On the Regulation of the Blood‐supply of the Brain

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

Iadecola, C. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.030 · Cited by 2,480

Neurovascular regulation in the normal brain and in Alzheimer's disease

Iadecola, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1387 · Cited by 2,213

Physiology of Astroglia

Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678

Sugar for the brain: the role of glucose in physiological and pathological brain function

Mergenthaler, P., Lindauer, U., Dienel, G. A., & Meisel, A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.07.001 · Cited by 1,612

Interpreting the BOLD Signal

Logothetis, N. K., & Wandell, B. A. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.66.082602.092845 · Cited by 1,568

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

Magistretti, P. J., & Allaman, I. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.035 · Cited by 1,285

Bidirectional control of CNS capillary diameter by pericytes

Peppiatt, C. M., Howarth, C., Mobbs, P., & Attwell, D. (2006) · Nature · doi:10.1038/nature05193 · Cited by 1,150

Working Memory: A View from Neuroimaging

Smith, E. E., & Jonides, J. (1997) · Cognitive Psychology · doi:10.1006/cogp.1997.0658 · Cited by 1,046

The neural basis of functional brain imaging signals

Attwell, D., & Iadecola, C. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02264-6 · Cited by 957

Behind the scenes of functional brain imaging: A historical and physiological perspective

Raichle, M. E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.765 · Cited by 616

Functional neuroimaging of normal human sleep by positron emission tomography

Maquet (2000) · Journal of Sleep Research · doi:10.1046/j.1365-2869.2000.00214.x · Cited by 581

The neurovascular unit - concept review

Muoio, V., Persson, P. B., & Sendeski, M. M. (2014) · Acta Physiologica · doi:10.1111/apha.12250 · Cited by 564

The Roles of Cerebral Blood Flow, Capillary Transit Time Heterogeneity, and Oxygen Tension in Brain Oxygenation and Metabolism

Jespersen, S. N., & Østergaard, L. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.153 · Cited by 504

Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex

Hrvatin, S., Hochbaum, D. R., Nagy, M. A., Cicconet, M., Robertson, K., Cheadle, L., Zilionis, R., Ratner, A., Borges-Monroy, R., Klein, A. M., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-017-0029-5 · Cited by 497

In vivo NMR studies of the glutamate neurotransmitter flux and neuroenergetics: implications for brain function

Rothman, D. L., Behar, K. L., Hyder, F., & Shulman, R. G. (2003) · Annual Review of Physiology · doi:10.1146/annurev.physiol.65.092101.142131 · Cited by 337

The Cerebral Metabolic Landscape in Autism: Intercorrelations of Regional Glucose Utilization

Horwitz, B. (1988) · Archives of Neurology · doi:10.1001/archneur.1988.00520310055018 · Cited by 331

Solving neurodegeneration: common mechanisms and strategies for new treatments

Wareham, L. K., Liddelow, S. A., Temple, S., Benowitz, L. I., Di Polo, A., Wellington, C., Goldberg, J. L., He, Z., Duan, X., Bu, G., et al. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00524-0 · Cited by 324

The “wet mind”: Water and functional neuroimaging

Bihan, D. L. (2007) · Physics in Medicine and Biology · doi:10.1088/0031-9155/52/7/r02 · Cited by 320

SEROTONIN IN THE REGULATION OF BRAIN MICROCIRCULATION

COHEN, Z., BONVENTO, G., LACOMBE, P., & HAMEL, E. (1996) · Progress in Neurobiology · doi:10.1016/s0301-0082(96)00033-0 · Cited by 314

Technical aspects and utility of fMRI using BOLD and ASL

Detre, J. A., & Wang, J. (2002) · Clinical Neurophysiology · doi:10.1016/s1388-2457(02)00038-x · Cited by 291

A brief history of human brain mapping

Raichle, M. E. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2008.11.001 · Cited by 286

Cerebral Blood Flow Response to Functional Activation

Paulson, O. B., Hasselbalch, S. G., Rostrup, E., Knudsen, G. M., & Pelligrino, D. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.188 · Cited by 264

Neuronal and vascular interactions

Andreone, B. J., Lacoste, B., & Gu, C. (2015) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071714-033835 · Cited by 256

Nonlinear coupling between cerebral blood flow, oxygen consumption, and ATP production in human visual cortex.

