Immunity, Inflammation, and Allergy in the Gut

CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes

Tiede, I., Fritz, G., Strand, S., Poppe, D., Dvorsky, R., Strand, D., Lehr, H. A., Wirtz, S., Becker, C., Atreya, R., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16432 · Cited by 828

Bacterial flagellin is a dominant antigen in Crohn disease

Lodes, M. J., Cong, Y., Elson, C. O., Mohamath, R., Landers, C. J., Targan, S. R., Fort, M., & Hershberg, R. M. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420295 · Cited by 802

Controlled trial of metronidazole treatment for prevention of crohn's recurrence after ileal resection

Rutgeerts, P., Hiele, M., Geboes, K., Peeters, M., Penninckx, F., Aerts, R., & Kerremans, R. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90121-3 · Cited by 743

Development of the Human Infant Intestinal Microbiota

Palmer, C., Bik, E. M., DiGiulio, D. B., Relman, D. A., & Brown, P. O. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050177 · Cited by 2,877

Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut

Artis, D. (2008) · Nature reviews. Immunology · doi:10.1038/nri2316 · Cited by 1,136

Brain-gut-microbe communication in health and disease

Grenham, S., Clarke, G., Cryan, J. F., & Dinan, T. G. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00094 · Cited by 952

Comparative metagenomics revealed commonly enriched gene sets in human gut microbiomes

Kurokawa, K., Itoh, T., Kuwahara, T., Oshima, K., Toh, H., Toyoda, A., Takami, H., Morita, H., Sharma, V. K., Srivastava, T. P., et al. (2007) · DNA Research · doi:10.1093/dnares/dsm018 · Cited by 869

Surface area of the digestive tract – revisited

Helander, H. F., & Fändriks, L. (2014) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2014.898326 · Cited by 860

Interleukin-23 drives innate and T cell–mediated intestinal inflammation

Hue, S., Ahern, P., Buonocore, S., Kullberg, M. C., Cua, D. J., McKenzie, B. S., Powrie, F., & Maloy, K. J. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061099 · Cited by 823

Chylomicrons promote intestinal absorption of lipopolysaccharides

Ghoshal, S., Witta, J., Zhong, J., de Villiers, W., & Eckhardt, E. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800156-jlr200 · Cited by 662

The bile acid receptor FXR is a modulator of intestinal innate immunity

Vavassori, P., Mencarelli, A., Renga, B., Distrutti, E., & Fiorucci, S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803978 · Cited by 655

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

Welz, P.-S., Wullaert, A., Vlantis, K., Kondylis, V., Fernández-Majada, V., Ermolaeva, M., Kirsch, P., Sterner-Kock, A., van Loo, G., & Pasparakis, M. (2011) · Nature · doi:10.1038/nature10273 · Cited by 594

Diet and Immune Function

Childs, C. E., Calder, P. C., & Miles, E. A. (2019) · Nutrients · doi:10.3390/nu11081933 · Cited by 532

Assembly of the human intestinal microbiota

Dethlefsen, L., Eckburg, P. B., Bik, E. M., & Relman, D. A. (2006) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2006.06.013 · Cited by 509

Feeding the microbiota–gut–brain axis: Diet, microbiome, and neuropsychiatry

Sandhu, K. V., Sherwin, E., Schellekens, H., Stanton, C., Dinan, T. G., & Cryan, J. F. (2017) · Translational Research · doi:10.1016/j.trsl.2016.10.002 · Cited by 491

Paneth cells, defensins, and the commensal microbiota: A hypothesis on intimate interplay at the intestinal mucosa

Salzman, N. H., Underwood, M. A., & Bevins, C. L. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.04.002 · Cited by 414

TH9 cells that express the transcription factor PU.1 drive T cell–mediated colitis via IL-9 receptor signaling in intestinal epithelial cells

Gerlach, K., Hwang, Y., Nikolaev, A., Atreya, R., Dornhoff, H., Steiner, S., Lehr, H.-A., Wirtz, S., Vieth, M., Waisman, A., et al. (2014) · Nature Immunology · doi:10.1038/ni.2920 · Cited by 407

Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome

Zhou, Q., Zhang, B., & Verne, N. G. (2009) · Pain · doi:10.1016/j.pain.2009.06.017 · Cited by 373

Increased susceptibility to colitis and colorectal tumors in mice lacking core 3–derived O-glycans

An, G., Wei, B., Xia, B., McDaniel, J. M., Ju, T., Cummings, R. D., Braun, J., & Xia, L. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061929 · Cited by 352

Ageing and gut microbes: Perspectives for health maintenance and longevity

Biagi, E., Candela, M., Turroni, S., Garagnani, P., Franceschi, C., & Brigidi, P. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.10.005 · Cited by 276

Nonalcoholic fatty liver disease and aging: epidemiology to management.

