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DNA methylation and healthy human aging
Open accessAbstract
Summary: The process of aging results in a host of changes at the cellular and molecular levels, which include senescence, telomere shortening, and changes in gene expression. Epigenetic patterns also change over the lifespan, suggesting that epigenetic changes may constitute an important component of the aging process. The epigenetic mark that has been most highly studied is DNA methylation, the presence of methyl groups at CpG dinucleotides. These dinucleotides are often located near gene promoters and associate with gene expression levels. Early studies indicated that global levels of DNA methylation increase over the first few years of life and then decrease beginning in late adulthood. Recently, with the advent of microarray and next‐generation sequencing technologies, increases in variability of DNA methylation with age have been observed, and a number of site‐specific patterns have been identified. It has also been shown that certain CpG sites are highly associated with age, to the extent that prediction models using a small number of these sites can accurately predict the chronological age of the donor. Together, these observations point to the existence of two phenomena that both contribute to age‐related DNA methylation changes: epigenetic drift and the epigenetic clock. In this review, we focus on healthy human aging throughout the lifetime and discuss the dynamics of DNA methylation as well as how interactions between the genome, environment, and the epigenome influence aging rates. We also discuss the impact of determining ‘epigenetic age’ for human health and outline some important caveats to existing and future studies.
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Cites
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
DNA methylation age of human tissues and cell types
Horvath, S. (2013) · Genome Biology · doi:10.1186/gb-2013-14-10-r115 · Cited by 7,075
Functions of DNA methylation: islands, start sites, gene bodies and beyond
Jones, P. A. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3230 · Cited by 6,061
Human DNA methylomes at base resolution show widespread epigenomic differences
Lister, R., Pelizzola, M., Dowen, R. H., Hawkins, R. D., Hon, G., Tonti-Filippini, J., Nery, J. R., Lee, L., Ye, Z., Ngo, Q.-M., et al. (2009) · Nature · doi:10.1038/nature08514 · Cited by 4,673
Genome-wide methylation profiles reveal quantitative views of human aging rates
Hannum, G., Guinney, J., Zhao, L., Zhang, L., Hughes, G., Sadda, S., Klotzle, B., Bibikova, M., Fan, J.-B., Gao, Y., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.016 · Cited by 4,270
Epigenetic differences arise during the lifetime of monozygotic twins
Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500398102 · Cited by 3,602
Epigenetics in human disease and prospects for epigenetic therapy
Egger, G., Liang, G., Aparicio, A., & Jones, P. A. (2004) · Nature · doi:10.1038/nature02625 · Cited by 3,232
Bird, A. (2007) · Nature · doi:10.1038/nature05913 · Cited by 3,011
A decade of exploring the cancer epigenome—biological and translational implications
Baylin, S. B., & Jones, P. A. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3130 · Cited by 2,871
Weber, M., Hellmann, I., Stadler, M. B., Ramos, L., Pääbo, S., Rebhan, M., & Schübeler, D. (2007) · Nature Genetics · doi:10.1038/ng1990 · Cited by 2,221
The Polycomb group protein EZH2 directly controls DNA methylation
Viré, E., Brenner, C., Deplus, R., Blanchon, L., Fraga, M., Didelot, C., Morey, L., Van Eynde, A., Bernard, D., Vanderwinden, J.-M., et al. (2006) · Nature · doi:10.1038/nature04431 · Cited by 2,204
Epigenetics and the environment: emerging patterns and implications
Feil, R., & Fraga, M. F. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3142 · Cited by 1,929
Global epigenomic reconfiguration during mammalian brain development
Lister, R., Mukamel, E. A., Nery, J. R., Urich, M., Puddifoot, C. A., Johnson, N. D., Lucero, J., Huang, Y., Dwork, A. J., Schultz, M. D., et al. (2013) · Science · doi:10.1126/science.1237905 · Cited by 1,830
Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions
Klengel, T., Mehta, D., Anacker, C., Rex-Haffner, M., Pruessner, J. C., Pariante, C. M., Pace, T. W. W., Mercer, K. B., Mayberg, H. S., Bradley, B., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3275 · Cited by 1,447
Saxonov, S., Berg, P., & Brutlag, D. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510310103 · Cited by 1,401
Charting a dynamic DNA methylation landscape of the human genome
Ziller, M. J., Gu, H., Müller, F., Donaghey, J., Tsai, L. T.-Y., Kohlbacher, O., De Jager, P. L., Rosen, E. D., Bennett, D. A., Bernstein, B. E., et al. (2013) · Nature · doi:10.1038/nature12433 · Cited by 1,357
Epigenome-wide association studies for common human diseases
Rakyan, V. K., Down, T. A., Balding, D. J., & Beck, S. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3000 · Cited by 1,267
DNA methylation age of blood predicts all-cause mortality in later life
Marioni, R. E., Shah, S., McRae, A. F., Chen, B. H., Colicino, E., Harris, S. E., Gibson, J., Henders, A. K., Redmond, P., Cox, S. R., et al. (2015) · Genome Biology · doi:10.1186/s13059-015-0584-6 · Cited by 1,261
Epigenetics and the biological definition of gene×environment interactions
Meaney, M. J. (2010) · Child Development · doi:10.1111/j.1467-8624.2009.01381.x · Cited by 1,239
Accounting for cellular heterogeneity is critical in epigenome-wide association studies
Jaffe, A. E., & Irizarry, R. A. (2014) · Genome Biology · doi:10.1186/gb-2014-15-2-r31 · Cited by 1,067
Bocklandt, S., Lin, W., Sehl, M. E., Sánchez, F. J., Sinsheimer, J. S., Horvath, S., & Vilain, E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014821 · Cited by 1,012
Illingworth, R. S., & Bird, A. P. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.04.012 · Cited by 887
Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer
Teschendorff, A. E., Menon, U., Gentry-Maharaj, A., Ramus, S. J., Weisenberger, D. J., Shen, H., Campan, M., Noushmehr, H., Bell, C. G., Maxwell, A. P., et al. (2010) · Genome Research · doi:10.1101/gr.103606.109 · Cited by 855
DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines
Bell, J. T., Pai, A. A., Pickrell, J. K., Gaffney, D. J., Pique-Regi, R., Degner, J. F., Gilad, Y., & Pritchard, J. K. (2011) · Genome Biology · doi:10.1186/gb-2011-12-1-r10 · Cited by 838
Aging of blood can be tracked by DNA methylation changes at just three CpG sites
Weidner, C. I., Lin, Q., Koch, C. M., Eisele, L., Beier, F., Ziegler, P., Bauerschlag, D. O., Jöckel, K.-H., Erbel, R., Mühleisen, T. W., et al. (2014) · Genome Biology · doi:10.1186/gb-2014-15-2-r24 · Cited by 837
Distinct DNA methylomes of newborns and centenarians
Heyn, H., Li, N., Ferreira, H. J., Moran, S., Pisano, D. G., Gomez, A., Diez, J., Sanchez-Mut, J. V., Setien, F., Carmona, F. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120658109 · Cited by 802
Obesity accelerates epigenetic aging of human liver
Horvath, S., Erhart, W., Brosch, M., Ammerpohl, O., von Schönfels, W., Ahrens, M., Heits, N., Bell, J. T., Tsai, P.-C., Spector, T. D., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412759111 · Cited by 766
Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains
Rakyan, V. K., Down, T. A., Maslau, S., Andrew, T., Yang, T.-P., Beyan, H., Whittaker, P., McCann, O. T., Finer, S., Valdes, A. M., et al. (2010) · Genome Research · doi:10.1101/gr.103101.109 · Cited by 750
Joubert, B. R., Håberg, S. E., Nilsen, R. M., Wang, X., Vollset, S. E., Murphy, S. K., Huang, Z., Hoyo, C., Midttun, Ø., Cupul-Uicab, L. A., et al. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1205412 · Cited by 716
Epigenetic Instability in ES Cells and Cloned Mice
Humpherys, D., Eggan, K., Akutsu, H., Hochedlinger, K., Rideout, W. M., Biniszkiewicz, D., Yanagimachi, R., & Jaenisch, R. (2001) · Science · doi:10.1126/science.1061402 · Cited by 711
Epigenetics and aging: the targets and the marks
Fraga, M. F., & Esteller, M. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.05.008 · Cited by 690 · cited 5×
“The concept was then used to describe the increase in discordance of DNA methylation between monozygotic twins as they age (Fraga et al., 2005; Fraga & Esteller, 2007; Poulsen et al., 2007).”
