blumberg, H. M., Jarvis, W. R., Soucie, J. M., Edwards, J. E., Patterson, J. E., Pfaller, M. A., Rangel‐Frausto, M. S., Rinaldi, M. G., Saiman, L., Wiblin, R. T., et al. (2001) · Clinical Infectious Diseases · doi:10.1086/321811 · Cited by 661

Delirium and its motoric subtypes: A study of 614 critically ill patients

Peterson, J. F., Pun, B. T., Dittus, R. S., Thomason, J. W. W., Jackson, J. C., Shintani, A. K., & Ely, E. W. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.00621.x · Cited by 660

A bedside scoring system (“Candida score”) for early antifungal treatment in nonneutropenic critically ill patients with Candida colonization*

León, C., Ruiz-Santana, S., Saavedra, P., Almirante, B., Nolla-Salas, J., Álvarez-Lerma, F., Garnacho-Montero, J., & León, M. Á. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000202208.37364.7d · Cited by 659

Clinical Identifiers of Complicated Staphylococcus aureus Bacteremia

Fowler, V. G., Olsen, M. K., Corey, G. R., Woods, C. W., Cabell, C. H., Reller, L. B., Cheng, A. C., Dudley, T., & Oddone, E. Z. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.17.2066 · Cited by 652

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

Cheng, S.-C., Scicluna, B. P., Arts, R. J. W., Gresnigt, M. S., Lachmandas, E., Giamarellos-Bourboulis, E. J., Kox, M., Manjeri, G. R., Wagenaars, J. A. L., Cremer, O. L., et al. (2016) · Nature Immunology · doi:10.1038/ni.3398 · Cited by 637

Beneficial effects of the “open lung approach” with low distending pressures in acute respiratory distress syndrome. A prospective randomized study on mechanical ventilation.

Amato, M. B., Barbas, C. S., Medeiros, D. M., Schettino, G. D. P., Lorenzi Filho, G., Kairalla, R. A., Deheinzelin, D., Morais, C., Fernandes, E. D. O., & Takagaki, T. Y. (1995) · American journal of respiratory and critical care medicine · doi:10.1164/ajrccm.152.6.8520744 · Cited by 625

Trial of the Route of Early Nutritional Support in Critically Ill Adults

Harvey, S. E., Parrott, F., Harrison, D. A., Bear, D. E., Segaran, E., Beale, R., Bellingan, G., Leonard, R., Mythen, M. G., & Rowan, K. M. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1409860 · Cited by 618

Physical Complications in Acute Lung Injury Survivors: A Two-Year Longitudinal Prospective Study

Fan, E., Dowdy, D. W., Colantuoni, E., Mendez-Tellez, P. A., Sevransky, J. E., Shanholtz, C., Dennison Himmelfarb, C. R., Desai, S. V., Ciesla, N., Herridge, M. S., et al. (2014) · Critical Care Medicine · doi:10.1097/ccm.0000000000000040 · Cited by 615

Outcomes analysis of delayed antibiotic treatment for hospital-acquired Staphylococcus aureus bacteremia.

Lodise, T. P., McKinnon, P. S., Swiderski, L., & Rybak, M. J. (2003) · Clinical Infectious Diseases · doi:10.1086/375057 · Cited by 604

Implementation of a bundle of quality indicators for the early management of severe sepsis and septic shock is associated with decreased mortality*

Nguyen, H. B., Corbett, S. W., Steele, R., Banta, J., Clark, R. T., Hayes, S. R., Edwards, J., Cho, T. W., & Wittlake, W. A. (2007) · Critical Care Medicine · doi:10.1097/01.ccm.0000259463.33848.3d · Cited by 555

Hospital Characteristics and Mortality Rates

Hartz, A. J., Krakauer, H., Kuhn, E. M., Young, M., Jacobsen, S. J., Gay, G., Muenz, L., Katzoff, M., Bailey, R. C., & Rimm, A. A. (1989) · New England Journal of Medicine · doi:10.1056/nejm198912213212506 · Cited by 513

