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Individual intestinal symbionts induce a distinct population of RORγ + regulatory T cells
Open accessAbstract
Gut microbes make T cells keep the peace: Our guts harbor trillions of microbial inhabitants, some of which regulate the types of immune cells that are present in the gut. For instance, Clostridium species of bacteria induce a type of T cell that promotes tolerance between the host and its microbial contents. Ohnmacht et al. and Sefik et al. characterized a population of gut regulatory T cells in mice, which required gut microbiota to survive. Multiple bacterial species of the microbiota could induce transcription factor–expressing regulatory T cells that helped maintain immune homeostasis. Mice engineered to lack these transcription factors exhibited enhanced susceptibility to colonic inflammation and had elevated amounts of proinflammatory molecules associated with allergies (see the Perspective by Hegazy and Powrie). Science , this issue pp. 989 and 993
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“Yet, Helios, Nrp-1 or ROR-γt are widely accepted for the discrimination of tTreg and pTreg cells under homeostatic conditions [364-366, 437-440].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [437]
Experimental — accuracy not yet measuredIn the citing paper
“In addition, the gut microbiome regulates the activity of retinoic acid receptor-related orphan receptor gamma-positive (RORγ+) Treg cells, dysregulation of which can lead to diseases such as colitis, food allergy, and colon cancer.622,701–704”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [701]
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Metadata
- Authors
- Sefik, E., Geva-Zatorsky, N., Oh, S., Konnikova, L., Zemmour, D., McGuire, A. M., Burzyn, D., Ortiz-Lopez, A., Lobera, M., Yang, J., Ghosh, S., Earl, A., Snapper, S. B., Jupp, R., Kasper, D., Mathis, D., & Benoist, C.
- Affiliations
- Harvard University (US)
- Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston 02115, MA, USA.
- Brigham and Women's Hospital (US)
- Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
- Tempero Pharmaceuticals, a GSK Company, Cambridge, MA 02115, USA.
- Broad Institute (US)
- UCB Pharma (United Kingdom) (GB)
- Corresponding author
- Mathis, Diane
- Benoist, Christophe
- ORCID
- Venue
- Science
- Published
- 2015-08-28
- Volume
- 349
- Issue
- 6251
- Pages
- 993-997
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4700932
- OpenAlex
- W2143889757
- Cited by
- 879
- References
- 60
- Citations by year
- 2026: 54 · 2025: 76 · 2024: 83 · 2023: 96 · 2022: 98 · 2021: 91 · 2020: 90 · 2019: 86 · 2018: 78 · 2017: 69 · 2016: 56 · 2015: 2
- FWCI
- 33.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (R01-AI51530, R56-AI110630)
- European Molecular Biology Organization
- Human Frontier Science Program
- Helmsley Charitable Trust
- Boehringer Ingelheim Fonds
- J.P.B. Foundation
- UCB Pharma
- Center for Inflammatory Bowel Disease Treatment and Research
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- RORγ, regulatory T cells, Foxp3, gut microbiota, intestinal symbionts, Th17 cells, colonic inflammation, Th1/Th17 balance, transcriptional regulation, immune homeostasis
- MeSH terms
- Animals, Bacteria, Colitis, Ulcerative, Colon, Homeostasis, Humans, Intestinal Mucosa, Mice, Inbred C57BL, Symbiosis, Transcription, Genetic, T-Lymphocyte Subsets, Immunity, Mucosal, Bacteroidetes, T-Lymphocytes, Regulatory, Forkhead Transcription Factors, Nuclear Receptor Subfamily 1, Group F, Member 3, Th17 Cells, Transcriptome, Microbiota
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