BackgroundMethodInfluentialBell, J. T., Tsai, P.-C., Yang, T.-P., Pidsley, R., Nisbet, J., Glass, D., Mangino, M., Zhai, G., Zhang, F., Valdes, A., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002629 · Cited by 685
DNA methylation profiles in monozygotic and dizygotic twins
Kaminsky, Z. A., Tang, T., Wang, S.-C., Ptak, C., Oh, G. H. T., Wong, A. H. C., Feldcamp, L. A., Virtanen, C., Halfvarson, J., Tysk, C., et al. (2009) · Nature Genetics · doi:10.1038/ng.286 · Cited by 668
Aging effects on DNA methylation modules in human brain and blood tissue
Horvath, S., Zhang, Y., Langfelder, P., Kahn, R. S., Boks, M. P., van Eijk, K., van den Berg, L. H., & Ophoff, R. A. (2012) · Genome Biology · doi:10.1186/gb-2012-13-10-r97 · Cited by 645
CD28− T cells: their role in the age-associated decline of immune function
Weng, N.-P., Akbar, A. N., & Goronzy, J. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.03.013 · Cited by 633
Davies, M. N., Volta, M., Pidsley, R., Lunnon, K., Dixit, A., Lovestone, S., Coarfa, C., Harris, R. A., Milosavljevic, A., Troakes, C., et al. (2012) · Genome Biology · doi:10.1186/gb-2012-13-6-r43 · Cited by 630
Decline in genomic DNA methylation through aging in a cohort of elderly subjects
Bollati, V., Schwartz, J., Wright, R., Litonjua, A., Tarantini, L., Suh, H., Sparrow, D., Vokonas, P., & Baccarelli, A. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.12.003 · Cited by 594
DNA methylation dynamics in health and disease
Bergman, Y., & Cedar, H. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2518 · Cited by 592
Genomic 5-methyldeoxycytidine decreases with age.
Wilson, V. L., Smith, R. A., Ma, S., & Cutler, R. G. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61057-9 · Cited by 521
Factors underlying variable DNA methylation in a human community cohort
Lam, L. L., Emberly, E., Fraser, H. B., Neumann, S. M., Chen, E., Miller, G. E., & Kobor, M. S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121249109 · Cited by 476
Self-citationEssex, M. J., Thomas Boyce, W., Hertzman, C., Lam, L. L., Armstrong, J. M., Neumann, S. M. A., & Kobor, M. S. (2013) · Child Development · doi:10.1111/j.1467-8624.2011.01641.x · Cited by 462
Self-citationAn integrated epigenetic and genetic approach to common human disease
BJORNSSON, H. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.06.009 · Cited by 448
Wagner, J. R., Busche, S., Ge, B., Kwan, T., Pastinen, T., & Blanchette, M. (2014) · Genome biology · doi:10.1186/gb-2014-15-2-r37 · Cited by 446
Passive and active DNA methylation and the interplay with genetic variation in gene regulation
Gutierrez-Arcelus, M., Lappalainen, T., Montgomery, S. B., Buil, A., Ongen, H., Yurovsky, A., Bryois, J., Giger, T., Romano, L., Planchon, A., et al. (2013) · eLife · doi:10.7554/elife.00523 · Cited by 440
