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Circos: An information aesthetic for comparative genomics

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Krzywinski, Martin, Schein, Jacqueline, Birol, İnanç, Connors, Joseph, Gascoyne, Randy, Horsman, Doug, Jones, Steven J., Marra, Marco A.·2009·Genome Research

DOI 10.1101/gr.092759.109

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Abstract

We created a visualization tool called Circos to facilitate the identification and analysis of similarities and differences arising from comparisons of genomes. Our tool is effective in displaying variation in genome structure and, generally, any other kind of positional relationships between genomic intervals. Such data are routinely produced by sequence alignments, hybridization arrays, genome mapping, and genotyping studies. Circos uses a circular ideogram layout to facilitate the display of relationships between pairs of positions by the use of ribbons, which encode the position, size, and orientation of related genomic elements. Circos is capable of displaying data as scatter, line, and histogram plots, heat maps, tiles, connectors, and text. Bitmap or vector images can be created from GFF-style data inputs and hierarchical configuration files, which can be easily generated by automated tools, making Circos suitable for rapid deployment in data analysis and reporting pipelines.

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Authors: Krzywinski, M., Schein, J., Birol, İ., Connors, J., Gascoyne, R., Horsman, D., Jones, S. J., & Marra, M. A.
Venue: Genome Research
Publisher: Cold Spring Harbor Laboratory
Published: 2009-06-18
Volume: 19
Issue: 9
Pages: 1639-1645
ISSN: 1088-9051 (ISSN-L)
DOI: 10.1101/gr.092759.109
OpenAlex: W2158804744
Cited by: 10,964
References: 2
Type: posted content
Language: en
Open access: bronze

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Circos: An information aesthetic for comparative genomics

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