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A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

Miki, Yoshio, Swensen, Jeff, Shattuck-Eidens, Donna, Futreal, P. Andrew, Harshman, Keith, Tavtigian, Sean, Liu, Qingyun, Cochran, Charles, Bennett, L. Michelle, Ding, Wei, Bell, Russell, Rosenthal, Judith, Hussey, Charles, Tran, Thanh, McClure, Melody, Frye, Cheryl, Hattier, Tom, Phelps, Robert, Haugen-Strano, Astrid, Katcher, Harold, Yakumo, Kazuko, Gholami, Zahra, Shaffer, Daniel, Stone, Steven, Bayer, Steven, Wray, Christian, Bogden, Robert, Dayananth, Priya, Ward, John, Tonin, Patricia, Narod, Steven, Bristow, Pam K., Norris, Frank H., Helvering, Leah, Morrison, Paul, Rosteck, Paul, Lai, Mei, Barrett, J. Carl, Lewis, Cathryn, Neuhausen, Susan, Cannon-Albright, Lisa, Goldgar, David, Wiseman, Roger, Kamb, Alexander, Skolnick, Mark H.·1994·Science
DOI 10.1126/science.7545954
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Abstract

A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast and ovarian cancer, has been identified by positional cloning methods. Probable predisposing mutations have been detected in five of eight kindreds presumed to segregate BRCA1 susceptibility alleles. The mutations include an 11-base pair deletion, a 1-base pair insertion, a stop codon, a missense substitution, and an inferred regulatory mutation. The BRCA1 gene is expressed in numerous tissues, including breast and ovary, and encodes a predicted protein of 1863 amino acids. This protein contains a zinc finger domain in its amino-terminal region, but is otherwise unrelated to previously described proteins. Identification of BRCA1 should facilitate early diagnosis of breast and ovarian cancer susceptibility in some individuals as well as a better understanding of breast cancer biology.

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Cited by

Metadata

Authors
Miki, Y., Swensen, J., Shattuck-Eidens, D., Futreal, P. A., Harshman, K., Tavtigian, S., Liu, Q., Cochran, C., Bennett, L. M., Ding, W., Bell, R., Rosenthal, J., Hussey, C., Tran, T., McClure, M., Frye, C., Hattier, T., Phelps, R., Haugen-Strano, A., Katcher, H., Yakumo, K., Gholami, Z., Shaffer, D., Stone, S., Bayer, S., Wray, C., Bogden, R., Dayananth, P., Ward, J., Tonin, P., Narod, S., Bristow, P. K., Norris, F. H., Helvering, L., Morrison, P., Rosteck, P., Lai, M., Barrett, J. C., Lewis, C., Neuhausen, S., Cannon-Albright, L., Goldgar, D., Wiseman, R., Kamb, A., & Skolnick, M. H.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1994-10-07
Volume
266
Issue
5182
Pages
66-71
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.7545954
OpenAlex
W2109465247
Cited by
6,071
References
0
FWCI
138.64
Type
journal article
Language
en
Open access
closed

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