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*

Rice, T. W., Wheeler, A. P., Bernard, G. R., Vincent, J.-L., Angus, D. C., Aikawa, N., Demeyer, I., Sainati, S., Amlot, N., Cao, C., et al. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181e7c5c9 · Cited by 512

A randomized and blinded multicenter trial of high-dose fluconazole plus placebo versus fluconazole plus amphotericin B as therapy for candidemia and its consequences in nonneutropenic subjects

Rex, J. H., Pappas, P. G., Karchmer, A. W., Sobel, J., Edwards, J. E., Hadley, S., Brass, C., Vazquez, J. A., Chapman, S. W., Horowitz, H. W., et al. (2003) · Clinical Infectious Diseases · doi:10.1086/374850 · Cited by 495

Septic shock attributed to Candida infection: Importance of empiric therapy and source control.

Kollef, M., Micek, S., Hampton, N., Doherty, J. A., & Kumar, A. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis305 · Cited by 477

Reduced Cortisol Metabolism during Critical Illness

Boonen, E., Vervenne, H., Meersseman, P., Andrew, R., Mortier, L., Declercq, P. E., Vanwijngaerden, Y.-M., Spriet, I., Wouters, P. J., Vander Perre, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1214969 · Cited by 477

Intensive versus conventional insulin therapy: A randomized controlled trial in medical and surgical critically ill patients*

Arabi, Y. M., Dabbagh, O. C., Tamim, H. M., Al-Shimemeri, A. A., Memish, Z. A., Haddad, S. H., Syed, S. J., Giridhar, H. R., Rishu, A. H., Al-Daker, M. O., et al. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e31818f21aa · Cited by 471

Impact of delayed admission to intensive care units on mortality of critically ill patients: A cohort study.

Cardoso, L. T., Grion, C. M., Matsuo, T., Anami, E. H., Kauss, I. A., Seko, L., & Bonametti, A. M. (2011) · Critical Care · doi:10.1186/cc9975 · Cited by 461

Current knowledge of hypertriglyceridemic pancreatitis

Valdivielso, P., Ramírez-Bueno, A., & Ewald, N. (2014) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2014.08.008 · Cited by 439

Circulating Mitochondrial DNA in Patients in the ICU as a Marker of Mortality: Derivation and Validation

Nakahira, K., Kyung, S.-Y., Rogers, A. J., Gazourian, L., Youn, S., Massaro, A. F., Quintana, C., Osorio, J. C., Wang, Z., Zhao, Y., et al. (2013) · PLoS Medicine · doi:10.1371/journal.pmed.1001577 · Cited by 445

Deep venous thrombosis in medical-surgical critically ill patients: Prevalence, incidence, and risk factors.

Cook, D., Crowther, M., Meade, M., Rabbat, C., Griffith, L., Schiff, D., Geerts, W., & Guyatt, G. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000171207.95319.b2 · Cited by 430

Early Predictors of In-Hospital Death in Infective Endocarditis

Chu, V. H., Cabell, C. H., Benjamin, D. K., Kuniholm, E. F., Fowler, V. G., Engemann, J., Sexton, D. J., Corey, G. R., & Wang, A. (2004) · Circulation · doi:10.1161/01.cir.0000124719.61827.7f · Cited by 429

Withdrawal of Mechanical Ventilation in Anticipation of Death in the Intensive Care Unit

Cook, D., Rocker, G., Marshall, J., Sjokvist, P., Dodek, P., Griffith, L., Freitag, A., Varon, J., Bradley, C., Levy, M., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030083 · Cited by 434

National epidemiology of mycoses survey (NEMIS): variations in rates of bloodstream infections due to Candida species in seven surgical intensive care units and six neonatal intensive care units

Rangel‐Frausto, M. S., Wiblin, T., Blumberg, H. M., Saiman, L., Patterson, J., Rinaldi, M., Pfaller, M., Edwards, Jr., Jarvis, W., Dawson, J., et al. (1999) · Clinical Infectious Diseases · doi:10.1086/520194 · Cited by 430

