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Cited by 515

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Chemotherapy‐driven dysbiosis in the intestinal microbiome

Open access
Montassier, E., Gastinne, T., Vangay, P., Al‐Ghalith, G. A., Bruley des Varannes, S., Massart, S., Moreau, P., Potel, G., de La Cochetière, M. F., Batard, E., Knights, D.·2015·Alimentary Pharmacology & Therapeutics
DOI 10.1111/apt.13302
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Abstract

Summary: Background: Chemotherapy is commonly used as myeloablative conditioning treatment to prepare patients for haematopoietic stem cell transplantation (HSCT). Chemotherapy leads to several side effects, with gastrointestinal (GI) mucositis being one of the most frequent. Current models of GI mucositis pathophysiology are generally silent on the role of the intestinal microbiome. Aim: To identify functional mechanisms by which the intestinal microbiome may play a key role in the pathophysiology of GI mucositis, we applied high‐throughput DNA‐sequencing analysis to identify microbes and microbial functions that are modulated following chemotherapy. Methods: We amplified and sequenced 16S rRNA genes from faecal samples before and after chemotherapy in 28 patients with non‐Hodgkin's lymphoma who received the same myeloablative conditioning regimen and no other concomitant therapy such as antibiotics. Results: We found that faecal samples collected after chemotherapy exhibited significant decreases in abundances of Firmicutes (P = 0.0002) and Actinobacteria (P = 0.002) and significant increases in abundances of Proteobacteria (P = 0.0002) compared to samples collected before chemotherapy. Following chemotherapy, patients had reduced capacity for nucleotide metabolism (P = 0.0001), energy metabolism (P = 0.001), metabolism of cofactors and vitamins (P = 0.006), and increased capacity for glycan metabolism (P = 0.0002), signal transduction (P = 0.0002) and xenobiotics biodegradation (P = 0.002). Conclusions: Our study identifies a severe compositional and functional imbalance in the gut microbial community associated with chemotherapy‐induced GI mucositis. The functional pathways implicated in our analysis suggest potential directions for the development of intestinal microbiome‐targeted interventions in cancer patients.

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Metadata

Authors
Montassier, E., Gastinne, T., Vangay, P., Al‐Ghalith, G. A., Bruley des Varannes, S., Massart, S., Moreau, P., Potel, G., de La Cochetière, M. F., Batard, E., & Knights, D.
Venue
Alimentary Pharmacology & Therapeutics
Publisher
Wiley
Published
2015-07-06
Volume
42
Issue
5
Pages
515-528
ISSN
  • 0269-2813 (ISSN-L)
  • 1365-2036
DOI
10.1111/apt.13302
OpenAlex
W1716533099
Cited by
515
References
13
FWCI
8.75
Type
journal article
Language
en
Open access
bronze
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders
Nantes University Hospital (BRD/10/04-Q)

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