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Suppression of TNF-α-Induced Apoptosis by NF-κB
Abstract
Tumor necrosis factor α (TNF-α) signaling gives rise to a number of events, including activation of transcription factor NF-κB and programmed cell death (apoptosis). Previous studies of TNF-α signaling have suggested that these two events occur independently. The sensitivity and kinetics of TNF-α-induced apoptosis are shown to be enhanced in a number of cell types expressing a dominant-negative IκBα (IκBαM). These findings suggest that a negative feedback mechanism results from TNF-α signaling in which NF-κB activation suppresses the signals for cell death.
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Metadata
- Authors
- Van Antwerp, D. J., Martin, S. J., Kafri, T., Green, D. R., & Verma, I. M.
- Venue
- Science
- Published
- 1996-11
- Volume
- 274
- Issue
- 5288
- Pages
- 787-789
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1492606093
- Cited by
- 2,581
- References
- 2
- FWCI
- 100.28
- Type
- journal article
- Language
- en
- Open access
- closed
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