One-Year Outcomes in Caregivers of Critically Ill Patients

Cameron, J. I., Chu, L. M., Matte, A., Tomlinson, G., Chan, L., Thomas, C., Friedrich, J. O., Mehta, S., Lamontagne, F., Levasseur, M., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1511160 · Cited by 429

One-Year Trajectories of Care and Resource Utilization for Recipients of Prolonged Mechanical Ventilation: A Cohort Study

Unroe, M., Kahn, J. M., Carson, S. S., Govert, J. A., Martinu, T., Sathy, S. J., Clay, A. S., Chia, J., Gray, A., Tulsky, J. A., et al. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-153-3-201008030-00007 · Cited by 427

Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes

Carr, A. C., Rosengrave, P. C., Bayer, S., Chambers, S., Mehrtens, J., & Shaw, G. M. (2017) · Critical Care · doi:10.1186/s13054-017-1891-y · Cited by 413

Increased intestinal permeability is associated with the development of multiple organ dysfunction syndrome in critically ill ICU patients

DOIG, C. J., SUTHERLAND, L. R., DEAN SANDHAM, J., FICK, G. H., VERHOEF, M., & MEDDINGS, J. B. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.2.9710092 · Cited by 411

Low mobility during hospitalization and functional decline in older adults

Zisberg, A., Shadmi, E., Sinoff, G., Gur‐Yaish, N., Srulovici, E., & Admi, H. (2011) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.03276.x · Cited by 393

Effects of a Multicomponent Intervention on Functional Outcomes and Process of Care in Hospitalized Older Patients: A Randomized Controlled Trial of Acute Care for Elders (ACE) in a Community Hospital

Counsell, S. R., Holder, C. M., Liebenauer, L. L., Palmer, R. M., Fortinsky, R. H., Kresevic, D. M., Quinn, L. M., Allen, K. R., Covinsky, K. E., & Landefeld, C. S. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb03866.x · Cited by 406

Respiratory rate predicts cardiopulmonary arrest for internal medicine inpatients.

Fieselmann, J. F., Hendryx, M. S., Helms, C. M., & Wakefield, D. S. (1993) · Journal of General Internal Medicine · doi:10.1007/bf02600071 · Cited by 399

Mortality prediction in intensive care units with the Super ICU Learner Algorithm (SICULA): a population-based study.

Pirracchio, R., Petersen, M. L., Carone, M., Rigon, M. R., Chevret, S., & van der Laan, M. J. (2015) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(14)70239-5 · Cited by 374

Provision of protein and energy in relation to measured requirements in intensive care patients

Allingstrup, M. J., Esmailzadeh, N., Wilkens Knudsen, A., Espersen, K., Hartvig Jensen, T., Wiis, J., Perner, A., & Kondrup, J. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2011.12.006 · Cited by 381

Continuous versus intermittent β-lactam infusion in severe sepsis. A meta-analysis of individual patient data from randomized trials.

Roberts, J. A., Abdul-Aziz, M.-H., Davis, J. S., Dulhunty, J. M., Cotta, M. O., Myburgh, J., Bellomo, R., & Lipman, J. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201601-0024oc · Cited by 379

Effects of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in septic shock: Which is best?*

De Backer, D., Creteur, J., Silva, E., & Vincent, J.-L. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000063045.77339.b6 · Cited by 371

A comparison of epinephrine and norepinephrine in critically ill patients

Myburgh, J. A., Higgins, A., Jovanovska, A., Lipman, J., Ramakrishnan, N., Santamaria, J., & the CAT Study investigators (2008) · Intensive Care Medicine · doi:10.1007/s00134-008-1219-0 · Cited by 368

Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension: A Randomized Clinical Trial

Lamontagne, F., Richards-Belle, A., Thomas, K., Harrison, D. A., Sadique, M. Z., Grieve, R. D., Camsooksai, J., Darnell, R., Gordon, A. C., Henry, D., et al. (2020) · JAMA · doi:10.1001/jama.2020.0930 · Cited by 354

Machine learning for real-time prediction of complications in critical care: a retrospective study

