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Cited by 451

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Clinico‐Neuropathological Correlation of Alzheimer's Disease in a Community‐Based Case Series

Lim, Alfredo, Tsuang, Debby, Kukull, Walter, Nochlin, David, Leverenz, James, McCormick, Wayne, Bowen, Jim, Teri, Linda, Thompson, Jill, Peskind, Elaine R., Raskind, Murray, Larson, Eric B.·1999·Journal of the American Geriatrics Society
DOI 10.1111/j.1532-5415.1999.tb02571.x
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Abstract

OBJECTIVES : Most clinico‐neuropathological correlative studies of Alzheimer's Disease (AD) are based on research cohorts that are not necessarily generalizable to patients seen in the general medical community. In this study, we examine the accuracy of the criteria used in diagnosing AD in a community‐based case series of patients with memory complaints. DESIGN AND PARTICIPANTS : Clinical and neuropathological diagnoses were obtained from 134 patients evaluated for dementia who subsequently underwent autopsy. SETTING : Subjects who exhibited new symptoms of dementia and were enrolled in the University of Washington/Group Health Cooperative Alzheimer's Disease Patient Registry were eligible for this study. MEASUREMENTS : Clinico‐pathological correlation was performed using NINCDS‐ADRDA (National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association) and CERAD (Consortium to Establish a Registry for Alzheimer's Disease) criteria. RESULTS : Ninety‐five of the 134 cases studied met CERAD neuropathological criteria for AD. The sensitivity of NINCDS‐ADRDA “probable AD” was 83% (diagnosing AD correctly) and overall clinical diagnostic accuracy was 75%. However, there was a high rate of additional neuropathological findings. Only 34 of the 94 cases had pure AD on neuropathology, whereas the remainder frequently had coexisting vascular or Parkinson's disease lesions. CONCLUSIONS : This study of a large series of community‐based incident dementia cases provides a way of judging the adequacy of currently available clinical diagnostic criteria. It also shows that co‐existing neuropathological findings are common in community‐based AD. J Am Geriatr Soc 47:564–569, 1999.

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Research works printed but not linked: 27

  1. 10.1001/archneur.1985.04060100083029 · DOI · Paper page
  2. 10.1097/00002093-199307030-00004 · DOI · Paper page
  3. 10.1177/089198879500800401 · DOI
  4. 10.1212/WNL.34.7.939 · DOI · Paper page
  5. Larson EB, 1990, University of Washington Alzheimer's Disease Patient Registry (ADPR): 1987–1988, Aging, 2, 404
  6. 10.1212/WNL.42.3.607 · DOI
  7. Coblentz JM, 1973, Presenile dementia: Clinical aspects and evaluation of cerebrospinal fluid dynamics, Arch Neurol, 29, 229, 10.1001/archneur.1973.00490290039003 · DOI · Paper page
  8. 10.1080/00223980.1945.9917223 · DOI · Paper page
  9. Fuld PA, 1977, Fuld Object‐Memory Evaluation
  10. 10.1044/jshd.1401.09 · DOI
  11. Wechsler D., 1981, Wechsler Adult Intelligence Scale‐Revised Manual
  12. 10.2466/pms.1958.8.3.271 · DOI · Paper page
  13. 10.1016/0022-3956(75)90026-6 · DOI · Paper page
  14. 10.1007/BF00294305 · DOI
  15. 10.1097/00002093-199601040-00002 · DOI
  16. 10.1176/ajp.152.10.1476 · DOI
  17. 10.1093/gerona/51A.6.M313 · DOI
  18. 10.1136/jnnp.48.11.1085 · DOI
  19. 10.1001/archneur.1987.00520130016010 · DOI · Paper page
  20. 10.1001/archneur.1986.00520070020010 · DOI
  21. 10.1212/WNL.45.3.461 · DOI · Paper page
  22. 10.1001/archneur.1996.00550010045015 · DOI · Paper page
  23. 10.1016/S0140-6736(96)09328-2 · DOI · Paper page
  24. Dickson DW, 1994, Hippocampal sclerosis: A common pathological feature of dementia in very old (≥ 80 years of age) humans, Acta Neuropathol, 88, 212, 10.1007/BF00293396 · DOI · Paper page
  25. 10.1212/WNL.48.1.154 · DOI
  26. Stergachis A., 1989, Pharmacoepidemiology, 149
  27. Consensus recommendation for the postmortem diagnosis of Alzheimer's disease, 1997, The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease, Neurobiol Aging, 18, S1

Cited by

Metadata

Authors
Lim, A., Tsuang, D., Kukull, W., Nochlin, D., Leverenz, J., McCormick, W., Bowen, J., Teri, L., Thompson, J., Peskind, E. R., Raskind, M., & Larson, E. B.
Venue
Journal of the American Geriatrics Society
Publisher
Wiley
Published
1999-05
Volume
47
Issue
5
Pages
564-569
ISSN
  • 0002-8614 (ISSN-L)
  • 1532-5415
DOI
10.1111/j.1532-5415.1999.tb02571.x
OpenAlex
W2093144777
Cited by
451
References
5
FWCI
10.30
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5840 d)

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