Associations with early-life socio-economic position in adult DNA methylation
Borghol, N., Suderman, M., McArdle, W., Racine, A., Hallett, M., Pembrey, M., Hertzman, C., Power, C., & Szyf, M. (2012) · International Journal of Epidemiology · doi:10.1093/ije/dyr147 · Cited by 418
Fuke, C., Shimabukuro, M., Petronis, A., Sugimoto, J., Oda, T., Miura, K., Miyazaki, T., Ogura, C., Okazaki, Y., & Jinno, Y. (2004) · Annals of Human Genetics · doi:10.1046/j.1529-8817.2004.00081.x · Cited by 401
Shenker, N. S., Polidoro, S., van Veldhoven, K., Sacerdote, C., Ricceri, F., Birrell, M. A., Belvisi, M. G., Brown, R., Vineis, P., & Flanagan, J. M. (2013) · Human Molecular Genetics · doi:10.1093/hmg/dds488 · Cited by 396
Age-associated DNA methylation in pediatric populations
Alisch, R. S., Barwick, B. G., Chopra, P., Myrick, L. K., Satten, G. A., Conneely, K. N., & Warren, S. T. (2012) · Genome Research · doi:10.1101/gr.125187.111 · Cited by 389
Continuous Aging of the Human DNA Methylome Throughout the Human Lifespan
Johansson, Å., Enroth, S., & Gyllensten, U. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067378 · Cited by 380
The Relationship of DNA Methylation with Age, Gender and Genotype in Twins and Healthy Controls
Boks, M. P., Derks, E. M., Weisenberger, D. J., Strengman, E., Janson, E., Sommer, I. E., Kahn, R. S., & Ophoff, R. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006767 · Cited by 369
Guintivano, J., Aryee, M. J., & Kaminsky, Z. A. (2013) · Epigenetics · doi:10.4161/epi.23924 · Cited by 368
Schoenmaker, M., de Craen, A. J. M., de Meijer, P. H. E. M., Beekman, M., Blauw, G. J., Slagboom, P. E., & Westendorp, R. G. J. (2006) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201508 · Cited by 368
DNA methylation signatures in development and aging of the human prefrontal cortex
Numata, S., Ye, T., Hyde, T. M., Guitart-Navarro, X., Tao, R., Wininger, M., Colantuoni, C., Weinberger, D. R., Kleinman, J. E., & Lipska, B. K. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.12.020 · Cited by 364
Day, K., Waite, L. L., Thalacker-Mercer, A., West, A., Bamman, M. M., Brooks, J. D., Myers, R. M., & Absher, D. (2013) · Genome Biology · doi:10.1186/gb-2013-14-9-r102 · Cited by 364
Florath, I., Butterbach, K., Muller, H., Bewerunge-Hudler, M., & Brenner, H. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddt531 · Cited by 335
Cortessis, V. K., Thomas, D. C., Levine, A. J., Breton, C. V., Mack, T. M., Siegmund, K. D., Haile, R. W., & Laird, P. W. (2012) · Human Genetics · doi:10.1007/s00439-012-1189-8 · Cited by 319
Age-associated epigenetic drift: implications, and a case of epigenetic thrift?