Meyer, A., Zverinski, D., Pfahringer, B., Kempfert, J., Kuehne, T., Sündermann, S. H., Stamm, C., Hofmann, T., Falk, V., & Eickhoff, C. (2018) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(18)30300-x · Cited by 350

Early versus On-Demand Nasoenteric Tube Feeding in Acute Pancreatitis

Bakker, O. J., van Brunschot, S., van Santvoort, H. C., Besselink, M. G., Bollen, T. L., Boermeester, M. A., Dejong, C. H., van Goor, H., Bosscha, K., Ali, U. A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1404393 · Cited by 339

Signaling by the Matrix Proteoglycan Decorin Controls Inflammation and Cancer Through PDCD4 and MicroRNA-21

Merline, R., Moreth, K., Beckmann, J., Nastase, M. V., Zeng-Brouwers, J., Tralhão, J. G., Lemarchand, P., Pfeilschifter, J., Schaefer, R. M., Iozzo, R. V., et al. (2011) · Science Signaling · doi:10.1126/scisignal.2001868 · Cited by 333

Expectations and outcomes of prolonged mechanical ventilation*

Cox, C. E., Martinu, T., Sathy, S. J., Clay, A. S., Chia, J., Gray, A. L., Olsen, M. K., Govert, J. A., Carson, S. S., & Tulsky, J. A. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181ab86ed · Cited by 319

Strict glycaemic control in patients hospitalised in a mixed medical and surgical intensive care unit: a randomised clinical trial

De La Rosa, G. D. C., Donado, J. H., Restrepo, A. H., Quintero, A. M., González, L. G., Saldarriaga, N. E., Bedoya, M., Toro, J. M., Velásquez, J. B., Valencia, J. C., et al. (2008) · Critical Care · doi:10.1186/cc7017 · Cited by 319

Impact of Body Mass Index on Outcomes Following Critical Care

Tremblay, A., & Bandi, V. (2003) · Chest · doi:10.1378/chest.123.4.1202 · Cited by 318

Role of Disease and Macronutrient Dose in the Randomized Controlled EPaNIC Trial

Casaer, M. P., Wilmer, A., Hermans, G., Wouters, P. J., Mesotten, D., & Van den Berghe, G. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201206-0999oc · Cited by 307

Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: a randomised, parallel-group, multicentre, single-blind controlled trial

Doig, G. S., Simpson, F., Heighes, P. T., Bellomo, R., Chesher, D., Caterson, I. D., Reade, M. C., & Harrigan, P. W. J. (2015) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00418-x · Cited by 308

Clinical Outcomes Related to Protein Delivery in a Critically Ill Population: A Multicenter, Multinational Observation Study

Nicolo, M., Heyland, D. K., Chittams, J., Sammarco, T., & Compher, C. (2016) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607115583675 · Cited by 294

Tutorial in biostatistics: data‐driven subgroup identification and analysis in clinical trials

Lipkovich, I., Dmitrienko, A., & B., R. (2017) · Statistics in Medicine · doi:10.1002/sim.7064 · Cited by 291

Medical Emergency Triage and Treatment System (METTS): a new protocol in primary triage and secondary priority decision in emergency medicine

Widgren, B. R., & Jourak, M. (2011) · The Journal of Emergency Medicine · doi:10.1016/j.jemermed.2008.04.003 · Cited by 288

Open Lung Approach for the Acute Respiratory Distress Syndrome: A Pilot, Randomized Controlled Trial*

Kacmarek, R. M., Villar, J., Sulemanji, D., Montiel, R., Ferrando, C., Blanco, J., Koh, Y., Soler, J. A., Martínez, D., Hernández, M., et al. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001383 · Cited by 288

Multicenter, prospective, randomized, single-blind study comparing the efficacy and gastrointestinal complications of early jejunal feeding with early gastric feeding in critically ill patients

Montejo, J. C., Grau, T., Acosta, J., Ruiz-Santana, S., Planas, M., García-de-Lorenzo, A., Mesejo, A., Cervera, M., Sánchez-Álvarez, C., Núñez-Ruiz, R., et al. (2002) · Critical Care Medicine · doi:10.1097/00003246-200204000-00013 · Cited by 278