Bertolotti, M. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i39.14185 · Cited by 270

Altered gut flora and environment in patients with severe SIRS

Shimizu, K., Ogura, H., Goto, M., Asahara, T., Nomoto, K., Morotomi, M., Yoshiya, K., Matsushima, A., Sumi, Y., Kuwagata, Y., et al. (2006) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/01.ta.0000197374.99755.fe · Cited by 257

Nanoparticle uptake by the oral route: Fulfilling its potential?

Florence, A. T. (2005) · Drug Discovery Today: Technologies · doi:10.1016/j.ddtec.2005.05.019 · Cited by 248

Gut-Liver Physiomimetics Reveal Paradoxical Modulation of IBD-Related Inflammation by Short-Chain Fatty Acids

Trapecar, M., Communal, C., Velazquez, J., Maass, C. A., Huang, Y.-J., Schneider, K., Wright, C. W., Butty, V., Eng, G., Yilmaz, O., et al. (2020) · Cell Systems · doi:10.1016/j.cels.2020.02.008 · Cited by 218

Cytokines IL-17 and IL-22 in the host response to infection

Valeri, M., & Raffatellu, M. (2016) · Pathogens and Disease · doi:10.1093/femspd/ftw111 · Cited by 202

Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome

Zhou, Q., Verne, M. L., Fields, J. Z., Lefante, J. J., Basra, S., Salameh, H., & Verne, G. N. (2019) · Gut · doi:10.1136/gutjnl-2017-315136 · Cited by 195

Fecal microbiota transplantation ameliorates bone loss in mice with ovariectomy-induced osteoporosis via modulating gut microbiota and metabolic function

Zhang, Y.-W., Cao, M.-M., Li, Y.-J., Lu, P.-P., Dai, G.-C., Zhang, M., Wang, H., & Rui, Y.-F. (2022) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2022.08.003 · Cited by 184

Obeticholic acid reduces bacterial translocation and inhibits intestinal inflammation in cirrhotic rats

Úbeda, M., Lario, M., Muñoz, L., Borrero, M.-J., Rodríguez-Serrano, M., Sánchez-Díaz, A.-M., del Campo, R., Lledó, L., Pastor, Ó., García-Bermejo, L., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2015.12.010 · Cited by 178

Role of gut microbiota in intestinal wound healing and barrier function

Alam, A., & Neish, A. (2018) · Tissue Barriers · doi:10.1080/21688370.2018.1539595 · Cited by 166

Dysfunction of the Microbiota-Gut-Brain Axis in Neurodegenerative Disease: The Promise of Therapeutic Modulation With Prebiotics, Medicinal Herbs, Probiotics, and Synbiotics

Peterson, C. T. (2020) · Journal of Evidence-Based Integrative Medicine · doi:10.1177/2515690x20957225 · Cited by 160

Role of the Gut Microbiome in Autism Spectrum Disorders

Pulikkan, J., Mazumder, A., & Grace, T. (2019) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-030-05542-4_13 · Cited by 142

Commensal and Probiotic Bacteria Influence Intestinal Barrier Function and Susceptibility to Colitis in Nod1−/−;Nod2−/− Mice

Natividad, J. M. M., Petit, V., Huang, X., de Palma, G., Jury, J., Sanz, Y., Philpott, D., Garcia Rodenas, C. L., McCoy, K. D., & Verdu, E. F. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.22848 · Cited by 139

Polyamines are required for expression of Toll-like receptor 2 modulating intestinal epithelial barrier integrity

Chen, J., Rao, J. N., Zou, T., Liu, L., Marasa, B. S., Xiao, L., Zeng, X., Turner, D. J., & Wang, J.-Y. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00201.2007 · Cited by 107

Well‐controlled proinflammatory cytokine responses of Peyer’s patch cells to probiotic Lactobacillus casei

Chiba, Y., Shida, K., Nagata, S., Wada, M., Bian, L., Wang, C., Shimizu, T., Yamashiro, Y., Kiyoshima‐Shibata, J., Nanno, M., et al. (2010) · Immunology · doi:10.1111/j.1365-2567.2009.03204.x · Cited by 102