Teschendorff, A. E., West, J., & Beck, S. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt375 · Cited by 316
Population-specificity of human DNA methylation
Fraser, H. B., Lam, L. L., Neumann, S. M., & Kobor, M. S. (2012) · Genome Biology · doi:10.1186/gb-2012-13-2-r8 · Cited by 313
Self-citationTalens, R. P., Christensen, K., Putter, H., Willemsen, G., Christiansen, L., Kremer, D., Suchiman, H. E. D., Slagboom, P. E., Boomsma, D. I., & Heijmans, B. T. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00835.x · Cited by 300
Differences in smoking associated DNA methylation patterns in south asians and europeans
Elliott, H. R., Tillin, T., McArdle, W. L., Ho, K., Duggirala, A., Frayling, T. M., Davey Smith, G., Hughes, A. D., Chaturvedi, N., & Relton, C. L. (2014) · Clinical Epigenetics · doi:10.1186/1868-7083-6-4 · Cited by 282
Coordinated changes in AHRR methylation in lymphoblasts and pulmonary macrophages from smokers
Monick, M. M., Beach, S. R. H., Plume, J., Sears, R., Gerrard, M., Brody, G. H., & Philibert, R. A. (2012) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32021 · Cited by 264
Aging and Chronic Sun Exposure Cause Distinct Epigenetic Changes in Human Skin
Grönniger, E., Weber, B., Heil, O., Peters, N., Stäb, F., Wenck, H., Korn, B., Winnefeld, M., & Lyko, F. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000971 · Cited by 263
Byun, H.-M., Siegmund, K. D., Pan, F., Weisenberger, D. J., Kanel, G., Laird, P. W., & Yang, A. S. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp445 · Cited by 254
Boks, M. P., Mierlo, H. C. V., Rutten, B. P. F., Radstake, T. R. D. J., De Witte, L., Geuze, E., Horvath, S., Schalkwyk, L. C., Vinkers, C. H., Broen, J. C. A., et al. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.07.011 · Cited by 231
van Eijk, K. R., de Jong, S., Boks, M. P., Langeveld, T., Colas, F., Veldink, J. H., de Kovel, C. G., Janson, E., Strengman, E., Langfelder, P., et al. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-636 · Cited by 225
Age-Related DNA Methylation Changes in Normal Human Prostate Tissues
Kwabi-Addo, B., Chung, W., Shen, L., Ittmann, M., Wheeler, T., Jelinek, J., & Issa, J.-P. J. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0085 · Cited by 214
The Epigenetic Basis of Twin Discordance in Age-Related Diseases
Poulsen, P., Esteller, M., Vaag, A., & Fraga, M. F. (2007) · Pediatric Research · doi:10.1203/pdr.0b013e31803c7b98 · Cited by 213
Gentilini, D., Mari, D., Castaldi, D., Remondini, D., Ogliari, G., Ostan, R., Bucci, L., Sirchia, S. M., Tabano, S., Cavagnini, F., et al. (2013) · AGE · doi:10.1007/s11357-012-9463-1 · Cited by 212
Dogan, M. V., Shields, B., Cutrona, C., Gao, L., Gibbons, F. X., Simons, R., Monick, M., Brody, G. H., Tan, K., Beach, S. R., et al. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-151 · Cited by 200
Epigenetic drift in aging identical twins
Martin, G. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504743102 · Cited by 194
Martino, D., Loke, Y. J., Gordon, L., Ollikainen, M., Cruickshank, M. N., Saffery, R., & Craig, J. M. (2013) · Genome Biology · doi:10.1186/gb-2013-14-5-r42 · Cited by 187
Lee, K. W. K., Richmond, R., Hu, P., French, L., Shin, J., Bourdon, C., Reischl, E., Waldenberger, M., Zeilinger, S., Gaunt, T., et al. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1408614 · Cited by 186
Teschendorff, A. E., Jones, A., Fiegl, H., Sargent, A., Zhuang, J. J., Kitchener, H. C., & Widschwendter, M. (2012) · Genome Medicine · doi:10.1186/gm323 · Cited by 182
Wang, T., Pan, Q., Lin, L., Szulwach, K. E., Song, C.-X., He, C., Wu, H., Warren, S. T., Jin, P., Duan, R., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds394 · Cited by 175
DNA methylation in the Alu sequences of diploid and haploid primary human cells.