Lin, A.-L., Fox, P. T., Hardies, J., Duong, T. Q., & Gao, J.-H. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909711107 · Cited by 213

Molecular Mechanisms and Genetics of Oxidative Stress in Alzheimer’s Disease

Cioffi, F., Adam, R. H. I., & Broersen, K. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190863 · Cited by 204

Localized Dynamic Changes in Cortical Blood Flow with Whisker Stimulation Corresponds to Matched Vascular and Neuronal Architecture of Rat Barrels

Cox, S. B., Woolsey, T. A., & Rovainen, C. M. (1993) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1993.113 · Cited by 198

Traumatic cerebral vascular injury: the effects of concussive brain injury on the cerebral vasculature

DeWitt, D. S., & Prough, D. S. (2003) · Journal of Neurotrauma · doi:10.1089/089771503322385755 · Cited by 195

Heart rate variability and slow-paced breathing:when coherence meets resonance

Sevoz-Couche, C., & Laborde, S. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104576 · Cited by 195

Transient decrease in water diffusion observed in human occipital cortex during visual stimulation

Darquié, A., Poline, J.-B., Poupon, C., Saint-Jalmes, H., & Le Bihan, D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151125698 · Cited by 194

The role of neuronal signaling in controlling cerebral blood flow

DRAKE, C., & IADECOLA, C. (2007) · Brain and Language · doi:10.1016/j.bandl.2006.08.002 · Cited by 177

Regional cerebral blood flow during volitional expiration in man: a comparison with volitional inspiration

Ramsay, S. C., Adams, L., Murphy, K., Corfield, D. R., Grootoonk, S., Bailey, D. L., Frackowiak, R. S., & Guz, A. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019503 · Cited by 162

Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions

Kasischke, K. A., Lambert, E. M., Panepento, B., Sun, A., Gelbard, H. A., Burgess, R. W., Foster, T. H., & Nedergaard, M. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.158 · Cited by 160

The physiology of developmental changes in BOLD functional imaging signals

Harris, J. J., Reynell, C., & Attwell, D. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.04.001 · Cited by 142

Glial Cell Calcium Signaling Mediates Capillary Regulation of Blood Flow in the Retina

Biesecker, K. R., Srienc, A. I., Shimoda, A. M., Agarwal, A., Bergles, D. E., Kofuji, P., & Newman, E. A. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.1782-16.2016 · Cited by 144

Ion channel networks in the control of cerebral blood flow

Longden, T. A., Hill-Eubanks, D. C., & Nelson, M. T. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15616138 · Cited by 137

Brain temperature and its role in physiology and pathophysiology: lessons from 20 years of thermorecording

Kiyatkin, E. A. (2019) · Temperature · doi:10.1080/23328940.2019.1691896 · Cited by 122

Unraveling why we sleep: quantitative analysis reveals abrupt transition from neural reorganization to repair in early development

Cao, J., Herman, A. B., West, G. B., Poe, G., & Savage, V. M. (2020) · Science Advances · doi:10.1126/sciadv.aba0398 · Cited by 105

Mapping the functional neuroanatomy of the intact human brain with brain work imaging

Haxby, J. V., Grady, C. L., Ungerleider, L. G., & Horwitz, B. (1991) · Neuropsychologia · doi:10.1016/0028-3932(91)90009-w · Cited by 104

Stimulated changes in localized cerebral energy consumption under anesthesia

Shulman, R. G., Rothman, D. L., & Hyder, F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3245 · Cited by 93

Water diffusion in brain cortex closely tracks underlying neuronal activity

Tsurugizawa, T., Ciobanu, L., & Le Bihan, D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303178110 · Cited by 93

Sharing neuroimaging studies of human cognition

Horn, J. D. V., Grafton, S. T., Rockmore, D., & Gazzaniga, M. S. (2004) · Nature Neuroscience · doi:10.1038/nn1231 · Cited by 83

A neuronal MCT2 knockdown in the rat somatosensory cortex reduces both the NMR lactate signal and the BOLD response during whisker stimulation

Mazuel, L., Blanc, J., Repond, C., Bouchaud, V., Raffard, G., Déglon, N., Bonvento, G., Pellerin, L., & Bouzier-Sore, A.-K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174990 · Cited by 44

Subjective Cognitive Decline Modifies the Relationship Between Cerebral Blood Flow and Memory Function in Cognitively Normal Older Adults

Hays, C. C., Zlatar, Z. Z., Campbell, L., Meloy, M. J., & Wierenga, C. E. (2018) · Journal of the International Neuropsychological Society · doi:10.1017/s135561771700087x · Cited by 34

Synaptic micromechanics and brain softening as a mechanobiological hypothesis for Alzheimer’s disease

Le Bihan, D. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1858655 · Cited by 1

40 Years of diffusion MRI in the brain: From history to emerging frontiers

Le Bihan, D. (2026) · Imaging Neuroscience · doi:10.1162/imag.a.1365