The prebiotic potential of polysaccharides and extracts of seaweeds

Zaporozhets, T. S., Besednova, N. N., Kuznetsova, T. A., Zvyagintseva, T. N., Makarenkova, I. D., Kryzhanovsky, S. P., & Melnikov, V. G. (2014) · Russian Journal of Marine Biology · doi:10.1134/s1063074014010106 · Cited by 98

Immune Development and Intestinal Microbiota in Celiac Disease

Pozo-Rubio, T., Olivares, M., Nova, E., De Palma, G., Mujico, J. R., Ferrer, M. D., Marcos, A., & Sanz, Y. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/654143 · Cited by 82

5-Caffeoylquinic Acid and Caffeic Acid Down-Regulate the Oxidative Stress- and TNF-α-Induced Secretion of Interleukin-8 from Caco-2 Cells

Zhao, Z., Shin, H. S., Satsu, H., Totsuka, M., & Shimizu, M. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf073168d · Cited by 77

Altered intestinal permeability in patients with primary fibromyalgia and in patients with complex regional pain syndrome

Goebel, A., Buhner, S., Schedel, R., Lochs, H., & Sprotte, G. (2008) · Rheumatology · doi:10.1093/rheumatology/ken140 · Cited by 76

Microbiota‐microglia connections in age‐related cognition decline

Zhou, R., Qian, S., Cho, W. C. S., Zhou, J., Jin, C., Zhong, Y., Wang, J., Zhang, X., Xu, Z., Tian, M., et al. (2022) · Aging Cell · doi:10.1111/acel.13599 · Cited by 71

Gut microbiota as a candidate for lifespan extension: an ecological/evolutionary perspective targeted on living organisms as metaorganisms

Ottaviani, E., Ventura, N., Mandrioli, M., Candela, M., Franchini, A., & Franceschi, C. (2011) · Biogerontology · doi:10.1007/s10522-011-9352-5 · Cited by 64

Unfractionated heparin and new heparin analogues from ascidians (chordate-tunicate) ameliorate colitis in rats

Belmiro, C. L. R., Castelo-Branco, M. T. L., Melim, L. M. C., Schanaider, A., Elia, C., Madi, K., Pavão, M. S. G., & de Souza, H. S. P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807211200 · Cited by 57

Interactions between prebiotics, probiotics, polyunsaturated fatty acids and polyphenols: diet or supplementation for metabolic syndrome prevention?

Peluso, I., Romanelli, L., & Palmery, M. (2014) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2014.880670 · Cited by 48

Enrichment and identification of small proteins in a simplified human gut microbiome

Petruschke, H., Anders, J., Stadler, P. F., Jehmlich, N., & von Bergen, M. (2020) · Journal of Proteomics · doi:10.1016/j.jprot.2019.103604 · Cited by 43

Helminth therapy: Advances in the use of parasitic worms against Inflammatory Bowel Diseases and its challenges

Maruszewska-Cheruiyot, M., Donskow-Łysoniewska, K., & Doligalska, M. (2018) · Helminthologia · doi:10.1515/helm-2017-0048 · Cited by 38

Effects of bread yeast cell wall beta-glucans on mice with loperamide-induced constipation

Chen, Z., Lin, S., Jiang, Y., Liu, L., Jiang, J., Chen, S., Tong, Y., & Wang, P. (2019) · Journal of Medicinal Food · doi:10.1089/jmf.2019.4407 · Cited by 34

Molecular analysis of the intestinal microflora in IBD

Tannock, G. W. (2008) · Mucosal Immunology · doi:10.1038/mi.2008.54 · Cited by 33

Altered profiles of fecal metabolites correlate with visceral hypersensitivity and may contribute to symptom severity of diarrhea-predominant irritable bowel syndrome

Zhang, W.-X., Zhang, Y., Qin, G., Li, K.-M., Wei, W., Li, S.-Y., & Yao, S.-K. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i43.6416 · Cited by 32

Bacterial biofilms associated with food particles in the human large bowel

Van Wey, A. S., Cookson, A. L., Roy, N. C., McNabb, W. C., Soboleva, T. K., & Shorten, P. R. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000589 · Cited by 31

Hydroxycarboxylic Acid Receptor 2, a Pleiotropically Linked Receptor for the Multiple Sclerosis Drug, Monomethyl Fumarate. Possible Implications for the Inflammatory Response

Parodi, B., Sanna, A., Cedola, A., Uccelli, A., & Kerlero de Rosbo, N. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.655212 · Cited by 20

The knowns and unknowns of cardiac autoimmunity in viral myocarditis

Mone, K., & Reddy, J. (2023) · Reviews in Medical Virology · doi:10.1002/rmv.2478 · Cited by 19