Kochanek, S., Renz, D., & Doerfler, W. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05755.x · Cited by 173
Genetic and environmental exposures constrain epigenetic drift over the human life course
Shah, S., McRae, A. F., Marioni, R. E., Harris, S. E., Gibson, J., Henders, A. K., Redmond, P., Cox, S. R., Pattie, A., Corley, J., et al. (2014) · Genome Research · doi:10.1101/gr.176933.114 · Cited by 169
McClay, J. L., Aberg, K. A., Clark, S. L., Nerella, S., Kumar, G., Xie, L. Y., Hudson, A. D., Harada, A., Hultman, C. M., Magnusson, P. K. E., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddt511 · Cited by 164
Potential forensic application of DNA methylation profiling to body fluid identification
Lee, H. Y., Park, M. J., Choi, A., An, J. H., Yang, W. I., & Shin, K. (2011) · International Journal of Legal Medicine · doi:10.1007/s00414-011-0569-2 · Cited by 161
Gamazon, E. R., Badner, J. A., Cheng, L., Zhang, C., Zhang, D., Cox, N. J., Gershon, E. S., Kelsoe, J. R., Greenwood, T. A., Nievergelt, C. M., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.174 · Cited by 158
Sun, Y. V., Smith, A. K., Conneely, K. N., Chang, Q., Li, W., Zagel, A. L., Smith, J. A., Almli, L. M., Binder, E. B., Klengel, T., et al. (2013) · Human Genetics · doi:10.1007/s00439-013-1311-6 · Cited by 144
Smoking, F2RL3 methylation, and prognosis in stable coronary heart disease
Breitling, L. P., Salzmann, K., Rothenbacher, D., Burwinkel, B., & Brenner, H. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs091 · Cited by 138
Martino, D., Tulić, M. K., Gordon, L., Hodder, M. L., Richman, T. R., Metcalfe, J. R., Prescott, S. L., & Saffery, R. (2011) · Epigenetics · doi:10.4161/epi.6.9.16401 · Cited by 135
Moen, E. L., Zhang, X., Mu, W., Delaney, S. M., Wing, C., McQuade, J. L., Myers, J. L., Godley, L. A., Dolan, M. E., & Zhang, W. (2013) · Genetics · doi:10.1534/genetics.113.151381 · Cited by 134
Parental ages and levels of DNA methylation in the newborn are correlated
Adkins, R. M., Thomas, F., Tylavsky, F. A., & Krushkal, J. (2011) · BMC Medical Genetics · doi:10.1186/1471-2350-12-47 · Cited by 122
Measuring cell-type specific differential methylation in human brain tissue
Montaño, C., Irizarry, R. A., Kaufmann, W. E., Talbot, K., Gur, R. E., Feinberg, A. P., & Taub, M. A. (2013) · Genome biology · doi:10.1186/gb-2013-14-8-r94 · Cited by 109
Differential methylation of human LINE-1 retrotransposons in malignant cells
Alves, G., Tatro, A. V., & Fanning, T. G. (1996) · Gene · doi:10.1016/0378-1119(96)00205-3 · Cited by 108
Nutritional factors and gender influence age‐related DNA methylation in the human rectal mucosa
Tapp, H. S., Commane, D. M., Bradburn, D. M., Arasaradnam, R. P., Mathers, J. C., Johnson, I. T., & Belshaw, N. J. (2012) · Aging Cell · doi:10.1111/acel.12030 · Cited by 103
Cooney, C. A. (1993) · PubMed · Cited by 100
Jenkins, T. G., Aston, K. I., Cairns, B. R., & Carrell, D. T. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.05.039 · Cited by 99
Predictors and Consequences of Global DNA Methylation in Cord Blood and at Three Years
Herbstman, J. B., Wang, S., Perera, F. P., Lederman, S. A., Vishnevetsky, J., Rundle, A., Hoepner, L., Qu, L., & Tang, D. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072824 · Cited by 93
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Discordance of DNA Methylation Variance Between two Accessible Human Tissues
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Metadata
- Authors
- Jones, M. J., Goodman, S. J., & Kobor, M. S.
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2015-04-25
- Volume
- 14
- Issue
- 6
- Pages
- 924-932
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- OpenAlex
- W2036284273
- Cited by
- 928
- References
- 95
- FWCI
- 26.76
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
